GO:0008783

MF

agmatinase activity

Catalysis of the reaction: agmatine + H(2)O = putrescine + urea.

AGMAT

GO:0008794

MF

arsenate reductase (glutaredoxin) activity

Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.

GLRX2

GO:0008798

MF

beta-aspartyl-peptidase activity

Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide.

ASRGL1

GO:0008802

MF

betaine-aldehyde dehydrogenase activity

Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+.

ALDH7A1

GO:0008808

MF

cardiolipin synthase activity

Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol.

CRLS1

GO:0008817

MF

cob(I)yrinic acid a,c-diamide adenosyltransferase activity

Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin.

MMAB

GO:0008821

MF

crossover junction endodeoxyribonuclease activity

Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).

EME2, RAD51C, EME1

GO:0008823

MF

cupric reductase activity

Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH.

STEAP4

GO:0008829

MF

dCTP deaminase activity

Catalysis of the reaction: dCTP + H2O = dUTP + NH3.

APOBEC3G

GO:0008832

MF

dGTPase activity

Catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate.

SAMHD1

GO:0008843

MF

endochitinase activity

Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain.

CHIT1

GO:0008853

MF

exodeoxyribonuclease III activity

Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides.

RAD1, RAD9A, TREX2

GO:0008859

MF

exoribonuclease II activity

Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction.

ISG20

GO:0008865

MF

fructokinase activity

Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate.

HK1, HKDC1

GO:0008889

MF

glycerophosphodiester phosphodiesterase activity

Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate.

GDE1

GO:0008894

MF

guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity

Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate.

ENTPD6

GO:0008897

MF

holo-[acyl-carrier-protein] synthase activity

Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.

AASDHPPT

GO:0008898

MF

S-adenosylmethionine-homocysteine S-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine.

MTR

GO:0008900

MF

hydrogen:potassium-exchanging ATPase activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in).

ATP12A

GO:0008934

MF

inositol monophosphate 1-phosphatase activity

Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate.

IMPA1

GO:0008940

MF

nitrate reductase activity

Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor.

MARC1

GO:0008941

MF

nitric oxide dioxygenase activity

Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+.

CYGB

GO:0008948

MF

oxaloacetate decarboxylase activity

Catalysis of the reaction: oxaloacetate = pyruvate + CO2.

ME2, ME3

GO:0008955

MF

peptidoglycan glycosyltransferase activity

Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.

CSGALNACT1

GO:0008962

MF

phosphatidylglycerophosphatase activity

Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.

PTPMT1

GO:0008969

MF

phosphohistidine phosphatase activity

Catalysis of the reaction: phosphohistidine + H2O = histidine + phosphate.

PHPT1, MINPP1

GO:0008970

MF

phosphatidylcholine 1-acylhydrolase activity

Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.

PLA2G4A, PLA2G16, PLA1A, PLA2G4C, LIPG

GO:0008973

MF

phosphopentomutase activity

Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate.

PGM2

GO:0009000

MF

selenocysteine lyase activity

Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor.

SCLY

GO:0009007

MF

site-specific DNA-methyltransferase (adenine-specific) activity

Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

METTL4

GO:0009008

MF

DNA-methyltransferase activity

Catalysis of the transfer of a methyl group to a DNA molecule.

DNMT1, DNMT3B

GO:0009032

MF

thymidine phosphorylase activity

Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate.

TYMP

GO:0009041

MF

uridylate kinase activity

Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP.

DTYMK, CMPK1

GO:0009055

MF

electron carrier activity

Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

HSD17B6, UQCR11, ACOX3, P4HA2, PHGDH, AKR7A2, IDH3B, UGDH, AOC2, NDUFS2, NDUFS6, DHRS3, AIFM1, GSR, CYBB, ALDH2, QDPR, FDX1, CYP19A1, AKR1B1, NQO2, SRD5A1, NDUFV2, NCF2, COX5A, SDHB, ME2, MAOB, NDUFS1, GLRX, ACADSB, XDH, ACADVL, AOX1, ASPH, ACOX1, ETFDH, TXNRD1, FDX1L, NDUFAF2, ACOX2, SDHC, SH3BGRL3, NOX4, GLRX2, DMGDH, LOXL2, COX11

GO:0009374

MF

biotin binding

Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.

ACACB, PCCA, PC, MCCC1

GO:0009378

MF

four-way junction helicase activity

Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions.

RECQL4, RECQL, BLM

GO:0009383

MF

rRNA (cytosine-C5-)-methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA.

NOP2

GO:0009384

MF

N-acylmannosamine kinase activity

Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate.

GNE

GO:0009673

MF

low-affinity phosphate transmembrane transporter activity

Enables the transfer of phosphate from one side of the membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.

ADAMTS8

GO:0009881

MF

photoreceptor activity

The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation.

OPN3

GO:0009882

MF

blue light photoreceptor activity

The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation.

CRY1

GO:0009917

MF

sterol 5-alpha reductase activity

Catalysis of the removal of a C-5 double bond in the B ring of a sterol.

SRD5A2

GO:0009922

MF

fatty acid elongase activity

Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C).

ELOVL7, ELOVL1, ELOVL4, ELOVL6, ELOVL5

GO:0009931

MF

calcium-dependent protein serine/threonine kinase activity

Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions are dependent on the presence of calcium ions.

MAPKAPK2, MKNK1, MKNK2

GO:0009982

MF

pseudouridine synthase activity

Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.

DKC1, RPUSD3, TRUB1, RPUSD4, PUS7, PUS3

GO:0010181

MF

FMN binding

Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.

CREG1, NOS3, DHODH, HAO2

GO:0010309

MF

acireductone dioxygenase [iron(II)-requiring] activity

Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+).

ADI1

GO:0010314

MF

phosphatidylinositol-5-phosphate binding

Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position.

SH3PXD2B, SNX3, PLEKHA5, SNX24

GO:0010385

MF

double-stranded methylated DNA binding

Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.

H2AFY, EGR1, WT1

GO:0010428

MF

methyl-CpNpG binding

Interacting selectively and non-covalently with a methylated cytosine/unspecified/guanine trinucleotide.

ZBTB4

GO:0010465

MF

nerve growth factor receptor activity

Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity.

NTRK1

GO:0010484

MF

H3 histone acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3.

BRCA2, ELP3

GO:0010485

MF

H4 histone acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4.

BRCA2, NAA50, NAA60, ELP3, USP22

GO:0010521

MF

telomerase inhibitor activity

Stops, prevents or reduces the activity of a telomerase. Telomerase catalyzes the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.

PIF1, OBFC1, POT1

GO:0010698

MF

acetyltransferase activator activity

Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule.

PDCD5

GO:0010857

MF

calcium-dependent protein kinase activity

Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium.

PINK1

GO:0010997

MF

anaphase-promoting complex binding

Interacting selectively and non-covalently with an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis.

PLK1, PTEN, CDC20, FZR1

GO:0015016

MF

[heparan sulfate]-glucosamine N-sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine.

NDST1

GO:0015019

MF

heparan-alpha-glucosaminide N-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide.

HGSNAT

GO:0015020

MF

glucuronosyltransferase activity

Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

B4GAT1, LARGE, UGT2B4, EXT1, UGT2A3, CSGALNACT1, EXT2

GO:0015026

MF

coreceptor activity

Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.

NRP1, RAMP1, RAMP3, CD4, ITGB3, ITGB1, ITGAV, CD28, ACVR2A, CXCR4, TGFBR3, NECTIN1, RGMB

GO:0015035

MF

protein disulfide oxidoreductase activity

Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.

CCS, TXN, GFER, TXNRD1, ERO1B, DNAJC10, STAB2, ERO1A, TXN2, SH3BGRL3, GLRX2, STAB1, GSTK1

GO:0015036

MF

disulfide oxidoreductase activity

Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.

PDIA3, DNAJC10, ERO1A

GO:0015037

MF

peptide disulfide oxidoreductase activity

Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds.

TXN

GO:0015038

MF

glutathione disulfide oxidoreductase activity

Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor.

GLRX, GLRX2

GO:0015052

MF

beta3-adrenergic receptor activity

Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors.

ADRB3

GO:0015054

MF

gastrin receptor activity

Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity.

CCKBR

GO:0015057

MF

thrombin receptor activity

Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.

F2R, F2RL1

GO:0015068

MF

glycine amidinotransferase activity

Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate.

GATM

GO:0015075

MF

ion transmembrane transporter activity

Enables the transfer of an ion from one side of a membrane to the other.

S100A6, GJA1, SFXN4, SFXN3, SFXN1, ATP11B, TRPV2

GO:0015078

MF

hydrogen ion transmembrane transporter activity

Enables the transfer of hydrogen ions from one side of a membrane to the other.

ATP5L, ATP5J, ATP6V1B2, SLC11A2, ATP5I, ATP6V1F, SLC36A1, SLC46A1

GO:0015079

MF

potassium ion transmembrane transporter activity

Enables the transfer of potassium ions (K+) from one side of a membrane to the other.

KCNA1

GO:0015081

MF

sodium ion transmembrane transporter activity

Enables the transfer of sodium ions (Na+) from one side of a membrane to the other.

TRAPPC10

GO:0015085

MF

calcium ion transmembrane transporter activity

Enables the transfer of calcium (Ca) ions from one side of a membrane to the other.

ITPR2, ITPR1

GO:0015086

MF

cadmium ion transmembrane transporter activity

Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other.

SLC11A2

GO:0015087

MF

cobalt ion transmembrane transporter activity

Enables the transfer of cobalt (Co) ions from one side of a membrane to the other.

SLC11A2

GO:0015088

MF

copper uptake transmembrane transporter activity

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu+(out) = Cu+(in).

SLC31A1

GO:0015091

MF

ferric iron transmembrane transporter activity

Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other.

TF

GO:0015093

MF

ferrous iron transmembrane transporter activity

Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other.

SLC11A2, SLC39A14, SLC40A1, SLC25A37

GO:0015094

MF

lead ion transmembrane transporter activity

Enables the transfer of lead (Pb) ions from one side of a membrane to the other.

SLC11A2

GO:0015095

MF

magnesium ion transmembrane transporter activity

Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.

ZDHHC17, NIPA2, SLC41A2, CNNM2, MRS2

GO:0015098

MF

molybdate ion transmembrane transporter activity

Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid.

MFSD5

GO:0015101

MF

organic cation transmembrane transporter activity

Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage.

SLC22A1, SLC22A3, SLC7A8

GO:0015105

MF

arsenite transmembrane transporter activity

Enables the transfer of arsenite from one side of a membrane to the other.

ASNA1

GO:0015106

MF

bicarbonate transmembrane transporter activity

Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.

BEST1, CFTR, SLC26A2, SLC26A11, SLC26A1

GO:0015108

MF

chloride transmembrane transporter activity

Enables the transfer of chloride ions from one side of a membrane to the other.

CFTR, SLC26A1

GO:0015111

MF

iodide transmembrane transporter activity

Enables the transfer of iodide ions from one side of a membrane to the other.

SLC5A5

GO:0015114

MF

phosphate ion transmembrane transporter activity

Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other.

ANKH

GO:0015116

MF

sulfate transmembrane transporter activity

Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other.

SLC26A2, SLC26A11, SLC26A1

GO:0015125

MF

bile acid transmembrane transporter activity

Enables the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

SLCO2B1

GO:0015129

MF

lactate transmembrane transporter activity

Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.

SLC16A6, SLC16A3, SLC16A7, SLC16A12

GO:0015132

MF

prostaglandin transmembrane transporter activity

Enables the transfer of prostaglandins from one side of the membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.

SLCO2A1

GO:0015137

MF

citrate transmembrane transporter activity

Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other.

SLC25A1

GO:0015142

MF

tricarboxylic acid transmembrane transporter activity

Enables the transfer of tricarboxylic acids from one side of the membrane to the other. Tricarboxylic acid are organic acids with three COOH groups.

SLC25A1

GO:0015152

MF

glucose-6-phosphate transmembrane transporter activity

Catalysis of the transfer of glucose-6-phosphate from one side of the membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6.

SLC37A4

GO:0015165

MF

pyrimidine nucleotide-sugar transmembrane transporter activity

Enables the transfer of a pyrimidine nucleotide-sugar from one side of the membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative.

SLC35D2, SLC35D1

GO:0015166

MF

polyol transmembrane transporter activity

Enables the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol.

AQP9, SLC5A11

GO:0015168

MF

glycerol transmembrane transporter activity

Enables the transfer of glycerol from one side of the membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.

AQP2

GO:0015171

MF

amino acid transmembrane transporter activity

Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.

SLC6A6, SLC1A3, SLC1A2, SLC1A4, SLC1A6, SLC7A2, PEX3, SLC7A5, SLC1A5, SLC36A1, SLC38A9, SLC16A10, SLC38A5, SLC7A6, SLC38A1, SLC38A10, SLC7A8, SLC6A14

GO:0015172

MF

acidic amino acid transmembrane transporter activity

Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7.

SLC25A12, SLC25A13