GO:0045352

MF

interleukin-1 Type I receptor antagonist activity

Blocks the binding of interleukin-1 to interleukin-1 Type I receptors.

IL1RN

GO:0045353

MF

interleukin-1 Type II receptor antagonist activity

Blocks the binding of interleukin-1 to interleukin-1 Type II receptors.

IL1RN

GO:0045485

MF

omega-6 fatty acid desaturase activity

Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain.

FADS1

GO:0045499

MF

chemorepellent activity

Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal.

SEMA3E, FLRT2, SEMA3D, APOA1, EFNA5, NRG1, SEMA3B, SEMA5A, SEMA3A, SEMA6D, SEMA3C, SEMA6A, SEMA4A, SEMA6B, FLRT3

GO:0045502

MF

dynein binding

Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules.

RAB29, BCL2L11, NEFH, SNCA, CENPF, FMR1, DCTN1, BICD1, KATNB1, SMC3

GO:0045503

MF

dynein light chain binding

Interacting selectively and non-covalently with a light chain of the dynein complex.

DYNC1I1

GO:0045504

MF

dynein heavy chain binding

Interacting selectively and non-covalently with a heavy chain of the dynein complex.

DNALI1, DYNC2LI1

GO:0045505

MF

dynein intermediate chain binding

Interacting selectively and non-covalently with an intermediate chain of the dynein complex.

HTT, DNAAF5

GO:0045509

MF

interleukin-27 receptor activity

Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL6ST

GO:0045513

MF

interleukin-27 binding

Interacting selectively and non-covalently with interleukin-27.

IL12A

GO:0045545

MF

syndecan binding

Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.

SDCBP, TNC, SEMA5A, HPSE

GO:0045550

MF

geranylgeranyl reductase activity

Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group.

AKR1C3

GO:0045569

MF

TRAIL binding

Interacting selectively and non-covalently with TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines.

TNFRSF10C

GO:0045703

MF

ketoreductase activity

Catalysis of the reduction of a ketone group to form the corresponding alcohol.

AKR1C3

GO:0046030

MF

inositol trisphosphate phosphatase activity

Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate.

INPP5K

GO:0046316

MF

gluconokinase activity

Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H(+).

IDNK

GO:0046332

MF

SMAD binding

Interacting selectively and non-covalently with a SMAD signaling protein.

AXIN1, COL3A1, COL5A2, COL1A2, BMP2, SKI, SKIL, FLNA, YY1, CTNNB1, BMPR1A, ACVR1B, TGFBR1, TGFBR2, HMGA2, DAB2, PURA, MEF2A, TGFBR3, ACVR1, SMAD2, RNF111, MAGI2, EID2, PURB, TCF12, HIPK2, SMURF2, STUB1, USP15

GO:0046526

MF

D-xylulose reductase activity

Catalysis of the reaction: NAD(+) + xylitol = D-xylulose + H(+) + NADH.

SORD

GO:0046527

MF

glucosyltransferase activity

Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

KDELC1, KDELC2, ALG6

GO:0046538

MF

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity

Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction requires the cofactor 2,3-bisphosphoglycerate.

BPGM, PGAM1

GO:0046539

MF

histamine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+).

HNMT

GO:0046554

MF

malate dehydrogenase (NADP+) activity

Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+.

MDH2

GO:0046577

MF

long-chain-alcohol oxidase activity

Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O.

ALDH3A2

GO:0046625

MF

sphingolipid binding

Interacting selectively and non-covalently with sphingolipids, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

S1PR1

GO:0046703

MF

natural killer cell lectin-like receptor binding

Interacting selectively and non-covalently with a lectin-like natural killer cell receptor.

HLA-E, MICB, MICA, ULBP3, ULBP2

GO:0046789

MF

host cell surface receptor binding

Interacting selectively and non-covalently with a receptor on the host cell surface.

INHBB

GO:0046790

MF

virion binding

Interacting selectively and non-covalently with a virion, either by binding to components of the capsid or the viral envelope.

APCS, HSP90B1, PTX3, PPIA, NECTIN1, HIPK2, CD209

GO:0046811

MF

histone deacetylase inhibitor activity

Stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes.

SKI

GO:0046817

MF

chemokine receptor antagonist activity

Interacts with chemokine receptors to reduce the action of a chemokine.

CCL5

GO:0046848

MF

hydroxyapatite binding

Interacting selectively and non-covalently with hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin.

BGLAP

GO:0046870

MF

cadmium ion binding

Interacting selectively and non-covalently with cadmium (Cd) ions.

MT3, NOS3, SLC11A2, MT1X

GO:0046872

MF

metal ion binding

Interacting selectively and non-covalently with any metal ion.

TMEM129, ZC3H12D, ZNF320, ZNF233, SOBP, ZNF785, PHF20L1, NUDT19, ZNF879, NDUFS8, CDC7, PPP6C, NME4, FBP2, ACACB, TRAFD1, CTDSP2, UTY, ENPP3, ADAM10, RIOK3, ZNF213, TPP1, NRP1, ZNF646, ZBTB5, PFAS, SMAD7, ANGPT2, MUSK, CTDSPL, SMAD9, SIVA1, PPM1G, BIRC5, FOXP2, NUPL2, ZSCAN9, KDM6A, ASAP2, ZBTB24, CYB5B, ADAM12, ZNHIT1, MAP3K13, B4GALT5, ZNF264, RASA4, ERI3, CBFA2T2, OIP5, B4GAT1, SMAD6, SNAI2, ASNA1, ADCY3, NUAK1, ZNF862, ZFC3H1, ZEB2, NRP2, ADCY9, B4GALT4, PDE8A, REV3L, JAK2, PRMT3, YPEL1, EIF5B, DNAJA2, FAM20B, ROCK2, ZNF623, ZC3H11A, NDUFS2, ZNF217, NME6, ITGA10, USP2, ADAP1, RNASEH2A, ZNF189, PAK3, CLPX, PDE5A, PDE9A, DDAH1, SORBS2, PDE8B, ZBTB7A, PARN, NPTXR, STAMBP, ECEL1, EYA4, WIZ, ZBED1, CYB5A, F13A1, TIMP1, GH1, COL1A1, COL3A1, CRYAB, FGA, FGG, RAF1, CYBB, GNAI2, ITGB2, CFI, MPO, PCCA, ALPL, ITGB1, COL5A2, FYN, ITGAV, PRSS1, ZFY, COL1A2, CYC1, ITGA5, GNAI3, STS, FBP1, HMOX1, POLA1, FURIN, ZNF688, ZNF853, MT1HL1, GLI3, TROVE2, COX5B, KIT, EGR2, ITGAM, PC, COL11A1, BCKDHA, COL11A2, FDPS, VAV1, GNS, ZNF44, ZNF250, HIVEP1, ARSB, CHN1, RAG1, TIMP2, NQO2, ZNF823, PRLR, FAH, ZFX, ZNF12, ZNF14, ZNF17, ZNF19, ZNF20, ZNF182, ZNF23, ZKSCAN1, ZNF25, ZNF43, ITGA2, ATF7, PFKL, IGFBP3, ERCC2, LIG1, NDUFV2, TNNI3, AMY2B, ATP2B1, COX5A, ITGAX, COL9A1, COL5A1, NT5E, SDHB, TGM2, GART, NME2, XPA, PTGS1, ITGA6, ME2, JAK1, ATP2B4, POLR2A, CDK2, ITGA3, ZFP36, ACVR2A, NDUFS1, POLD1, MZF1, TKT, GNA11, SLC6A1, CLIP1, POLR2B, MAT2A, RRM2, HIVEP2, DNAJA1, GALNS, PTGS2, CBS, TIMP3, HMGCL, MAP2K2, NUDT1, PPP1CC, BMPR1A, ACVR1B, TGFBR1, GMPR, TGFBR2, ITGAE, CDKN1A, COL18A1, BCL6, CSK, PRKCI, HELZ, ECE1, ATRX, NSF, BRCC3, NPTX2, ZFP36L2, UQCRFS1, TGM4, PPM1F, PRIM1, PRIM2, MCM2, MTHFS, GNAQ, METAP2, TNFSF10, ZNF83, DNA2, SGSH, ARSD, CLCNKA, CLCNKB, ADCY7, NEK2, NEK3, AGFG1, ZNF133, ZNF136, ZNF140, ZNF138, THOP1, HCCS, CACNA2D1, PRKAA2, ATP12A, MAZ, PRDM15, KLF3, ANTXR2, YBEY, ZNF445, ELOF1, PPP4C, YPEL3, RPL37A, HSPE1, RPL37, PPP1CA, PPP1CB, PPP2CB, RPS27A, ADAM17, NTHL1, ADARB1, MT1X, ABAT, GNAS, ZBED6, ZXDB, ZNF200, ATP2C1, CYCS, INSM1, AMPD3, BNC1, OGDH, SP3, CREB5, GNA12, COL10A1, ZNF85, PRKCQ, ACVR1, EGR4, ZBTB16, PRKCD, RNASEL, PPAT, ZNF33A, EGR3, ZFP36L1, TNK2, DDR1, PDE4C, PDE4D, ZNF844, ZNF616, DMPK, ZNF763, ZNF816, KCNMA1, AKAP13, DPYD, TRIM26, ZBTB17, KLF10, MAP2K5, PDE3B, ZNF211, IKZF1, ADAM9, MYO9B, SMAD4, DGKZ, ACVR2B, ITGA9, BMPR2, KLF9, IDI1, CACNA1C, PDE7A, VEZF1, GIT2, PDE3A, ZNF345, ZNF268, ZNF273, RASA3, ZNF846, MTF1, CLCA4, SUZ12, KARS, ACAP2, POSTN, PRKD1, RASA2, RHEB, FCN2, TESK1, ZNHIT3, JMJD1C, MYLK, MPPED2, SMAD2, SMAD1, ZIC1, ZNF141, ZNF77, ZNF124, ETFDH, PDCD2, EXT1, ZSCAN26, AMHR2, HAGH, ME3, PCK2, UGP2, TATDN3, ZNF423, ZNF630, ZNF791, TKFC, ZSCAN23, MGAT5B, ZNF568, ZNF404, MMEL1, ZFP69, ZBED5, FLYWCH1, ATP13A5, ARHGAP29, ACSM3, TAF1B, CYBRD1, ESCO2, PAN3, ZNF326, ZNF789, ZNF766, ZNF667, ZC3H12B, ZNF506, GNAS, DGKK, COLEC12, ZBTB41, HIVEP3, ZC3H13, PDSS1, ZNF684, ZNF648, ZNF618, RBM26, ZC2HC1B, ZNF658, CDKAL1, MBNL2, TNS2, STEAP4, ZNF776, ZNF57, ZNF518A, ZNF787, PLAG1, ASPHD2, ADNP2, ZNF280D, FAAP20, TATDN1, ZNF529, ZNF585A, FDX1L, ALKBH5, CYB5D1, ZNF449, ZNF880, HAGHL, PAPD4, ZC3H14, ZNF474, ARSK, ZNF562, BNC2, DEF8, ZNF600, ZNF621, TSHZ1, FGD6, PHLPP2, NEK10, MOB3C, CHSY3, RPS27L, ZNF534, ASXL2, RHOU, ZNF765, ZNF771, MCM10, ZNF627, ZNF367, ERMP1, TRMT1L, ZNF550, ZFYVE16, ZNF804A, IRF2BP2, FGD2, CMC1, ZNF467, ZSCAN2, GALNT5, GALNT7, NEK8, GALNT10, ZBTB33, MOB3B, PRUNE, STK32C, NT5DC3, CASZ1, ADIPOR2, TRABD2A, TAX1BP1, JAZF1, ZSCAN30, CHSY1, DGKH, ZNF677, FRAS1, ZNF573, ZNF280B, FOXP4, ZC3H7A, ZBTB8OS, ADHFE1, ZC3H3, ZNF440, ZNF101, ZNF654, ZFP82, ZNF567, ARHGEF28, PPM1K, GALNT15, GTPBP8, ZNF843, PNKD, GALNT4, ZNF808, CISD2, ARFGAP2, ZNF655, ZNF283, ZNF513, ZNF615, CYB561D1, ZNF709, ZNF557, ZNF565, ZNF610, THAP8, ZNF579, ZBTB38, ZNF511, SUMF1, DAGLB, ZNF485, ZBTB34, PAPD5, ZNF248, GLIS3, ZNF548, PDZD8, ZNF555, TRPV1, ZNF397, NUDT10, NEK11, ZFP28, PPTC7, CTCFL, RP9, RHEBL1, ZNF420, OSR1, NUBPL, THAP6, ZSCAN18, ZNF502, ZNF564, ZNF596, NT5C, ZNF507, NEK9, CSGALNACT1, NEK7, ZNF721, ZNF526, ZNF384, THAP3, ZC3H15, HDAC7, PRUNE2, NUDT8, DNAJA4, ARAP3, RASSF5, ZNF606, PPM1E, ARAP2, GTF3A, TANK, RAD50, EXT2, HGD, RFK, ZNF566, ADIPOR1, ZUFSP, EME1, ISG20, ZNF669, ZNF689, OPTN, ZBTB10, OMA1, ZNF503, STAMBPL1, GALNT14, DPH3, NUDT11, ZNF274, AURKB, FAHD2A, ZC2HC1A, ZNF486, ZNF764, ZNF419, ZNF625, ZNF845, HPDL, ZBED3, HIC2, ZNF333, ZNF462, CHAMP1, ZFP91, ZFYVE19, ZBTB45, ZC3H10, ZNF521, ZNF512B, ZSCAN31, FGD4, ZNF75A, ZNF578, ZNF641, ZNF285, ZFP3, ARAP1, AGAP4, MCEE, ZNF317, NEK1, SMG1, YPEL2, PPP1R10, TRPM7, ZNF300, MCCC1, ZNF347, ZNF607, ZNF587, ZNF382, YME1L1, STAC, KLF6, PKMYT1, SDHC, SMAD5, NPAS2, MIPEP, ZFYVE21, ELAC2, ZNF559, CPPED1, PELO, AGMAT, ESYT1, ALKBH7, ZNF692, DOHH, SPON2, ZNF426, MLPH, REPIN1, PAPOLG, TRPM6, SALL3, CLEC7A, IDI2, HDAC8, HELZ2, NLN, PRKD2, FOXP3, INO80B, UNK, ZNF518B, ZC3H12C, EPT1, LNP, ZNF436, PEG3, CTDSP1, ZNF350, UBA5, ADAM19, RACGAP1, ZNF700, LMAN2L, THAP2, BCL11A, TRPV6, TNKS2, IKZF4, FOXP1, ZNF335, IKZF5, FAM96A, ZNF552, SMYD3, ATP13A3, NT5DC2, ZNF430, ZNF395, MOB1A, PLEKHF2, ELP3, SAP30L, EBF2, PATZ1, MKNK2, ZNF287, ZBTB20, SPON1, ZNF532, ZNF160, ZNF334, CD209, PDE7B, ARFGAP3, ADAP2, NGB, PRDM10, PRDM6, GPHN, ZNF71, ZNF302, MBNL1, SLC2A4RG, TSHZ2, ZNF277, LATS2, GLRX2, ZFP64, MBNL3, TRMT13, NUDT15, ARMC1, ZNF358, POLR3B, RBM22, RNF216, NMRK1, LYAR, SMPD4, ZNF586, MTMR4, MIS18A, ZNF226, CISD1, GDE1, ZNF224, PDP1, ZKSCAN7, ZBTB4, ZNF492, ANKFY1, SUCLA2, DNMT3B, ASH2L, VPS29, POLK, B4GALT6, ZC3H7B, NUFIP1, ZNF639, ZNF230, MUTYH, KLF15, CNOT7, ENPP5, ZFP69B, ZNF112, ZNF222, ZNF580, NOCT, GPATCH8, ADAM21, FBXO5, HDAC9, AGO2, VAV3, ITGA11, ZHX1, ZNF236, ZNF608, ASAP1, RIMKLB, ZBTB21, CNOT6, NOB1, MGAT4A, PLAGL1, NENF, POLI, AGAP1, ZC3H4, DICER1, RIMS2, MGAT4B, EXO1, HDAC5, ZNF148, GNE, POLH, EXOG, GIT1, KLF13, RTCB, ZNF337, ZNF330, ZNF175, ZNF451, HSPB11, NME7, TIMM10B, ZNF706, KLF2, CPQ, POMT1, SAR1B, STK24, XRCC6BP1, CEPT1, TNFRSF11A, MAP3K4, ENPP4

GO:0046875

MF

ephrin receptor binding

Interacting selectively and non-covalently with an ephrin receptor.

SDCBP, FYN, CHN1, EFNA1, PIK3CG, EFNA4, EFNB2, EFNA5, EPHA4, GRB2, CDK5, ANKS1A

GO:0046899

MF

nucleoside triphosphate adenylate kinase activity

Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP.

AK4, AK3

GO:0046904

MF

calcium oxalate binding

Interacting selectively and non-covalently with calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi.

AMBP

GO:0046911

MF

metal chelating activity

The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring.

APOE

GO:0046914

MF

transition metal ion binding

Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

APP, HRSP12, APLP2

GO:0046915

MF

transition metal ion transmembrane transporter activity

Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

SLC11A1, SLC11A2

GO:0046920

MF

alpha-(1->3)-fucosyltransferase activity

Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage.

FUT4

GO:0046923

MF

ER retention sequence binding

Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER.

KDELR3, CEMIP, KCNIP2

GO:0046933

MF

proton-transporting ATP synthase activity, rotational mechanism

Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism.

ATP5H, ATP5D, ATP5C1, ATP5O, ATP5G3, ATP5E, ATP5G2

GO:0046934

MF

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).

PIK3CD, EREG, FGF18, FGF19, EGFR, PDGFB, PDGFA, ERBB2, FYN, FGF2, PDGFRB, KIT, CD28, FGFR1, VAV1, PDGFRA, KITLG, FGF7, FGFR2, ERBB3, PIK3R1, FGF9, BTC, IRS1, PIK3CA, PIK3CB, PIK3CG, GRB2, NRG1, PTPN11, GAB1, ERBB4, FRS2, HBEGF, KL, IRS2

GO:0046935

MF

1-phosphatidylinositol-3-kinase regulator activity

Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity.

PIK3R1, CCKBR

GO:0046943

MF

carboxylic acid transmembrane transporter activity

Enables the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

AQP9

GO:0046961

MF

proton-transporting ATPase activity, rotational mechanism

Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

ATP6V0E1, ATP6V1B2, ATP6V1C1, ATP5D, ATP5C1, ATP5E, TCIRG1, ATP6V1F, ATP6V0A1, ATP6V1H

GO:0046965

MF

retinoid X receptor binding

Interacting selectively and non-covalently with a retinoid X receptor.

VDR, HMGA1, FUS, PPARG, NR4A2, NRIP1, NR1H2, NR0B2, NCOA1, NR1H4

GO:0046966

MF

thyroid hormone receptor binding

Interacting selectively and non-covalently with a thyroid hormone receptor.

NCOR1, FUS, NUP62, GTF2B, NR0B2, TAF11, ZNHIT3, JMJD1C, TRIP6, MED12, MED30, MED4, MED17, THRAP3, MED16, NCOA3

GO:0046970

MF

NAD-dependent histone deacetylase activity (H4-K16 specific)

Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.

SIRT2

GO:0046972

MF

histone acetyltransferase activity (H4-K16 specific)

Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4.

OGT, PHF20, KANSL3

GO:0046974

MF

histone methyltransferase activity (H3-K9 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.

EHMT2, SETDB2, SUV39H2

GO:0046975

MF

histone methyltransferase activity (H3-K36 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein.

ASH1L

GO:0046976

MF

histone methyltransferase activity (H3-K27 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group onto lysine at position 27 of the histone H3 protein.

EZH2, EHMT2

GO:0046978

MF

TAP1 binding

Interacting selectively and non-covalently with the TAP1 subunit of TAP (transporter associated with antigen processing) protein.

HLA-F

GO:0046979

MF

TAP2 binding

Interacting selectively and non-covalently with the TAP2 subunit of TAP (transporter associated with antigen processing) protein.

HLA-F

GO:0046982

MF

protein heterodimerization activity

Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.

SUPT5H, MEIS1, SDCBP, BHLHE40, KCNK3, MID1, FOXP2, MAFG, IRAK2, BNIP3L, SOX15, TLR2, HIST1H2BK, H2AFY, SUPT3H, FLOT1, VAPB, SMC2, EGFR, FOS, PDGFB, TGFB1, APOA2, RBP4, TTR, RAF1, PDGFA, ERBB2, TP53, CYBB, ITGB2, INHA, JUN, ITGB1, NPM1, HEXA, P4HB, INHBA, ADRB1, POLA1, H2AFZ, HIST1H2AG, BCL2, HSPD1, ITGAM, TOP2A, BMP2, ENO3, HGF, DRD2, TYR, VEGFA, TCF4, TCF3, H2AFX, ITGA2, TAL1, CEBPB, XBP1, ATF1, ATF3, ATF4, ATF6, NFKB1, HIST1H2AD, ERBB3, BMP6, NR4A1, NFYB, ITGA3, ARNT, PIK3R1, IL12A, PPP2R1A, ADORA1, AGTR1, SRI, HIST1H2BB, ADRA1A, ADRA1B, DDIT3, SOX6, AHR, PBX1, NR4A2, NOTCH1, SOX9, GCLC, GCLM, CENPA, CEBPD, PGF, VEGFB, FXR1, IRAK1, CAV2, CLCN3, GTF2A1, GTF2A2, CEBPG, LIMK2, TPD52, SOX8, JAM2, TIRAP, HIST1H2BD, TGFB2, YWHAE, HIST1H4A, HIST1H2BC, PAFAH1B2, HIST1H3D, SIM1, SMAD3, H3F3A, DR1, MEF2A, CAV1, PPARD, RELA, YWHAH, MEF2C, TYRO3, GABPA, FMR1, SOX4, BAX, MCL1, SOS1, SOS2, PPP3CA, BNIP3, SMAD4, NAE1, SNX1, CUL3, NFYC, POLA2, SIM2, SMC1A, MEF2D, DRAP1, PAFAH1B3, NECTIN1, PPP2R4, TLR1, TAF11, TWIST1, SMAD2, SMAD1, USF2, EXT1, TAF12, HIF1A, HIST2H2BE, AOC3, TPD52L1, RALGAPA2, CENPW, PDSS1, HIST2H2AA3, RALGAPA1, TENM4, H2AFV, HIST3H2A, SLC51A, ADIPOR2, RALGAPB, PDSS2, SCUBE1, MICU2, APITD1, ABTB2, FAM73A, GABPB2, JDP2, BCL2L2, BAD, EXT2, HIST1H2AC, HIST1H2BH, ADIPOR1, PANX1, TCF12, BARD1, EPAS1, H2AFJ, KATNB1, JAM3, SDCBP2, ABCG8, RAB3GAP2, IKZF4, SOX17, RRAGC, TAF9B, HMG20A, HEYL, ANO2, RRAGD, NECTIN3, POLE4, POLE3, CHRAC1, SMC4, TXLNG, VAPA, H2AFY2, HMG20B, TENM3, CLCF1, SAE1, MLX, ZHX1, FZD4, BOK, SNX6, TIMELESS, SMC3, SNX5, IRAK3

GO:0046983

MF

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

AHRR, ARNTL, TFEC, POLR1C, TCF21, ZNF862, MITF, PDCD6, AIFM1, ZBED1, MYC, MYCN, ERBB2, DBI, AR, TFEB, HNF1A, STX2, ACTN2, AHR, SREBF1, STAT3, ID4, MXI1, STAT5B, POLR2J, PEX3, ZBED6, E2F1, ID2, ID3, MXD1, PPP3CA, SREBF2, TCF15, STK4, E2F2, MXD4, NCF4, TAF5, NCOA2, NCOA1, MGA, NLGN1, ATP6V1C2, BHLHE22, NUP210, ARNTL2, HPS1, HES6, ATOH8, MNT, NPAS2, POLR2J2, HES4, HPS4, TCFL5, HPSE, BTRC, HIF3A, POLR1D, HES2, HEY1, NCOA3

GO:0047006

MF

17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity

Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone.

HSD17B2, AKR1C1

GO:0047012

MF

sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity

Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one.

NSDHL

GO:0047015

MF

3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity

Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA.

HSD17B10

GO:0047016

MF

cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity

Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one.

HSD3B7

GO:0047017

MF

prostaglandin-F synthase activity

Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.

AKR1C3

GO:0047020

MF

15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate.

AKR1C3

GO:0047021

MF

15-hydroxyprostaglandin dehydrogenase (NADP+) activity

Catalysis of the reaction: NADP(+) + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H(+) + NADPH.

CBR1

GO:0047023

MF

androsterone dehydrogenase activity

Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione.

AKR1C3

GO:0047035

MF

testosterone dehydrogenase (NAD+) activity

Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH.

HSD17B6, HSD17B1, HSD17B2, AKR1C3, DHRS9

GO:0047042

MF

androsterone dehydrogenase (B-specific) activity

Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+.

AKR1C1

GO:0047045

MF

testosterone 17-beta-dehydrogenase (NADP+) activity

Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione.

AKR1C3

GO:0047057

MF

vitamin-K-epoxide reductase (warfarin-sensitive) activity

Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.

VKORC1

GO:0047066

MF

phospholipid-hydroperoxide glutathione peroxidase activity

Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione.

GPX4

GO:0047086

MF

ketosteroid monooxygenase activity

Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate.

AKR1C3, AKR1C2, AKR1C1

GO:0047105

MF

4-trimethylammoniobutyraldehyde dehydrogenase activity

Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate.

ALDH1L1, ALDH9A1, ALDH1L2, ALDH16A1

GO:0047115

MF

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol.

AKR1C3, AKR1C2, AKR1C1

GO:0047117

MF

enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity

Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+.

FASN

GO:0047130

MF

saccharopine dehydrogenase (NADP+, L-lysine-forming) activity

Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = 2-oxoglutarate + L-lysine + H(+) + NADPH.

AASS

GO:0047131

MF

saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity

Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH.

AASS

GO:0047144

MF

2-acylglycerol-3-phosphate O-acyltransferase activity

Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA.

LPCAT3, MBOAT2, LPCAT2, LPGAT1, MBOAT7, CRLS1

GO:0047179

MF

platelet-activating factor acetyltransferase activity

Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid.

PAFAH1B2, PAFAH1B3

GO:0047184

MF

1-acylglycerophosphocholine O-acyltransferase activity

Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA.

LPCAT3, LPCAT2

GO:0047192

MF

1-alkylglycerophosphocholine O-acetyltransferase activity

Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA.

LPCAT2

GO:0047237

MF

glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP.

CSGALNACT1

GO:0047238

MF

glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP.

CHSY3, CHSY1, CSGALNACT1

GO:0047256

MF

lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity

Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP.

B3GNT5

GO:0047280

MF

nicotinamide phosphoribosyltransferase activity

Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide.

NAMPT

GO:0047288

MF

monosialoganglioside sialyltransferase activity

Catalysis of the reaction: D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP-N-acetylneuraminate = N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP.

ST3GAL4

GO:0047290

MF

(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity

Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP.

ST6GALNAC4

GO:0047293

MF

4-hydroxybenzoate nonaprenyltransferase activity

Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate.

COQ2

GO:0047298

MF

(S)-3-amino-2-methylpropionate transaminase activity

Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

ABAT

GO:0047322

MF

[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity

Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP.

PRKAA2

GO:0047325

MF

inositol tetrakisphosphate 1-kinase activity

Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP.

ITPK1

GO:0047372

MF

acylglycerol lipase activity

Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol.

ABHD12, DAGLB, MGLL, ABHD6

GO:0047391

MF

alkylglycerophosphoethanolamine phosphodiesterase activity

Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate.

GNB1, ENPP2

GO:0047395

MF

glycerophosphoinositol glycerophosphodiesterase activity

Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = sn-glycerol 3-phosphate + myo-inositol + H(+).

GDE1

GO:0047429

MF

nucleoside-triphosphate diphosphatase activity

Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide.

ENPP3, ENPP1, DCTPP1, NUDT15

GO:0047442

MF

17-alpha-hydroxyprogesterone aldolase activity

Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione.

CYP17A1

GO:0047451

MF

3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity

Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein].

FASN

GO:0047453

MF

ATP-dependent NAD(P)H-hydrate dehydratase activity

Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H(+) + NADH + phosphate.

CARKD

GO:0047485

MF

protein N-terminus binding

Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.

HAX1, EXOC5, SDCBP, ACTN4, SYNGR3, NBN, PEX14, ZWINT, TGFB1, VWF, TP53, DCN, SCT, PARP1, ERCC2, GLRX, PPP1CC, SNCA, ID1, SMARCA4, STXBP1, RPS21, EIF5A, MAP2K1, RELA, HDAC1, GTF2H2, NPAT, ACOX1, TAF11, NCOA1, NIPBL, ERCC4, SMARCC1, EXOC4, PDLIM5, EXOC2, PHB2, FEZ1, PDCD10, TBL1XR1, KCNIP2, MORF4L1, SRRM2, NCOR2, NCOA3

GO:0047493

MF

ceramide cholinephosphotransferase activity

Catalysis of the reaction: CDP-choline + ceramide = CMP + H(+) + sphingomyelin.

SGMS1, SGMS2

GO:0047498

MF

calcium-dependent phospholipase A2 activity

Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+.

PLA2G2A, PLA2G5, PLA2G4A, PLA2G12A

GO:0047499

MF

calcium-independent phospholipase A2 activity

Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+.

PLA2G7, PNPLA8, PLA2G4C