GO:0032393

MF

MHC class I receptor activity

Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.

LILRB1, MR1

GO:0032395

MF

MHC class II receptor activity

Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

HLA-DRA, HLA-DQA2, HLA-DQA1, HLA-DQB1, HLA-DOB, HLA-DPA1, HLA-DRB3, KRT17

GO:0032403

MF

protein complex binding

Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).

APBB1, NDUFA4, KRIT1, ITGB1BP1, FYB, CFLAR, ULK1, TULP3, CRTAP, MYC, NRAS, KRAS, NR3C1, ITGB2, ITGB1, KRT8, C8G, TUBB, KRT19, RRAS, PTPRF, HSPD1, THRA, CDK4, HCLS1, EPCAM, ITGA2, ATF1, UQCRC2, FBLN1, PPIB, NFYB, UQCRC1, YWHAB, FBN1, PPP1CC, SREBF1, CDKN1A, CAPG, MTHFR, NSF, CDKN1B, IQGAP1, UQCRFS1, TMED10, RANBP2, BCAP31, KIF11, IST1, EPHB1, ATP6V0D1, PPP1CA, RAP1A, GNB1, RBX1, GNB2, AP2B1, IGBP1, DLG4, SLC25A3, SPTBN1, RELA, KHDRBS1, PPARA, TWF1, STRN3, FADD, PDCL, MAPK8IP2, RIPK1, CUL2, PTCH1, DAG1, GIT2, COG2, CASP8, TCEB1, NR0B2, TRADD, TSN, TAB1, NCOA1, LRRC16A, CYFIP1, SLF2, ABI1, FLCN, KAT6B, KAT2B, UFD1L, TXN2, SLF1, TAPBPL, NDEL1, STRN4, RAD18, ABI2, PLK2, CRIPT, GIT1, WASF2

GO:0032405

MF

MutLalpha complex binding

Interacting selectively and non-covalently with the mismatch repair complex MutLalpha.

PCNA, MSH2, MSH6

GO:0032407

MF

MutSalpha complex binding

Interacting selectively and non-covalently with the mismatch repair complex MutSalpha.

MLH1, MUTYH

GO:0032422

MF

purine-rich negative regulatory element binding

Interacting selectively and non-covalently with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes.

ELK3, PURA

GO:0032427

MF

GBD domain binding

Interacting selectively and non-covalently with the GTPase protein binding domain (GDB) domain of a protein. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac.

RHOQ

GO:0032428

MF

beta-N-acetylgalactosaminidase activity

Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides.

GM2A

GO:0032440

MF

2-alkenal reductase [NAD(P)] activity

Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+.

PTGR1

GO:0032448

MF

DNA hairpin binding

Interacting selectively and non-covalently with DNA containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences.

NR0B1

GO:0032450

MF

maltose alpha-glucosidase activity

Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose.

MGAM, GAA

GO:0032451

MF

demethylase activity

Catalysis of the removal of a methyl group from a substrate.

KDM1A, CYP1A1

GO:0032452

MF

histone demethylase activity

Catalysis of the removal of a methyl group from a histone.

UTY, KDM6A, KDM1A, KDM4B, KDM5A, ARID5B, JMJD6, KDM7A, KDM5B, KDM2A

GO:0032453

MF

histone demethylase activity (H3-K4 specific)

Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.

KDM1A, KDM5B

GO:0032454

MF

histone demethylase activity (H3-K9 specific)

Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.

KDM1A, JMJD1C, KDM7A

GO:0032542

MF

sulfiredoxin activity

Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.

SESN2

GO:0032549

MF

ribonucleoside binding

Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.

POLR2B, POLR3B

GO:0032556

MF

pyrimidine deoxyribonucleotide binding

Interacting selectively and non-covalently with a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety.

DCTPP1

GO:0032557

MF

pyrimidine ribonucleotide binding

Interacting selectively and non-covalently with a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

UGP2

GO:0032564

MF

dATP binding

Interacting selectively and non-covalently with dATP, deoxyadenosine triphosphate.

HSP90AA1, HSP90AB1

GO:0032567

MF

dGTP binding

Interacting selectively and non-covalently with dGTP, deoxyguanosine triphosphate.

SAMHD1

GO:0032767

MF

copper-dependent protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of copper.

ATOX1, FKBP4

GO:0032791

MF

lead ion binding

Interacting selectively and non-covalently with lead (Pb) ions.

ALAD

GO:0032794

MF

GTPase activating protein binding

Interacting selectively and non-covalently with a GTPase activating protein.

TUBB, GNAI3, AKT1, PLCD1, GNAI1

GO:0032795

MF

heterotrimeric G-protein binding

Interacting selectively and non-covalently with a heterotrimeric G-protein.

ADORA1

GO:0032810

MF

sterol response element binding

Interacting selectively and non-covalently with the sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism.

SREBF1, NR1H3

GO:0032813

MF

tumor necrosis factor receptor superfamily binding

Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily.

TNFSF11, TNFSF4, FADD

GO:0032947

MF

protein complex scaffold

Functions to provide a physical support for the assembly of a multiprotein complex.

CNOT1, AXIN1, CAPN3, CAV2, EIF3B, RACK1, CAV1, AKAP13, DLG1, AKAP6, SEPT2, ITSN1, WWC2, LAMTOR1, WWC1, RB1CC1, SMARCD1, MAGI1, PKP2, LAMTOR3, WWC3, LAMTOR2

GO:0033130

MF

acetylcholine receptor binding

Interacting selectively and non-covalently with an acetylcholine receptor.

JAK2, DLG4, LYPD1, NRXN1

GO:0033142

MF

progesterone receptor binding

Interacting selectively and non-covalently with a progesterone receptor.

NCOA1

GO:0033149

MF

FFAT motif binding

Interacting selectively and non-covalently with the FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family.

VAPB, VAPA

GO:0033188

MF

sphingomyelin synthase activity

Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin.

SGMS1, SGMS2

GO:0033192

MF

calmodulin-dependent protein phosphatase activity

Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin.

PPM1F, PPP3CA

GO:0033204

MF

ribonuclease P RNA binding

Interacting selectively and non-covalently with the RNA subunit of ribonuclease P.

POP4

GO:0033218

MF

amide binding

Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.

SRD5A1, SRD5A2, PHB2

GO:0033265

MF

choline binding

Interacting selectively and non-covalently with choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium.

CRP, CHKA

GO:0033300

MF

dehydroascorbic acid transporter activity

Enables the directed movement of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

SLC2A1, SLC2A3

GO:0033549

MF

MAP kinase phosphatase activity

Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate.

DUSP3, DUSP10

GO:0033558

MF

protein deacetylase activity

Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.

HDAC3, HDAC4, HDAC1, SIRT2, HDAC2, HDAC9, HDAC5

GO:0033560

MF

folate reductase activity

Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+.

DHFR

GO:0033570

MF

transferrin transmembrane transporter activity

Enables the transfer of transferrin from one side of a membrane to the other.

TFRC, SLC11A2

GO:0033592

MF

RNA strand annealing activity

Facilitates the base-pairing of complementary single-stranded RNA.

EIF4B, FXR1, FMR1

GO:0033612

MF

receptor serine/threonine kinase binding

Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity.

BMP10

GO:0033613

MF

activating transcription factor binding

Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.

PPARG, GATA4, HDAC4, MEF2A, RELA, MEF2C, EP300, HDAC1, MEF2D, SMAD2, HDAC7, ATOH8

GO:0033676

MF

double-stranded DNA-dependent ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of double-stranded DNA, and it drives another reaction.

ANXA1

GO:0033682

MF

ATP-dependent 5'-3' DNA/RNA helicase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 5' to 3'.

PIF1

GO:0033691

MF

sialic acid binding

Interacting selectively and non-covalently with sialic acid, any of a variety of N- or O- substituted derivatives of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria.

SELE, ADIPOQ, ST8SIA4

GO:0033737

MF

1-pyrroline dehydrogenase activity

Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+.

ALDH9A1

GO:0033743

MF

peptide-methionine (R)-S-oxide reductase activity

Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.

MSRB3, TXN2

GO:0033746

MF

histone demethylase activity (H3-R2 specific)

Catalysis of the removal of a methyl group from arginine at position 2 of the histone H3 protein.

JMJD6

GO:0033749

MF

histone demethylase activity (H4-R3 specific)

Catalysis of the removal of a methyl group from arginine at position 3 of the histone H4 protein.

JMJD6

GO:0033778

MF

7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity

Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O(2) = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(2)O + NADP(+).

CYP8B1

GO:0033780

MF

taurochenodeoxycholate 6alpha-hydroxylase activity

Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O.

CYP3A4

GO:0033791

MF

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity

Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor.

ACOX2

GO:0033814

MF

propanoyl-CoA C-acyltransferase activity

Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA.

SCP2

GO:0033857

MF

diphosphoinositol-pentakisphosphate kinase activity

Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate.

PPIP5K1

GO:0033858

MF

N-acetylgalactosamine kinase activity

Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate.

GALK2

GO:0033862

MF

UMP kinase activity

Catalysis of the reaction: ATP + UMP = ADP + UDP.

CMPK2

GO:0033867

MF

Fas-activated serine/threonine kinase activity

Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein.

FASTK

GO:0033872

MF

[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity

Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.

HS3ST3B1

GO:0033878

MF

hormone-sensitive lipase activity

Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate.

LIPE

GO:0033882

MF

choloyl-CoA hydrolase activity

Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA.

ACOT8

GO:0033897

MF

ribonuclease T2 activity

Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates.

RNASET2

GO:0033906

MF

hyaluronoglucuronidase activity

Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate.

HYAL2

GO:0033919

MF

glucan 1,3-alpha-glucosidase activity

Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans.

GANAB

GO:0033925

MF

mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity

Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.

ENGASE

GO:0033961

MF

cis-stilbene-oxide hydrolase activity

Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.

EPHX1

GO:0033981

MF

D-dopachrome decarboxylase activity

Catalysis of the reaction: D-dopachrome + H(+) = 5,6-dihydroxyindole + CO(2).

DDT

GO:0033989

MF

3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity

Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O.

HSD17B4

GO:0034012

MF

FAD-AMP lyase (cyclizing) activity

Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate.

TKFC

GO:0034038

MF

deoxyhypusine synthase activity

Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+.

DHPS

GO:0034046

MF

poly(G) binding

Interacting selectively and non-covalently with a sequence of guanine residues in an RNA molecule.

ATXN1, HNRNPU, FMR1, PNPT1

GO:0034056

MF

estrogen response element binding

Interacting selectively and non-covalently with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen.

TOX3, ESR1, ESR2

GO:0034057

MF

RNA strand-exchange activity

Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity.

EIF4B

GO:0034062

MF

RNA polymerase activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template.

TRNT1

GO:0034185

MF

apolipoprotein binding

Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex.

LRP6, ABCA1, PLG, LPL, MAPT, CANX, VLDLR, PCSK9, SCARB1

GO:0034186

MF

apolipoprotein A-I binding

Interacting selectively and non-covalently with apolipoprotein A-I.

ABCA1, SCARB1

GO:0034188

MF

apolipoprotein A-I receptor activity

Combining with apolipoprotein A-I and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

ABCA1

GO:0034189

MF

very-low-density lipoprotein particle binding

Interacting selectively and non-covalently with a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm.

VLDLR, PCSK9

GO:0034190

MF

apolipoprotein receptor binding

Interacting selectively and non-covalently with an apolipoprotein receptor.

APOA1, APOA2, PCSK9

GO:0034191

MF

apolipoprotein A-I receptor binding

Interacting selectively and non-covalently with an apolipoprotein A-I receptor.

APOA1, NR1H2, CDC42

GO:0034212

MF

peptide N-acetyltransferase activity

Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide.

EP300, CREBBP

GO:0034235

MF

GPI anchor binding

Interacting selectively and non-covalently with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes.

PIGK, PIGU

GO:0034236

MF

protein kinase A catalytic subunit binding

Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A.

PRKAR1A, PRKAR2A, EZR, PRKAR2B, CSK, SOX9, GSK3B, PKIA, RYR2

GO:0034237

MF

protein kinase A regulatory subunit binding

Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A.

EZR, PRKACA, AKAP6, AKAP1, RYR2, ACBD3, AKAP7, ARFGEF2

GO:0034353

MF

RNA pyrophosphohydrolase activity

Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end.

DXO

GO:0034417

MF

bisphosphoglycerate 3-phosphatase activity

Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phospho-D-glycerate + phosphate.

MINPP1

GO:0034431

MF

bis(5'-adenosyl)-hexaphosphatase activity

Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate.

NUDT3, NUDT10, NUDT11

GO:0034432

MF

bis(5'-adenosyl)-pentaphosphatase activity

Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate.

NUDT3, NUDT10, NUDT11

GO:0034437

MF

glycoprotein transporter activity

Enables the directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells.

VLDLR

GO:0034450

MF

ubiquitin-ubiquitin ligase activity

Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.

UBR5, UBE4B, RBX1, PPIL2, PELI1, PELI2, AMFR, PRPF19, STUB1

GO:0034452

MF

dynactin binding

Interacting selectively and non-covalently with any part of a dynactin complex; dynactin is a large protein complex that activates dynein-based motor activity.

HTT, BICD1, SNX6, SNX5

GO:0034458

MF

3'-5' RNA helicase activity

Catalysis of the unwinding of an RNA helix in the direction 3' to 5'.

SUPV3L1

GO:0034485

MF

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate.

INPP5D, INPP5K

GO:0034511

MF

U3 snoRNA binding

Interacting selectively and non-covalently with U3 small nucleolar RNA.

SNU13, TSR1, ISG20

GO:0034512

MF

box C/D snoRNA binding

Interacting selectively and non-covalently with box C/D small nucleolar RNA.

SNU13

GO:0034513

MF

box H/ACA snoRNA binding

Interacting selectively and non-covalently with box H/ACA small nucleolar RNA.

DKC1, NOP10, GAR1

GO:0034584

MF

piRNA binding

Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.

PIWIL4

GO:0034590

MF

L-hydroxyproline transmembrane transporter activity

Enables the transfer of L-hydroxyproline from one side of a membrane to the other.

SLC1A4

GO:0034594

MF

phosphatidylinositol trisphosphate phosphatase activity

Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate.

INPP5K