GO:0008094

MF

DNA-dependent ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.

RAD51C, RAD51D, TOP2A, ERCC2, SMARCA1, GTF2H1, CDK7, SMARCA2, SMARCA4, RBBP4, GTF2H2, GTF2H4, DHX36, CHD8, TTF2

GO:0008097

MF

5S rRNA binding

Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome.

EEF2, RPL5

GO:0008107

MF

galactoside 2-alpha-L-fucosyltransferase activity

Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R.

FUT1, FUT2

GO:0008108

MF

UDP-glucose:hexose-1-phosphate uridylyltransferase activity

Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose.

GALT

GO:0008109

MF

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.

GCNT2

GO:0008112

MF

nicotinamide N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine.

NNMT

GO:0008113

MF

peptide-methionine (S)-S-oxide reductase activity

Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.

TXN2

GO:0008115

MF

sarcosine oxidase activity

Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2).

PIPOX

GO:0008116

MF

prostaglandin-I synthase activity

Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2).

PTGIS

GO:0008118

MF

N-acetyllactosaminide alpha-2,3-sialyltransferase activity

Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein.

ST3GAL3

GO:0008119

MF

thiopurine S-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.

TPMT

GO:0008120

MF

ceramide glucosyltransferase activity

Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.

UGCG

GO:0008121

MF

ubiquinol-cytochrome-c reductase activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+.

UQCRHL, UQCRQ, UQCR11, UQCRH, UQCRB, UQCRC1, UQCRFS1, UQCR10

GO:0008131

MF

primary amine oxidase activity

Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide.

AOC2, VCAM1, MAOA, MAOB, AOC3

GO:0008134

MF

transcription factor binding

Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.

MED19, AIP, APBB1, WWP2, DDX3X, HDAC3, PER1, RBFOX2, KDM1A, SORBS3, CCNT1, TBL1X, NBN, MED6, CREG1, PSMD10, UBXN7, APBB3, BCL10, FOS, MYC, ESR1, TP53, JUN, RB1, HMGB1, PARP1, TRAPPC2, AR, BCL2, THRA, ETS1, TCF3, HMGA1, JUNB, JUND, ATF7, CEBPB, NFKB1, BCL3, FLNA, GPX3, HMGB2, ARNT, PIK3R1, MAPK1, RBL1, CTNNB1, GTF2F1, RORA, DDIT3, AHR, PPARG, ZEB1, PBX2, STAT3, ID1, HTT, GATA4, MAPK9, CENPF, AGTR2, SMARCA4, NR0B1, GTF2A1, GTF2A2, HMGA2, FOSB, CEBPG, HDAC4, SOX8, LMO4, YWHAZ, UBE2I, PRKDC, SMAD3, FOXO4, GTF2B, PURA, E2F1, DR1, ID3, HHEX, PPARD, RELA, TLE1, C1QBP, PPARA, PPID, EP300, FOXC1, STK4, NFATC2, HDAC1, TDG, ENPP2, NFYC, HNRNPD, TFDP1, E2F2, HES1, NFATC4, NR0B2, NCOA2, TWIST1, SMAD2, TAF12, CRY1, HIF1A, IFI16, SMARCD3, KCTD1, CXXC5, PPARGC1B, SIRT2, PPP1R13L, ZFPM2, KAT6B, TRIB2, HDAC2, CREBBP, KAT6A, KAT2B, APBB2, GATA6, ARHGEF2, HES6, PURB, TRIB1, TCF12, PITX2, MDFI, EPAS1, SOST, MYBBP1A, HDAC8, TRIM6, NIF3L1, NUCKS1, SOX17, TAF9B, HES4, PARD6A, BRD7, HEYL, TCF7L2, RNF19A, RCOR3, NLK, PPARGC1A, MLX, HDAC9, SUFU, HDAC5, DRG1, CSDC2, HES2, PAXBP1, HEY1, MAFB, NCOR2, CHCHD2

GO:0008135

MF

translation factor activity, RNA binding

Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome.

EIF4G3, EIF4E2, GATB, EEF1D, EIF2S3, EIF1, EIF1AX, EIF5, EIF4A1, EEF1A2, GTF2H2, CPEB4, CPEB2, CPEB3, ABCF1, GCN1, MTIF3, EIF2B3

GO:0008137

MF

NADH dehydrogenase (ubiquinone) activity

Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol.

NDUFS8, NDUFA4, NDUFAB1, NDUFA1, NDUFS4, NDUFA2, NDUFS2, NDUFS6, NDUFB6, NDUFB4, NDUFB8, NDUFA7, NDUFA10, NDUFB10, NDUFB7, NDUFV2, NDUFS1, NDUFV3, NDUFA5, NDUFAF2, NMES1, NDUFA13

GO:0008138

MF

protein tyrosine/serine/threonine phosphatase activity

Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

PTPDC1, CDC14B, DUSP11, SBF1, DUSP3, TPTE, PTEN, MTMR2, CDKN3, DUSP5, DUSP6, DUSP7, SSH2, DUSP18, SSH3, PTPMT1, PTP4A1, DUSP9, DUSP26, DUSP23, DUSP22, DUSP13, CDC14A

GO:0008139

MF

nuclear localization sequence binding

Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.

IPO5, KPNA3, KPNA4, TNPO2, KPNA5, RANBP6, NUP153, KPNA2, KPNA1, KPNB1, IPO4, NUP58, TNPO3

GO:0008140

MF

cAMP response element binding protein binding

Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein).

DAPK3, DDIT3, SIK1, CREM, CRTC3

GO:0008142

MF

oxysterol binding

Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol.

OSBP, GPR183, RORA

GO:0008143

MF

poly(A) binding

Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.

DDX3X, SYNCRIP, TIA1, KHDRBS1, ZC3H14, RBPMS, PABPC3

GO:0008144

MF

drug binding

Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.

DHFR, PNP, ALB, MT2A, TYMS, ATP1B1, CHRM2, HSP90AB1, GSTP1, CYP2D6, TOP2A, CYP2C9, ACE, DRD2, FOLR1, CHRM3, CNR1, NME2, MT3, HMGB2, DCK, HTR2C, CHKA, PPARG, HTR2B, NAMPT, ATP5O, GLRB, FASN, ATP1A2, PGGT1B, SRP54, HMGCS1, DHODH, PPARD, PPARA, PPP3CA, PDE4D, FSCN1, SFRP1, P2RX4, SIGMAR1

GO:0008146

MF

sulfotransferase activity

Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.

HS3ST1, HS6ST1, SULT1A3, SULT2A1, CHST3, DSEL, CHST4, CHST5, CHST2

GO:0008147

MF

structural constituent of bone

The action of a molecule that contributes to the structural integrity of bone.

BGLAP, MGP

GO:0008157

MF

protein phosphatase 1 binding

Interacting selectively and non-covalently with the enzyme protein phosphatase 1.

PPP1R15A, STAU1, PPP1CC, PPP1CA, PHACTR4, LILRB1, SH3RF2, CDC5L, AKAP11

GO:0008158

MF

hedgehog receptor activity

Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity.

PTCH1, B9D1

GO:0008160

MF

protein tyrosine phosphatase activator activity

Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein.

IGFBP3, PPP2R4

GO:0008168

MF

methyltransferase activity

Catalysis of the transfer of a methyl group to an acceptor molecule.

PRMT3, COMT, PRDM15, NDUFAF5, TYW3, METTL23, PRMT1, METTL17, METTL8, PRDM10, METTL5, FAM86C1

GO:0008170

MF

N-methyltransferase activity

Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule.

PRMT1

GO:0008171

MF

O-methyltransferase activity

Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.

COMT, BCDIN3D, COQ3

GO:0008173

MF

RNA methyltransferase activity

Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.

BCDIN3D

GO:0008175

MF

tRNA methyltransferase activity

Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.

TRMT13

GO:0008177

MF

succinate dehydrogenase (ubiquinone) activity

Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol.

SDHB, SDHA

GO:0008179

MF

adenylate cyclase binding

Interacting selectively and non-covalently with the enzyme adenylate cyclase.

ADRB2, ADCYAP1R1, CALM2, AKAP6

GO:0008184

MF

glycogen phosphorylase activity

Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate.

PYGB, PYGM

GO:0008186

MF

RNA-dependent ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction.

DDX17, YTHDC2

GO:0008187

MF

poly-pyrimidine tract binding

Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule.

PTBP1

GO:0008188

MF

neuropeptide receptor activity

Combining with a neuropeptide to initiate a change in cell activity.

NPBWR1, KISS1R

GO:0008190

MF

eukaryotic initiation factor 4E binding

Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation.

DDX3X, OTX2, HHEX, EIF4EBP1, EIF4EBP2, LARP1, ANGEL1

GO:0008191

MF

metalloendopeptidase inhibitor activity

Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.

RECK, TIMP1, NGF, TIMP2, TIMP3, COL4A3, BST2, SPOCK2, SPOCK3, LXN, FETUB

GO:0008194

MF

UDP-glycosyltransferase activity

Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule.

PIGA

GO:0008195

MF

phosphatidate phosphatase activity

Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

PLPP1, PLPP3, LPIN1, PLPPR4, PLPP5, PLPPR2

GO:0008198

MF

ferrous iron binding

Interacting selectively and non-covalently with ferrous iron, Fe(II).

TF, TH, SNCA, ALKBH1, FXN, CDO1, HEPH, ISCA1, FTO

GO:0008199

MF

ferric iron binding

Interacting selectively and non-covalently with ferric iron, Fe(III).

TF, FTL, FTH1, TH, FXN, MIOX

GO:0008200

MF

ion channel inhibitor activity

Stops, prevents, or reduces the activity of an ion channel.

ENSA, RACK1

GO:0008201

MF

heparin binding

Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

CYR61, PDCD5, NRP1, MSTN, ZNF207, NRP2, WISP2, ECM2, SLIT2, WISP1, SERPINC1, KNG1, APOE, APOH, FN1, PF4, ANG, VTN, APOB, APP, SERPINA5, MPO, CLEC3B, LPL, SERPINE2, THBS1, SOD3, CFH, FGF2, SAA1, PTPRF, FGFR1, BMP4, CCL2, PRG2, SELL, VEGFA, OGN, COL5A1, MDK, FGF7, FGFR2, TNXB, ANOS1, COL5A3, PCSK6, CTGF, LRPAP1, FGF9, RPL22, THBS4, FBN1, PLA2G5, RPL29, COMP, PGF, VEGFB, HDGF, CCL8, CXCL6, TGFBR3, APLP2, FMOD, FSTL1, PTCH1, GPNMB, POSTN, PCOLCE, HSD17B12, COL13A1, APOA5, CCDC80, NAV2, SFRP1, NDNF, ADAMTS15, LIPH, HBEGF, EPYC, SOST, LXN, RSPO3, CRISPLD2, SMOC2, GREM2, ADAMTS1, PCOLCE2, ADAMTS5, ADAMTS8, LIPG, ADGRG1

GO:0008233

MF

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

MASP2, TPP1, DHH, CAPN15, CTSB, CTSH, FURIN, BMP1, UCHL3, CAPN3, PSMB5, CASP9, FGL2, CASP8, SPCS2, CLPP, DESI1, LONP2, MPND, HM13, APH1B, BAP1, PCSK5, USP25, MYRF

GO:0008234

MF

cysteine-type peptidase activity

Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.

CAPN15, CTSL, CTSB, CTSH, CAPN3, CTSK, CTSC, CASP6, BLMH, ESPL1, CASP8, OTUD7B, PIGK, PGPEP1, CTSZ

GO:0008235

MF

metalloexopeptidase activity

Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

LAP3, METAP2, NUDT16, ERAP1

GO:0008236

MF

serine-type peptidase activity

Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

TPP1, KLK10, C1R, PLG, KLK3, PRSS1, DPP4, PRSS3, DPP6, PREP, PRSS12, HTRA3, CTRB2, HTRA1, SEC11C

GO:0008237

MF

metallopeptidase activity

Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

ADAM10, ADAM12, ADAM23, STAMBP, ECEL1, MMP2, MME, ACE, BMP1, MMP9, BRCC3, ADAM8, ADAM17, PAPPA, ADAM9, ERAP2, ERMP1, AOPEP, STAMBPL1, YME1L1, XPNPEP3, ADAMTS9, ADAMTS1, LNPEP, ADAM21, ADAMTS7, ADAMTS6, ADAMTS5, ADAMTS8

GO:0008238

MF

exopeptidase activity

Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.

MME, ACE, GGH

GO:0008239

MF

dipeptidyl-peptidase activity

Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain.

DPP4

GO:0008240

MF

tripeptidyl-peptidase activity

Catalysis of the release of an N-terminal tripeptide from a polypeptide.

TPP1, ACE, TPP2

GO:0008241

MF

peptidyl-dipeptidase activity

Catalysis of the release of C-terminal dipeptides from a polypeptide chain.

ACE

GO:0008242

MF

omega peptidase activity

Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups).

UCHL1, GGH

GO:0008252

MF

nucleotidase activity

Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.

NT5C

GO:0008253

MF

5'-nucleotidase activity

Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

ACPP, NT5E, NT5DC3, NT5C, NT5DC2

GO:0008260

MF

3-oxoacid CoA-transferase activity

Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA.

OXCT1

GO:0008263

MF

pyrimidine-specific mismatch base pair DNA N-glycosylase activity

Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.

MBD4, TDG

GO:0008265

MF

Mo-molybdopterin cofactor sulfurase activity

Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase.

MOCOS

GO:0008266

MF

poly(U) RNA binding

Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule.

HNRNPC, HNRNPH1, ATXN1, FMR1, KHDRBS1, PNPT1, MSI2

GO:0008267

MF

poly-glutamine tract binding

Interacting selectively and non-covalently with a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein.

RERE

GO:0008269

MF

JAK pathway signal transduction adaptor activity

The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way.

SOCS2

GO:0008270

MF

zinc ion binding

Interacting selectively and non-covalently with zinc (Zn) ions.

MEX3A, ZSWIM8, ERI2, NEURL1B, ZBBX, PDLIM1, RNF103, NR5A2, ZNF593, PEX12, TRIM38, MAN2B1, PDXK, CCS, ABLIM1, MDM4, ZNF185, MID1, SIAH2, TGFB1I1, DHH, KLF4, CA12, ZNF207, NRDC, PARK2, LPXN, TRIM13, LDB3, ZPR1, ZNF253, PMPCB, MYCBP2, TCEA3, CAPN15, KLF7, RNF8, ZFAND5, MICAL2, SEC24D, ABLIM3, KDM4B, TRIM37, UBR5, ZFPL1, ZNF205, ZRANB2, TNKS, PAPLN, POLR1A, CNOT4, ZMYM6, CRYZL1, WHSC1, ADH1B, ADA, CA2, KNG1, CD4, MT2A, ESR1, MMP1, NR3C1, TK1, S100B, TP53, MT1E, MT1F, S100A8, PRKCB, PGR, S100A9, S100A6, CA3, GALT, MMP2, SOD3, MME, SNRPC, MMP10, PARP1, GLI2, AR, NR2F1, THRA, VDR, ESRRA, DMD, SKI, ACE, BMP1, MT1G, ALAD, CPM, IDE, MMP9, CPN1, RAG1, CPE, ZNF22, ZNF24, PRKCA, EGR1, PAM, WT1, NR1D1, PTMS, CSRP1, TNFAIP3, ENPP1, UQCRC2, NR4A1, CA4, MMP8, MMP11, NR2F2, YY1, MT3, LMO2, DNMT1, CAD, CALR, RXRB, KDM5A, CLIP1, S100A7, UQCRC1, DCTD, CA8, RORA, FUS, ZNF93, TRIM23, POLR2I, PPARG, ZEB1, SNCA, BRCA1, ADH7, RPS27, MATR3, NR4A2, GATA4, LIMS1, MAN2A2, NUP153, RANBP2, MMP14, LHX2, PDLIM4, RNF144A, MMP15, MMP16, ZNF84, RBM5, PGGT1B, RABGGTB, LIMK2, POLR2K, TTC3, NR1H2, MLLT10, NPEPPS, HDAC4, ADAMTS12, ADAMTS20, LMO4, POLR2L, RBX1, ADAM8, MT1H, MT1X, SMAD3, XIAP, GTF2B, SORD, MDM2, EWSR1, PPARD, ZNF117, ZNF92, GLO1, ZNF91, RING1, POLE, PPARA, CRYZ, EP300, PMPCA, SF3A3, GRIN2A, TRIM26, PRDM2, TRAF1, NR1H3, CBLB, PAPPA, TRIM28, MTA1, BIRC3, SQSTM1, FHL1, ENPP2, GTF2H2, TRIM14, MORC3, ZMYM3, TRIM25, NBR1, CHD4, PTGR1, ZNF638, KPNB1, NR1D2, SHPRH, EEA1, ZMYND11, SEC23A, RGN, TRIP6, ZFHX3, ZYX, CSRP2, QPCT, LONRF1, LONRF2, PCGF3, LONRF3, LACTB2, ZNF385B, TRIM61, DNAJC21, ZMAT1, EARS2, PITRM1, MARCH8, UBR4, PHF19, MEX3C, ZCCHC6, RNF219, BSPRY, ZDHHC20, CPZ, ZFAND6, XAF1, OTUD7B, JADE1, NAPEPLD, ERAP2, GTF2H2C_2, RFWD3, CYHR1, PDZRN4, KDM7A, RNF19B, RNF111, NFXL1, RNF165, UBR3, USP51, USP45, CBLL1, CXXC5, RNF144B, RBBP6, PCGF5, PEG10, TADA2B, SYVN1, TRIM73, TRIM69, MEX3D, RNF130, ZGRF1, GATAD2A, MIB1, ZDHHC17, SIAH1, AEBP1, SLC30A8, UBR1, TRIM42, SIRT2, MSRB3, YAF2, TRIM22, KMT2E, ZDHHC14, CA13, ZCCHC24, MT1M, VPS8, ZCCHC7, ZADH2, ZNF276, ZCCHC9, TAB3, RNF182, AOPEP, RNF152, SREK1IP1, TRIML1, RNF149, RNF169, RNF214, PHC3, KMT2C, ZMIZ2, DBF4B, MYRIP, NEIL3, FBXO30, ZCRB1, ZCCHC10, TMEM163, MARCH1, ZNF675, MICAL1, ADAMTS17, ADAMTS15, ADAMTS18, MORC4, RNF128, SH3RF2, PHF10, CHURC1, FBLIM1, GATAD1, TRIM41, ZFAND2B, RNF141, ZFPM2, RTN4IP1, NANOS1, MYLIP, KAT6B, ZCCHC14, RFFL, NR4A3, JADE3, ESR2, DPF3, CREBBP, KAT6A, TAF15, GATA6, ARHGEF2, USP13, LPP, L3MBTL2, MIB2, TRIM43, PTER, RSPRY1, RNFT2, PDLIM5, AJUBA, CPB2, PDLIM2, EHMT2, ZFR, AGBL1, PRICKLE1, ZMAT2, PGLYRP2, UHRF2, PHF12, HHIP, NR1H4, RSF1, SETDB2, UHRF1, MMP19, P2RX4, S100A13, SCAF11, MTR, BARD1, RBM4B, PYGO2, ZNF2, DIDO1, RNF126, MECR, TRIM62, PHF20, RBM4, CDADC1, SCAPER, TRIM34, WHSC1L1, TRIM8, TRIM9, TRIM6, TRIM4, TRIM2, ZCCHC2, ZNF407, MKRN2, USP44, RNF38, C11orf54, ADAMTS10, SUV39H2, ZDHHC6, ZFAND3, RNF121, MARCH7, LIN28A, SP110, RC3H2, ZFYVE1, APOBEC3G, ZSWIM6, TRIM39, MMP25, MYNN, ATP13A2, CYLD, ZNF331, PDLIM7, ASH1L, MMP26, BAZ1A, RASSF1, RAD18, RNF146, RNF19A, THAP1, RLIM, ZDHHC7, ING3, RBAK, ERAP1, LMCD1, RNF181, ZNRD1, PHRF1, ZSWIM5, ZNFX1, ADAMTS9, RERE, HDAC6, RNF14, DBF4, ZMYM2, ZRANB1, TES, KDM5B, LIMD1, TCF20, APOBEC3B, LIMA1, MKRN1, CHORDC1, TRPS1, ADAMTS1, BAZ1B, ZDHHC2, LNPEP, RABGEF1, ZMYM5, ADAMTS7, ADAMTS6, AMFR, PNMA3, MYT1L, ZMIZ1, RNF150, CIZ1, KMT2B, ADAMTS5, TTF2, ADAMTS8, TRIM33, LIMCH1, TRIM35, PDZRN3, USP22, AGTPBP1, RNF24, TCF19, RNF6, MAN2B2, PIKFYVE, USP20, KDM2A, POLR3K, ZDHHC9, ZNF330, SAMHD1, L3MBTL1, MTF2, DTNA, ARIH1, RNF114, MMP24, LOC440434

GO:0008271

MF

secondary active sulfate transmembrane transporter activity

Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.

SLC26A2, SLC26A11, SLC26A1

GO:0008273

MF

calcium, potassium:sodium antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).

SLC24A3

GO:0008276

MF

protein methyltransferase activity

Catalysis of the transfer of a methyl group (CH3-) to a protein.

CARM1, PRMT1, N6AMT1

GO:0008289

MF

lipid binding

Interacting selectively and non-covalently with a lipid.

FABP12, UNC119B, NME4, PLIN1, AP2A2, APOE, APOA2, APOH, DBI, PSAP, ANXA6, CD55, CD36, MAL, PTGS2, ATP5G3, PITPNB, PCYT1A, FABP6, VCP, PEX3, PTEN, HDLBP, FABP5, PPARD, ATP5G2, BAX, PPARA, ARHGEF5, TIAM1, UNC119, MELK, TRIP10, FNBP1L, ACBD5, IQSEC1, APOA5, RASGRP2, BPIFB1, STARD8, BAD, AP2M1, MVB12A, APOLD1, DLC1, FNBP1, OSBPL9, S1PR3, S100A13, SH3GL2, APOL2, ESYT1, OSBPL11, OSBPL6, STARD7, GLTP, STARD9, PCTP, SH3GLB1, STARD13

GO:0008296

MF

3'-5'-exodeoxyribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule.

POLD1, TREX2

GO:0008297

MF

single-stranded DNA exodeoxyribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule.

MGME1

GO:0008301

MF

DNA binding, bending

The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.

HMGB3, HMGB1, TOP2A, HMGB2, HMGA2, TERF1, TFAM, HHEX, FOXC1

GO:0008307

MF

structural constituent of muscle

The action of a molecule that contributes to the structural integrity of a muscle fiber.

NEBL, SORBS2, TPM2, KRT19, TPM1, DMD, MYL6B, CAPN3, MYL9, ACTN2, MYH11, SMTN, MYL6, TPM4, MYBPC1, MYL5, NEXN, ASPH, DAG1, TTN, MYOT

GO:0008308

MF

voltage-gated anion channel activity

Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

GPR89A, GPR89B, VDAC2, VDAC3

GO:0008309

MF

double-stranded DNA exodeoxyribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule.

FEN1

GO:0008310

MF

single-stranded DNA 3'-5' exodeoxyribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule.

ISG20

GO:0008312

MF

7S RNA binding

Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP).

SRP72, SRP14, SRP9, SRP54, EXOSC2

GO:0008320

MF

protein transmembrane transporter activity

Enables the transfer of a protein from one side of a membrane to the other.

TOMM40, AZGP1, NUTF2, TOMM22, TOMM7

GO:0008321

MF

Ral guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

RALGPS1, RGL1

GO:0008324

MF

cation transmembrane transporter activity

Enables the transfer of cation from one side of the membrane to the other.

SLC30A9, SLC41A3

GO:0008327

MF

methyl-CpG binding

Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide.

MBD3, DNMT1, ERH, ZBTB33, ZBTB38, UHRF1, PRMT1, ZBTB4, LRWD1, ZBTB21

GO:0008329

MF

signaling pattern recognition receptor activity

Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity.

TLR2, COLEC12, CLEC7A, DMBT1

GO:0008330

MF

protein tyrosine/threonine phosphatase activity

Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

DUSP1, DUSP2

GO:0008331

MF

high voltage-gated calcium channel activity

Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.

CACNB3, CACNA1C, CACNA1E

GO:0008332

MF

low voltage-gated calcium channel activity

Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded.

CACNA1G

GO:0008349

MF

MAP kinase kinase kinase kinase activity

Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.

MAP4K3, MAP4K5

GO:0008353

MF

RNA polymerase II carboxy-terminal domain kinase activity

Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats.

CDK1, ERCC2, MAPK1, GTF2H1, CDK8, CDK7, GTF2H2, CDK13, GTF2H4, CDK12

GO:0008373

MF

sialyltransferase activity

Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.

ST6GAL1, ST8SIA6, ST6GALNAC5, ST6GALNAC4, ST6GALNAC2

GO:0008374

MF

O-acyltransferase activity

Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.

LCLAT1, PIGW

GO:0008375

MF

acetylglucosaminyltransferase activity

Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar.

OGT, LARGE, HEXA, EXT1, POMGNT2, EXT2, XYLT2

GO:0008376

MF

acetylgalactosaminyltransferase activity

Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide.

CSGALNACT1

GO:0008378

MF

galactosyltransferase activity

Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

B4GALT5, B4GALT4, B4GALT1, B3GNT9, B4GALT6

GO:0008379

MF

thioredoxin peroxidase activity

Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O.

PRDX2, PRDX1, PRDX4

GO:0008381

MF

mechanically-gated ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress.

PIEZO1

GO:0008386

MF

cholesterol monooxygenase (side-chain-cleaving) activity

Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.

CYP11A1

GO:0008389

MF

coumarin 7-hydroxylase activity

Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+.

CYP2A6

GO:0008392

MF

arachidonic acid epoxygenase activity

Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid.

CYP2E1, CYP2D6, CYP2A6, CYP2C9, CYP2B6

GO:0008395

MF

steroid hydroxylase activity

Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.

CH25H, CYP2E1, CYP3A4, CYP21A2, CYP2D6, CYP2A6, CYP19A1, CYP2C9, CYP11B2, CYP2B6, CYP3A7, CYP2R1, CYP2U1, CYP2W1

GO:0008397

MF

sterol 12-alpha-hydroxylase activity

Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O.

CYP8B1