GO:0034595

MF

phosphatidylinositol phosphate 5-phosphatase activity

Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate.

SYNJ1, INPP5K

GO:0034596

MF

phosphatidylinositol phosphate 4-phosphatase activity

Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate.

SYNJ2, SYNJ1

GO:0034597

MF

phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity

Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

INPP4B, INPP4A

GO:0034602

MF

oxoglutarate dehydrogenase (NAD+) activity

Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH.

OGDH

GO:0034604

MF

pyruvate dehydrogenase (NAD+) activity

Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH.

PDHA1, DLD, DLAT, PDHB

GO:0034617

MF

tetrahydrobiopterin binding

Interacting selectively and non-covalently with a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions.

TH, NOS3

GO:0034618

MF

arginine binding

Interacting selectively and non-covalently with 2-amino-5-(carbamimidamido)pentanoic acid.

NOS3, RARS

GO:0034632

MF

retinol transporter activity

Enables the directed movement of retinol into, out of or within a cell, or between cells. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A.

RBP4

GO:0034647

MF

histone demethylase activity (H3-trimethyl-K4 specific)

Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein.

KDM5B

GO:0034648

MF

histone demethylase activity (H3-dimethyl-K4 specific)

Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein.

KDM1A, KDM5B

GO:0034711

MF

inhibin binding

Interacting selectively and non-covalently with an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers.

INHA, INHBA, ACVR2A, ACVR1B

GO:0034713

MF

type I transforming growth factor beta receptor binding

Interacting selectively and non-covalently with a type I transforming growth factor beta receptor.

SMAD7, SMAD6, TGFB1, TGFBR2, SMAD2

GO:0034714

MF

type III transforming growth factor beta receptor binding

Interacting selectively and non-covalently with a type III transforming growth factor beta receptor.

TGFB1, TGFB2

GO:0034722

MF

gamma-glutamyl-peptidase activity

Catalysis of the cleavage of a gamma-linked glutamate bond.

GGH

GO:0034736

MF

cholesterol O-acyltransferase activity

Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA.

SOAT1

GO:0034875

MF

caffeine oxidase activity

Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O.

CYP3A4, CYP2C9

GO:0034979

MF

NAD-dependent protein deacetylase activity

Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.

SIRT2

GO:0034986

MF

iron chaperone activity

Assists in the delivery of iron ions to target proteins or compartments.

FXN

GO:0034987

MF

immunoglobulin receptor binding

Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule.

IGLL5, FGR, CLEC4D

GO:0034988

MF

Fc-gamma receptor I complex binding

Interacting selectively and non-covalently with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG.

FGR, FLNA

GO:0035004

MF

phosphatidylinositol 3-kinase activity

Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring.

PIK3CD, PIK3C2A, PIK3CA, PIK3CB, PIK3CG

GO:0035005

MF

1-phosphatidylinositol-4-phosphate 3-kinase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+).

PIK3CD, PIK3C2A, PIK3CA, PIK3CB, PIK3CG

GO:0035014

MF

phosphatidylinositol 3-kinase regulator activity

Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.

KLF4, PIK3R1

GO:0035033

MF

histone deacetylase regulator activity

Modulates the activity of histone deacetylase.

MAPK8

GO:0035034

MF

histone acetyltransferase regulator activity

Modulates the activity of histone acetyltransferase.

PYGO2, EID1

GO:0035035

MF

histone acetyltransferase binding

Interacting selectively and non-covalently with the enzyme histone acetyltransferase.

ZBTB7A, TP53, GLI3, PCNA, ETS1, CREB1, CEBPB, EGR1, MEF2A, MTF1, HIF1A, SIRT2, NR4A3, EPAS1, CITED2, FOXP3, EID1

GO:0035064

MF

methylated histone binding

Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.

CHD1, CBX7, NCAPD3, CBX5, ATRX, MSH6, FMR1, SUZ12, RBBP5, ZMYND11, GLYR1, PHF19, KDM7A, NCAPG2, L3MBTL2, SGF29, UHRF1, MPHOSPH8, CHD8, ING3, LRWD1, CDYL, L3MBTL1, MTF2, LOXL2, SPIN1

GO:0035091

MF

phosphatidylinositol binding

Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

ESYT2, HIP1, PIK3C2A, ARHGAP33, TULP3, SNX4, SNX16, PITPNA, FCHO2, MYO1E, PLD1, MTM1, SNX1, ITPR2, ITPR3, ITPR1, CCDC88A, HS1BP3, PXK, TRPV1, SNX29, SNX33, MITD1, ZCCHC14, SGK3, SH3YL1, PHF12, PASK, ZCCHC2, PLEKHA2, TULP4, SNX15, WDR35, PITPNC1, SNX12, SNX6, NISCH, SNX9, SNX5

GO:0035173

MF

histone kinase activity

Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.

CDK1, CCNB1, CDK2, BAZ1B

GO:0035174

MF

histone serine kinase activity

Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.

AURKA, PRKAA2, AURKB

GO:0035175

MF

histone kinase activity (H3-S10 specific)

Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3.

RPS6KA5, VRK1

GO:0035197

MF

siRNA binding

Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.

FMR1, AGO2, DICER1

GO:0035198

MF

miRNA binding

Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.

HNRNPA2B1, POU5F1, MEF2C, FMR1, PNPT1, RBM4, LIN28A, AGO4, AGO2

GO:0035226

MF

glutamate-cysteine ligase catalytic subunit binding

Interacting selectively and non-covalently with the catalytic subunit of glutamate-cysteine ligase.

GCLM

GO:0035240

MF

dopamine binding

Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine.

TH, DRD2

GO:0035241

MF

protein-arginine omega-N monomethyltransferase activity

Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue.

PRMT6

GO:0035242

MF

protein-arginine omega-N asymmetric methyltransferase activity

Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues.

PRMT3, CARM1, PRMT6, PRMT1

GO:0035250

MF

UDP-galactosyltransferase activity

Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule.

B4GALT1

GO:0035252

MF

UDP-xylosyltransferase activity

Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule.

LARGE, XXYLT1

GO:0035255

MF

ionotropic glutamate receptor binding

Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.

FLOT1, DRD2, CANX, FUS, DLG4, GNAS, DLG1, GNAS, NETO2

GO:0035256

MF

G-protein coupled glutamate receptor binding

Interacting selectively and non-covalently with a G-protein coupled glutamate receptor (a metabotropic glutamate receptor).

HOMER1, HOMER3

GO:0035257

MF

nuclear hormone receptor binding

Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.

ACTN4, NCOR1, TACC2, CTNNB1, BUD31, NRIP1, EP300, NCOA2, NCOA1, CRY1, HIF1A, SMARCD3, NCOA7, TCF7L2, NCOA3

GO:0035258

MF

steroid hormone receptor binding

Interacting selectively and non-covalently with a steroid hormone receptor.

NR0B1

GO:0035259

MF

glucocorticoid receptor binding

Interacting selectively and non-covalently with a glucocorticoid receptor.

ETS2, CEBPB, STAT3, NR4A2, NRIP1, STAT5B, FKBP4, YWHAH, NR4A3

GO:0035276

MF

ethanol binding

Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH.

ADH7

GO:0035312

MF

5'-3' exodeoxyribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule.

DCLRE1C, EXO1

GO:0035325

MF

Toll-like receptor binding

Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.

TLR2, TOLLIP

GO:0035326

MF

enhancer binding

Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.

TCF3, ARNT, AHR, SOX9, SMAD3, HNRNPU, SMAD2, TCF12

GO:0035368

MF

selenocysteine insertion sequence binding

Interacting selectively and non-covalently with the selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation.

SECISBP2L, SECISBP2

GO:0035373

MF

chondroitin sulfate proteoglycan binding

Interacting selectively and non-covalently with a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit.

PTPRF, SEMA5A

GO:0035374

MF

chondroitin sulfate binding

Interacting selectively and non-covalently with chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc).

DPYSL3

GO:0035375

MF

zymogen binding

Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.

DMBT1

GO:0035401

MF

histone kinase activity (H3-Y41 specific)

The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone.

JAK2

GO:0035402

MF

histone kinase activity (H3-T11 specific)

Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3.

CHEK1, PKN1

GO:0035403

MF

histone kinase activity (H3-T6 specific)

Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3.

PRKCB, PRKCA

GO:0035410

MF

dihydrotestosterone 17-beta-dehydrogenase activity

Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH.

AKR1C3

GO:0035472

MF

choriogonadotropin hormone receptor activity

Combining with the choriogonadotropin hormone to initiate a change in cell activity.

LHCGR

GO:0035473

MF

lipase binding

Interacting selectively and non-covalently with any lipase.

APOB, LRPAP1, PLIN5, APOA5, FAF2

GO:0035497

MF

cAMP response element binding

Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP.

JUN, CREB1, ATF6, HMGA2, CREB3L1, TCF12

GO:0035500

MF

MH2 domain binding

Interacting selectively and non-covalently with the MH2 (MAD homology 2) domain of a protein. The MH2 domain is found at the carboxy terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers.

HMGA2

GO:0035501

MF

MH1 domain binding

Interacting selectively and non-covalently with the MH1 (MAD homology 1) domain of a protein. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors.

HMGA2

GO:0035515

MF

oxidative RNA demethylase activity

Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.

ALKBH5, FTO

GO:0035516

MF

oxidative DNA demethylase activity

Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.

FTO

GO:0035529

MF

NADH pyrophosphatase activity

Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+.

ENPP3, ENPP1

GO:0035539

MF

8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity

Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.

NUDT1, NUDT15

GO:0035575

MF

histone demethylase activity (H4-K20 specific)

Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein.

KDM7A

GO:0035591

MF

signaling adaptor activity

The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.

RACK1, LDLRAP1, HOMER1, AFAP1L2, SH2B1, SH2B3

GO:0035598

MF

N6-threonylcarbomyladenosine methylthiotransferase activity

Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A).

CDKAL1

GO:0035605

MF

peptidyl-cysteine S-nitrosylase activity

Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein.

GAPDH

GO:0035612

MF

AP-2 adaptor complex binding

Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).

AAK1, LDLRAP1, TBC1D5

GO:0035613

MF

RNA stem-loop binding

Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.

DDX3X, EPRS, FMR1, CPEB3, DAZAP1

GO:0035614

MF

snRNA stem-loop binding

Interacting selectively and non-covalently with a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.

SNRPA

GO:0035615

MF

clathrin adaptor activity

The binding activity of a molecule that brings together clathrin and one or more other molecules, permitting them to function in a coordinated way.

AP2A2, AP2S1, AP2B1, DAB2, PICALM, LDLRAP1, AP2M1

GO:0035642

MF

histone methyltransferase activity (H3-R17 specific)

Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to arginine at position 17 of histone H3.

CARM1

GO:0035650

MF

AP-1 adaptor complex binding

Interacting selectively and non-covalently with the AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).

RAB32

GO:0035651

MF

AP-3 adaptor complex binding

Interacting selectively and non-covalently with the AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).

RAB32

GO:0035662

MF

Toll-like receptor 4 binding

Interacting selectively and non-covalently with a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response.

S100A8, S100A9, TIRAP

GO:0035663

MF

Toll-like receptor 2 binding

Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response.

TIRAP, TLR1

GO:0035718

MF

macrophage migration inhibitory factor binding

Interacting selectively and non-covalently with the cytokine, macrophage migration inhibitory factor.

CD74

GO:0035727

MF

lysophosphatidic acid binding

Interacting selectively and non-covalently with lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G-protein-coupled receptors.

GAP43

GO:0035730

MF

S-nitrosoglutathione binding

Interacting selectively and non-covalently with S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems.

GSTP1

GO:0035731

MF

dinitrosyl-iron complex binding

Interacting selectively and non-covalently with a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO.

GSTP1

GO:0035800

MF

deubiquitinase activator activity

Increases the activity of deubiquitinase, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences.

VCP, TANK

GO:0035851

MF

Krueppel-associated box domain binding

Interacting selectively and non-covalently with a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors.

TRIM28

GO:0035870

MF

dITP diphosphatase activity

Catalysis of the reaction: dITP + H2O = dIMP + diphosphate.

NUDT16

GO:0035877

MF

death effector domain binding

Interacting selectively and non-covalently with a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD).

NOL3, FADD, CASP8

GO:0035925

MF

mRNA 3'-UTR AU-rich region binding

Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.

ZFP36, ZFP36L2, ZFP36L1, CPSF1, HNRNPD, ELAVL1, CPEB2, CPEB3, KHSRP

GO:0035939

MF

microsatellite binding

Interacting selectively and non-covalently with a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem.

HEYL, HEY1

GO:0036002

MF

pre-mRNA binding

Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.

DDX5, PTBP1, TRA2B, SRSF2, SRSF6, RBM22, PTBP2

GO:0036004

MF

GAF domain binding

Interacting selectively and non-covalently with the GAF domain of a protein.

AIP

GO:0036033

MF

mediator complex binding

Interacting selectively and non-covalently with a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

SMC1A, NIPBL, SMC3

GO:0036041

MF

long-chain fatty acid binding

Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.

FABP3, HRSP12

GO:0036042

MF

long-chain fatty acyl-CoA binding

Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.

ACOT7, DBI, SCP2

GO:0036094

MF

small molecule binding

Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule.

AMBP, PAEP, PTGDS, LCN2

GO:0036122

MF

BMP binding

Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family.

GREM1, NBL1, GDF5, BMPR2, GREM2

GO:0036130

MF

prostaglandin H2 endoperoxidase reductase activity

Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate).

AKR1C3

GO:0036131

MF

prostaglandin D2 11-ketoreductase activity

Catalysis of the reaction: prostaglandin D2 + H+ + NADPH -> 11-epi-prostaglandin F2alpha + NADP+.

AKR1C3

GO:0036132

MF

13-prostaglandin reductase activity

Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin.

PTGR1

GO:0036143

MF

kringle domain binding

Interacting selectively and non-covalently with a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors.

CLEC3B

GO:0036219

MF

GTP diphosphatase activity

Catalysis of the reaction: GTP + H2O = GMP + diphosphate.

NUDT1