GO:0004887

MF

thyroid hormone receptor activity

Combining with thyroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.

THRA, NR4A3, NR1H4

GO:0004888

MF

transmembrane signaling receptor activity

Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.

TLR4, CLDN4, TNFRSF10C, NPC1, TLR3, CLDN3, LY75, TLR5, TLR2, LGR5, EGFR, CD4, ERBB2, ICAM1, NGFR, GP1BB, IL1R1, SELE, LAG3, ERBB3, EVI2A, MRC1, KLRC1, CD27, TNFRSF8, LEPR, CD97, BCAM, PLXNA3, SCARF1, EBP, TLR1, TRPV1, DNER, SORL1, LGR4, LGR6, INTS6, LYVE1, TNFRSF11A

GO:0004889

MF

acetylcholine-activated cation-selective channel activity

Enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.

CHRNB1, CHRNA5, CHRNA7

GO:0004890

MF

GABA-A receptor activity

Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.

GABRA5

GO:0004896

MF

cytokine receptor activity

Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

CD74, GHR, CD44, IL12RB1, IL1RL1, CSF3R, IL17RB

GO:0004897

MF

ciliary neurotrophic factor receptor activity

Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL6R, IL6ST, LIFR

GO:0004900

MF

erythropoietin receptor activity

Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

EPOR

GO:0004905

MF

type I interferon receptor activity

Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.

IFNAR1, IFNAR2

GO:0004906

MF

interferon-gamma receptor activity

Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IFNGR1, IFNGR2

GO:0004908

MF

interleukin-1 receptor activity

Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.

IL1R1, IL1R2, IL1RL1, IL18R1, IL1RAP

GO:0004909

MF

interleukin-1, Type I, activating receptor activity

Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins.

IL1R1

GO:0004910

MF

interleukin-1, Type II, blocking receptor activity

Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors.

IL1R2

GO:0004913

MF

interleukin-4 receptor activity

Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL4R

GO:0004914

MF

interleukin-5 receptor activity

Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL5RA

GO:0004915

MF

interleukin-6 receptor activity

Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL6R, IL6ST

GO:0004917

MF

interleukin-7 receptor activity

Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL7R

GO:0004918

MF

interleukin-8 receptor activity

Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

CXCR2

GO:0004919

MF

interleukin-9 receptor activity

Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL9R

GO:0004920

MF

interleukin-10 receptor activity

Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL10RB

GO:0004921

MF

interleukin-11 receptor activity

Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL6ST

GO:0004923

MF

leukemia inhibitory factor receptor activity

Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL6ST, LIFR

GO:0004924

MF

oncostatin-M receptor activity

Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL6ST, LIFR, OSMR

GO:0004925

MF

prolactin receptor activity

Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

PRLR

GO:0004930

MF

G-protein coupled receptor activity

Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

GRM8, GRM6, GPR37, FZD6, FZD7, GPR32, ADGRL2, IGF2R, S1PR1, C5AR1, FPR2, PTAFR, F2R, GPR183, HRH1, OPRL1, OR3A3, CD97, MTNR1B, F2RL1, CXCR4, ADGRE1, GPR176, GRM3, SFRP5, GPR158, GPR157, SFRP4, OR52E8, ADGRD1, GPR126, TPRA1, ADGRA3, SFRP1, GPRC5A, OR5A2, OR5L2, OR14C36, GPR98, GHSR, GPR146, OR2A5, S1PR3, GPER1, TM2D1, GPR63, OPN3, OR51E2, FZD8, ADGRL3, GPRC5C, GPR27, CELSR3, GPRC5B, GPR160, FZD4, GPR34, ADGRG1

GO:0004931

MF

extracellular ATP-gated cation channel activity

Enables the transmembrane transfer of a cation by a channel that opens when extracellular ATP has been bound by the channel complex or one of its constituent parts.

P2RX4

GO:0004937

MF

alpha1-adrenergic receptor activity

Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.

ADRA1D, ADRA1A, ADRA1B

GO:0004938

MF

alpha2-adrenergic receptor activity

Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein.

ADRA2B

GO:0004939

MF

beta-adrenergic receptor activity

Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein.

ADRB1, ADRB3

GO:0004940

MF

beta1-adrenergic receptor activity

Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors.

ADRB1

GO:0004941

MF

beta2-adrenergic receptor activity

Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors.

ADRB2

GO:0004945

MF

angiotensin type II receptor activity

An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms.

AGTR1, AGTR2, AGTRAP

GO:0004948

MF

calcitonin receptor activity

Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

RAMP1

GO:0004949

MF

cannabinoid receptor activity

Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids.

CNR1

GO:0004950

MF

chemokine receptor activity

Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.

ACKR4

GO:0004951

MF

cholecystokinin receptor activity

Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone.

CCKBR

GO:0004955

MF

prostaglandin receptor activity

Combining with a prostaglandin (PG) to initiate a change in cell activity.

PPARG

GO:0004956

MF

prostaglandin D receptor activity

Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity.

PTGDR

GO:0004957

MF

prostaglandin E receptor activity

Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity.

HPGD, PTGER4, PTGER3, PTGER2

GO:0004958

MF

prostaglandin F receptor activity

Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity.

PTGFR

GO:0004962

MF

endothelin receptor activity

Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

EDNRA

GO:0004963

MF

follicle-stimulating hormone receptor activity

Combining with follicle-stimulating hormone to initiate a change in cell activity.

FSHR

GO:0004964

MF

luteinizing hormone receptor activity

Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity.

LHCGR

GO:0004965

MF

G-protein coupled GABA receptor activity

Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

GABBR2, GABBR1

GO:0004966

MF

galanin receptor activity

Combining with galanin to initiate a change in cell activity.

GAL

GO:0004968

MF

gonadotropin-releasing hormone receptor activity

Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.

GNRHR

GO:0004969

MF

histamine receptor activity

Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.

HRH1, HRH3

GO:0004970

MF

ionotropic glutamate receptor activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.

GRIA4

GO:0004971

MF

AMPA glutamate receptor activity

An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium.

GRIA4

GO:0004972

MF

NMDA glutamate receptor activity

An ionotropic glutamate receptor activity that exhibits slow gating by glutamate, acts by opening a nonselective cation channel, and can be activated by L-aspartate.

GRIN2A

GO:0004977

MF

melanocortin receptor activity

Combining with melanocortin to initiate a change in cell activity.

MC4R, MC2R

GO:0004978

MF

corticotropin receptor activity

Combining with corticotropin to initiate a change in cell activity.

MC2R

GO:0004980

MF

melanocyte-stimulating hormone receptor activity

Combining with melanocyte-stimulating hormone to initiate a change in cell activity.

MC4R

GO:0004982

MF

N-formyl peptide receptor activity

Combining with an N-formyl peptide to initiate a change in cell activity.

GPR32, FPR1, FPR2

GO:0004983

MF

neuropeptide Y receptor activity

Combining with neuropeptide Y to initiate a change in cell activity.

NPY1R, NPY2R, NPY5R

GO:0004984

MF

olfactory receptor activity

Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell.

OR3A3, OR52E8, OR5A2, OR5L2, OR14C36, OR2A5, OR51E2

GO:0004985

MF

opioid receptor activity

Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein.

NPBWR1, SIGMAR1

GO:0004990

MF

oxytocin receptor activity

Combining with oxytocin to initiate a change in cell activity.

OXTR

GO:0004991

MF

parathyroid hormone receptor activity

Combining with parathyroid hormone to initiate a change in cell activity.

PTH2R

GO:0004992

MF

platelet activating factor receptor activity

Combining with platelet activating factor to initiate a change in cell activity.

PDGFRB, PTAFR

GO:0004993

MF

G-protein coupled serotonin receptor activity

Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.

HTR2C, HTR7, HTR2B

GO:0004994

MF

somatostatin receptor activity

Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G-protein coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28).

SSTR1, SSTR5

GO:0004996

MF

thyroid-stimulating hormone receptor activity

Combining with thyroid-stimulating hormone to initiate a change in cell activity.

PAX8

GO:0004998

MF

transferrin receptor activity

Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates.

TFRC, TFR2

GO:0004999

MF

vasoactive intestinal polypeptide receptor activity

Combining with vasoactive intestinal polypeptide to initiate a change in cell activity.

ADCYAP1R1

GO:0005000

MF

vasopressin receptor activity

Combining with vasopressin to initiate a change in cell activity.

AVPR2, OXTR, INPP5K

GO:0005001

MF

transmembrane receptor protein tyrosine phosphatase activity

Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

PTPRC, PTPRF, PTPRB, PTPRD, PTPRG, PTPRM, PTPRK, PTPRO

GO:0005003

MF

ephrin receptor activity

Combining with an ephrin to initiate a change in cell activity.

EPHA5, EPHB4, EPHA6

GO:0005004

MF

GPI-linked ephrin receptor activity

Combining with a GPI-anchored ephrin to initiate a change in cell activity.

NTRK1, EPHA3, EPHA5, EPHA4

GO:0005005

MF

transmembrane-ephrin receptor activity

Combining with a transmembrane ephrin to initiate a change in cell activity.

EPHB2, EFNA4, EPHA5, EPHB1, EPHA4

GO:0005006

MF

epidermal growth factor-activated receptor activity

Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.

EGFR, EFEMP1

GO:0005007

MF

fibroblast growth factor-activated receptor activity

Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.

FGFR1, FGFR2

GO:0005008

MF

hepatocyte growth factor-activated receptor activity

Combining with hepatocyte growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.

MET

GO:0005009

MF

insulin-activated receptor activity

Combining with insulin and transmitting the signal across the plasma membrane to initiate a change in cell activity.

INSR

GO:0005010

MF

insulin-like growth factor-activated receptor activity

Combining with insulin-like growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.

IGF1R, IGF2R, CRIM1

GO:0005011

MF

macrophage colony-stimulating factor receptor activity

Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

CSF1R

GO:0005017

MF

platelet-derived growth factor-activated receptor activity

Combining with platelet-derived growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.

PDGFRB

GO:0005018

MF

platelet-derived growth factor alpha-receptor activity

Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity.

PDGFRA

GO:0005019

MF

platelet-derived growth factor beta-receptor activity

Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity.

PDGFRB

GO:0005020

MF

stem cell factor receptor activity

Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation.

KIT

GO:0005021

MF

vascular endothelial growth factor-activated receptor activity

Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.

NRP1, NRP2, PDGFRA, FLT4

GO:0005024

MF

transforming growth factor beta-activated receptor activity

Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

TGFBR1, TGFBR2, TGFBR3, LTBP1

GO:0005025

MF

transforming growth factor beta receptor activity, type I

Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals.

TGFBR1, ACVR1

GO:0005026

MF

transforming growth factor beta receptor activity, type II

Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor.

TGFBR2, AMHR2

GO:0005031

MF

tumor necrosis factor-activated receptor activity

Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function.

TNFRSF11B, TNFRSF10C, TNFRSF21, NGFR, TNFRSF1B, FAS, CD27, TNFRSF8, LTBR, TNFRSF25, TNFRSF19, TNFRSF11A

GO:0005034

MF

osmosensor activity

Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell.

TRPV4

GO:0005041

MF

low-density lipoprotein receptor activity

Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein into the cell via endocytosis.

LRP6, LDLR, CD36, OLR1, VLDLR, LRP2, LRP10, STAB2, CXCL16, STAB1

GO:0005042

MF

netrin receptor activity

Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

UNC5C

GO:0005044

MF

scavenger receptor activity

Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs).

ENPP3, CD5L, VTN, CFI, ENPP1, CD6, PRSS12, ENPP2, SCARF1, COLEC12, CD163, SBSPON, STAB2, PRG4, LOXL4, TINAGL1, CXCL16, ACKR4, CD163L1, STAB1, DMBT1, LOXL2

GO:0005046

MF

KDEL sequence binding

Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.

KDELR1

GO:0005047

MF

signal recognition particle binding

Interacting selectively and non-covalently with the signal recognition particle.

SRP72, SRP9, SRPRB

GO:0005048

MF

signal sequence binding

Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.

AP2B1, AP2M1

GO:0005049

MF

nuclear export signal receptor activity

Combining with a nuclear export signal (NES) to mediate transport of the NES-containing protein through the nuclear pore to the cytoplasm.

XPO1, NUPL2, CSE1L, XPO4

GO:0005055

MF

laminin receptor activity

Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity.

RPSA, BCAM

GO:0005057

MF

receptor signaling protein activity

Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell.

RGS12, DCLK1, FLRT2, TYROBP, ADRB1, FCGR1A, IFITM1, IL4R, TGFBR1, PIP4K2B, ARF1, IL1RL1, TIAM1, PDCL, SMAD1, NSMAF, DOK1, SMAD5, FLRT3, FLRT1, DOK5

GO:0005068

MF

transmembrane receptor protein tyrosine kinase adaptor activity

The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.

PIK3R1, IRS1, FRS2, BLNK, PAG1

GO:0005070

MF

SH3/SH2 adaptor activity

Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).

SOCS2, IRS4, ARHGAP6, SKAP2, CD28, CHN1, CRKL, SH3BGR, GRB2, PTPN11, KHDRBS1, EPS8, GRB10, GAB1, TP53BP2, GRB14, SHB, BLNK, STAM, SORBS1, PAG1, ITSN2, VAV3

GO:0005072

MF

transforming growth factor beta receptor, cytoplasmic mediator activity

Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus.

CDKN1B

GO:0005078

MF

MAP-kinase scaffold activity

The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.

SPAG9, AKAP13, MAPK8IP2, DUSP19, MAPK8IP3, MAPK8IP1

GO:0005080

MF

protein kinase C binding

Interacting selectively and non-covalently with protein kinase C.

LDB3, HSPB1, PRKCB, ITGAV, TOP2A, PRKCSH, DSP, MARCKS, SDC4, AKT1, GRK5, IRS1, HINT1, TIRAP, RACK1, SRSF2, C1QBP, ADAM9, SQSTM1, TDG, PKN1, TWF2, HDAC7, PRKCDBP, DACT3, PDLIM5, FEZ1, PKP2, TRPV4, PARD6A, DACT1, HDAC9, HDAC5

GO:0005085

MF

guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

BCAR3, PLEKHG5, VAV1, SOS1, SOS2, ARHGEF5, AKAP13, RALGDS, ABR, TIAM1, EIF2B5, ARHGEF7, EIF2B1, RAB3GAP1, ITSN1, RALGPS1, ARHGEF16, LAMTOR1, FGD6, RASGRP2, NET1, FGD2, RALGPS2, TAGAP, ARHGEF28, DOCK8, FLCN, RAPGEF6, FNIP1, RAPGEF4, GBF1, ELMO1, RPGR, HPS1, ARHGEF2, DOCK10, DOCK6, FGD4, DOCK7, SPATA13, ANKRD27, ALS2, DOCK5, PLEKHG2, ECT2, RANGRF, HPS4, EIF2B3, ARHGEF4, ARHGEF3, LAMTOR3, EIF2B4, VAV3, DIS3, LAMTOR2, ARFGEF2