GO:0008398

MF

sterol 14-demethylase activity

Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O.

CYP51A1

GO:0008401

MF

retinoic acid 4-hydroxylase activity

Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid.

CYP26A1, CYP26B1

GO:0008408

MF

3'-5' exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.

RAD1, REV3L, POLA1, MRE11A, POLG, POLE, RAD9B, RAD50, RAD9A, REXO2

GO:0008409

MF

5'-3' exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.

DXO, FEN1, DCLRE1C, EXO1, EXOG, FAN1

GO:0008413

MF

8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity

Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate = 8-oxo-7,8-dihydroguanosine phosphate + diphosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription.

NUDT1, NUDT15

GO:0008417

MF

fucosyltransferase activity

Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

FUT1, FUT4, FUT2

GO:0008420

MF

CTD phosphatase activity

Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate.

CTDSP2, CTDSP1, SSU72

GO:0008422

MF

beta-glucosidase activity

Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.

LCT, GBA2, KL

GO:0008424

MF

glycoprotein 6-alpha-L-fucosyltransferase activity

Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H(+).

FUT8

GO:0008425

MF

2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.

COQ3

GO:0008426

MF

protein kinase C inhibitor activity

Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein.

HSPB1, SFN

GO:0008427

MF

calcium-dependent protein kinase inhibitor activity

Stops, prevents or reduces the activity of a calcium-dependent protein kinase.

CAMK2N1, CIB1

GO:0008428

MF

ribonuclease inhibitor activity

Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA.

RNH1

GO:0008429

MF

phosphatidylethanolamine binding

Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.

ESYT2, PEBP1, ANXA11, MFGE8, MAP1LC3A, PEMT

GO:0008430

MF

selenium binding

Interacting selectively and non-covalently with selenium (Se).

SELENOF, GPX3, SEPP1, SELT, SELENBP1, DIO2

GO:0008431

MF

vitamin E binding

Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.

SEC14L2

GO:0008432

MF

JUN kinase binding

Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.

SPAG9, GSTP1, PTK2, MAPK8IP3, MAPK8IP1

GO:0008434

MF

calcitriol receptor activity

Combining with calcitriol, the hormonally active form of vitamin D3, and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.

VDR

GO:0008437

MF

thyrotropin-releasing hormone activity

The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.

TRH

GO:0008440

MF

inositol-1,4,5-trisphosphate 3-kinase activity

Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).

ITPKA, CALM2, IP6K2

GO:0008442

MF

3-hydroxyisobutyrate dehydrogenase activity

Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+.

HIBADH

GO:0008444

MF

CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity

Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+).

PGS1

GO:0008446

MF

GDP-mannose 4,6-dehydratase activity

Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O.

GMDS

GO:0008449

MF

N-acetylglucosamine-6-sulfatase activity

Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.

GNS, SULF2, SULF1

GO:0008453

MF

alanine-glyoxylate transaminase activity

Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.

AGXT

GO:0008454

MF

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R.

MGAT4A, MGAT4B

GO:0008455

MF

alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R.

MGAT2

GO:0008457

MF

beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide.

B3GNT5

GO:0008458

MF

carnitine O-octanoyltransferase activity

Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA.

CROT

GO:0008459

MF

chondroitin 6-sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.

CHST3, CHST7

GO:0008460

MF

dTDP-glucose 4,6-dehydratase activity

Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O.

TGDS

GO:0008465

MF

glycerate dehydrogenase activity

Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+.

GRHPR

GO:0008466

MF

glycogenin glucosyltransferase activity

Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin.

GYG2

GO:0008467

MF

[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S.

HS3ST1, HS3ST3B1

GO:0008469

MF

histone-arginine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine.

PRMT3, CARM1, PRMT6

GO:0008474

MF

palmitoyl-(protein) hydrolase activity

Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.

LYPLA1, LYPLA2, PPT1, PPT2

GO:0008475

MF

procollagen-lysine 5-dioxygenase activity

Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2.

PLOD2, PLOD1

GO:0008476

MF

protein-tyrosine sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.

TPST1, TPST2

GO:0008478

MF

pyridoxal kinase activity

Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.

PDXK

GO:0008479

MF

queuine tRNA-ribosyltransferase activity

Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine.

PDC, PDCL, PDCL3

GO:0008480

MF

sarcosine dehydrogenase activity

Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein.

SARDH

GO:0008481

MF

sphinganine kinase activity

Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate.

SPHK1

GO:0008482

MF

sulfite oxidase activity

Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate.

SUOX

GO:0008483

MF

transaminase activity

Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.

AGXT, PHYKPL

GO:0008484

MF

sulfuric ester hydrolase activity

Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2.

STS, ARSA, GNS, GALNS, SGSH

GO:0008486

MF

diphosphoinositol-polyphosphate diphosphatase activity

Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.

NUDT3, NUDT10, NUDT11

GO:0008488

MF

gamma-glutamyl carboxylase activity

Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide.

GGCX

GO:0008494

MF

translation activator activity

Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide.

LARP1, RPS27L, PAIP1

GO:0008496

MF

mannan endo-1,6-alpha-mannosidase activity

Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans.

MAN2B2

GO:0008499

MF

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP.

B3GALT2, B3GALT4, B3GNT7, B3GNT5, B3GNT2

GO:0008502

MF

melatonin receptor activity

Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin.

MTNR1A, MTNR1B

GO:0008503

MF

benzodiazepine receptor activity

Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity.

TSPO

GO:0008504

MF

monoamine transmembrane transporter activity

Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other.

SLC18A2

GO:0008506

MF

sucrose:proton symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in).

SLC45A2

GO:0008507

MF

sodium:iodide symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in).

SLC5A5

GO:0008509

MF

anion transmembrane transporter activity

Enables the transfer of a negatively charged ion from one side of a membrane to the other.

ABCA1, SLC4A2, SLC4A8, SLC26A11

GO:0008510

MF

sodium:bicarbonate symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).

SLC4A4

GO:0008511

MF

sodium:potassium:chloride symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in).

SLC12A2

GO:0008513

MF

secondary active organic cation transmembrane transporter activity

Catalysis of the transfer of organic cations from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.

SLC22A1

GO:0008514

MF

organic anion transmembrane transporter activity

Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.

SLC22A23, ABCC5, SLCO2B1

GO:0008517

MF

folic acid transporter activity

Enables the directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.

SLC19A2, FOLR1, SLC19A1, SLC46A1

GO:0008518

MF

reduced folate carrier activity

Catalysis of the transfer of reduced folate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.

SLC19A1

GO:0008519

MF

ammonium transmembrane transporter activity

Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals.

SLC12A2, RHBG

GO:0008520

MF

L-ascorbate:sodium symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in).

SLC23A2

GO:0008521

MF

acetyl-CoA transporter activity

Enables the directed movement of acetyl-CoA into, out of or within a cell, or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.

SLC33A1

GO:0008523

MF

sodium-dependent multivitamin transmembrane transporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate.

SLC23A2

GO:0008525

MF

phosphatidylcholine transporter activity

Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.

PITPNA, PCTP

GO:0008526

MF

phosphatidylinositol transporter activity

Enables the directed movement of phosphatidylinositol into, out of or within a cell, or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.

PITPNA, PITPNC1

GO:0008528

MF

G-protein coupled peptide receptor activity

Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

GPR37, NPR3, LHCGR, FSHR

GO:0008531

MF

riboflavin kinase activity

Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+).

RFK

GO:0008532

MF

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.

B4GAT1, B3GNT7, B3GNT2

GO:0008534

MF

oxidized purine nucleobase lesion DNA N-glycosylase activity

Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.

NTHL1

GO:0008536

MF

Ran GTPase binding

Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.

IPO5, TNPO2, XPO1, BIRC5, RANBP1, RANGAP1, RANBP2, CSE1L, NUTF2, KPNB1, IPO4, IPO9, RANBP9, XPO4, RANGRF, NXT1, NUP50

GO:0008553

MF

hydrogen-exporting ATPase activity, phosphorylative mechanism

Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle.

ATP6V1G1, ATP6V1G2, ATP6V1C1, ATP6V0D1, ATP6V1C2

GO:0008555

MF

chloride-transporting ATPase activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cl-(out) = ADP + phosphate + Cl-(in).

PCYOX1

GO:0008559

MF

xenobiotic-transporting ATPase activity

Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).

ABCA8

GO:0008565

MF

protein transporter activity

Enables the directed movement of proteins into, out of or within a cell, or between cells.

IPO5, KPNA3, KPNA4, ITGB1BP1, TNPO2, DSCR3, KPNA5, RANBP6, RAMP1, RAMP3, VPS26A, AP1G2, AP2A2, KPNA2, KPNA1, AP2S1, AP1S2, AP3S2, SEC61G, AP1S1, RAP1A, AP2B1, AP1B1, COG2, KPNB1, C11orf73, ZFYVE16, TOMM5, IPO4, TMCO6, IPO9, VPS35, SEC62, RANGRF, ARFGAP3, EIF4ENIF1, VPS29, AP4S1, TNPO3

GO:0008568

MF

microtubule-severing ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP.

ATAD1, KATNB1, KATNAL1, SPAST

GO:0008574

MF

ATP-dependent microtubule motor activity, plus-end-directed

Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP.

KIF5C, KIF4A, KIF11, KIF14, KIF18B, KIF18A, KIF20B, KIF3A

GO:0008579

MF

JUN kinase phosphatase activity

Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate.

DUSP19

GO:0008597

MF

calcium-dependent protein serine/threonine phosphatase regulator activity

Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase.

RCAN1

GO:0008599

MF

protein phosphatase type 1 regulator activity

Modulation of the activity of the enzyme protein phosphatase type 1.

PPP1R15A, PPP1R7

GO:0008601

MF

protein phosphatase type 2A regulator activity

Modulation of the activity of the enzyme protein phosphatase type 2A.

ENSA, PPP2R1A, PPP2R1B, ARPP19, IGBP1, SET, PPP2R3A, PPP2R5C, PPP2R5D, PPP2R5A, PPP2R5B, PPP2R4, ANKLE2, PPME1

GO:0008603

MF

cAMP-dependent protein kinase regulator activity

Modulation of the activity of the enzyme cAMP-dependent protein kinase.

PRKAR1A, PRKAR2A, PRKAR2B, PRKAG1

GO:0008607

MF

phosphorylase kinase regulator activity

Modulation of the activity of the enzyme phosphorylase kinase.

IKBKAP, ELP4, ELP3

GO:0008609

MF

alkylglycerone-phosphate synthase activity

Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion.

AGPS

GO:0008613

MF

diuretic hormone activity

The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion.

NPPB

GO:0008656

MF

cysteine-type endopeptidase activator activity involved in apoptotic process

Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.

CTSH, CASP1, CDKN1B, RACK1, RPS27L, BAD, PYCARD

GO:0008670

MF

2,4-dienoyl-CoA reductase (NADPH) activity

Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+.

DECR1

GO:0008689

MF

3-demethylubiquinone-9 3-O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9.

COQ3

GO:0008705

MF

methionine synthase activity

Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.

MTR

GO:0008709

MF

cholate 7-alpha-dehydrogenase activity

Catalysis of the reaction: cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH.

HSD17B10

GO:0008725

MF

DNA-3-methyladenine glycosylase activity

Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site.

MPG

GO:0008732

MF

L-allo-threonine aldolase activity

Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde.

SHMT1

GO:0008745

MF

N-acetylmuramoyl-L-alanine amidase activity

Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides.

PGLYRP2

GO:0008747

MF

N-acetylneuraminate lyase activity

Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.

NPL

GO:0008753

MF

NADPH dehydrogenase (quinone) activity

Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor.

NQO2

GO:0008757

MF

S-adenosylmethionine-dependent methyltransferase activity

Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.

METTL7A, AS3MT, COQ3, LCMT1

GO:0008761

MF

UDP-N-acetylglucosamine 2-epimerase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine.

GNE

GO:0008781

MF

N-acylneuraminate cytidylyltransferase activity

Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.

CMAS