GO:0019003

MF

GDP binding

Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.

RAB27B, RAB29, KRAS, GNAI3, RRAS, RALA, RALB, RAB3B, RAB5A, PCK1, TRIM23, RAB5C, RAB7A, RAB9A, RAB28, RAB27A, GEM, PRPS1, SRP54, RAB2A, RAB5B, RAP2B, RHOB, GNAI1, ARF1, RAB31, RAB11B, RAB12, RAB8B, RERG, RRAGC, ARL8B, RAB21, RAB22A

GO:0019103

MF

pyrimidine nucleotide binding

Interacting selectively and non-covalently with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate.

NT5C

GO:0019104

MF

DNA N-glycosylase activity

Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.

MBD4, MPG, NTHL1, TDG, SMUG1, NEIL3, MUTYH

GO:0019119

MF

phenanthrene-9,10-epoxide hydrolase activity

Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene.

AKR7A2

GO:0019135

MF

deoxyhypusine monooxygenase activity

Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O.

DOHH

GO:0019144

MF

ADP-sugar diphosphatase activity

Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate.

NUDT9, NUDT5

GO:0019145

MF

aminobutyraldehyde dehydrogenase activity

Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+.

ALDH1L1, ALDH9A1, ALDH1L2, ALDH16A1

GO:0019158

MF

mannokinase activity

Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate.

HK1, HKDC1

GO:0019166

MF

trans-2-enoyl-CoA reductase (NADPH) activity

Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+.

MECR

GO:0019172

MF

glyoxalase III activity

Catalysis of the reaction: methylglyoxal + H2O = D-lactate.

PDDC1

GO:0019206

MF

nucleoside kinase activity

Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate.

TK2, TK1, DCK, DGUOK, AK8, UCK2, UCK1

GO:0019207

MF

kinase regulator activity

Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

GSTP1, BCCIP

GO:0019208

MF

phosphatase regulator activity

Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.

PPP1R12A, PPP1R12B, ZEB2, SBF1, BMP2K

GO:0019209

MF

kinase activator activity

Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

BCL10, TAB1, ITSN1, LAMTOR3

GO:0019210

MF

kinase inhibitor activity

Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

SOCS1, LRP6, AHSG

GO:0019211

MF

phosphatase activator activity

Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.

BMP2, GTF2F1, FRS2

GO:0019212

MF

phosphatase inhibitor activity

Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.

ENSA, URI1, ARPP19, ANP32E

GO:0019213

MF

deacetylase activity

Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.

MACROD2, AADAC, HDAC1, HDAC2, MACROD1

GO:0019215

MF

intermediate filament binding

Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space.

NME1, NME2, NES, MTM1, PKP2

GO:0019237

MF

centromeric DNA binding

Interacting selectively and non-covalently with a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis.

CENPB, MSH2, CENPA, CENPC, KIF2C, MLH3

GO:0019239

MF

deaminase activity

Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3).

RPUSD3, RPUSD4

GO:0019531

MF

oxalate transmembrane transporter activity

Enables the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.

SLC26A2, SLC26A11, SLC26A1

GO:0019534

MF

toxin transporter activity

Enables the directed movement of a toxin into, out of or within a cell, or between cells. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.

LRP6, SLC22A3, SLC7A8

GO:0019706

MF

protein-cysteine S-palmitoyltransferase activity

Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule.

ZDHHC20, ZDHHC17, ZDHHC14, ZDHHC6, ZDHHC7, ZDHHC2, ZDHHC9

GO:0019763

MF

immunoglobulin receptor activity

Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

FCGR1B

GO:0019776

MF

Atg8 ligase activity

Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate.

ATG12

GO:0019777

MF

Atg12 transferase activity

Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y --> Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages.

ATG10

GO:0019780

MF

FAT10 activating enzyme activity

Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond.

UBA6

GO:0019781

MF

NEDD8 activating enzyme activity

Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.

NAE1

GO:0019782

MF

ISG15 activating enzyme activity

Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond.

UBA7

GO:0019784

MF

NEDD8-specific protease activity

Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates.

OTUB2, OTUB1

GO:0019787

MF

ubiquitin-like protein transferase activity

Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.

ITCH, RNF14, ARIH1

GO:0019788

MF

NEDD8 transferase activity

Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.

UBE2M, RBX1

GO:0019789

MF

SUMO transferase activity

Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages.

RANBP2, SUMO2, UBE2I, MDM2, HDAC7

GO:0019797

MF

procollagen-proline 3-dioxygenase activity

Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2.

P3H2

GO:0019809

MF

spermidine binding

Interacting selectively and non-covalently with spermidine, N-(3-aminopropyl)-1,4-diaminobutane.

SAT1, SAT2

GO:0019810

MF

putrescine binding

Interacting selectively and non-covalently with putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.

AMD1

GO:0019825

MF

oxygen binding

Interacting selectively and non-covalently with oxygen (O2).

CYP26A1, ALB, CYP1A1, CYP17A1, CYP2E1, TH, CYP3A4, CYP2D6, CYP19A1, CYP2C9, CYP2B6, CYP3A5, CYP3A7, CBS, HBB, HBG1, HBA1, CYP1B1, CYP2U1, CYGB, NGB, CYP8B1

GO:0019826

MF

oxygen sensor activity

Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2).

NOX4

GO:0019828

MF

aspartic-type endopeptidase inhibitor activity

Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.

WFDC2

GO:0019829

MF

cation-transporting ATPase activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).

ATP13A5, ATP13A3, ATP13A2

GO:0019834

MF

phospholipase A2 inhibitor activity

Stops, prevents or reduces the activity of the enzyme phospholipase A2.

ANXA1, ANXA2, ANXA3

GO:0019838

MF

growth factor binding

Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.

SDCBP, NRP1, NRP2, A2M, ERBB2, ERBB3, ACVR2A, DUSP1, FLT4, ACVR1B, TGFBR1, IL6ST, LIFR, TEK, ACVR2B, BMPR2, RHBDF1, OSMR

GO:0019840

MF

isoprenoid binding

Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.

PGGT1B

GO:0019841

MF

retinol binding

Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation.

RBP4, C8G, RBP1, ADH7

GO:0019843

MF

rRNA binding

Interacting selectively and non-covalently with ribosomal RNA.

ANG, RPS4Y1, RPL12, RPS9, RPS5, RPL37, RPS18, RPS11, RPL23A, RPL11, RNASEL, EMG1, PTCD3, DDX28, MRPL16, NOL12, SBDS

GO:0019855

MF

calcium channel inhibitor activity

Stops, prevents, or reduces the activity of a calcium channel.

AMBP, TNNI3, ITPR1, PHPT1, SLC30A1

GO:0019862

MF

IgA binding

Interacting selectively and non-covalently with an immunoglobulin of an IgA isotype.

AMBP

GO:0019863

MF

IgE binding

Interacting selectively and non-covalently with an immunoglobulin of the IgE isotype.

LGALS3

GO:0019864

MF

IgG binding

Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype.

FCGR3B, FCGR1A, FCGR2A, FCGR2B, FCGR1B

GO:0019865

MF

immunoglobulin binding

Interacting selectively and non-covalently with an immunoglobulin.

CD4, VWF

GO:0019869

MF

chloride channel inhibitor activity

Stops, prevents, or reduces the activity of a chloride channel.

STX7, CFTR, WNK3, WNK1, VTI1B

GO:0019870

MF

potassium channel inhibitor activity

Stops, prevents, or reduces the activity of a potassium channel.

ENSA, RASA1, NEDD4L, WNK1

GO:0019871

MF

sodium channel inhibitor activity

Stops, prevents, or reduces the activity of a sodium channel.

CAMK2D, PCSK9, NEDD4L

GO:0019887

MF

protein kinase regulator activity

Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein.

HSP90AB1, RAC2, APC, CDC37, GCN1, KIDINS220, FAF1

GO:0019888

MF

protein phosphatase regulator activity

Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

PPP1R3B

GO:0019894

MF

kinesin binding

Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.

TOR1A, RAB29, ARHGEF10, PRC1, SPAG9, KIF1B, CLSTN1, NEFH, NUP62, SNCA, ACTB, MAPK8IP2, CROCC, KLC3, KTN1, KIF18B, PIFO, KIFAP3, FAM83D, NEK6, SYBU, MAPK8IP3, MAPK8IP1

GO:0019899

MF

enzyme binding

Interacting selectively and non-covalently with any enzyme.

SUPT5H, MAP2K7, SLC27A2, MDM4, PLSCR1, AXIN1, HDAC3, BIRC5, LDB2, PARK2, TRAK2, KDM1A, H2AFY, TULP3, ERN1, PRKRA, STC2, UBE4B, VAPB, PPP1R3D, BCL10, CYB5A, GOT2, EGFR, A2M, TGFB1, CD4, APOA1, ESR1, SLPI, TP53, CYP1A1, SLC4A2, APP, ITGB3, PCCA, CYP2E1, JUN, FYN, PGR, EIF4E, TH, P4HB, CYP3A4, IL6R, GSTM1, HMOX1, PDGFRB, PARP1, HIST1H2AG, HSPA1A, HSPA1B, AR, MAPT, HSPA5, BCR, LAMP1, TOP2A, CYP2A6, IGF2R, PCNA, UNG, LAMP2, CFTR, RPS2, H2AFX, CREB1, ATP2A2, HSPA6, HMGA1, PRKCA, JUND, TAL1, ATF7, DDX5, MSH3, GSTM3, NME2, ZFP36, CAD, GSTM2, POLD1, PEBP1, AKT1, YWHAB, GBP1, CTNNB1, PHB, RFC4, RFC2, PTGS2, CBS, PPARG, BRCA1, RFC5, MSH2, NKX2-1, MAPK8, NOTCH1, SERPINB4, MCM2, ARPC4, PTEN, NPC2, TSPAN5, YWHAE, SNRPD3, BTG1, RAC1, RACK1, UBE2I, TUBA4A, PRKDC, CBX1, FOXO4, MDM2, ANK2, GSTM4, CAV1, PLAUR, YWHAH, PRKCD, PPP3CA, PDE4D, CPSF1, CDC20, HYAL2, TAF10, CBX3, HDAC1, COTL1, MLEC, KPNB1, DHCR24, NCOA1, ZFHX3, PDCD2, MAPK14, HIF1A, PDE4DIP, HACD4, PHLDB3, APOA5, HACD2, MCM10, NOXA1, LONP2, RPS19BP1, PPP1R3B, KMT2E, CCAR2, TSPAN14, TTN, ESR2, RYR2, HDAC2, N4BP2L2, SPDL1, PAWR, PUS7, RANBP9, RAD9A, PRMT1, TEP1, NABP2, VIMP, HNRNPUL1, CDK19, BLZF1, TNKS2, SUDS3, PLCB1, PLSCR4, MAT2B, HACD3, RCOR3, ATXN10, HDAC6, PYCARD, SNX12, STUB1, USP22, LUC7L2

GO:0019900

MF

kinase binding

Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.

PER1, PARK2, BCL10, LDHA, NTRK1, RB1, LDHB, HSP90AB1, SLC2A1, PFKFB1, CEBPB, PFKL, FLNA, TNFAIP3, SP100, FAS, CTNNB1, HTT, EMP2, BTG1, DLG4, PRKCD, TIAM1, PPP2R5A, TRADD, TRIP6, CDC37, MIDN, SGOL1, TNS2, WWC2, TAX1BP1, WWC1, JAKMIP2, CHP1, BARD1, CDC6, TOLLIP, ABI2, WWC3, STUB1, IGSF9B, PTPN22, CAB39

GO:0019901

MF

protein kinase binding

Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

RHOD, ADAM10, ITGB1BP1, MAP2K7, AURKA, PPP1R12A, AXIN1, SOCS1, MAP3K13, FOXO3, SPRY2, PRC1, PPP1R12B, PARK2, JAK2, CTNND1, PFKFB2, ATG13, H2AFY, PPP1R15A, AP2A2, CEP152, KIF20A, PARN, LATS1, BCL10, CCNE2, EGFR, CD4, TP53, HSPB1, ITGB2, NPM1, HSP90AA1, HSP90AB1, PTPRC, PDGFRB, FGR, PARP1, POLA1, MAPT, CD28, GHR, NEFH, SKI, EEF2, GYS1, HCLS1, CCNB1, JUP, NME1, SYN1, PRKACA, PTPN2, PGAM1, PAM, TNNI3, CCNA2, MAG, APC, CD24, ZFP36, PEBP1, CCND2, CCND3, CDC25A, CDC25B, CDC25C, SFN, CKS2, CTNNB1, PPP1CC, SREBF1, STAT3, CDKN2B, CDKN2C, MSH2, SYK, GATA4, NSF, IQGAP1, LIMS1, IFNAR2, GSK3B, DUSP3, CAV2, MAP2K6, KIF11, PLK1, CACNB3, PRKAG1, EMP2, SLC12A2, CASP9, HDAC4, SIK1, PTEN, CDC42, CKS1B, STXBP1, PPP1CB, CALM2, NCS1, RPS18, ACTA2, RPS6, GRB2, RAC1, YWHAZ, EEF1A1, SMAD3, PKD1, CDK5, E2F1, ANK2, MEF2A, MAP2K1, CAV1, RELA, PTK2, LIPE, EEF1A2, PRKCD, FOXM1, GOLGA2, AP1B1, PTPRJ, DLG1, PAK2, DNAJC3, MAPK8IP2, ILK, SQSTM1, ARHGEF7, KIF14, PTPRK, RHEB, ELAVL1, SMAD1, CRY1, CDC37, DPYSL2, HIF1A, KIZ, BORA, RICTOR, CSPG4, FAM83H, SV2A, RAB11FIP2, MAVS, SPRED1, CAMK2N1, CACUL1, TEX14, TRIM22, DBF4B, TPCN2, OSR1, PIFO, NEK9, RB1CC1, HDAC7, TTN, RFFL, NR4A3, GCN1, KAT2B, GATA6, BAD, FBXW5, ADIPOR1, EXOC2, TRIB3, CCNL2, CDC5L, RAD9A, MAP3K5, CIB1, VRK1, MAPKAP1, PDCD10, TRIM6, RACGAP1, WNK1, FAM83D, RGCC, TRPV4, CENPJ, NEK6, TCF7L2, CYLD, KIF13B, GPRC5B, AKAP7, ZBTB4, TBC1D14, PRKAG3, ERRFI1, TSKS, CCNL1, FBXO5, BAG5, TPX2, SUFU, FAF1, TPRKB, IRS2, TBL2, PPME1

GO:0019902

MF

phosphatase binding

Interacting selectively and non-covalently with any phosphatase.

MAPK3, MAPK1, TSC2, CTSC, SMAD3, PPARA, DLG1, SMAD2, CRY1, MAST2, CNST, SPRED1, MAGI2, PPP1R35, SH3RF2, SH3YL1, CSRNP2, SPTBN4, WNK1, SYTL2, CARHSP1

GO:0019903

MF

protein phosphatase binding

Interacting selectively and non-covalently with any protein phosphatase.

MAP2K7, SNX3, EGFR, ERBB2, TP53, CSF1R, HSP90AA1, MET, HSP90B1, JUP, CDH2, JAK1, PIK3R1, CDC27, CDH5, CTNNB1, FLT4, PPARG, STAT3, CSK, CDKN1B, IQGAP1, STAT5B, NEK2, JAK3, VCP, GRB2, RACK1, DLG4, MAPK14, PPP1R3F, PARD3, MAP3K5, ANAPC5, ANAPC4, FBXL2, PPP6R1, IRS2, PPME1

GO:0019904

MF

protein domain specific binding

Interacting selectively and non-covalently with a specific domain of a protein.

CNOT1, RAB27B, BHLHE40, XPO1, CHMP2A, TBL1X, TADA3, MYO1D, STAMBP, PLG, IL1B, TH, TUBB, ERCC1, GNAI3, THRA, HSPA5, LAMP1, ESRRA, SKI, LAMP2, EZR, TNNI3, TGM2, OSBP, XPA, SP100, ITGA3, HMGB2, PRKAR2B, YWHAB, SFN, RDX, MYH9, ACTN2, PPP1CC, SNCA, CAPG, WNT5A, PRKCI, IQGAP1, RAB27A, NR0B1, HNRNPM, ARFIP1, IST1, ATN1, VCP, WNT3, RAP2B, STXBP1, CALM2, YWHAE, HIST1H4A, YWHAZ, IGBP1, PKD1, ID3, PLAUR, YWHAH, ICA1, ZBTB16, PTPN11, TJP1, PPARA, CBX3, TDG, RUNX2, TFDP1, KPNB1, NR0B2, DIXDC1, TWIST1, OCLN, TUBA1A, CNTROB, MPP5, ICA1L, MITD1, KCTD13, MRPS31, MED12, ZNF521, LIN7B, CENPJ, ARHGEF4, MRPL17, HOMER3, LIN7C, NDE1, STMN3, VAPA, PHRF1, TJP2, DDX20, HPCAL4, ANGEL1, FAF1, DICER1, SSX2IP, PLXND1, IRS2

GO:0019905

MF

syntaxin binding

Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.

SNAP23, STX7, STX6, SEC22B, ABCA1, SNAP29, PTPN2, TMED10, VAMP7, STXBP1, RAB11A, VAMP2, GOLGA2, STXBP5, VPS52, SYTL5, SYTL4, SYT11, NAPB, SYTL2, TXLNG, BLOC1S6, RPH3AL, STXBP5L

GO:0019911

MF

structural constituent of myelin sheath

The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve.

MAL, PLP1

GO:0019912

MF

cyclin-dependent protein kinase activating kinase activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK).

CDKN1A

GO:0019948

MF

SUMO activating enzyme activity

Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.

SAE1

GO:0019955

MF

cytokine binding

Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.

NRP1, NRP2, CD74, CSF1R, KIT, GBP1, CXCR4, FZD4, TNFRSF11A

GO:0019956

MF

chemokine binding

Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.

ACKR4

GO:0019957

MF

C-C chemokine binding

Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.

ZFP36

GO:0019958

MF

C-X-C chemokine binding

Interacting selectively and non-covalently with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif.

HMGB1

GO:0019959

MF

interleukin-8 binding

Interacting selectively and non-covalently with interleukin-8.

A2M, CXCR2

GO:0019960

MF

C-X3-C chemokine binding

Interacting selectively and non-covalently with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif.

ITGB3, ITGB1, ITGAV

GO:0019962

MF

type I interferon binding

Interacting selectively and non-covalently with a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.

IFNAR1

GO:0019966

MF

interleukin-1 binding

Interacting selectively and non-covalently with interleukin-1.

HAX1, A2M, IL1R1, IL1R2

GO:0019970

MF

interleukin-11 binding

Interacting selectively and non-covalently with interleukin-11.

IL6ST

GO:0019981

MF

interleukin-6 binding

Interacting selectively and non-covalently with interleukin-6.

IL6R, IL6ST

GO:0019983

MF

interleukin-9 binding

Interacting selectively and non-covalently with interleukin-9.

IL9R

GO:0019992

MF

diacylglycerol binding

Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids.

RASGRP2

GO:0020037

MF

heme binding

Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

BACH1, PGRMC2, CYP27B1, CYB5B, CYP26A1, JAK2, STC2, CYB5A, AMBP, CYP1A1, CYBB, CYP17A1, CYP11A1, MPO, CYP2E1, CYC1, CYP3A4, CYP21A2, HMOX1, CYP2D6, CYP2A6, CYP19A1, CYP2C9, CYP11B1, CYP11B2, NR1D1, CYP2B6, CYP3A5, PTGS1, CYP3A7, NOS3, PTGS2, CBS, SUOX, HBB, HBG1, HBA1, CYCS, PTGIS, CYP1B1, CYP51A1, CYP2R1, CYP4V2, FA2H, CYP2U1, CYP2W1, CYB5D2, CYGB, NOX5, SDHC, CYP3A43, ABCB6, NGB, NOX4, CYP26B1, DUOX2, DUOX1, CYP8B1, FLVCR2

GO:0022839

MF

ion gated channel activity

Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus.

ASIC2

GO:0022840

MF

leak channel activity

Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.

PANX1

GO:0022841

MF

potassium ion leak channel activity

Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.

KCNK1, KCNK3, KCNK17, KCNK12, KCNK6

GO:0022843

MF

voltage-gated cation channel activity

Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

PKD2

GO:0022848

MF

acetylcholine-gated cation channel activity

Enables the transmembrane transfer of a cation by a channel that opens when acetylcholine has been bound by the channel complex or one of its constituent parts.

CHRNA7

GO:0022857

MF

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

ATP5H, ATP5L, ATP5J, ATP5D, ATP5C1, ATP5O, ATP5E, ATP5I, SEC61A1, RALBP1, NDUFAF6, SLC18B1, SV2A, SV2B

GO:0023024

MF

MHC class I protein complex binding

Interacting selectively and non-covalently with the class I major histocompatibility complex.

KLRC1

GO:0023026

MF

MHC class II protein complex binding

Interacting selectively and non-covalently with the class II major histocompatibility complex.

HLA-DRA, CD74, ATP1B1, HSP90AA1, HSP90AB1, HLA-DOB, PKM, HLA-DMB, ANXA11, CD81, YWHAE

GO:0030020

MF

extracellular matrix structural constituent conferring tensile strength

A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.

COL11A2, COL9A1, COL12A1

GO:0030023

MF

extracellular matrix constituent conferring elasticity

A component of the extracellular matrix that enables the matrix to recoil after transient stretching.

FBN1, FBN2, EMILIN2

GO:0030060

MF

L-malate dehydrogenase activity

Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.

MDH1, MDH2, MDH1B

GO:0030107

MF

HLA-A specific inhibitory MHC class I receptor activity

Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte.

LILRB1

GO:0030108

MF

HLA-A specific activating MHC class I receptor activity

Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte.

CTSH

GO:0030109

MF

HLA-B specific inhibitory MHC class I receptor activity

Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte.

LILRB1

GO:0030144

MF

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors.

MGAT5B

GO:0030145

MF

manganese ion binding

Interacting selectively and non-covalently with manganese (Mn) ions.

PPM1B, LARGE, TDP2, SOD2, NUDT7, B4GALT1, LAP3, IMPA1, PCK1, HMGCL, ABL2, MRE11A, PAPOLA, NEK4, GALNT2, GALNT1, DCP2, FAM20C, XXYLT1, DYRK2, NUDT16, PRIMPOL, ATP13A2, XPNPEP3, MTPAP

GO:0030151

MF

molybdenum ion binding

Interacting selectively and non-covalently with molybdenum (Mo) ions.

SUOX, MARC1, MOCOS

GO:0030156

MF

benzodiazepine receptor binding

Interacting selectively and non-covalently with the peripheral benzodiazepine receptor (PBR).

DBI

GO:0030158

MF

protein xylosyltransferase activity

Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate.

XYLT2

GO:0030159

MF

receptor signaling complex scaffold activity

Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.

AXIN1, SPAG9, NUP62, LDLRAP1, MAGI2, DLG5, CARD10, G3BP2, MAPK8IP3