GO:0016829

MF

lyase activity

Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

HMGB1, PHYKPL, MOCOS

GO:0016831

MF

carboxy-lyase activity

Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.

BCKDHA, BCKDHB, ECHDC1

GO:0016836

MF

hydro-lyase activity

Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.

L3HYPDH

GO:0016844

MF

strictosidine synthase activity

Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine.

APMAP

GO:0016846

MF

carbon-sulfur lyase activity

Catalysis of the elimination of hydrogen sulfide or substituted H2S.

CTH, CENPV

GO:0016853

MF

isomerase activity

Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

PBLD, HSD17B4, HMGCS1, ECH1, ITPK1, ENOSF1

GO:0016854

MF

racemase and epimerase activity

Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule.

DHRS9

GO:0016860

MF

intramolecular oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears.

ECI1

GO:0016866

MF

intramolecular transferase activity

Catalysis of the transfer of a functional group from one position to another within a single molecule.

GPI

GO:0016874

MF

ligase activity

Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.

TMEM129, NEURL1B, RNF103, TRIM38, MID1, SIAH2, PARK2, TRIM13, MYCBP2, RNF8, TRIM37, UBE4B, CNOT4, UCHL1, EGR2, RAG1, TNFAIP3, TRIM23, BRCA1, RANBP2, RNF144A, TTC3, RBX1, UBE2I, XIAP, MDM2, RING1, CBLB, TRIM28, PPIL2, BIRC3, SHPRH, TTLL9, MARCH8, UBR4, MEX3C, RFWD3, RNF19B, RNF111, UBR3, CBLL1, RNF144B, RBBP6, SYVN1, TRIM69, RNF130, MIB1, SIAH1, UBR1, TRIM22, RNF182, TRIML2, RNF152, TRIML1, RNF149, RNF169, MARCH1, RNF128, SH3RF2, TRIM41, MYLIP, RFFL, MIB2, PELI1, ZFP91, UHRF2, UHRF1, BARD1, RNF126, TRIM62, TRIM8, TRIM9, TRIM6, TRIM4, TRIM2, MKRN2, RNF38, ATG10, MARCH7, PELI2, RC3H2, TRIM39, RAD18, RNF146, RNF19A, RLIM, RNF216, RNF181, RNF14, MKRN1, AMFR, PRPF19, STUB1, TRIM33, PDZRN3, RNF6, BTRC, ZNF451, ARIH1, RNF114

GO:0016878

MF

acid-thiol ligase activity

Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.

AASDH

GO:0016881

MF

acid-amino acid ligase activity

Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.

TRIM25

GO:0016887

MF

ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.

VWA8, DDX39A, DDX3X, TOR1A, KIF1C, DHX16, SMARCA5, KIF1B, VPS4B, ATP5H, ATP5L, CLPX, RHOBTB3, KIF20A, ABCA1, ATP1B1, HSP90AA1, HSPA1A, HSPA1B, HSPD1, HSPA5, IDE, PSMC3, ATP5J, ABCD3, ATP5D, ABCC1, MYH9, PSMC2, ATP5C1, MLH1, RFC3, MSH2, PSMC4, NSF, ATP5O, ATP1A2, DNA2, MSH6, BLM, PMS1, VCP, ATP5E, ATP5I, ABCE1, PSMC1, PSMC6, ACTC1, CENPE, KIF23, MYO9B, DYNC1H1, EIF4A2, KIF22, KIF14, PPP2R4, RALBP1, ATAD2, ATF7IP, DNAH12, CHD1L, DNAH10, ATAD1, ABCF1, DNAH5, DNAH11, MYO19, KIF20B, KIF2C, KIFC1, ABCG8, TOR3A, ATP13A2, KIF13B, KIF15, MDN1, DNAH9, DNAH1, STARD9, ABCF2, MLH3, ATP6V1H, MACF1, RUVBL2, RUVBL1, MYH4

GO:0016888

MF

endodeoxyribonuclease activity, producing 5'-phosphomonoesters

Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.

TATDN1

GO:0016890

MF

site-specific endodeoxyribonuclease activity, specific for altered base

Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks.

DNA2

GO:0016892

MF

endoribonuclease activity, producing 3'-phosphomonoesters

Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters.

HRSP12

GO:0016896

MF

exoribonuclease activity, producing 5'-phosphomonoesters

Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters.

DCP2

GO:0016901

MF

oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.

HHIP

GO:0016903

MF

oxidoreductase activity, acting on the aldehyde or oxo group of donors

Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

XDH

GO:0016907

MF

G-protein coupled acetylcholine receptor activity

Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

CHRM2, CHRM3, HRH3

GO:0016913

MF

follicle-stimulating hormone activity

The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis.

FSHB

GO:0016918

MF

retinal binding

Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina.

ALDH1A2, RBP4, RBP1

GO:0016920

MF

pyroglutamyl-peptidase activity

Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein.

PGPEP1

GO:0016922

MF

ligand-dependent nuclear receptor binding

Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein.

ARID1A, NCOR1, TADA3, JUND, C1D, NCOA2, NCOA1, SLC30A9, PROX1, NR1H4, PPARGC1A, NCOR2, NCOA3

GO:0016929

MF

SUMO-specific protease activity

Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates.

FAM76B, FAM76A, SENP5, SENP6, SENP3

GO:0016933

MF

extracellular-glycine-gated ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts.

GLRB

GO:0016934

MF

extracellular-glycine-gated chloride channel activity

Enables the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts.

GLRB

GO:0016941

MF

natriuretic peptide receptor activity

Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.

NPR3, NPR2

GO:0016971

MF

flavin-linked sulfhydryl oxidase activity

Catalysis of the formation of disulfide bridges.

GFER, QSOX2

GO:0016990

MF

arginine deiminase activity

Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3.

PADI4

GO:0017002

MF

activin-activated receptor activity

Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta.

ACVR2A, ACVR1B

GO:0017005

MF

3'-tyrosyl-DNA phosphodiesterase activity

Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA.

TDP1

GO:0017016

MF

Ras GTPase binding

Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.

RAP1A, RAPGEF6, RASSF5, RAPGEF4, CIB1, MAPKAP1, SH3BP4

GO:0017017

MF

MAP kinase tyrosine/serine/threonine phosphatase activity

Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate.

DUSP1, DUSP2, DUSP8, DUSP5, DUSP6, DUSP7, DUSP18, DUSP9, DUSP16, DUSP21, DUSP10

GO:0017018

MF

myosin phosphatase activity

Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.

PPP1CB

GO:0017020

MF

myosin phosphatase regulator activity

Modulation of the activity of the enzyme myosin phosphatase.

DMPK

GO:0017022

MF

myosin binding

Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.

RALA, DMD, RHOA, ACTC1, CALD1, STX4, MYRIP, TRPM7, MLPH, VEZT, ARFGEF2

GO:0017024

MF

myosin I binding

Interacting selectively and non-covalently with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments.

PYCARD

GO:0017025

MF

TBP-class protein binding

Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).

THRA, PSMC3, PSMC2, PSMC4, GTF2A1, GTF2A2, PSMC1, PSMC6, GTF2B, DR1, HHEX, TAF1B, CAND1, YEATS2

GO:0017034

MF

Rap guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

RAP1A, RAPGEF1

GO:0017040

MF

ceramidase activity

Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine.

ASAH1

GO:0017042

MF

glycosylceramidase activity

Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine.

LCT

GO:0017046

MF

peptide hormone binding

Interacting selectively and non-covalently with any peptide with hormonal activity in animals.

INHBA, GHR, PRLR, NPR3, NPR2, OXTR, MC4R, ECE1, AGTR2, ACVR1, GHSR, SLC40A1

GO:0017048

MF

Rho GTPase binding

Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.

DAPK3, DIAPH2, ROCK2, PAK3, PFN1, FLNA, AKAP13, MYO9B, IQGAP2, DOCK11, ARHGEF16, IQGAP3, ARHGEF2, FMNL2, ECT2, PARD6A, DIAPH3, DAAM1, CDC42BPB

GO:0017049

MF

GTP-Rho binding

Interacting selectively and non-covalently with the GTP-bound form of the Rho protein.

PKN1, NET1, STXBP6, KCTD13, TRIOBP, EXOC1, CDC42EP3

GO:0017050

MF

D-erythro-sphingosine kinase activity

Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP.

SPHK1

GO:0017056

MF

structural constituent of nuclear pore

The action of a molecule that contributes to the structural integrity of the nuclear pore complex.

NUP155, NUP62, NUP153, NUP107, NUP93, NUP205, NDC1, NUP85, NUP62CL

GO:0017057

MF

6-phosphogluconolactonase activity

Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+).

PGLS, H6PD

GO:0017061

MF

S-methyl-5-thioadenosine phosphorylase activity

Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate.

MTAP

GO:0017065

MF

single-strand selective uracil DNA N-glycosylase activity

Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA.

SMUG1

GO:0017069

MF

snRNA binding

Interacting selectively and non-covalently with a small nuclear RNA (snRNA).

HEXIM1, SNRNP35, GEMIN5, RBPMS

GO:0017070

MF

U6 snRNA binding

Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA).

LSM8, EIF5A, SART3, RBM22, LSM7, LSM2, LSM4

GO:0017075

MF

syntaxin-1 binding

Interacting selectively and non-covalently with the SNAP receptor syntaxin-1.

SYT1, NSF, DAPK1, SNAP25, STXBP1, VAMP2, STXBP2, VAMP3, STXBP5, CPLX2, SYBU

GO:0017077

MF

oxidative phosphorylation uncoupler activity

Catalysis of the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.

UCP1, UCP3

GO:0017080

MF

sodium channel regulator activity

Modulates the activity of a sodium channel.

FXYD1, ATP2B4, FXYD4, FGF12, GPLD1, YWHAH, SNTA1, FGF13, SGK3, NEDD4L, PKP2, RANGRF

GO:0017081

MF

chloride channel regulator activity

Modulates the activity of a chloride channel.

CFTR, CHRNA7, TRPV1, SGK3

GO:0017082

MF

mineralocorticoid receptor activity

Combining with a mineralocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.

GPER1

GO:0017084

MF

delta1-pyrroline-5-carboxylate synthetase activity

Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate.

ALDH18A1

GO:0017089

MF

glycolipid transporter activity

Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells.

GLTP

GO:0017091

MF

AU-rich element binding

Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases.

NUDT21, ZFP36, TIA1, ZFP36L2, EXOSC9, ELAVL3, EXOSC7, ELAVL1, MEX3D, EXOSC8, EXOSC4

GO:0017095

MF

heparan sulfate 6-O-sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate.

HS6ST1, HS6ST2

GO:0017098

MF

sulfonylurea receptor binding

Interacting selectively and non-covalently with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel.

HSP90AA1, HSP90AB1

GO:0017099

MF

very-long-chain-acyl-CoA dehydrogenase activity

Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22.

ACADVL

GO:0017108

MF

5'-flap endonuclease activity

Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.

FEN1, DNA2, FAN1

GO:0017110

MF

nucleoside-diphosphatase activity

Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate.

ENTPD3, NUDT15

GO:0017111

MF

nucleoside-triphosphatase activity

Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.

DDX3X, ENTPD6, ENTPD3

GO:0017112

MF

Rab guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

DENND3, SBF1, RAB3GAP1, DENND4C, DENND2C, DENND5A, DENND5B, DENND4A, RIN3, DENND1A, RIN2, ALS2, RAB3IP, RAB3GAP2, RABGEF1, TRAPPC1

GO:0017113

MF

dihydropyrimidine dehydrogenase (NADP+) activity

Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+.

DPYD

GO:0017116

MF

single-stranded DNA-dependent ATP-dependent DNA helicase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix.

PIF1

GO:0017124

MF

SH3 domain binding

Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

WIPF3, ADAM10, PLSCR1, ARHGAP6, ADAM12, SH3BP5, PARK2, KHDRBS3, PAK3, PTTG1, GPX1, LYN, MAPT, HCLS1, GJA1, EPS15, CASP9, SH3BGR, GRB2, SIRPA, ADAM17, LRP2, KHDRBS1, SOS1, CBLB, ILK, ADAM9, TP53BP2, RAPGEF1, DPYSL3, CCDC6, ARHGAP31, SH3BP5L, NOXA1, AFAP1L2, ENAH, ENKUR, MICAL1, DENND1A, ELMO1, INPP5D, REPS1, MVB12A, QKI, SYNGAP1, RAD9A, FUT8, ADAM19, PLSCR4, ABI2, EVL, ERRFI1, PTPN22

GO:0017127

MF

cholesterol transporter activity

Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

ABCA1, APOA1, APOE, APOA2, APOB, STAR, APOA5, STARD4, ABCG8

GO:0017128

MF

phospholipid scramblase activity

Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism.

PLSCR1, ANO6, PLSCR4

GO:0017129

MF

triglyceride binding

Interacting selectively and non-covalently with any triester of glycerol.

LPL

GO:0017134

MF

fibroblast growth factor binding

Interacting selectively and non-covalently with a fibroblast growth factor.

ITGB3, ITGAV, THBS1, FGFR1, RPS2, FGFR2, GPC1, TGFBR3, CEP57, GLG1, S100A13, KL

GO:0017136

MF

NAD-dependent histone deacetylase activity

Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone.

SIRT2

GO:0017137

MF

Rab GTPase binding

Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.

RAB29, PDE6D, TBC1D4, TBC1D12, RAB11FIP3, ULK1, RHOBTB3, TBC1D8, ANXA2, NGFR, TBC1D3H, CHM, CHML, GDI1, NSF, RABGGTB, RAC1, TBC1D8B, RAB3GAP1, ACAP2, RABGAP1L, STXBP5, GRTP1, TBC1D9B, TBC1D3C, DENND5A, RAB11FIP1, TBC1D9, RAB11FIP2, ERC1, HACE1, TBC1D3, EXPH5, MYRIP, RIN3, TBC1D16, TBC1D15, PIFO, BICD2, DMXL2, SYTL5, MICAL1, DENND1A, NDRG1, TBC1D5, USP6NL, SYTL4, RUNDC1, EVI5L, OPTN, BICD1, C9orf72, ANKRD27, ALS2, MLPH, RAB3GAP2, SYTL2, HPS4, TBC1D14, ANKFY1, RABGEF1, MYO5B, RPH3AL, TBC1D2B, RIMS2, STXBP5L, AP3M1, RABGAP1, KIF3A, MYO5A

GO:0017147

MF

Wnt-protein binding

Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.

FZD6, FZD7, LRP5, LRP6, ROR1, PTPRO, SFRP5, WLS, SFRP4, TRABD2A, APCDD1, SFRP1, CTHRC1, FZD8, FZD4, WIF1

GO:0017150

MF

tRNA dihydrouridine synthase activity

Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor.

DUS4L

GO:0017151

MF

DEAD/H-box RNA helicase binding

Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase.

POT1

GO:0017154

MF

semaphorin receptor activity

Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

NRP1, PLXNB2, NRP2, PLXNC1, PLXNA2, PLXNA3, PLXNA1, PLXND1

GO:0017159

MF

pantetheine hydrolase activity

Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine.

VNN1, VNN3

GO:0017160

MF

Ral GTPase binding

Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases.

MYO1C, EXOC5, FLNA, RALBP1, EXOC4, EXOC2, RAB34, LSM2

GO:0017161

MF

inositol-1,3,4-trisphosphate 4-phosphatase activity

Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate.

INPP4B, INPP4A

GO:0017162

MF

aryl hydrocarbon receptor binding

Interacting selectively and non-covalently with an aryl hydrocarbon receptor.

AIP, ARNTL, ARNT

GO:0017166

MF

vinculin binding

Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane.

SORBS3, DMD, ACTN1, CTNNA1, DAG1, RTCB, TLN1

GO:0017168

MF

5-oxoprolinase (ATP-hydrolyzing) activity

Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate.

OPLAH

GO:0017171

MF

serine hydrolase activity

Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

CELA2A, AADAC

GO:0017172

MF

cysteine dioxygenase activity

Catalysis of the reaction: L-cysteine + O(2) = 3-sulfino-L-alanine + H(+).

CDO1

GO:0017176

MF

phosphatidylinositol N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol.

PIGA, PIGH, PIGC

GO:0018024

MF

histone-lysine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.

WHSC1, PRDM2, RBBP5, EZH2, KMT5B, KMT2E, KMT2C, SETD7, EZH1, EHMT2, SETDB2, WHSC1L1, SUV39H2, SMYD3, KMT5A, PRDM6, ASH2L, KMT2B

GO:0018169

MF

ribosomal S6-glutamic acid ligase activity

Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6.

UBE2M

GO:0018423

MF

protein C-terminal leucine carboxyl O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein.

LCMT1

GO:0018455

MF

alcohol dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+.

DHRS4

GO:0018478

MF

malonate-semialdehyde dehydrogenase (acetylating) activity

Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+.

ALDH6A1

GO:0018479

MF

benzaldehyde dehydrogenase (NAD+) activity

Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+.

ALDH1A1

GO:0018636

MF

phenanthrene 9,10-monooxygenase activity

Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide.

AKR1C3, AKR1C2, AKR1C1

GO:0018675

MF

(S)-limonene 6-monooxygenase activity

Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O.

CYP2C9

GO:0018676

MF

(S)-limonene 7-monooxygenase activity

Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (4S)-perillyl alcohol + H(2)O + NADP(+).

CYP2C9

GO:0018812

MF

3-hydroxyacyl-CoA dehydratase activity

Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA).

HACD4, HACD2, HACD3

GO:0019002

MF

GMP binding

Interacting selectively and non-covalently with GMP, guanosine monophosphate.

KRAS