GO:0052741

MF

(R)-limonene 6-monooxygenase activity

Catalysis of the reaction: (4R)-limonene + H+ + NADPH + O2 = (1R,5S)-carveol + H2O + NADP+.

CYP2C9

GO:0052745

MF

inositol phosphate phosphatase activity

Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate.

OCRL, MINPP1

GO:0052794

MF

exo-alpha-(2->3)-sialidase activity

Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates.

NEU1

GO:0052795

MF

exo-alpha-(2->6)-sialidase activity

Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates.

NEU1

GO:0052796

MF

exo-alpha-(2->8)-sialidase activity

Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates.

NEU1

GO:0052798

MF

beta-galactoside alpha-2,3-sialyltransferase activity

Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor.

ST3GAL6

GO:0052810

MF

1-phosphatidylinositol-5-kinase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H(+).

PIP5K1B

GO:0052811

MF

1-phosphatidylinositol-3-phosphate 4-kinase activity

Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+).

PIP5K1B, PIP5K1C, PIP4K2B

GO:0052812

MF

phosphatidylinositol-3,4-bisphosphate 5-kinase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).

PIP5K1B, PIP5K1C

GO:0052815

MF

medium-chain acyl-CoA hydrolase activity

Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length.

ACOT8

GO:0052821

MF

DNA-7-methyladenine glycosylase activity

Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site.

MPG

GO:0052822

MF

DNA-3-methylguanine glycosylase activity

Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site.

MPG

GO:0052825

MF

inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity

Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate.

ITPK1

GO:0052826

MF

inositol hexakisphosphate 2-phosphatase activity

Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate.

MINPP1

GO:0052828

MF

inositol-3,4-bisphosphate 4-phosphatase activity

Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate.

INPP4B, INPP4A

GO:0052829

MF

inositol-1,3,4-trisphosphate 1-phosphatase activity

Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate.

INPP1

GO:0052830

MF

inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity

Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate.

ITPK1

GO:0052831

MF

inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity

Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate.

ITPK1

GO:0052832

MF

inositol monophosphate 3-phosphatase activity

Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate.

IMPA1

GO:0052833

MF

inositol monophosphate 4-phosphatase activity

Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate.

IMPA1

GO:0052834

MF

inositol monophosphate phosphatase activity

Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate.

IMPA1

GO:0052835

MF

inositol-3,4,6-trisphosphate 1-kinase activity

Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+).

ITPK1

GO:0052836

MF

inositol 5-diphosphate pentakisphosphate 5-kinase activity

Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate.

IP6K2

GO:0052839

MF

inositol diphosphate tetrakisphosphate kinase activity

Catalysis of the reaction: Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate.

IP6K2

GO:0052840

MF

inositol diphosphate tetrakisphosphate diphosphatase activity

Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate.

NUDT3, NUDT10, NUDT11

GO:0052841

MF

inositol bisdiphosphate tetrakisphosphate diphosphatase activity

Catalysis of the reaction: inositol bisdiphosphate tetrakisphosphate + H2O = inositol diphosphate pentakisphosphate + phosphate.

NUDT3, NUDT10, NUDT11

GO:0052842

MF

inositol diphosphate pentakisphosphate diphosphatase activity

Catalysis of the reaction: inositol diphosphate pentakisphosphate + H2O = inositol hexakisphosphate + phosphate.

NUDT3, NUDT10, NUDT11

GO:0052843

MF

inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity

Catalysis of the reaction: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.

NUDT3, NUDT10, NUDT11

GO:0052844

MF

inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity

Catalysis of the reaction: inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.

NUDT3, NUDT10, NUDT11

GO:0052845

MF

inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity

Catalysis of the reaction: inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.

NUDT3, NUDT10, NUDT11

GO:0052846

MF

inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity

Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+.

NUDT3, NUDT10, NUDT11

GO:0052847

MF

inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity

Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+.

NUDT3, NUDT10, NUDT11

GO:0052848

MF

inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity

Catalysis of the reaction: 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + H+.

NUDT3, NUDT10, NUDT11

GO:0052851

MF

ferric-chelate reductase (NADPH) activity

Catalysis of the reaction: 2 Fe3+ + NADPH = 2 Fe2+ + H+ + NADP+ .

STEAP4

GO:0052852

MF

very-long-chain-(S)-2-hydroxy-acid oxidase activity

Catalysis of the reaction: very-long-chain (S)-2-hydroxy-acid + O2 = very-long-chain 2-oxo acid + hydrogen peroxide. Very long chain refers to a chain length of greater than 18 carbons.

HAO2

GO:0052853

MF

long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity

Catalysis of the reaction: long-chain-(S)-2-hydroxy-acid + O2 = long-chain-2-oxo acid + hydrogen peroxide. Long chain refers to a chain length of 14 to 18 carbons.

HAO2

GO:0052854

MF

medium-chain-(S)-2-hydroxy-acid oxidase activity

Catalysis of the reaction: medium-chain-(S)-2-hydroxy-acid + O2 = medium-chain-2-oxo acid + hydrogen peroxide. Medium chain refers to a chain length of between 8 and 12 carbons.

HAO2

GO:0052855

MF

ADP-dependent NAD(P)H-hydrate dehydratase activity

Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + 3 H(+) + NADH + phosphate.

CARKD

GO:0052858

MF

peptidyl-lysine acetyltransferase activity

Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine.

NAA50

GO:0052890

MF

oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin.

ACOX3, ACADSB, ACADVL, ACOX1, ACOX2

GO:0052906

MF

tRNA (guanine(37)-N(1))-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine.

TRMT5

GO:0052907

MF

23S rRNA (adenine(1618)-N(6))-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA.

METTL16

GO:0052909

MF

18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity

Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA.

DIMT1

GO:0052918

MF

dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity

Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.

ALG9

GO:0052926

MF

dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity

Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.

ALG9

GO:0052927

MF

CTP:tRNA cytidylyltransferase activity

Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate.

TRNT1

GO:0052928

MF

CTP:3'-cytidine-tRNA cytidylyltransferase activity

Catalysis of the reaction: a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate.

TRNT1

GO:0052929

MF

ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity

Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate.

TRNT1

GO:0055056

MF

D-glucose transmembrane transporter activity

Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of the membrane to the other.

SLC2A10, SLC2A1, SLC2A3, SLC2A4, SLC2A6

GO:0055077

MF

gap junction hemi-channel activity

A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction.

GJA5, PANX2, PANX1

GO:0055100

MF

adiponectin binding

Interacting selectively and non-covalently with adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism.

CDH13, ADIPOR2, ADIPOR1

GO:0055102

MF

lipase inhibitor activity

Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.

APOA1, APOA2, APOC1, APOC3, FAF2

GO:0055103

MF

ligase regulator activity

Modulates the activity of a ligase.

CAPN3

GO:0055105

MF

ubiquitin-protein transferase inhibitor activity

Stops, prevents or reduces the activity of a ubiquitin-protein transferase.

GLMN

GO:0055106

MF

ubiquitin-protein transferase regulator activity

Modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein.

TRIB2, TRIB3, TRIB1

GO:0055131

MF

C3HC4-type RING finger domain binding

Interacting selectively and non-covalently with a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway.

HSPA1A, HSPA1B, DNAJA1, KCNH2, PINK1

GO:0060001

MF

minus-end directed microfilament motor activity

Catalysis of movement along a microfilament towards the minus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The minus end of an actin filament is the end that does not preferentially add actin monomers.

MYO6

GO:0060002

MF

plus-end directed microfilament motor activity

Catalysis of movement along a microfilament towards the plus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The plus end of an actin filament is the end that preferentially adds actin monomers.

MYO19, MYO10

GO:0060072

MF

large conductance calcium-activated potassium channel activity

Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.

KCNMA1

GO:0060090

MF

binding, bridging

The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.

PDCD6, GAS6, TRADD

GO:0060175

MF

brain-derived neurotrophic factor-activated receptor activity

Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.

NTRK2

GO:0060228

MF

phosphatidylcholine-sterol O-acyltransferase activator activity

Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines.

APOA1, APOE, APOA2, APOC1, APOA5

GO:0060229

MF

lipase activator activity

Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.

APOA5

GO:0060230

MF

lipoprotein lipase activator activity

Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein.

APOH, APOA5

GO:0060698

MF

endoribonuclease inhibitor activity

Stops, prevents or reduces the activity of an endoribonuclease, any enzyme that catalyzes the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.

ABCE1

GO:0061133

MF

endopeptidase activator activity

Increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

PSME3, ADRM1

GO:0061503

MF

tRNA threonylcarbamoyladenosine dehydratase

Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A.

UBA5

GO:0061513

MF

glucose 6-phosphate:inorganic phosphate antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + inorganic phosphate(in) = glucose 6-phosphate(in) + inorganic phosphate(out).

SLC37A4

GO:0061547

MF

glycogen synthase activity, transferring glucose-1-phosphate

Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate.

GYS1, GYS2

GO:0061575

MF

cyclin-dependent protein serine/threonine kinase activator activity

Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase.

CKS2, CKS1B

GO:0061578

MF

Lys63-specific deubiquitinase activity

Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein.

USP27X, ATXN3, CYLD

GO:0061598

MF

molybdopterin adenylyltransferase activity

Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin.

GPHN

GO:0061599

MF

molybdopterin molybdotransferase activity

Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.

GPHN

GO:0061630

MF

ubiquitin protein ligase activity

Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S --> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate. Note that this may include the extension of ubiquitin chains.

TMEM189, WWP2, UBE2C, MDM4, SIAH2, MED7, PARK2, TRIM37, RAG1, CDC34, UBE2A, RNF144A, CDC42, UBE2H, RBX1, UBE2B, SKP1, XIAP, MDM2, CBLB, SKP2, PPIL2, UBE2V1, MED21, CUL2, CUL3, CUL4A, CUL4B, UBE2V2, UBE2S, MARCH8, RNF19B, RNF111, RNF165, UBR3, CBLL1, RNF144B, RBBP6, SYVN1, C19orf68, CACUL1, SIAH1, UBR1, UBE2J2, RNF152, RNF149, FBXO30, MARCH1, RNF128, MYLIP, RFFL, CUL5, MED12, MIB2, UBE2W, MED30, ITCH, UHRF2, UHRF1, RNF126, TRIM6, RNF38, WWP1, UBE2Z, AKTIP, RNF121, MED20, SMURF2, UBE2T, RAD18, RNF146, RNF19A, MED17, RLIM, RNF216, RNF181, RNF14, RABGEF1, AMFR, PRPF19, STUB1, PDZRN3, RNF24, RNF6, BTRC, ARIH1, RNF114

GO:0061631

MF

ubiquitin conjugating enzyme activity

Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.

UBE2QL1, UBE2C, CDC34, UBE2A, UBE2E1, UBE2D3, UBE2H, UBE2B, UBE2V2, UBE2S, UBE2J2, UBE2E3, UBE2E2, UBE2Z, UBE2T, UBE2D4

GO:0061649

MF

ubiquitinated histone binding

Interacting selectively and non-covalently with a histone protein in which a residue has been modified by ubiquitination. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.

USP15

GO:0061656

MF

SUMO conjugating enzyme activity

Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y -> Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue.

UBE2I

GO:0061665

MF

SUMO ligase activity

Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S --> X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate.

ZNF451

GO:0061676

MF

importin-alpha family protein binding

Interacting selectively and non-covalently with any member of the importin-alpha family.

GOLGA2, TPX2

GO:0061712

MF

tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase

Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine.

CDKAL1

GO:0061714

MF

folic acid receptor activity

Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis.

FOLR1

GO:0061752

MF

telomeric repeat-containing RNA binding

Interacting selectively and non-covalently with long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats.

KDM1A, HNRNPA1

GO:0070006

MF

metalloaminopeptidase activity

Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

MMP14, METAP2, MMP15, MMP16, NPEPPS, ERAP2, AOPEP, ERAP1, LNPEP, LOC440434

GO:0070008

MF

serine-type exopeptidase activity

Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

PREP, PREPL

GO:0070012

MF

oligopeptidase activity

Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds.

NDEL1

GO:0070016

MF

armadillo repeat domain binding

Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation.

CNOT1, AXIN1, STRN3, CHD8, TCF7L2, STRN4

GO:0070025

MF

carbon monoxide binding

Interacting selectively and non-covalently with carbon monoxide (CO).

CBS

GO:0070026

MF

nitric oxide binding

Interacting selectively and non-covalently with nitric oxide (NO).

GSTP1, CBS

GO:0070034

MF

telomerase RNA binding

Interacting selectively and non-covalently with the telomerase RNA template.

DKC1, HNRNPC, SNRPB, SNRPD3, HNRNPU, NAF1, TEP1, NOP10, GAR1, SMG5

GO:0070037

MF

rRNA (pseudouridine) methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule.

EMG1

GO:0070039

MF

rRNA (guanosine-2'-O-)-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine.

MRM1

GO:0070051

MF

fibrinogen binding

Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade.

THBS1, FBLN1

GO:0070052

MF

collagen V binding

Interacting selectively and non-covalently with a type V collagen trimer.

ECM2, THBS1

GO:0070053

MF

thrombospondin receptor activity

Combining with thrombospondin and transmitting the signal to initiate a change in cell activity.

F2, CD36, SDC4, CD47

GO:0070061

MF

fructose binding

Interacting selectively and non-covalently with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose.

ALDOA, PFKL, SLC2A5

GO:0070063

MF

RNA polymerase binding

Interacting selectively and non-covalently with an RNA polymerase molecule or complex.

BIN1, CCNT1, CCNT2, PPIB, ZFP36, STOM, TAF10, PKN2, PABPN1, ANP32B, YTHDC2, RRN3, PHRF1

GO:0070064

MF

proline-rich region binding

Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.

APBB1, PRPF40A, PFN1, GHR, CSK, YAP1, ITSN1, GAREM1, CYLD, ABI2, BAIAP2L1

GO:0070080

MF

titin Z domain binding

Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.

ACTN2

GO:0070087

MF

chromo shadow domain binding

Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.

SP100, ATRX, CHAF1A, TRIM28, NIPBL

GO:0070095

MF

fructose-6-phosphate binding

Interacting selectively and non-covalently with fructose 6-phosphate.

PFKFB1, PFKL