GO:0036310

MF

annealing helicase activity

Catalysis of the ATP-dependent rewinding of single-stranded DNA (ssDNA) to reform base pairs between strands. Often acts on ssDNA bubbles bound by replication protein A (RPA).

RECQL4, ANXA1, SMARCA1, RECQL, BLM, RAD54L

GO:0036312

MF

phosphatidylinositol 3-kinase regulatory subunit binding

Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.

XBP1, PIK3R1, FBXL2

GO:0036317

MF

tyrosyl-RNA phosphodiesterase activity

Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis.

TDP2

GO:0036374

MF

glutathione hydrolase activity

Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate.

GGT7

GO:0036402

MF

proteasome-activating ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.

PSMC3, PSMC2, PSMC4, PSMC1, PSMC6

GO:0036435

MF

K48-linked polyubiquitin binding

Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers.

VCP, UFD1L

GO:0036458

MF

hepatocyte growth factor binding

Interacting selectively and non-covalently with a hepatocyte growth factor.

SRPX2

GO:0036459

MF

thiol-dependent ubiquitinyl hydrolase activity

Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.

USP53, USP54, ALG13

GO:0036461

MF

BLOC-2 complex binding

Interacting selectively and non-covalently with a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules.

RAB32

GO:0036487

MF

nitric-oxide synthase inhibitor activity

Interacts with, and stops, prevents or reduces the activity of nitric oxide synthase.

ATP2B4

GO:0036505

MF

prosaposin receptor activity

Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D).

GPR37

GO:0038021

MF

leptin receptor activity

Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

LEPR

GO:0038023

MF

signaling receptor activity

Receiving a signal and transmitting the signal in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.

OR51E2

GO:0038024

MF

cargo receptor activity

Combining selectively with an extracellular substance and delivering the substance into the cell via endocytosis.

DAB2

GO:0038025

MF

reelin receptor activity

Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

VLDLR

GO:0038036

MF

sphingosine-1-phosphate receptor activity

Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein.

S1PR1, S1PR3, SPHK1

GO:0038049

MF

transcription factor activity, ligand-activated RNA polymerase II transcription factor binding

Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, some steroid hormone receptors bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain hormone response elements.

NOTCH2

GO:0038051

MF

glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity

Combining with a glucocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, glucocorticoid-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain glucocorticoid response elements.

NR3C1

GO:0038052

MF

RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding

Combining with estrogen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.

ESR1, ESR2

GO:0038062

MF

protein tyrosine kinase collagen receptor activity

Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

DDR1

GO:0038064

MF

collagen receptor activity

Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

ITGA2, ITGA11

GO:0038085

MF

vascular endothelial growth factor binding

Interacting selectively and non-covalently with a vascular endothelial growth factor.

NRP1, PDGFRB, PDGFRA

GO:0038106

MF

choriogonadotropin hormone binding

Interacting selectively and non-covalently with choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit.

LHCGR

GO:0038132

MF

neuregulin binding

Interacting selectively and non-covalently with a neuregulin, a member of the EGF family of growth factors.

ITGB3, ITGAV, ITGB4, ERBB3, ITGA6

GO:0038181

MF

bile acid receptor activity

Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile.

NR1H4

GO:0038186

MF

lithocholic acid receptor activity

Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity.

VDR

GO:0038191

MF

neuropilin binding

Interacting selectively and non-covalently with a member of the neuropilin family.

SEMA3E, SEMA7A, SEMA3D, SEMA3B, SEMA3A, SEMA3C

GO:0039552

MF

RIG-I binding

Interacting selectively and non-covalently with RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA.

SEC14L1

GO:0039706

MF

co-receptor binding

Interacting selectively and non-covalently with a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell.

DKK1, BMP2, BMP4, HFE, DKK2, TFR2

GO:0042008

MF

interleukin-18 receptor activity

Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL18R1

GO:0042015

MF

interleukin-20 binding

Interacting selectively and non-covalently with interleukin-20.

IFNGR1, IFNAR2

GO:0042019

MF

interleukin-23 binding

Interacting selectively and non-covalently with interleukin-23.

IL12RB1

GO:0042020

MF

interleukin-23 receptor activity

Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL12RB1

GO:0042030

MF

ATPase inhibitor activity

Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of ATP to ADP and orthophosphate.

PLN

GO:0042043

MF

neurexin family protein binding

Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals.

SDCBP, CASK, CPE, NLGN4X, NLGN1, SYTL4, SYTL2

GO:0042054

MF

histone methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.

SUZ12, EZH2, CARM1, PRMT6, PRMT1

GO:0042056

MF

chemoattractant activity

Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.

PDGFB, FGF2, HMGB1, SAA1, SAA2, CCL3, BMP4, CCL5, SCG2, MIF, HGF, VEGFA, LGALS3, FGF7, HMGB2, CXCL12, VEGFC, ALKBH1

GO:0042131

MF

thiamine phosphate phosphatase activity

Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate.

ACPP

GO:0042132

MF

fructose 1,6-bisphosphate 1-phosphatase activity

Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.

FBP2, FBP1

GO:0042134

MF

rRNA primary transcript binding

Interacting selectively and non-covalently with an unprocessed ribosomal RNA transcript.

PTRF

GO:0042162

MF

telomeric DNA binding

Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.

KDM1A, XRCC5, TERF1, HNRNPD, ACD, SMG1, UPF3A, PIF1, OBFC1, UPF2, POT1, SMG5

GO:0042163

MF

interleukin-12 beta subunit binding

Interacting selectively and non-covalently with the beta subunit of interleukin-12.

IL12A

GO:0042165

MF

neurotransmitter binding

Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.

NIPSNAP1

GO:0042166

MF

acetylcholine binding

Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.

CHRNB1, CHRM3, CHRNA5, CHRNA7

GO:0042169

MF

SH2 domain binding

Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.

SH3PXD2B, SYNGR3, JAK2, IRS1, NUP62, RACK1, PTK2, ARHGAP5, SQSTM1, DAG1, AFAP1L2, SHCBP1, LILRB1, DLC1, TRPV4, PAG1, NLK

GO:0042171

MF

lysophosphatidic acid acyltransferase activity

Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid.

ABHD5

GO:0042277

MF

peptide binding

Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.

TPP1, GPR37, ANG, RPLP0, MME, CLTA, FURIN, IDE, PPIB, CALR, TPP2, AVPR2, OXTR, GNRHR, CSNK1D, THOP1, PGGT1B, NPEPPS, PPIA, TUBB3, ERAP2, AOPEP, TMEM158, PCSK5, NLN, ERAP1, LNPEP, LOC440434

GO:0042281

MF

dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.

ALG8, ALG6

GO:0042282

MF

hydroxymethylglutaryl-CoA reductase activity

Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH.

HMGCR

GO:0042285

MF

xylosyltransferase activity

Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

LARGE

GO:0042287

MF

MHC protein binding

Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.

MARCH1, CLEC7A

GO:0042288

MF

MHC class I protein binding

Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.

TUBB, HLA-E, BCAP31, VCP, TUBB4B, LILRB1, CD244, PILRB, PILRA

GO:0042289

MF

MHC class II protein binding

Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.

CD4, CD74, LAG3, KRT17, MARCH8

GO:0042296

MF

ISG15 transferase activity

Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages.

UBE2E1, UBE2E2

GO:0042301

MF

phosphate ion binding

Interacting selectively and non-covalently with phosphate.

PNP, MTHFD2, ADSS, G6PC, RELA, ADSSL1

GO:0042328

MF

heparan sulfate N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate.

EXT1, EXT2

GO:0042379

MF

chemokine receptor binding

Interacting selectively and non-covalently with any chemokine receptor.

CCL5, CXCL12

GO:0042392

MF

sphingosine-1-phosphate phosphatase activity

Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate.

PLPP1, PLPP3, SGPP2

GO:0042393

MF

histone binding

Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.

APBB1, CHD2, SMARCA5, JAK2, TBL1X, RNF8, TNKS, PRKCB, PTMA, NPM1, CTSL, CD1D, RAG1, H2AFX, RCC1, CKS2, DEK, SNCA, ANP32A, ATRX, MCM2, SMARCA2, CKS1B, HIST1H4A, HIST1H3D, H3F3A, SET, RBBP4, CHAF1B, SART3, NCAPD2, ZMYND11, PKN1, SPTY2D1, ATAD2, SUPT6H, HJURP, CTCFL, ANP32B, L3MBTL2, TONSL, PRMT6, IPO9, UHRF2, PHF12, RSF1, UHRF1, PYGO2, ANP32E, TBL1XR1, CHD8, BRD7, ASF1B, NAP1L2, ASF1A, NOC2L, L3MBTL1

GO:0042497

MF

triacyl lipopeptide binding

Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups.

TLR2

GO:0042500

MF

aspartic endopeptidase activity, intramembrane cleaving

Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane.

SPPL3, SPPL2A, HM13

GO:0042562

MF

hormone binding

Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.

NPR3, NPR2, CALR, MTNR1A, AMHR2

GO:0042577

MF

lipid phosphatase activity

Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate.

PLPP1, PLPP3, PLPPR4, PLPPR2, INPP5K

GO:0042578

MF

phosphoric ester hydrolase activity

Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.

PGAP1

GO:0042602

MF

riboflavin reductase (NADPH) activity

Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+.

BLVRB

GO:0042605

MF

peptide antigen binding

Interacting selectively and non-covalently with an antigen peptide.

HLA-B, HLA-DRA, HLA-DQA1, HLA-DQB1, HLA-E, HLA-DPA1, HLA-A, HLA-F, HLA-DRB3, SLC7A9, SLC7A5, DHCR24, HLA-DRB5, CD209, SLC7A8

GO:0042608

MF

T cell receptor binding

Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells.

FYN, DOCK2

GO:0042609

MF

CD4 receptor binding

Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages.

PLSCR1, FYN, PLSCR4

GO:0042610

MF

CD8 receptor binding

Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes.

FYN

GO:0042623

MF

ATPase activity, coupled

Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.

VPS4B, HSPA1A, HSPA1B, HSPA6, NSF, CCT8, MYO1E

GO:0042624

MF

ATPase activity, uncoupled

Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction is not directly coupled to any other reaction.

ATP6V1F

GO:0042625

MF

ATPase coupled ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate.

ATP6V0E1, ATP6V1F

GO:0042626

MF

ATPase activity, coupled to transmembrane movement of substances

Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.

ABCD4, ABCA8, ABCA1, ABCD3, ABCC1, ABCA6, ABCA5, ABCG8, ABCB10, ATP6V1D

GO:0042658

MF

MHC class II protein binding, via antigen binding groove

Interacting selectively and non-covalently with the antigen binding groove of major histocompatibility complex class II molecules.

CD74

GO:0042731

MF

PH domain binding

Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.

EPHA4, INPP5A

GO:0042799

MF

histone methyltransferase activity (H4-K20 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein.

WHSC1, KMT5B, KMT5C, KMT5A

GO:0042800

MF

histone methyltransferase activity (H3-K4 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein.

RBBP5, KMT2E, KMT2C, ASH1L, ASH2L, KMT2B

GO:0042802

MF

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

PLK4, SDCBP, CLDN4, AXIN1, MID1, KDM6A, CLDN3, SSNA1, BNIP3L, PARK2, SRPX2, VPS4B, PRKRA, USP2, BRI3, CLDN1, LDHA, GOT2, EGFR, SERPINA1, CST3, LDLR, GCG, INS, TNF, COL1A1, CRYAB, APOA1, APOE, TTR, ALB, FTL, ESR1, VTN, ALDOA, PRNP, CD74, S100B, VWF, ERBB2, TP53, HSPB1, APP, ITGB3, JUN, LDHB, HSP90AA1, HNRNPC, THBS1, COL1A2, INHBA, VIM, FBP1, ANXA4, CCL3, CD28, IAPP, FGFR1, G6PD, PCNA, CCL4, ALAD, LCP1, DRD2, ACPP, NME1, NQO1, VEGFA, PFKFB1, DES, PFKL, NFKB1, NPR2, GSTM3, SYT1, PAICS, FBLN1, PTPRG, AHCY, MPST, PTX3, S100A4, PLN, DPP4, CAD, MAPK1, S100A2, EPHB2, GBP1, ACTN2, TRIM23, SNCA, RBMX, CSK, EPS15, FHIT, NUP153, SEPHS1, CPT1A, DAPK1, CTSC, ATXN3, ATXN1, BCAT1, EPHA4, ALDH18A1, VCP, CASP6, SNX16, PTEN, ACTB, PSME3, LYZ, STXBP1, B2M, GRB2, DYNLT1, GPSM2, SORD, PLIN5, CAV1, RELA, TLE1, ZBTB16, FMR1, PRDX1, BAX, KCNH2, BNIP3, TARDBP, FADD, SMAD4, SQSTM1, RIPK1, PKD2, TP53BP2, PAFAH1B3, PCM1, TRIP10, TRIP13, MAPRE1, SMAD1, ADIPOQ, CLPP, UGP2, KLHL12, CDC42BPA, ATL3, DESI1, RGMB, JMJD6, CBLL1, SETX, SDK1, CCDC91, ADIPOR2, HOOK3, ZDHHC17, PHYKPL, PLEKHH2, SCUBE1, KLHL7, AMOTL1, SFRP1, HJURP, MNS1, TRPV1, ATL2, PPP1R13L, KCTD13, TTN, TOPBP1, TFG, RYR2, ADIPOR1, DACT3, OPTN, YIPF6, HOOK2, EDC3, UHRF1, CCT7, CORO1B, SDF4, NIF3L1, CHMP4B, DCTPP1, C10orf88, SMURF2, ROBO2, TRIM39, RAD18, MTPAP, THAP1, NDE1, ATXN10, NUFIP1, PYCARD, PRPF19, MAPRE3, MAPK8IP1, RUVBL2, SH3GLB1, L3MBTL1, USP15, TNPO3, FHOD1, SNCAIP

GO:0042803

MF

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

E2F8, ACOT7, SDCBP, PDXK, BHLHE40, KCNK3, ADAM10, AXIN1, GSTA4, SLC22A1, GRM6, MID1, TOX3, FOXP2, IRAK2, MAP3K13, DAPK3, RIPK2, TBX1, ACTN4, GSTZ1, NUDT21, BNIP3L, RAB11FIP3, PDCD6, VPS4B, ERN1, BANF1, PRKRA, LRP6, IDH1, STC2, RNF8, SLIT2, TRIM37, VAPB, PEX11B, GOT2, PDGFB, TGFB1, CD4, CRYAB, APOE, APOA2, AMBP, TFRC, ANG, HMGCR, ANXA1, PDGFA, S100B, VWF, NTRK1, TYMS, JUN, S100A6, NPM1, CSF1R, ADRB2, HSP90AA1, ANXA6, ASNS, IL6R, SNRPC, LGALS1, QDPR, GSTM1, INHBB, HMOX1, BCL2, MGST1, KIT, GHR, FGFR1, TOP2A, G6PD, PRPS2, ODC1, TPR, ACTN1, CCL5, ENO3, ADRB3, DRD2, TYR, IDE, JUP, PVR, HPGD, VEGFA, TCF4, RAG1, TCF3, PDGFRA, PRLR, NPR3, CEBPB, HLA-G, RPL7, ATF3, SRM, NFKB1, GSTM3, FLNA, AGXT, FGFR2, ERBB3, ENPP1, XPA, CBLN1, SP100, NR2F2, TARS, STOM, PON1, MAOB, DPP4, DCK, GSTM2, ABCD3, MZF1, IMPA1, TKT, ERP29, CLIP1, CORO1A, S100A11, SHMT1, RDX, PTGS2, CBS, MYH9, ACTN2, CHKA, HMGCL, CHRNA7, CPOX, BMPR1A, IL6ST, ID1, CD200, NBL1, ECE1, MSH2, NR4A2, NAMPT, CBX5, ALDH1A3, XDH, SLC11A1, FASN, CENPF, PCYT1A, HARS2, CEBPD, PGF, VEGFB, TSC2, ASCL1, FXR1, IRAK1, CAV2, HSD17B4, PSMD7, CLCN3, NR0B1, GTF2A2, HRSP12, CEBPG, MVD, TERF1, GYS2, CDH13, TPD52, OXCT1, CTBP2, TIRAP, PRPS1, S100A10, TGFB2, RACK1, PAFAH1B2, ABAT, CBX1, SMAD3, NDP, HMGCS1, PLOD1, GSTM4, HHEX, RELA, ACVR1, ZBTB16, FMR1, BAX, MCL1, SMAGP, BST2, KCNH2, DPYD, BNIP3, STK4, CALCOCO2, PRDX4, MAD2L1, SMAD4, SQSTM1, CAMK2D, PKD2, TDG, SNX1, MTMR1, MTMR2, CUL3, GALE, HES1, MEF2D, EEA1, NECTIN1, PPP2R4, QPRT, RABEP1, ERBB4, NR0B2, TWIST1, ELAVL1, SMAD2, SMAD1, ADIPOQ, USF2, EXT1, NTRK2, KYNU, PTPRO, AOC3, TPD52L1, LRRFIP1, CCDC88A, NADK2, ANO6, MLK4, OLFML2A, TENM4, JMJD6, SLC27A1, MTHFD1L, OLFM4, RBPMS2, RAB11FIP2, EMSY, SLC51A, SPATA24, CARM1, CEP57, CCDC103, SLC30A8, KLHL7, SUPV3L1, NLGN4X, ADSSL1, CISD2, COMMD1, FAM73A, ZBTB38, SUMF1, UXS1, LILRB1, GABPB2, SPPL3, SPPL2A, HM13, SCARB1, PDCD6IP, MITD1, NR4A3, BCL2L2, RBPMS, NUDT16, S100A16, DGAT2, ALS2, KIF20B, TCF12, P2RX4, S100A13, MAP3K5, MGLL, BARD1, ARID3A, CITED1, TREX2, SYT11, PDCD10, JAM3, CADM1, TRIM8, FOXP3, TRIM9, MFF, DNTTIP1, SDCBP2, IKZF4, MUC13, CHMP4B, GLIPR2, GREM2, ECT2, GRPEL1, CACYBP, APOBEC3G, GOPC, PLCB1, HEYL, ANO2, HPS4, NECTIN3, PRDM6, PDGFC, PRTFDC1, ABCB10, FGFR1OP2, MTPAP, CLN6, FLRT3, ZBTB4, TENM3, GRHPR, PLEKHB1, MLX, GNPTG, NUDT5, ACSL6, BLOC1S6, FZD4, PYCARD, BOK, STUB1, SNX6, TIMELESS, CRYL1, SH3GLB1, SNX9, IRAK3, CPQ

GO:0042805

MF

actinin binding

Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.

NFKB1, RELA, PKD2, TTN, PDLIM5, TRPC6

GO:0042809

MF

vitamin D receptor binding

Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes.

MED14, TOB2, TAF11, MED12, MED30, MED4, MED17, THRAP3, MED16

GO:0042813

MF

Wnt-activated receptor activity

Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.

FZD6, FZD7, LRP5, LRP6, SFRP5, SFRP4, SFRP1, FZD8, FZD4

GO:0042826

MF

histone deacetylase binding

Interacting selectively and non-covalently with the enzyme histone deacetylase.

HDAC3, ZNHIT1, KLF4, TCF21, NUDT21, PARK2, NCOR1, GMNN, HSP90AA1, HSP90AB1, PARP1, HSPA1A, HSPA1B, GLI3, TOP2A, TAL1, CEBPB, XBP1, SFPQ, YY1, HOXA10, YWHAB, PHB, CBX5, MAPK8, NRIP1, KPNA2, HDAC4, YWHAE, RAC1, INSM1, MEF2A, RELA, MEF2C, RBBP4, CDC20, HDAC1, HNRNPD, HES1, MEF2D, ANKRD1, PKN1, PKN2, CRY1, HIF1A, BRMS1L, NIPBL, SIRT2, KAT2B, RAD9A, FOXP3, DHX36, SUDS3, DACT1, DNMT3B, HDAC6, DDX20, HDAC9, SMG5, HDAC5, NCOR2

GO:0042834

MF

peptidoglycan binding

Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.

TLR2, PGLYRP2

GO:0042903

MF

tubulin deacetylase activity

Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate.

SIRT2, HDAC6

GO:0042910

MF

xenobiotic transporter activity

Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells.

SLC2A1

GO:0042922

MF

neuromedin U receptor binding

Interacting selectively and non-covalently with one or more specific sites on a neuromedin U receptor.

NMU

GO:0042923

MF

neuropeptide binding

Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).

SSTR1, MC4R, SSTR5, OPRL1, ADCYAP1R1, NPBWR1

GO:0042931

MF

enterobactin transporter activity

Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells.

ASIC3

GO:0042954

MF

lipoprotein transporter activity

Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells.

LRP2

GO:0042974

MF

retinoic acid receptor binding

Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.

CNOT1, ACTN4, HMGA1, CTBP2, LRIF1

GO:0042975

MF

peroxisome proliferator activated receptor binding

Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma.

HMGA1, MDM2, NFATC4, NR0B2, ASXL2, PPARGC1A

GO:0042978

MF

ornithine decarboxylase activator activity

Upregulation of the activity of the enzyme ornithine decarboxylase.

AZIN1, PRLR

GO:0042988

MF

X11-like protein binding

Interacting selectively and non-covalently with X11-like protein, a neuron-specific adaptor protein.

CLSTN1

GO:0043008

MF

ATP-dependent protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP.

PRNP, PLK2, SAE1

GO:0043014

MF

alpha-tubulin binding

Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.

WASH1, OFD1, SNCA, NCALD, FAM110C, HSPH1, ARL8A, PACRG, NDEL1, RACGAP1, TRPV4, ARL8B, PPARGC1A, HDAC6, SPAST

GO:0043015

MF

gamma-tubulin binding

Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin.

OFD1, RAD51D, LYN, NME1, BRCA2, MZT1, DIXDC1, CEP57, PIFO, NDRG1, TUBGCP3, MARK4, FEZ1, RACGAP1

GO:0043021

MF

ribonucleoprotein complex binding

Interacting selectively and non-covalently with any complex of RNA and protein.

PPIH, PQBP1, CD2BP2, SRP54, PPP1CA, HNRNPU, RNASEL, BOP1, EZH2, TIMM50, UHMK1, PRPF31, SECISBP2L, ITCH, SECISBP2, WDR12, SMG5

GO:0043022

MF

ribosome binding

Interacting selectively and non-covalently with any part of a ribosome.

LETM1, EIF2S1, RPSA, HSPA5, EEF2, EIF6, SEC61A1, EIF5A, FMR1, ICT1, CPEB4, LETM2, LETMD1, RICTOR, CPEB2, GUF1, CPEB3, GCN1, NAA15, YTHDF1, EIF5A2, MTIF3, C12orf65, SEC61A2, IMPACT, EIF3K, SBDS

GO:0043023

MF

ribosomal large subunit binding

Interacting selectively and non-covalently with any part of the larger ribosomal subunit.

NPM1, EIF6, CPEB2, MALSU1