GO:0005086

MF

ARF guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

CYTH3, ARF4, TRIP10, FNBP1L, ARFGEF3, IQSEC1, GBF1, FNBP1, FBXO8, PSD3, ARFGEF2

GO:0005087

MF

Ran guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

RCC1, ALS2, RANGRF

GO:0005088

MF

Ras guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

EREG, JAK2, FGF18, FGF19, EGFR, PDGFB, PDGFA, ERBB2, FYN, ADRB1, FGF2, PDGFRB, KIT, FGFR1, NCAM1, PDGFRA, KITLG, FGF7, FGFR2, ERBB3, JAK1, FGF9, BTC, IRS1, ACTN2, JAK3, CALM2, GRB2, DLG4, SHC2, SPTBN1, IL5RA, NRG1, TEK, PTK2, SOS1, GRIN2A, CAMK2D, ERBB4, ANGPT1, KNDC1, FRS2, RAPGEF4, HBEGF, SPTBN4, KL, IRS2

GO:0005089

MF

Rho guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

ARHGEF10, PLEKHG5, FARP2, BCR, VAV1, SOS1, SOS2, ARHGEF5, AKAP13, ABR, TIAM1, ARHGEF7, ITSN1, DOCK11, ARHGEF16, DNMBP, FGD6, NET1, FGD2, MCF2L2, ARHGEF28, ARHGEF39, ARHGEF2, ARHGEF26, FGD4, PLEKHG2, ECT2, ARHGEF10L, ARHGEF4, ARHGEF3, ITSN2, VAV3, FARP1

GO:0005092

MF

GDP-dissociation inhibitor activity

Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding.

ITGB1BP1, CHM, CHML, GDI1, RANBP1, SESN2, GPSM2, GPSM1, SH3BP4

GO:0005093

MF

Rab GDP-dissociation inhibitor activity

Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding.

GDI1, GDI2

GO:0005094

MF

Rho GDP-dissociation inhibitor activity

Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding.

ARHGDIA, ARHGDIB

GO:0005095

MF

GTPase inhibitor activity

Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate.

IPO5, PDE6D, SLIT2, IQGAP1, TNK2, GPS2, IQGAP2, CPEB2, CDC42SE1

GO:0005096

MF

GTPase activator activity

Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

TBC1D3D, TBC1D3E, TBC1D3F, ARHGAP42, ARHGAP33, RGS12, AXIN1, RGS5, ASAP2, ARHGAP6, RASA4, RGS10, TBC1D4, TBC1D12, ADAP1, RP2, FAM13A, TBC1D8, ALDH1A1, A2M, JUN, TBC1D3H, BCR, CHN1, RASA1, CHM, CHML, GDI1, RGS2, HTR2B, ARHGAP25, RANBP1, RANGAP1, IQGAP1, RGS3, RGS4, RGS7, TSC2, GNAQ, GDI2, RAP1GDS1, ARHGDIA, ARHGDIB, AGFG1, OCRL, SOS1, TBC1D8B, ABR, NPRL3, ARHGAP5, MYO9B, GIT2, RASA3, ARHGAP19, RAB3GAP1, ACAP2, RABEP1, RASA2, RALBP1, TRIP10, ARHGAP31, RALGAPA2, ARHGAP29, RABGAP1L, STXBP5, ARHGAP21, DEPDC1, GRTP1, TBC1D9B, RALGAPA1, TBC1D3C, ARHGAP11A, TBC1D9, SYDE1, PREX2, ARHGAP22, SRGAP1, ARHGAP30, RALGAPB, TBC1D3, TAGAP, ARHGAP24, ARHGAP18, TBC1D19, ARFGAP2, RGS22, RIN3, TBC1D16, TBC1D15, DEPDC1B, ARAP3, RIN2, ARAP2, STARD8, DOCK2, TBC1D5, USP6NL, RUNDC1, EVI5L, ANKRD27, ARAP1, AGAP4, SYNGAP1, DLC1, TBCD, RACGAP1, SH3BGRL3, RAB3GAP2, ECT2, ARFGAP3, ADAP2, PLCB1, FAM13B, HACD3, ARHGAP23, ARHGAP20, SIPA1L2, TBC1D14, ERRFI1, CDC42EP3, VAV3, ASAP1, ARHGAP26, AGAP1, TBC1D2B, VPS9D1, STXBP5L, GIT1, STARD13, RABGAP1

GO:0005102

MF

receptor binding

Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

NUDT19, MYO1C, AGRP, ADAM10, ACOT8, MSTN, SLC27A2, FYB, ANGPT2, GNPAT, LEPROT, ACOX3, MTSS1, RIPK2, TRAF3IP2, ENSA, TYROBP, TRAK2, PLXNC1, JAK2, SRPX2, CTNND1, DIAPH2, PEX14, ECI2, LRP6, IDH1, TNFSF13, NXPH3, ABCA1, EML2, ANGPTL1, F2, PLG, PLAT, A2M, C3, KNG1, POMC, LHB, GCG, FGA, FGB, FGG, ANG, AMH, ANXA1, APP, INHA, SERPINE1, LPL, SERPINE2, PFN1, LYN, IGFBP1, CXCL1, PDGFRB, NUDT7, HSPA1A, HSPA1B, AR, IAPP, MBL2, BMP2, BMP3, TDGF1, CCL2, HLA-E, MIF, IDE, LIF, PVR, NPPB, GJA1, HLA-G, IGFBP2, CD58, EFNA1, MAG, RASA1, AGXT, SCP2, IGFBP4, JAK1, PTPRD, TNFSF4, LAMA2, IGFBP6, F2R, ITGB8, DPP4, GSTM2, SSFA2, EPHB2, HLA-F, LRPAP1, SRI, CDH5, ADM, HMGCL, CD200, CSK, NSG1, CRAT, CXCL12, NMU, TNFSF10, INSL3, HSD17B4, JAK3, F2RL1, ARPP19, NXPH1, TGFB2, RACK1, CAV1, PLAUR, PTK2, SMAGP, ECH1, PKD2, ALCAM, SELPLG, MAP7, GAS6, ACOX1, NECTIN1, PPP2R4, ADIPOQ, LAMA4, LAMA3, HFE, WIPI1, CD276, STYK1, SMARCD3, VTCN1, LONP2, ACOT4, DDX54, UFD1L, GLG1, RAB8B, SMARCD1, PANX1, ACOX2, P2RX4, RARRES2, APOL2, CNPY3, DHRS4, RSPO3, CADM1, WNT5B, FZD8, NECTIN3, HAO2, PIPOX, CLCF1, CROT, APLN, TNFSF13B, GSTK1, HILPDA

GO:0005104

MF

fibroblast growth factor receptor binding

Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR).

FLRT2, FGF19, FGF2, FGF7, FGF9, FRS2, FLRT3, FLRT1, KL

GO:0005105

MF

type 1 fibroblast growth factor receptor binding

Interacting selectively and non-covalently with the type 1 fibroblast growth factor receptor (FGFR1).

FGF18

GO:0005109

MF

frizzled binding

Interacting selectively and non-covalently with the frizzled (fz) receptor.

SDCBP, FZD7, LRP6, WNT2, WNT5A, WNT3, NDP, BAMBI, SFRP1, WNT2B, CTHRC1, RSPO3, WNT5B, GOPC, WNT6

GO:0005110

MF

frizzled-2 binding

Interacting selectively and non-covalently with frizzled-2 (fz2).

WNT5A

GO:0005111

MF

type 2 fibroblast growth factor receptor binding

Interacting selectively and non-covalently with the type 2 fibroblast growth factor receptor (FGFR2).

FGF18

GO:0005112

MF

Notch binding

Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.

NOTCH1, JAG1, ADAM17, AAK1, DNER, CHAC1, DLL4, NCOR2

GO:0005113

MF

patched binding

Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins.

DHH, CCNB1, CAV1, PTCH1, BBS1

GO:0005114

MF

type II transforming growth factor beta receptor binding

Interacting selectively and non-covalently with a type II transforming growth factor beta receptor.

TGFB1, TGFBR1, TGFB2, TGFBR3, BAMBI

GO:0005115

MF

receptor tyrosine kinase-like orphan receptor binding

Interacting selectively and non-covalently with the receptor tyrosine kinase-like orphan receptor (Ror).

WNT5A

GO:0005119

MF

smoothened binding

Interacting selectively and non-covalently with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals.

PTCH1, BBS1

GO:0005123

MF

death receptor binding

Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).

CFLAR, NOL3, BID, FADD, RIPK1, CASP8, TMBIM1, FEM1B

GO:0005125

MF

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

TNFRSF11B, TNFSF11, MSTN, GDF9, GREM1, TNFSF13, GDF11, BMP10, IL33, BMP15, TIMP1, TGFB1, TNF, IFNA1 , IL1A, IL1B, IFNA16, INHA, IL6, EDN1, GPI, INHBA, FGF2, HMGB1, INHBB, WNT2, SPP1, BMP2, BMP4, BMP3, CCL4, BMP1, SCG2, MIF, LIF, AREG, VEGFA, IL1RN, IL11, KITLG, BMP6, IL10, SP100, TNFSF4, IL32, GRN, IL12A, CD40LG, BMP8B, WNT5A, GDF5, NAMPT, TNFSF10, INHBC, TGFB2, NDP, NRG1, IL18, ADIPOQ, CTF1, IL34, BMP8A, IFNE, THNSL2, CMTM8, SECTM1, FAM3C, CMTM3, GDF15, GREM2, IL37, CLCF1, TNFSF13B

GO:0005126

MF

cytokine receptor binding

Interacting selectively and non-covalently with a cytokine receptor.

MIF

GO:0005127

MF

ciliary neurotrophic factor receptor binding

Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor.

IL6ST, LIFR, CLCF1

GO:0005131

MF

growth hormone receptor binding

Interacting selectively and non-covalently with the growth hormone receptor.

SOCS2, JAK2, GH1, JAK1

GO:0005132

MF

type I interferon receptor binding

Interacting selectively and non-covalently with an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2).

IFNA1 , IFNA16, IFNE

GO:0005134

MF

interleukin-2 receptor binding

Interacting selectively and non-covalently with the interleukin-2 receptor.

TIMM50

GO:0005136

MF

interleukin-4 receptor binding

Interacting selectively and non-covalently with the interleukin-4 receptor.

PIBF1

GO:0005137

MF

interleukin-5 receptor binding

Interacting selectively and non-covalently with the interleukin-5 receptor.

SDCBP

GO:0005138

MF

interleukin-6 receptor binding

Interacting selectively and non-covalently with the interleukin-6 receptor.

IL6, IL6R, IL6ST, ADAM17, ERAP1, PYCARD

GO:0005141

MF

interleukin-10 receptor binding

Interacting selectively and non-covalently with the interleukin-10 receptor.

IL10

GO:0005142

MF

interleukin-11 receptor binding

Interacting selectively and non-covalently with the interleukin-11 receptor.

IL11

GO:0005143

MF

interleukin-12 receptor binding

Interacting selectively and non-covalently with the interleukin-12 receptor.

JAK2, IL12A, IL12RB1

GO:0005146

MF

leukemia inhibitory factor receptor binding

Interacting selectively and non-covalently with the leukemia inhibitory factor receptor.

LIF, CTF1

GO:0005148

MF

prolactin receptor binding

Interacting selectively and non-covalently with the prolactin receptor.

PRL, GH1

GO:0005149

MF

interleukin-1 receptor binding

Interacting selectively and non-covalently with the interleukin-1 receptor.

TLR5, IL1A, IL1B, TRIP6, IL37

GO:0005150

MF

interleukin-1, Type I receptor binding

Interacting selectively and non-covalently with a Type I interleukin-1 receptor.

IL1RN, TOLLIP

GO:0005151

MF

interleukin-1, Type II receptor binding

Interacting selectively and non-covalently with a Type II interleukin-1 receptor.

IL1RN, ERAP1

GO:0005152

MF

interleukin-1 receptor antagonist activity

Blocks the binding of interleukin-1 to the interleukin-1 receptor complex.

IL1RN

GO:0005153

MF

interleukin-8 receptor binding

Interacting selectively and non-covalently with the interleukin-8 receptor.

CXCL8, YARS

GO:0005154

MF

epidermal growth factor receptor binding

Interacting selectively and non-covalently with the epidermal growth factor receptor.

EREG, PLSCR1, SOCS5, SNX4, TGFA, ITGA5, AREG, ARF4, BTC, GRB2, TNK2, EFEMP1, SNX1, ERBB4, HBEGF, RNF126, VAV3

GO:0005157

MF

macrophage colony-stimulating factor receptor binding

Interacting selectively and non-covalently with the macrophage colony-stimulating factor receptor.

IL34

GO:0005158

MF

insulin receptor binding

Interacting selectively and non-covalently with the insulin receptor.

IRS4, SNX4, INS, IGF2, IGF1, IGF1R, ENPP1, PIK3R1, IRS1, INSL3, PTPN11, GRB10, SNX1, FRS2, PHIP, DOK1, SORBS1, LMBRD1, DOK5, IRS2

GO:0005159

MF

insulin-like growth factor receptor binding

Interacting selectively and non-covalently with the insulin-like growth factor receptor.

SOCS2, SOCS1, INS, IGF2, IGF1, INSR, PIK3R1, IRS1, GNAS, YWHAH, GNAS

GO:0005160

MF

transforming growth factor beta receptor binding

Interacting selectively and non-covalently with the transforming growth factor beta receptor.

MSTN, GDF9, GDF11, BMP10, BMP15, TGFB1, LRG1, AMH, INHA, INHBA, INHBB, BMP2, BMP4, BMP3, BMP1, BMP6, BMP8B, GDF5, INHBC, TGFB2, SMAD3, TGFBR3, SMAD2, BMP8A, GDF15, RASL11B, SMURF2, USP15

GO:0005161

MF

platelet-derived growth factor receptor binding

Interacting selectively and non-covalently with the platelet-derived growth factor receptor.

ERN1, PDGFB, PDGFA, ITGB3, LYN, ITGA5, PDGFRB, IL1R1, VEGFA, PDGFRA, PTEN, PTPRJ, PDGFD, PDGFC

GO:0005163

MF

nerve growth factor receptor binding

Interacting selectively and non-covalently with the nerve growth factor receptor.

NGF

GO:0005164

MF

tumor necrosis factor receptor binding

Interacting selectively and non-covalently with the tumor necrosis factor receptor.

TNFSF11, TNFSF13, TRIM37, TNF, TNFSF4, CD40LG, TNFSF10, TRAF1, FADD, CASP8, TRADD, TNFSF13B

GO:0005166

MF

neurotrophin p75 receptor binding

Interacting selectively and non-covalently with the neurotrophin p75 receptor.

NTRK1, ZNF274

GO:0005168

MF

neurotrophin TRKA receptor binding

Interacting selectively and non-covalently with the neurotrophin TRKA receptor.

PIK3R1, EFNA5, GRB2, FRS2

GO:0005169

MF

neurotrophin TRKB receptor binding

Interacting selectively and non-covalently with the neurotrophin TRKB receptor.

BDNF, EFNA5

GO:0005170

MF

neurotrophin TRKC receptor binding

Interacting selectively and non-covalently with the neurotrophin TRKC receptor.

EFNA5

GO:0005171

MF

hepatocyte growth factor receptor binding

Interacting selectively and non-covalently with the hepatocyte growth factor receptor.

GLMN, ESM1

GO:0005172

MF

vascular endothelial growth factor receptor binding

Interacting selectively and non-covalently with any vascular endothelial growth factor receptor.

VEGFA, PGF

GO:0005173

MF

stem cell factor receptor binding

Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor.

KITLG, SPRED1

GO:0005174

MF

CD40 receptor binding

Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes.

CD40LG

GO:0005175

MF

CD27 receptor binding

Interacting selectively and non-covalently with a CD27, a receptor found on the surface of T cells and some B cells and NK cells.

SIVA1

GO:0005176

MF

ErbB-2 class receptor binding

Interacting selectively and non-covalently with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2.

CDK5, NRG1, MUC4

GO:0005178

MF

integrin binding

Interacting selectively and non-covalently with an integrin.

CYR61, PLPP3, ADAM10, ITGB1BP1, TSPAN4, ACTN4, EDIL3, ADAM23, SEMA7A, WISP2, ECM2, WISP1, EGFR, COL3A1, FN1, VTN, VWF, IGF1, ICAM1, ITGB1, P4HB, LYN, THBS1, ITGA5, ACTN1, TIMP2, ITGA2, PTPN2, TSPAN8, VCAM1, COL5A1, CD9, TNXB, ITGA6, ITGA3, CALR, CTGF, THBS4, FBN1, ACTN2, SYK, CD151, MMP14, EMP2, CXADR, ADAM17, COL4A3, NRG1, DST, COL16A1, MFGE8, CDH17, ILK, ADAM9, GPNMB, TGFBI, S1PR3, JAM3, ESM1, ADAMTS5, ADAMTS8, NISCH, TLN1

GO:0005179

MF

hormone activity

The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.

STC2, BMP10, AGT, GNRH1, POMC, CGA, FSHB, LHB, PRL, GH1, PTH, GCG, INS, IGF2, TTR, AMH, IGF1, CHGB, INHA, EDN1, CCK, INHBA, NMB, INHBB, SCT, CGB5, CGB7, IAPP, PTHLH, NPPB, EDN2, ADM, FBN1, LEP, INSL3, STC1, COPA, INHBC, HAMP, ADIPOQ, RETN, KL, APLN

GO:0005183

MF

gonadotropin hormone-releasing hormone activity

The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary.

GNRH1

GO:0005184

MF

neuropeptide hormone activity

The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.

AGRP, POMC, PENK, CCK, TRH, GAL, NTS, CARTPT, SPX

GO:0005198

MF

structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.

PSMD11, CLDN4, COPE, NPHP1, CLDN3, ROCK2, MPZL1, CLDN1, CSTA, LMNA, FGA, FGB, FGG, BGLAP, ANXA1, KRT1, KRT18, KRT8, TUBB, LAMB1, KRT7, CLTA, MAP2, KRT3, NEFH, KRT13, JUP, DSP, LMNB1, LAMA2, CTNNA1, SPRR2B, GNL1, COL18A1, MATR3, MAP1B, NES, COPA, PLP1, TUBA1B, JAG1, MAP1A, COL4A3, CAV1, LMNB2, IFFO1, ASPH, MAPK8IP2, SNTA1, SNTB2, SNTB1, EIF3A, MAP7, SEPT7, LAMA3, MAP7D1, ODF2, CROCC, KRT80, TUBA1A, BVES, TUBGCP3, ISCA1, SPRR2G, KRT23, PNN, SYNC, SPAG4, CDC42SE2, CDC42SE1, SPRR3, KLHL3, COPG1, LAMC3

GO:0005199

MF

structural constituent of cell wall

The action of a molecule that contributes to the structural integrity of a cell wall.

JUP

GO:0005200

MF

structural constituent of cytoskeleton

The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.

FRMD3, HIP1, NDC80, ARPC2, ARPC3, PPL, SORBS3, SORBS2, YEATS4, TUBB4A, TUBB, VIM, KRT19, KRT16, TPM1, MAPT, DMD, NEFH, DSP, DES, TUBG1, CTNNA2, KRT9, ARPC4, ACTB, ACTR3, ACTR2, ACTG1, TUBA1B, TUBA4A, TUBB4B, SPTBN1, ANK2, KRT17, ANK3, TUBB3, TUBA3C, TUBB2A, PLS1, CCDC6, TUBA1A, TUBGCP3, BICD1, FRMD6, TUBB6, TUBB2B, SPTBN4, EPB41L4B, TUBB1, EPB41L1, EPB41L4A, ADD3, TUBE1, TUBD1, EPB41L3, TLN1

GO:0005201

MF

extracellular matrix structural constituent

The action of a molecule that contributes to the structural integrity of the extracellular matrix.

NCAN, TECTA, EFEMP2, CD4, COL1A1, COL3A1, COL5A2, LAMB1, COL1A2, MGP, COL4A2, HAPLN1, LAMC1, COL11A1, VCAN, COL5A1, BGN, FBLN1, ANOS1, COL8A2, COL5A3, FBN1, FBN2, CHI3L1, COL15A1, TFPI2, COMP, LUM, MUC5AC, FBLN2, COL4A3, MUC3A, COL14A1, MFAP5, COL4A6, LAMA4, FBN3, BCAN, TINAGL1, DSPP

GO:0005212

MF

structural constituent of eye lens

The action of a molecule that contributes to the structural integrity of the lens of an eye.

CRYAB, VIM, MIP, CPOX

GO:0005215

MF

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.

FABP12, AP3D1, GOSR2, XPO1, ATP6V0E1, ASNA1, SLC37A4, NUP155, RASSF9, SEC14L2, KIF20A, PMP2, RBP1, IGF2R, FABP4, SYN1, ATP5J, ATP6V1C1, ATP5D, MIP, GABRA5, ABCC1, PTGDS, ATP5O, ATP5G3, FABP6, AP2S1, UCP3, LCN2, FABP5, ATP5G2, AP1B1, CDH17, TCOF1, TCIRG1, MFSD14B, SYPL2, SLC23A3, SLC51A, SLC16A10, SCARB1, AQP3, AP2M1, SEC22A, MFSD14A, NUP88, CHP1, TTPAL, TMEM245, STARD7, ABCB10, ABCF2, SLC25A13, VPS9D1, AP4S1

GO:0005216

MF

ion channel activity

Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).

KCNK3, GJC1, SCNN1G, TRPV2

GO:0005219

MF

ryanodine-sensitive calcium-release channel activity

Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.

RYR3, RYR2

GO:0005220

MF

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts.

ITPR2, ITPR3, ITPR1

GO:0005222

MF

intracellular cAMP activated cation channel activity

Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts.

CNGA1

GO:0005223

MF

intracellular cGMP activated cation channel activity

Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts.

CNGA1

GO:0005224

MF

ATP-binding and phosphorylation-dependent chloride channel activity

Enables the transmembrane transfer of a chloride ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts.

CFTR

GO:0005225

MF

volume-sensitive anion channel activity

Enables the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell.

LRRC8A, LRRC8C

GO:0005227

MF

calcium activated cation channel activity

Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient.

ANO6, TRPM4

GO:0005229

MF

intracellular calcium activated chloride channel activity

Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.

BEST1, CLCA4, ANO6, ANO2

GO:0005230

MF

extracellular ligand-gated ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts.

GABRA5, CHRNA7, CHRFAM7A, TRPV1

GO:0005231

MF

excitatory extracellular ligand-gated ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular excitatory ligand has been bound by the channel complex or one of its constituent parts. Excitatory ligands, such as acetylcholine or glutamate, open cation-selective channels.

GRIA4, TRPV1

GO:0005234

MF

extracellular-glutamate-gated ion channel activity

Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts.

GRIA4, GRIN2A

GO:0005242

MF

inward rectifier potassium channel activity

Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.

KCNK1, KCNH2, KCNJ12, KCNK6

GO:0005243

MF

gap junction channel activity

A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.

GJA1, MIP, GJC1

GO:0005244

MF

voltage-gated ion channel activity

Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

GPR89A, CLIC1, CLIC3, CYBB, GPR89B, PKD2, ANO6, TMEM37, CLIC6, KCNK17, KCNK12, CLIC5

GO:0005245

MF

voltage-gated calcium channel activity

Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

ITGAV, CACNB3, CACNA2D1, NCS1, PKD2, CACNA1C, GAS6, CACNA1E, TPCN2, CACNG8, CACNG6

GO:0005246

MF

calcium channel regulator activity

Modulates the activity of a calcium channel.

TSPAN13, PRKCB, PLN, SRI, NPY2R, GNB2, GRM3, SGK3, STIM2, NRXN1, HPCAL4

GO:0005247

MF

voltage-gated chloride channel activity

Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

CLCN3, CLCN4, CLCN5, CLCN6, CLCN7, CLCNKA, CLCNKB, ANO6

GO:0005248

MF

voltage-gated sodium channel activity

Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

PKD2, SCN9A

GO:0005249

MF

voltage-gated potassium channel activity

Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

CNGA1, KCNA1, KCNMA1, KCNH2, KCNC3, KCNJ11, KCNE4

GO:0005250

MF

A-type (transient outward) potassium channel activity

Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential.

KCNIP2

GO:0005251

MF

delayed rectifier potassium channel activity

Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.

KCNA1, KCNH2, KCNC3, KCNG3, KCNV2, KCNG1

GO:0005252

MF

open rectifier potassium channel activity

Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration.

KCNK3

GO:0005253

MF

anion channel activity

Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient.

LRRC8A

GO:0005254

MF

chloride channel activity

Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

FXYD1, CLIC1, BEST1, CLIC3, CFTR, GABRA5, SLC1A4, SLC26A2, CLCN3, CLCN4, CLCN5, CLCN7, CLCA4, SLC26A11, BEST3, CLIC6, SLC26A1, TTYH1, CLIC5

GO:0005260

MF

channel-conductance-controlling ATPase activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.

CFTR

GO:0005261

MF

cation channel activity

Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

TRPC1, FAM26F, PIEZO1, CALHM2, TRPV4, GAR1, ASIC3, TRPV2

GO:0005262

MF

calcium channel activity

Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

TRPC1, PSEN1, CACNB3, PKD1, GRIN2A, TRPC3, CACNA1E, DENND5A, DENND5B, TRPV1, TRPM4, TMEM37, RYR2, CUL5, TRPM7, PANX1, TRPM6, TRPV6, TRPV4, SLC24A3, TMCO1, TRPC6, TRPV2

GO:0005267

MF

potassium channel activity

Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

KCNK1, KCNK3, FXYD4, KCNA1, PKD2, KCNK17, TMEM38B, KCNG1, KCNK6

GO:0005272

MF

sodium channel activity

Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

KCNK1, SCNN1G, TRPM4, ASIC3

GO:0005275

MF

amine transmembrane transporter activity

Enables the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.

AQP9

GO:0005277

MF

acetylcholine transmembrane transporter activity

Enables the transfer of acetylcholine from one side of the membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.

SLC22A1