|
GO:0030165
|
MF
|
PDZ domain binding
|
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
|
PARK2,
FZD7,
SLC22A5,
ADRB1,
CFTR,
GJA1,
ATP2B1,
ATP2B4,
ACVR2A,
SDC2,
MAP2K2,
NSF,
PSEN1,
CLCN3,
PTEN,
GNG5,
CXADR,
DLG4,
ADAM17,
TGFBR3,
SNTA1,
SNTB1,
KIF14,
ACOX1,
ARHGAP29,
ARHGEF16,
ERC1,
NLGN1,
EXOC4,
CADM1,
FZD8,
LIN7B,
PLEKHA2,
LIN7C,
CRIM1,
MPP6,
CRIPT,
ASIC3,
KIDINS220,
FZD4,
DTNA,
F11R
|
|
GO:0030169
|
MF
|
low-density lipoprotein particle binding
|
Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.
|
LDLR,
CRP,
THBS1,
CD36,
CDH13,
SCARF1,
COLEC12,
PCSK9,
SCARB1,
STAB2,
SORL1,
STAB1
|
|
GO:0030170
|
MF
|
pyridoxal phosphate binding
|
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
|
PDXK,
SPTLC2,
PROSC,
GOT2,
ALB,
PYGB,
PYGM,
AGXT,
CTH,
SHMT1,
CBS,
BCAT1,
ABAT,
KYNU,
MARC1,
THNSL2,
PHYKPL,
THNSL1,
GPT2,
MOCOS,
CSAD
|
|
GO:0030172
|
MF
|
troponin C binding
|
Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex.
|
TNNI3
|
|
GO:0030197
|
MF
|
extracellular matrix constituent, lubricant activity
|
Functions as a lubricant for an extracellular matrix, such as a mucous membrane.
|
MUC3A,
MUC4
|
|
GO:0030215
|
MF
|
semaphorin receptor binding
|
Interacting selectively and non-covalently with semaphorin receptors.
|
SEMA3E,
SEMA3D,
SEMA3B,
SEMA5A,
SEMA3A,
SEMA6D,
SEMA3C,
SH3BGRL3,
SEMA6A,
SEMA4A,
SEMA6B
|
|
GO:0030229
|
MF
|
very-low-density lipoprotein particle receptor activity
|
Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis.
|
LDLR,
VLDLR,
APOBR
|
|
GO:0030233
|
MF
|
deoxynucleotide transmembrane transporter activity
|
Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP.
|
SLC25A19
|
|
GO:0030234
|
MF
|
enzyme regulator activity
|
Binds to and modulates the activity of an enzyme.
|
PSMD3,
APOC3,
BRCC3,
GCLM,
PSMD2,
SEPT2,
PPP1R7,
RGN,
MTMR9,
RAB3GAP2,
ATP6V1H
|
|
GO:0030235
|
MF
|
nitric-oxide synthase regulator activity
|
Modulates the activity of nitric oxide synthase.
|
EGFR,
ESR1,
HSP90AA1,
HSP90AB1,
AKT1,
CALM2
|
|
GO:0030246
|
MF
|
carbohydrate binding
|
Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
|
LGALS8,
MAN2B1,
NCAN,
MGAM,
LY75,
ADGRL2,
APCS,
KRT1,
CLEC3B,
C4A,
C4B,
GAA,
VCAN,
PRG2,
SELL,
LGALS3,
CD33,
MAG,
ZP3,
KLRC1,
CALR,
CANX,
CHI3L1,
LGALS7,
NPTX2,
MAN2A2,
EVA1C,
PRPS1,
OLR1,
PKD1,
SORD,
GBE1,
GFPT1,
MGAT2,
GALNT2,
GALNT1,
CNTN1,
OS9,
MLEC,
GANAB,
NOMO1,
NECTIN1,
UAP1,
LGALSL,
ATRNL1,
GALNT5,
GALNT7,
GALNT10,
CD302,
GALNT15,
GALNT4,
ITLN1,
CLEC4D,
CLEC2B,
GALNT14,
BCAN,
SIGLEC11,
CLEC7A,
SIGLEC1,
CHODL,
ADGRL3,
CD248,
CD209,
CD93,
LGALS13,
SIGLEC7,
MAN2B2,
AIM1
|
|
GO:0030247
|
MF
|
polysaccharide binding
|
Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
|
ENPP3,
VTN,
ENPP1,
AGL,
ENPP2,
SBSPON,
PRG4,
TINAGL1
|
|
GO:0030267
|
MF
|
glyoxylate reductase (NADP) activity
|
Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+.
|
GRHPR
|
|
GO:0030272
|
MF
|
5-formyltetrahydrofolate cyclo-ligase activity
|
Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate.
|
MTHFS
|
|
GO:0030274
|
MF
|
LIM domain binding
|
Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.
|
RIPK2,
LDB2,
ACTN2,
CSRP2BP,
RPH3AL,
TLN1
|
|
GO:0030275
|
MF
|
LRR domain binding
|
Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein.
|
KRAS,
POLR2J,
STK11,
LRRFIP2
|
|
GO:0030276
|
MF
|
clathrin binding
|
Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.
|
HIP1,
SYT1,
NCALD,
AP2B1,
PICALM,
LDLRAP1,
AFTPH,
DNER,
SYTL5,
SYTL4,
SYT11,
SYTL2,
RPH3AL,
TRPC6
|
|
GO:0030283
|
MF
|
testosterone dehydrogenase [NAD(P)] activity
|
Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+.
|
HSD17B10
|
|
GO:0030284
|
MF
|
estrogen receptor activity
|
Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.
|
ESR1,
ESR2,
GPER1
|
|
GO:0030290
|
MF
|
sphingolipid activator protein activity
|
Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase.
|
GM2A
|
|
GO:0030291
|
MF
|
protein serine/threonine kinase inhibitor activity
|
Stops, prevents or reduces the activity of a protein serine/threonine kinase.
|
SPRY2,
H2AFY,
SPRED1,
CIB1,
WNK1
|
|
GO:0030292
|
MF
|
protein tyrosine kinase inhibitor activity
|
Stops, prevents or reduces the activity of a protein tyrosine kinase.
|
RACK1
|
|
GO:0030294
|
MF
|
receptor signaling protein tyrosine kinase inhibitor activity
|
Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase.
|
HYAL2
|
|
GO:0030295
|
MF
|
protein kinase activator activity
|
Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
|
RPLP1,
MT3,
PIK3CA,
STK11,
DBF4B,
DUSP19,
FGF13,
WNK1,
RGCC,
GPRC5B,
CAB39
|
|
GO:0030296
|
MF
|
protein tyrosine kinase activator activity
|
Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.
|
ERBB3,
CD24,
PAK2,
GAS6,
ABI1,
AFAP1L2,
GHRL
|
|
GO:0030297
|
MF
|
transmembrane receptor protein tyrosine kinase activator activity
|
Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.
|
GREM1,
EFNA5,
NRG1
|
|
GO:0030298
|
MF
|
receptor signaling protein tyrosine kinase activator activity
|
Binds to and increases the activity of a receptor signaling protein tyrosine kinase.
|
CCL5,
FAM150B
|
|
GO:0030305
|
MF
|
heparanase activity
|
Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains.
|
HPSE
|
|
GO:0030306
|
MF
|
ADP-ribosylation factor binding
|
Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells.
|
RAB11FIP3,
ADCYAP1R1,
SORL1,
GGA2
|
|
GO:0030331
|
MF
|
estrogen receptor binding
|
Interacting selectively and non-covalently with an estrogen receptor.
|
CNOT1,
PARP1,
PCNA,
DDX5,
CTNNB1,
FUS,
PPARG,
NRIP1,
FOXL2,
PPID,
TAF10,
NCOA1,
WIPI1,
PPARGC1B,
DDX54,
DDX17,
RERG,
PHB2,
PAGR1,
PPARGC1A
|
|
GO:0030332
|
MF
|
cyclin binding
|
Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.
|
HDAC3,
USP2,
CDK1,
CDK4,
CDK2,
CDKN1A,
CDK6,
INSM1,
CUL3,
PTCH1,
CDK13,
FBXO31,
CDK12
|
|
GO:0030337
|
MF
|
DNA polymerase processivity factor activity
|
An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.
|
PCNA,
TEFM
|
|
GO:0030343
|
MF
|
vitamin D3 25-hydroxylase activity
|
Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O.
|
CYP3A4,
CYP2R1
|
|
GO:0030346
|
MF
|
protein phosphatase 2B binding
|
Interacting selectively and non-covalently with the enzyme protein phosphatase 2B.
|
ATP2B4,
BAD
|
|
GO:0030348
|
MF
|
syntaxin-3 binding
|
Interacting selectively and non-covalently with the SNAP receptor syntaxin-3.
|
STXBP2
|
|
GO:0030351
|
MF
|
inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
|
Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate.
|
MINPP1
|
|
GO:0030368
|
MF
|
interleukin-17 receptor activity
|
Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
IL17RB
|
|
GO:0030369
|
MF
|
ICAM-3 receptor activity
|
Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues.
|
ITGB2
|
|
GO:0030371
|
MF
|
translation repressor activity
|
Antagonizes ribosome-mediated translation of mRNA into a polypeptide.
|
FMR1,
EIF4EBP1,
EIF4EBP2,
CIRBP,
SAMD4B,
NANOS1,
PAIP2,
SAMD4A
|
|
GO:0030374
|
MF
|
ligand-dependent nuclear receptor transcription coactivator activity
|
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
|
ACTN4,
MED14,
KDM1A,
TADA3,
PRKCB,
FGF2,
ACTN1,
HMGA1,
PPARG,
BUD31,
NCOA2,
NCOA1,
PKN1,
DCAF6,
SLC30A9,
CARM1,
PPARGC1B,
CCAR1,
ZMIZ2,
NCOA7,
GLMP,
MED12,
MED30,
HELZ2,
SRA1,
ENY2,
MED4,
MED17,
PSMC3IP,
PPARGC1A,
USP22,
THRAP3,
NCOA3
|
|
GO:0030375
|
MF
|
thyroid hormone receptor coactivator activity
|
The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
|
ACTN2,
NCOA2,
MED16
|
|
GO:0030377
|
MF
|
urokinase plasminogen activator receptor activity
|
Combining with the urokinase plasminogen activator to initiate a change in cell activity.
|
PLAUR
|
|
GO:0030395
|
MF
|
lactose binding
|
Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk.
|
LGALS1,
LGALS12
|
|
GO:0030414
|
MF
|
peptidase inhibitor activity
|
Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
|
SSPO,
PI15,
PTTG1,
PI16,
PROL1
|
|
GO:0030429
|
MF
|
kynureninase activity
|
Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine.
|
KYNU
|
|
GO:0030492
|
MF
|
hemoglobin binding
|
Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
|
HP,
HBB
|
|
GO:0030504
|
MF
|
inorganic diphosphate transmembrane transporter activity
|
Enables the transfer of inorganic diphosphate across a membrane.
|
ANKH
|
|
GO:0030506
|
MF
|
ankyrin binding
|
Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.
|
SPTBN1,
FLNC,
KCNJ11,
KCTD6,
NRCAM,
SPTBN4,
RHBG
|
|
GO:0030507
|
MF
|
spectrin binding
|
Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.
|
DYNC1I1,
GNB3,
GBP1,
GNB1,
ANK2,
CAMSAP2,
ANK3,
DCTN2,
CAMSAP1,
SPTBN4,
MYO10,
CAMSAP3,
KIF3A
|
|
GO:0030515
|
MF
|
snoRNA binding
|
Interacting selectively and non-covalently with small nucleolar RNA.
|
NOP56,
NUDT7,
NUDT1,
SNU13,
TBL3,
NUDT16,
NUFIP1,
NUDT5,
WDR3
|
|
GO:0030544
|
MF
|
Hsp70 protein binding
|
Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size.
|
GPR37,
PARK2,
ERN1,
CDK1,
CREB1,
DNAJB1,
DNAJA1,
STIP1,
NUP62,
CDKN1B,
MVD,
PPID,
C11orf73,
DNAJC10,
METTL21A,
PACRG,
HDAC8,
IQCG,
STUB1
|
|
GO:0030546
|
MF
|
receptor activator activity
|
The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased.
|
IGF2,
ANXA2,
PPARGC1B
|
|
GO:0030547
|
MF
|
receptor inhibitor activity
|
The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased.
|
PCSK9
|
|
GO:0030549
|
MF
|
acetylcholine receptor activator activity
|
Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased.
|
CDK5
|
|
GO:0030550
|
MF
|
acetylcholine receptor inhibitor activity
|
Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is decreased.
|
LYPD1
|
|
GO:0030551
|
MF
|
cyclic nucleotide binding
|
Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.
|
CNP
|
|
GO:0030552
|
MF
|
cAMP binding
|
Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
|
PRKAR1A,
PRKAR2A,
PRKAR2B,
PDE4D,
PDE3A,
BVES,
RAPGEF4,
POPDC3
|
|
GO:0030553
|
MF
|
cGMP binding
|
Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
|
PDE5A,
CNGA1
|
|
GO:0030554
|
MF
|
adenyl nucleotide binding
|
Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.
|
AHCY
|
|
GO:0030594
|
MF
|
neurotransmitter receptor activity
|
Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.
|
HTR2C,
HTR7,
HTR2B
|
|
GO:0030616
|
MF
|
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
|
A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription.
|
SMAD4
|
|
GO:0030617
|
MF
|
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
|
A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators.
|
SMAD7,
SMAD6
|
|
GO:0030618
|
MF
|
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
|
A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription.
|
SMAD9,
SMAD3,
SMAD2,
SMAD1,
SMAD5
|
|
GO:0030619
|
MF
|
U1 snRNA binding
|
Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA).
|
SNRPA,
ISG20
|
|
GO:0030620
|
MF
|
U2 snRNA binding
|
Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA).
|
SNRPA1,
TROVE2,
SNRPB,
SNRPD3,
ISG20
|
|
GO:0030621
|
MF
|
U4 snRNA binding
|
Interacting selectively and non-covalently with the U4 small nuclear RNA (U4 snRNA).
|
SNU13,
SART3,
PRPF31
|
|
GO:0030622
|
MF
|
U4atac snRNA binding
|
Interacting selectively and non-covalently with the U4atac small nuclear RNA (U4atac snRNA).
|
SNU13,
PRPF31
|
|
GO:0030624
|
MF
|
U6atac snRNA binding
|
Interacting selectively and non-covalently with the U6atac small nuclear RNA (U6atac snRNA).
|
SART3
|
|
GO:0030626
|
MF
|
U12 snRNA binding
|
Interacting selectively and non-covalently with the U12 small nuclear RNA (U12 snRNA).
|
RNPC3
|
|
GO:0030627
|
MF
|
pre-mRNA 5'-splice site binding
|
Interacting selectively and non-covalently with the pre-mRNA 5' splice site sequence.
|
SNRPC,
PRPF39
|
|
GO:0030674
|
MF
|
protein binding, bridging
|
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
|
FLRT2,
CSTA,
FGA,
FGB,
FGG,
ANXA1,
COL1A2,
NEFH,
COL11A1,
COL11A2,
DSP,
BCL3,
COL8A2,
CBX5,
CAV2,
TIRAP,
ARPC4,
PSMC6,
CRADD,
ANK2,
FKBP4,
CAV1,
COL14A1,
ANK3,
CUX1,
FSCN1,
GATAD2A,
WWC1,
TRIM22,
RAD50,
OPTN,
TRIM6,
ADAP2,
FLRT3,
FLRT1,
FRMD4A,
TJP2,
DDX20,
NUFIP1,
C14orf1,
AMFR,
STUB1
|
|
GO:0030676
|
MF
|
Rac guanyl-nucleotide exchange factor activity
|
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
FARP2,
VAV1,
TIAM1,
PREX2,
DOCK2,
ARHGEF2,
SPATA13,
ALS2,
ARHGEF4,
VAV3,
FARP1
|
|
GO:0030695
|
MF
|
GTPase regulator activity
|
Modulates the rate of GTP hydrolysis by a GTPase.
|
WASL,
KRIT1,
RGS12,
RALGDS,
PCP2,
RIN2,
GOPC,
GPSM3
|
|
GO:0030729
|
MF
|
acetoacetate-CoA ligase activity
|
Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+).
|
AACS
|
|
GO:0030742
|
MF
|
GTP-dependent protein binding
|
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP.
|
RAB3B,
CDC42,
RAB5B,
RAC1,
RAB32,
EEA1,
RAPGEF6,
RAB34,
PARD6A
|
|
GO:0030760
|
MF
|
pyridine N-methyltransferase activity
|
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine.
|
NNMT
|
|
GO:0030791
|
MF
|
arsenite methyltransferase activity
|
Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.
|
AS3MT
|
|
GO:0030792
|
MF
|
methylarsonite methyltransferase activity
|
Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.
|
AS3MT
|
|
GO:0030881
|
MF
|
beta-2-microglobulin binding
|
Interacting selectively and non-covalently with beta-2-microglobulin.
|
HLA-E,
CD1D,
HLA-A,
HFE
|
|
GO:0030882
|
MF
|
lipid antigen binding
|
Interacting selectively and non-covalently with a lipid antigen.
|
CD1D
|
|
GO:0030883
|
MF
|
endogenous lipid antigen binding
|
Interacting selectively and non-covalently with an endogenous cellular lipid antigen.
|
CD1D
|
|
GO:0030884
|
MF
|
exogenous lipid antigen binding
|
Interacting selectively and non-covalently with an exogenous lipid antigen (examples include microbial lipids and glycolipids).
|
CD1D
|
|
GO:0030898
|
MF
|
actin-dependent ATPase activity
|
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate.
|
MYO1C,
MYO1D,
MYH9,
MYL6,
MYO10
|
|
GO:0030911
|
MF
|
TPR domain binding
|
Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices.
|
HSP90AA1,
HSP90AB1,
RAB8B,
STUB1
|
|
GO:0030942
|
MF
|
endoplasmic reticulum signal peptide binding
|
Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.
|
SRP14,
SRP54
|
|
GO:0030943
|
MF
|
mitochondrion targeting sequence binding
|
Interacting selectively and non-covalently with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion.
|
TOMM20
|
|
GO:0030955
|
MF
|
potassium ion binding
|
Interacting selectively and non-covalently with potassium (K+) ions.
|
PDXK,
ATP1B1,
PKM,
ATP1A2,
HDAC4,
KCNJ11,
SLC24A3
|
|
GO:0030957
|
MF
|
Tat protein binding
|
Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus.
|
NPM1,
DNAJA1,
SMARCA4,
ACTB,
GABARAPL1
|
|
GO:0030971
|
MF
|
receptor tyrosine kinase binding
|
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
ANGPT2,
SOCS5,
ZPR1,
TP53,
PCNA,
PTPN2,
MST1,
RACK1,
SHC2,
NRG1,
PTPN11,
HYAL2,
TIAM1,
CBLB,
SQSTM1,
EIF3A,
GAS6,
ANGPT1,
ARHGEF16,
FAM150B
|
|
GO:0030975
|
MF
|
thiamine binding
|
Interacting selectively and non-covalently with thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
|
TPK1
|
|
GO:0030976
|
MF
|
thiamine pyrophosphate binding
|
Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.
|
ILVBL,
OGDH
|
|
GO:0030983
|
MF
|
mismatched DNA binding
|
Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches.
|
MSH3,
MSH2,
MSH6,
PMS1,
TDG,
MLH3
|
|
GO:0030984
|
MF
|
kininogen binding
|
Interacting selectively and non-covalently with a kininogen, any of a group of plasma proteins that are kinin precursors.
|
C1QBP
|
|
GO:0031005
|
MF
|
filamin binding
|
Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
|
DPYSL4,
NEBL,
DPYSL3,
FAM101A,
FAM101B,
FBLIM1,
PDLIM2
|
|
GO:0031014
|
MF
|
troponin T binding
|
Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex.
|
TNNT1,
TNNI3
|
|
GO:0031072
|
MF
|
heat shock protein binding
|
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
|
GPR37,
PARK2,
DNAJA2,
DNAJB6,
HSPA1A,
HSPA1B,
TPR,
HSPA6,
ZFP36,
ADORA1,
HSPA1L,
IRAK1,
TFAM,
HSF1,
OGDH,
FKBP4,
PPID,
DMPK,
FKBP5,
KCNJ11,
CDC37,
DNAJA4,
DNAJC9,
HDAC2,
PACRG,
DNAJC7,
FAF1
|
|
GO:0031177
|
MF
|
phosphopantetheine binding
|
Interacting selectively and non-covalently with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate).
|
FASN
|
|
GO:0031208
|
MF
|
POZ domain binding
|
Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors.
|
CUL3
|
|
GO:0031210
|
MF
|
phosphatidylcholine binding
|
Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline.
|
ESYT2,
CHMP2A,
APOA1,
APOA2,
APOC1,
SERPINA5,
PCYT1A,
PITPNA,
APOA5,
PCTP
|
|
GO:0031267
|
MF
|
small GTPase binding
|
Interacting selectively and non-covalently with a small monomeric GTPase.
|
ABCA1,
FLNA,
TSC2,
GDI2,
FGD6,
FGD2,
RNF152,
FGD4,
ERRFI1
|