GO:0004708

MF

MAP kinase kinase activity

Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.

MAP2K7, PAK3, MAP2K2, MAP2K6, MAP2K1, MAPK14

GO:0004709

MF

MAP kinase kinase kinase activity

Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.

MAP3K13, MAP3K7, EGFR, RAF1, MAP3K8, MAP3K7CL, MLK4, MAP3K5, ZAK, MAP3K4

GO:0004711

MF

ribosomal protein S6 kinase activity

Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.

RPS6KA2

GO:0004712

MF

protein serine/threonine/tyrosine kinase activity

Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

AURKA, PRKACA, AKT1, TTK, MAP2K2, CLK2, PRKAA2, MAP2K1, TNK2, ACVR2B, RPS6KA2, RPS6KA1, TESK1, DSTYK, DYRK2, AURKB, CLK4

GO:0004713

MF

protein tyrosine kinase activity

Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

MAP2K7, EREG, MUSK, JAK2, FGF18, ERLIN2, EGFR, ERBB2, INSR, FYN, HSP90AA1, LYN, IGF1R, MET, FGF2, PDGFRB, FGR, KIT, BCR, FGFR1, FGF7, FGFR2, ERBB3, JAK1, EPHB2, LTK, WEE1, FGF9, TTK, BTC, MAP2K2, CSK, STAT5A, ABL2, SYK, CLK2, STAT5B, JAK3, MAP2K6, IL5RA, NRG1, MAP2K1, TEK, PTK2, TYRO3, TNK2, MAP2K5, CUX1, ERBB4, TESK1, CDC37, DSTYK, TTN, DYRK2, SCYL1, NEK1, HBEGF, CLK4, FGFR1OP2, ZMYM2, BAZ1B

GO:0004714

MF

transmembrane receptor protein tyrosine kinase activity

Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

MUSK, EGFR, ERBB2, NTRK1, KIT, PDGFRA, LTK, TIE1, FLT4, EPHB4, ROR1, TEK, TYRO3, DDR1, MERTK, ERBB4

GO:0004715

MF

non-membrane spanning protein tyrosine kinase activity

Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate.

RIPK2, JAK2, FYN, LYN, FGR, JAK1, WEE1, CSK, ABL2, SYK, JAK3, PTK2, PRKCD, TNK2, MELK, STYK1, SGK223, BAZ1B

GO:0004716

MF

receptor signaling protein tyrosine kinase activity

Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

EGFR, ERBB2, INSR, LYN, KIT, SYK, TYRO3, ERBB4

GO:0004719

MF

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester.

PCMT1, PCMTD1

GO:0004720

MF

protein-lysine 6-oxidase activity

Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide.

LOX, LOXL2

GO:0004721

MF

phosphoprotein phosphatase activity

Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.

PLPP3, CTDSPL, CDC25A, CDC25B, CDC25C, PPP1CC, PTEN, PPP1CA, PTPN11, DLG1, MTM1, DLGAP5, TIMM50, TNS2, SSH2, PPP1R3B, DUSP9, CPPED1, DUSP26, DUSP16, PHPT1, PPM1H, CDC14A, DUSP10

GO:0004722

MF

protein serine/threonine phosphatase activity

Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

PP2D1, PPP6C, PPM1G, CDC14B, PPM1B, CTDNEP1, PPP1R3D, PPP2R1A, PPP1CC, PPM1F, PTEN, PPP4C, PPP1CA, PPP2CB, CYCS, PPP3CA, PPP2R5D, TAB1, CDKN3, TIMM50, PPM1J, PHLPP2, PPM1K, PPTC7, UBLCP1, PPM1E, DUSP23, PPA2, MTMR4, PDP1, PPM1H, CDC14A

GO:0004725

MF

protein tyrosine phosphatase activity

Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

PTPDC1, EYA2, CDC14B, DUSP11, EYA4, PTPRC, PTPRF, PTPN2, PTPRG, PTPRM, CDC25A, CDC25B, CDC25C, PTPN9, DUSP3, TPTE, PTEN, DUSP2, PTPN11, PTPRJ, DUSP8, MTM1, MTMR1, MTMR2, PTPRK, CDKN3, DUSP5, PTPN21, PTPRO, DUSP6, DUSP7, TIMM50, SSH2, DUSP18, SSH3, UBASH3B, DUSP19, PTPMT1, PTP4A1, DUSP9, DUSP26, DUSP23, DUSP16, DUSP21, DUSP22, MTMR4, DUSP13, CDC14A, PTPN22, DUSP10

GO:0004726

MF

non-membrane spanning protein tyrosine phosphatase activity

Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.

PTPN2, DUSP1, PTPN4, PTPN9, PTPN11

GO:0004727

MF

prenylated protein tyrosine phosphatase activity

Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate.

PTP4A2

GO:0004728

MF

receptor signaling protein tyrosine phosphatase activity

Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

MAP2K1

GO:0004731

MF

purine-nucleoside phosphorylase activity

Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.

PNP

GO:0004735

MF

pyrroline-5-carboxylate reductase activity

Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.

PYCRL

GO:0004736

MF

pyruvate carboxylase activity

Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate.

PC

GO:0004738

MF

pyruvate dehydrogenase activity

Catalysis of the oxidative decarboxylation of pyruvate.

PDHA1, PDHB

GO:0004739

MF

pyruvate dehydrogenase (acetyl-transferring) activity

Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.

PDHA1, PDHB

GO:0004740

MF

pyruvate dehydrogenase (acetyl-transferring) kinase activity

Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate.

PDK1, PDK4

GO:0004741

MF

[pyruvate dehydrogenase (lipoamide)] phosphatase activity

Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate.

PDP1

GO:0004742

MF

dihydrolipoyllysine-residue acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide.

DLAT

GO:0004743

MF

pyruvate kinase activity

Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.

PKM

GO:0004745

MF

retinol dehydrogenase activity

Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.

HSD17B6, DHRS3, BMP2, ADH7, AKR1C3, RDH10, RDH11, DHRS9

GO:0004748

MF

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.

RRM1, RRM2

GO:0004749

MF

ribose phosphate diphosphokinase activity

Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+).

PRPS2, PRPS1

GO:0004756

MF

selenide, water dikinase activity

Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate.

SEPHS1

GO:0004758

MF

serine C-palmitoyltransferase activity

Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA.

SPTLC2, SPTSSB

GO:0004760

MF

serine-pyruvate transaminase activity

Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.

AGXT

GO:0004766

MF

spermidine synthase activity

Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine.

SRM

GO:0004767

MF

sphingomyelin phosphodiesterase activity

Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+).

SMPD4

GO:0004768

MF

stearoyl-CoA 9-desaturase activity

Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O.

SCD, FADS2, SCD5

GO:0004769

MF

steroid delta-isomerase activity

Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid.

HSD3B1, HSD3B2, EBP

GO:0004771

MF

sterol esterase activity

Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid.

LIPA

GO:0004772

MF

sterol O-acyltransferase activity

Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester.

SOAT1

GO:0004773

MF

steryl-sulfatase activity

Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.

STS

GO:0004775

MF

succinate-CoA ligase (ADP-forming) activity

Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate.

SUCLG1, SUCLA2

GO:0004776

MF

succinate-CoA ligase (GDP-forming) activity

Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate.

SUCLG1

GO:0004778

MF

succinyl-CoA hydrolase activity

Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate.

ACOT4

GO:0004781

MF

sulfate adenylyltransferase (ATP) activity

Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate.

PAPSS2

GO:0004782

MF

sulfinoalanine decarboxylase activity

Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2.

CSAD

GO:0004784

MF

superoxide dismutase activity

Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.

CCS, SOD2, SOD3, NQO1

GO:0004788

MF

thiamine diphosphokinase activity

Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate.

TPK1

GO:0004791

MF

thioredoxin-disulfide reductase activity

Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.

TXNRD1

GO:0004792

MF

thiosulfate sulfurtransferase activity

Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate.

MPST

GO:0004797

MF

thymidine kinase activity

Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate.

TK2, TK1

GO:0004798

MF

thymidylate kinase activity

Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.

DTYMK, CMPK2

GO:0004799

MF

thymidylate synthase activity

Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate.

TYMS

GO:0004800

MF

thyroxine 5'-deiodinase activity

Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2.

DIO2

GO:0004801

MF

sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity

Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

TALDO1

GO:0004802

MF

transketolase activity

Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor.

TKT

GO:0004803

MF

transposase activity

Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.

ZBED1

GO:0004806

MF

triglyceride lipase activity

Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

LPL, AADAC, LIPE, PNPLA5, PNPLA2, PNPLA3

GO:0004807

MF

triose-phosphate isomerase activity

Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate.

TPI1

GO:0004810

MF

tRNA adenylyltransferase activity

Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1).

TRNT1

GO:0004814

MF

arginine-tRNA ligase activity

Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

RARS

GO:0004815

MF

aspartate-tRNA ligase activity

Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).

DARS

GO:0004818

MF

glutamate-tRNA ligase activity

Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

EPRS, EARS2

GO:0004821

MF

histidine-tRNA ligase activity

Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

HARS, HARS2

GO:0004823

MF

leucine-tRNA ligase activity

Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

LARS2

GO:0004824

MF

lysine-tRNA ligase activity

Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).

KARS

GO:0004826

MF

phenylalanine-tRNA ligase activity

Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).

FARS2, FARSA

GO:0004827

MF

proline-tRNA ligase activity

Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

EPRS, PARS2

GO:0004828

MF

serine-tRNA ligase activity

Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).

SARS

GO:0004829

MF

threonine-tRNA ligase activity

Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

TARS

GO:0004831

MF

tyrosine-tRNA ligase activity

Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).

YARS

GO:0004832

MF

valine-tRNA ligase activity

Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

YARS

GO:0004835

MF

tubulin-tyrosine ligase activity

Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.

TTL

GO:0004839

MF

ubiquitin activating enzyme activity

Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.

UBA6, UBA1, UBA7, SAE1

GO:0004842

MF

ubiquitin-protein transferase activity

Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

ASB14, RNF103, WWP2, PEX12, UBE2C, BACH1, BIRC5, SIAH2, PARK2, TRIM13, FBXO24, RNF8, TRIM37, UBR5, CNOT4, RAG1, TNFAIP3, UBA1, TRIM23, BRCA1, UBA7, CDC34, UBE2A, UBE2E1, TTC3, UBE2D3, UBE2M, UBE2H, RBX1, UBE2B, SKP1, XIAP, MDM2, CBLB, TRIM28, SKP2, BIRC3, CUL3, TRIM25, SHPRH, HERC3, TCEB1, UBE3C, UBE2S, LONRF1, KLHL12, HERC4, MARCH8, UBR4, HECTD2, FBXO31, RFWD3, KLHL24, CYHR1, PDZRN4, RNF19B, UBR3, CBLL1, MAEA, RNF144B, RBBP6, HUWE1, TRIM69, RNF130, MIB1, SIAH1, KLHL7, KBTBD2, KLHDC8A, HACE1, KLHL36, RNF182, RNF152, KLHL23, FBXO22, FBXO25, MARCH1, RNF141, MYLIP, KCTD13, CUL5, FBXO32, UBE2E3, MIB2, UBE2W, KLHDC7B, RMND5B, ITCH, ZFP91, UBE2E2, KLHL15, KLHL32, ASB16, KLHL5, UHRF2, NEDD4L, UHRF1, MPHOSPH8, BARD1, FEM1A, TRIM62, BACH2, TRIM9, TRIM2, KLHL4, RNF38, WWP1, KCTD10, FBXL15, RMND5A, SMURF2, RC3H2, UBE2T, RNF146, RNF19A, RLIM, RNF216, KLHL28, DTL, RNF181, KLHL8, KLHL9, KLHL42, KLHL13, HECW2, KLHL3, MKRN1, FBXL7, CDC23, ANAPC4, FEM1B, FBXO10, FBXO9, FBXL2, AMFR, STUB1, TRIM33, PDZRN3, RNF6, BTRC, UBE2D4, ARIH1, RNF114, ASB3

GO:0004843

MF

thiol-dependent ubiquitin-specific protease activity

Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.

USP27X, USP12, USP2, USP1, STAMBP, UCHL1, UCHL3, TNFAIP3, USP6, BRCC3, USP11, ATXN3, USP46, JOSD1, OTUD1, OTUD7B, USP34, USP31, USP51, USP45, USP48, USP32, BAP1, TANK, UFD1L, USP13, OTUB2, OTUB1, VCPIP1, USP28, USP44, USP42, CYLD, USP36, USP35, ZRANB1, USP25, USP22, USP20, USP15, UCHL5

GO:0004844

MF

uracil DNA N-glycosylase activity

Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.

UNG, TDG, SMUG1

GO:0004849

MF

uridine kinase activity

Catalysis of the reaction: ATP + uridine = ADP + UMP.

CMPK1, UPRT, UCK2, UCK1, UCKL1

GO:0004850

MF

uridine phosphorylase activity

Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

UPP2, UPP1

GO:0004853

MF

uroporphyrinogen decarboxylase activity

Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2.

UROD

GO:0004854

MF

xanthine dehydrogenase activity

Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.

XDH, AOX1

GO:0004855

MF

xanthine oxidase activity

Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide.

XDH

GO:0004857

MF

enzyme inhibitor activity

Binds to and stops, prevents or reduces the activity of an enzyme.

PPP1R12A, SCG5, PLN, NOTCH1, FRY, CCAR2, TXNIP

GO:0004859

MF

phospholipase inhibitor activity

Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid.

APOC1, ANXA5, ANXA4, PDC

GO:0004860

MF

protein kinase inhibitor activity

Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.

SOCS2, SOCS3, SOCS6, SOCS1, FLRT2, SH3BP5, SOCS5, NPM1, DCN, BGN, DNAJC3, SH3BP5L, PODN, RTN4RL1, LRRTM4, DUSP19, TRIB2, TRIB3, TRIB1, CHP1, TAOK3, LRRC19, FLRT3, FLRT1, MAPK8IP1

GO:0004861

MF

cyclin-dependent protein serine/threonine kinase inhibitor activity

Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase.

HEXIM1, CDKN1A, CDKN2B, CDKN2C, CDKN1B, CDKN1C, KAT2B

GO:0004862

MF

cAMP-dependent protein kinase inhibitor activity

Stops, prevents or reduces the activity of a cAMP-dependent protein kinase.

PRKAR1A, PRKAR2A, PRKAR2B, PKIA, PKIG

GO:0004864

MF

protein phosphatase inhibitor activity

Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins.

ENSA, PHACTR2, URI1, ARPP19, SET, PPP1R35, SH3RF2, PPP1R10, PPME1, CABIN1

GO:0004865

MF

protein serine/threonine phosphatase inhibitor activity

Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.

PPP1R11, PPP1R2, PPP1R1A, PPP1R14C, PPP1R14A, PPP1R14B

GO:0004866

MF

endopeptidase inhibitor activity

Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

SPINT2, RECK, SPINK1, C3, CST3, AHSG, SLPI, CSTB, C4A, C4B, TFPI, CAST, SPP2, WFDC2, PROL1, UCHL5

GO:0004867

MF

serine-type endopeptidase inhibitor activity

Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

SPINT2, PAPLN, RECK, SPINK1, SERPINC1, SERPINA1, SERPINA3, AGT, A2M, AMBP, SLPI, APP, SERPINE1, SERPINA5, SERPING1, SERPINE2, FURIN, TFPI, COL6A3, ANOS1, SERPINB3, PEBP1, SERPINB1, SERPINB5, SERPINF1, TFPI2, SERPINB4, SERPINB9, SERPINH1, APLP2, WFDC2, ITIH5, WFDC3, SERPINA12, CPAMD8, SERPINI1, WFDC1, CRIM1, SERPINB13

GO:0004869

MF

cysteine-type endopeptidase inhibitor activity

Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.

BIRC5, PTTG1, CST3, CSTA, KNG1, AHSG, CSTB, CST2, CAST, SERPINB3, WFDC2, CARD16, FETUB, SERPINB13

GO:0004871

MF

signal transducer activity

Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.

GPR89A, AIP, TRIM38, IRS4, PPP1R12A, AXIN1, RIPK2, TSPAN6, GNG7, TRIM13, PLEKHG5, DKK1, IKBKAP, GNAI2, S100A9, NGFR, GNAI3, LGALS1, HMOX1, GPR89B, IL1R1, JUP, GNB3, PLCG2, STMN1, GJA1, FST, CAPN3, FLNA, ZP3, CXCR2, CD24, FAS, EEF1D, GNA11, LSP1, CTNNB1, IRS1, CHKA, STAT3, STAT5A, CRKL, MAPKAPK2, RGS7, GNAQ, GNG4, PLCD1, STAT5B, STAT2, YARS, GNG11, GNB1, GNB2, GNAI1, GNG5, GNAS, ATP2C1, GNA12, PTK2, PLCXD2, BST2, AKAP13, CBLB, ITGB3BP, ILK, GAB1, PLCL1, TRADD, GNAS, WLS, PLCXD3, CSPG4, CXXC5, MAVS, TMED4, MAGI2, ZDHHC17, SLC44A2, C18orf32, SLC20A1, SECTM1, TFG, CREBBP, MIB2, LITAF, NDFIP1, TOLLIP, ECT2, SP110, NEK6, IL1RAP, PLCB1, SH2B1, NDFIP2, PLK2, VAPA, KL, PLEKHB1, CNOT7, SUFU, PLCL2, SH2B3, GOLT1B, IRS2

GO:0004872

MF

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

TLR4, TNFRSF11B, NPC1, TLR3, MED14, LY75, NRP2, TLR5, TLR2, RAMP1, RAMP3, LDLR, CD4, OPN1SW, KRT1, ICAM1, NGFR, CD48, IGF2R, PVR, FOLR1, CD46, CD1D, ITGB4, CD33, CHRM3, ITGAX, MRC1, FAS, ITGB8, GABRA5, CD200, ADCYAP1R1, NOTCH1, NPY2R, F2RL1, ANTXR2, FKBP3, TEK, GUCY2D, PLAUR, NOTCH2, IL10RB, SLC20A2, SMAGP, IL18R1, TLR1, MMD, SLC1A5, AMHR2, AMOT, JMJD6, SV2A, RTN4RL1, PKHD1L1, NLGN4X, NLGN1, SLC20A1, CUL5, TNFRSF25, MED12, MED30, CSF3R, SEC62, VIMP, CADM1, CD244, SLC40A1, TREM1, MED4, CD93, NECTIN3, TNFRSF19, MED17, RRBP1, SEC63, PLXNA1, AMFR, NRXN1, PROCR, SIGLEC7, THRAP3, MED16, TNPO3, LYVE1, TNFRSF11A

GO:0004873

MF

asialoglycoprotein receptor activity

Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane.

LRPAP1

GO:0004874

MF

aryl hydrocarbon receptor activity

Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding.

ARNT, AHR

GO:0004875

MF

complement receptor activity

Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

GPR32, FPR1, FPR2

GO:0004877

MF

complement component C3b receptor activity

Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

CR1

GO:0004878

MF

complement component C5a receptor activity

Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

C5AR1

GO:0004879

MF

RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding

Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.

NR5A2, AR, NR2F1, ESRRA, NR1D1, NR4A1, NR2F2, RXRB, RORA, AHR, PPARG, STAT3, NR4A2, NR0B1, NR1H2, PPARD, PPARA, NR1H3, NR1D2, GLMP, ESR2, NR1H4

GO:0004882

MF

androgen receptor activity

Combining with an androgen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an androgen response element in DNA in order to modulate transcription by RNA polymerase II.

AR

GO:0004883

MF

glucocorticoid receptor activity

Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function.

NR3C1

GO:0004886

MF

9-cis retinoic acid receptor activity

Combining with 9-cis retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.

RXRB