GO:0047522

MF

15-oxoprostaglandin 13-oxidase activity

Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+.

PTGR1

GO:0047555

MF

3',5'-cyclic-GMP phosphodiesterase activity

Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

PDE5A, PDE9A, PDE3B, PDE3A

GO:0047598

MF

7-dehydrocholesterol reductase activity

Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+.

DHCR7

GO:0047617

MF

acyl-CoA hydrolase activity

Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.

NUDT19, ACOT7, ACOT8, THEM4, ACOT4, ACOT13, ACOT9

GO:0047631

MF

ADP-ribose diphosphatase activity

Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.

NUDT9, NUDT5

GO:0047638

MF

albendazole monooxygenase activity

Catalysis of the reaction: albendazole + H(+) + NADPH + O(2) = albendazole S-oxide + H(2)O + NADP(+).

CYP3A4

GO:0047676

MF

arachidonate-CoA ligase activity

Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+).

ACSL4

GO:0047693

MF

ATP diphosphatase activity

Catalysis of the reaction: ATP + H2O = AMP + diphosphate.

NUDT1

GO:0047696

MF

beta-adrenergic receptor kinase activity

Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor.

GRK5, ADRBK2, GRK6

GO:0047704

MF

bile-salt sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.

SULT2A1

GO:0047710

MF

bis(5'-adenosyl)-triphosphatase activity

Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP + 2 H(+).

FHIT, ENPP4

GO:0047718

MF

indanol dehydrogenase activity

Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+.

AKR1C3, AKR1C1

GO:0047750

MF

cholestenol delta-isomerase activity

Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol.

EBP, EBPL

GO:0047751

MF

cholestenone 5-alpha-reductase activity

Catalysis of the reaction: 5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH.

SRD5A1, SRD5A2

GO:0047756

MF

chondroitin 4-sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate.

CHST11

GO:0047757

MF

chondroitin-glucuronate 5-epimerase activity

Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate.

DSEL, DSE

GO:0047760

MF

butyrate-CoA ligase activity

Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA.

ACSM3, AACS

GO:0047783

MF

corticosterone 18-monooxygenase activity

Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O.

CYP11B1, CYP11B2

GO:0047787

MF

delta4-3-oxosteroid 5beta-reductase activity

Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+.

AKR1C3

GO:0047840

MF

dCTP diphosphatase activity

Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate.

DCTPP1

GO:0047844

MF

deoxycytidine deaminase activity

Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3.

APOBEC3G, APOBEC3B

GO:0047860

MF

diiodophenylpyruvate reductase activity

Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH.

MDH1

GO:0047865

MF

dimethylglycine dehydrogenase activity

Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein.

DMGDH

GO:0047888

MF

fatty acid peroxidase activity

Catalysis of the reaction: 2 H(2)O(2) + H(+) + palmitate = CO(2) + 3 H(2)O + pentadecanal.

CYGB

GO:0047915

MF

ganglioside galactosyltransferase activity

Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine.

B3GALT4

GO:0047936

MF

glucose 1-dehydrogenase [NAD(P)] activity

Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H.

H6PD

GO:0047977

MF

hepoxilin-epoxide hydrolase activity

Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate.

ALOX15

GO:0047982

MF

homocysteine desulfhydrase activity

Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate.

CTH

GO:0047988

MF

hydroxyacid-oxoacid transhydrogenase activity

Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate.

ADHFE1

GO:0048018

MF

receptor agonist activity

Interacts with receptors such that the proportion of receptors in the active form is increased.

GREM1, WNT2, VEGFA, WNT5A, WNT3, GAS6

GO:0048019

MF

receptor antagonist activity

Interacts with receptors to reduce the action of another ligand, the agonist.

DKK1, LRPAP1, ADH7, AGTR2, ESR2

GO:0048020

MF

CCR chemokine receptor binding

Interacting selectively and non-covalently with a CCR chemokine receptor.

CCL4, CCL20, CCL8

GO:0048027

MF

mRNA 5'-UTR binding

Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule.

IGF2BP3, DDX3X, RPS14, FMR1, LARP1, IGF2BP2

GO:0048029

MF

monosaccharide binding

Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.

GPI, FBP1, TALDO1

GO:0048037

MF

cofactor binding

Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

TYMS, ASNS, LMO2, TKT, SUCLG1, ME3

GO:0048038

MF

quinone binding

Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.

AOC2, NDUFS2, ETFDH, AOC3, HHIP, VKORC1

GO:0048039

MF

ubiquinone binding

Interacting selectively and non-covalently with ubiquinone, a quinone derivative with a tail of isoprene units.

SDHB, DHODH, ETFDH

GO:0048040

MF

UDP-glucuronate decarboxylase activity

Catalysis of the reaction: H(+) + UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose.

UXS1

GO:0048156

MF

tau protein binding

Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.

APBB1, BIN1, APOE, S100B, HSP90AA1, SNCA, FKBP4, AATF, HDAC6

GO:0048185

MF

activin binding

Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits.

SMAD7, FST, ACVR2A, ACVR1B, TGFBR3, ACVR1, ACVR2B

GO:0048248

MF

CXCR3 chemokine receptor binding

Interacting selectively and non-covalently with a the CXCR3 chemokine receptor.

PF4

GO:0048256

MF

flap endonuclease activity

Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis.

EXO1

GO:0048270

MF

methionine adenosyltransferase regulator activity

Modulates the activity of methionine adenosyltransferase.

MAT2B

GO:0048273

MF

mitogen-activated protein kinase p38 binding

Interacting selectively and non-covalently with mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation.

SPAG9, NFATC1, TAB1, PRMT1

GO:0048306

MF

calcium-dependent protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.

VPS37C, MASP2, PDCD6, MYO1D, SEC31A, A2M, ANXA1, S100B, S100A6, ANXA2, ANXA6, ANXA4, MBL2, ANXA3, SYN1, DDX5, TNNI3, SYT1, S100P, S100A4, S100A11, STX2, ANXA11, RAC3, SNAP25, CALM2, VAMP2, VLDLR, FCN2, CPLX2, NSMF, PDCD6IP, CHP1, RBM22, DMBT1

GO:0048365

MF

Rac GTPase binding

Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.

NCF2, FLNA, ITPKA, IQGAP1, RAB7A, ARHGDIB, OCRL, CAV1, EPS8, TIAM1, IQGAP2, RALBP1, PKN1, CYFIP1, SRGAP1, NOXA1, HACE1, ARHGEF2, DOCK7, ABI2, CORO1C

GO:0048403

MF

brain-derived neurotrophic factor binding

Interacting selectively and non-covalently with brain-derived neurotrophic factor.

NTRK2

GO:0048406

MF

nerve growth factor binding

Interacting selectively and non-covalently with nerve growth factor (NGF).

NTRK1, NGFR, FURIN, PCSK6

GO:0048407

MF

platelet-derived growth factor binding

Interacting selectively and non-covalently with platelet-derived growth factor.

PDGFB, COL1A1, COL3A1, PDGFA, COL1A2, PDGFRB, COL6A1, PDGFRA, COL5A1

GO:0048408

MF

epidermal growth factor binding

Interacting selectively and non-covalently with epidermal growth factor.

NRDC, EGFR

GO:0048487

MF

beta-tubulin binding

Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.

PDCD5, PEX14, VAPB, GJA1, SNCA, RGS2, LRPPRC, HTT, EMD, GABARAPL2, SIRT2, PIFO, FGF13, ARL8A, IFT74, PACRG, SYT11, TBCD, NDEL1, RACGAP1, GABARAPL1, TRPV4, ARL8B, UXT, HDAC6, SPAST

GO:0048495

MF

Roundabout binding

Interacting selectively and non-covalently with the Roundabout (ROBO) receptor, a transmembrane receptor.

TGFB1I1, SLIT2, MYO9B

GO:0048763

MF

calcium-induced calcium release activity

Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration.

PKD2, RYR3, RYR2

GO:0050023

MF

L-fuconate dehydratase activity

Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H(2)O.

ENOSF1

GO:0050031

MF

L-pipecolate oxidase activity

Catalysis of the reaction: L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2) + H(+). Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate.

PIPOX

GO:0050038

MF

L-xylulose reductase (NADP+) activity

Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH.

DCXR

GO:0050046

MF

lathosterol oxidase activity

Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol + O2 = cholesta-5,7-dien-3-beta-ol + H2O2.

SC5D

GO:0050062

MF

long-chain-fatty-acyl-CoA reductase activity

Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH.

FAR2

GO:0050072

MF

m7G(5')pppN diphosphatase activity

Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide.

NUDT3, DCP2, NUDT10, NUDT16, NUDT11

GO:0050104

MF

L-gulonate 3-dehydrogenase activity

Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH.

CRYL1

GO:0050113

MF

inositol oxygenase activity

Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+).

MIOX

GO:0050115

MF

myosin-light-chain-phosphatase activity

Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate.

PPP1CB

GO:0050119

MF

N-acetylglucosamine deacetylase activity

Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O = D-glucosamine + acetate.

NDST1

GO:0050145

MF

nucleoside phosphate kinase activity

Catalysis of the reaction: ATP + nucleoside phosphate = ADP + nucleoside diphosphate.

DTYMK, AK4, CMPK1

GO:0050178

MF

phenylpyruvate tautomerase activity

Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate.

MIF

GO:0050197

MF

phytanate-CoA ligase activity

Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H(+) + phytanoyl-CoA.

SLC27A2

GO:0050220

MF

prostaglandin-E synthase activity

Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2).

PTGES, PTGES3

GO:0050221

MF

prostaglandin-E2 9-reductase activity

Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.

CBR1

GO:0050252

MF

retinol O-fatty-acyltransferase activity

Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester.

DGAT2

GO:0050262

MF

ribosylnicotinamide kinase activity

Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide.

NMRK1

GO:0050265

MF

RNA uridylyltransferase activity

Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1).

ZCCHC6

GO:0050277

MF

sedoheptulokinase activity

Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H(+) + sedoheptulose 7-phosphate.

SHPK

GO:0050290

MF

sphingomyelin phosphodiesterase D activity

Catalysis of the reaction: H(2)O + sphingomyelin = ceramide 1-phosphate + choline + H(+).

SMPD4

GO:0050291

MF

sphingosine N-acyltransferase activity

Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine.

CERS6, CERS5, CERS4

GO:0050294

MF

steroid sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate.

SULT2A1

GO:0050313

MF

sulfur dioxygenase activity

Catalysis of the reaction: sulfur + O2 + H2O = sulfite.

ETHE1

GO:0050321

MF

tau-protein kinase activity

Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.

CSNK1D, GSK3B, CDK5, MARK4, MARK1

GO:0050346

MF

trans-L-3-hydroxyproline dehydratase activity

Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H(2)O + H(+).

L3HYPDH

GO:0050347

MF

trans-octaprenyltranstransferase activity

Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + diphosphate.

PDSS1, PDSS2

GO:0050354

MF

triokinase activity

Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H(+).

TKFC

GO:0050405

MF

[acetyl-CoA carboxylase] kinase activity

Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate.

PRKAA2

GO:0050421

MF

nitrite reductase (NO-forming) activity

Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+.

CBS

GO:0050431

MF

transforming growth factor beta binding

Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types.

ITGAV, THBS1, CD36, TGFBR1, TGFBR2, TGFBR3, ACVR1, HYAL2, LTBP1, LTBP3

GO:0050436

MF

microfibril binding

Interacting selectively and non-covalently with a microfibril, any small fibril occurring in biological material.

LTBP1

GO:0050473

MF

arachidonate 15-lipoxygenase activity

Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.

ALOX15, PTGS2

GO:0050501

MF

hyaluronan synthase activity

Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP.

HAS2

GO:0050508

MF

glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP.

EXT1, EXT2

GO:0050509

MF

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity

Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP.

EXT1, EXT2

GO:0050510

MF

N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP.

CHSY3, CHSY1

GO:0050528

MF

acyloxyacyl hydrolase activity

Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid.

AOAH

GO:0050543

MF

icosatetraenoic acid binding

Interacting selectively and non-covalently with icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule.

FABP3

GO:0050544

MF

arachidonic acid binding

Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.

S100A8, S100A9, PPARG, STX3

GO:0050561

MF

glutamate-tRNA(Gln) ligase activity

Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP.

EARS2

GO:0050567

MF

glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP.

GATC, GATB, QRSL1

GO:0050591

MF

quinine 3-monooxygenase activity

Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+).

CYP3A4

GO:0050610

MF

methylarsonate reductase activity

Catalysis of the reaction: 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H(2)O + methylarsonous acid.

GSTO1, GSTO2

GO:0050613

MF

delta14-sterol reductase activity

Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol.

TM7SF2

GO:0050614

MF

delta24-sterol reductase activity

Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol.

DHCR24

GO:0050632

MF

propionyl-CoA C2-trimethyltridecanoyltransferase activity

Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA.

SCP2

GO:0050649

MF

testosterone 6-beta-hydroxylase activity

Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O.

CYP3A4