GO:0004345

MF

glucose-6-phosphate dehydrogenase activity

Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.

H6PD, G6PD

GO:0004346

MF

glucose-6-phosphatase activity

Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate.

G6PC, G6PC3

GO:0004347

MF

glucose-6-phosphate isomerase activity

Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate.

GPI

GO:0004348

MF

glucosylceramidase activity

Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.

GBA2

GO:0004349

MF

glutamate 5-kinase activity

Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+).

ALDH18A1

GO:0004350

MF

glutamate-5-semialdehyde dehydrogenase activity

Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.

ALDH18A1

GO:0004352

MF

glutamate dehydrogenase (NAD+) activity

Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+.

GLUD2

GO:0004353

MF

glutamate dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.

GLUD2

GO:0004357

MF

glutamate-cysteine ligase activity

Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate.

GCLC, GCLM

GO:0004359

MF

glutaminase activity

Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.

GLS, NADSYN1

GO:0004360

MF

glutamine-fructose-6-phosphate transaminase (isomerizing) activity

Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.

GFPT1

GO:0004362

MF

glutathione-disulfide reductase activity

Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.

GSR

GO:0004364

MF

glutathione transferase activity

Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.

MGST3, GSTA4, EEF1E1, GSTZ1, GSTA1, GSTP1, GSTM1, GSTT2, MGST1, GSTM3, GSTM2, GSTT1, GSTO1, GSTM4, MGST2, GSTO2, GSTK1

GO:0004365

MF

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity

Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+.

GAPDH

GO:0004366

MF

glycerol-3-phosphate O-acyltransferase activity

Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.

GPAT3, GPAT4, GPAM

GO:0004368

MF

glycerol-3-phosphate dehydrogenase activity

Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

GPD2

GO:0004370

MF

glycerol kinase activity

Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+).

GK, GK5

GO:0004371

MF

glycerone kinase activity

Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+).

TKFC

GO:0004372

MF

glycine hydroxymethyltransferase activity

Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.

SHMT1

GO:0004373

MF

glycogen (starch) synthase activity

Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1).

GYS1, GYS2

GO:0004379

MF

glycylpeptide N-tetradecanoyltransferase activity

Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide.

NMT2

GO:0004383

MF

guanylate cyclase activity

Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.

NPR2, GUCY2D

GO:0004385

MF

guanylate kinase activity

Catalysis of the reaction: ATP + GMP = ADP + GDP.

CASK, DLG4, MPP1, DLG1, GUK1, TJP2

GO:0004386

MF

helicase activity

Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix.

BTAF1, SMARCA5, ANXA1, GTF2F2, EIF4B, SMARCA1, HELZ, ATRX, DNA2, SMARCA2, SMARCA4, BLM, EIF4A1, EIF4A2, SHPRH, ERCC6L, CHD9, DDX60L, NAV2, SUPV3L1, FANCM, HELQ, RAD54L, HELZ2, SMARCAD1, HELLS, CHD7, MCM8, DICER1

GO:0004392

MF

heme oxygenase (decyclizing) activity

Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O.

HMOX1

GO:0004394

MF

heparan sulfate 2-O-sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate.

HS2ST1

GO:0004395

MF

hexaprenyldihydroxybenzoate methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate.

COQ3

GO:0004396

MF

hexokinase activity

Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.

HK1

GO:0004402

MF

histone acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.

TADA2A, SUPT3H, TADA3, SUPT7L, EP300, TAF10, TAF5, NCOA2, NCOA1, EPC2, TADA2B, KAT6B, CREBBP, KAT6A, KAT2B, TADA1, ELP4, EPC1, CSRP2BP, TAF9B, ING3, GTF3C4, CDYL, NCOA3

GO:0004407

MF

histone deacetylase activity

Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.

SAP18, HDAC3, KDM1A, SIN3B, MBD3, HDAC4, RBBP4, MTA1, HDAC1, CHD4, ARID4B, BRMS1L, SIRT2, HDAC2, HDAC8, SUDS3, SAP30L, HMG20B, HDAC6, HDAC9, HDAC5

GO:0004408

MF

holocytochrome-c synthase activity

Catalysis of the reaction: holocytochrome c = apocytochrome c + heme.

HCCS

GO:0004411

MF

homogentisate 1,2-dioxygenase activity

Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).

HGD

GO:0004415

MF

hyalurononglucosaminidase activity

Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

MGEA5, SPAM1, HYAL2, CEMIP

GO:0004416

MF

hydroxyacylglutathione hydrolase activity

Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.

HAGH, PNKD

GO:0004419

MF

hydroxymethylglutaryl-CoA lyase activity

Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.

HMGCL

GO:0004420

MF

hydroxymethylglutaryl-CoA reductase (NADPH) activity

Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH.

HMGCR

GO:0004421

MF

hydroxymethylglutaryl-CoA synthase activity

Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).

HMGCS1

GO:0004427

MF

inorganic diphosphatase activity

Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate.

PRUNE, PPA2

GO:0004430

MF

1-phosphatidylinositol 4-kinase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).

PI4KB

GO:0004435

MF

phosphatidylinositol phospholipase C activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).

CCL5, PLCG2, CHRM3, EDNRA, CCKBR, PLCD1, PLCL1, PLCB1, PLCL2

GO:0004438

MF

phosphatidylinositol-3-phosphatase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.

SYNJ2, SYNJ1, PTEN, MTM1, MTMR1, MTMR2, MTMR4

GO:0004439

MF

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.

SYNJ2, SYNJ1, OCRL, PTPMT1, INPP5K, INPP5E

GO:0004441

MF

inositol-1,4-bisphosphate 1-phosphatase activity

Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.

INPP1

GO:0004445

MF

inositol-polyphosphate 5-phosphatase activity

Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.

INPP5A, INPP5D, INPP5K, INPP5E

GO:0004449

MF

isocitrate dehydrogenase (NAD+) activity

Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+.

IDH3B

GO:0004450

MF

isocitrate dehydrogenase (NADP+) activity

Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+.

IDH1, IDH2

GO:0004452

MF

isopentenyl-diphosphate delta-isomerase activity

Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate.

IDI1, IDI2

GO:0004459

MF

L-lactate dehydrogenase activity

Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.

LDHA, LDHB

GO:0004461

MF

lactose synthase activity

Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose.

B4GALT1

GO:0004462

MF

lactoylglutathione lyase activity

Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.

GLO1

GO:0004464

MF

leukotriene-C4 synthase activity

Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4).

MGST2

GO:0004465

MF

lipoprotein lipase activity

Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein.

LPL, AOAH, PNPLA2, PNPLA3, LIPG

GO:0004466

MF

long-chain-acyl-CoA dehydrogenase activity

Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF.

ACADVL

GO:0004467

MF

long-chain fatty acid-CoA ligase activity

Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.

SLC27A2, ACSL4, ACSL1, SLC27A4, SLC27A1, ACSL6, SLC27A6

GO:0004468

MF

lysine N-acetyltransferase activity, acting on acetyl phosphate as donor

Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.

EP300, ESCO2, KAT2B

GO:0004470

MF

malic enzyme activity

Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.

ME2, MDH1, ME3

GO:0004471

MF

malate dehydrogenase (decarboxylating) (NAD+) activity

Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+.

ME2, ME3

GO:0004473

MF

malate dehydrogenase (decarboxylating) (NADP+) activity

Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.

ME3

GO:0004474

MF

malate synthase activity

Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+).

CLYBL

GO:0004475

MF

mannose-1-phosphate guanylyltransferase activity

Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose.

GMPPB

GO:0004477

MF

methenyltetrahydrofolate cyclohydrolase activity

Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.

MTHFD1, MTHFD2, MTHFD2L

GO:0004478

MF

methionine adenosyltransferase activity

Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.

MAT2A

GO:0004479

MF

methionyl-tRNA formyltransferase activity

Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA.

MTFMT

GO:0004483

MF

mRNA (nucleoside-2'-O-)-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.

CMTR2

GO:0004485

MF

methylcrotonoyl-CoA carboxylase activity

Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate.

MCCC1, MCCC2

GO:0004486

MF

methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+.

MTHFD1

GO:0004487

MF

methylenetetrahydrofolate dehydrogenase (NAD+) activity

Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.

MTHFD1, MTHFD2, MTHFD2L

GO:0004488

MF

methylenetetrahydrofolate dehydrogenase (NADP+) activity

Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.

MTHFD1, MTHFD2, MTHFD2L

GO:0004489

MF

methylenetetrahydrofolate reductase (NAD(P)H) activity

Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.

MTHFR

GO:0004490

MF

methylglutaconyl-CoA hydratase activity

Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O.

AUH

GO:0004491

MF

methylmalonate-semialdehyde dehydrogenase (acylating) activity

Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.

ALDH6A1

GO:0004492

MF

methylmalonyl-CoA decarboxylase activity

Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2.

ECHDC1

GO:0004493

MF

methylmalonyl-CoA epimerase activity

Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA.

MCEE

GO:0004496

MF

mevalonate kinase activity

Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+).

MVK

GO:0004497

MF

monooxygenase activity

Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.

CYP1A1, CYP2E1, CYP3A4, CYP2D6, CYP2C9, TYR, CYP2B6, CYP3A5, CYP3A7, PTGIS, CYP1B1, CYP4V2, CYP2U1, CYP2W1, FMO2, CYP3A43

GO:0004498

MF

calcidiol 1-monooxygenase activity

Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).

CYP27B1

GO:0004499

MF

N,N-dimethylaniline monooxygenase activity

Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

FMO4, FMO2

GO:0004502

MF

kynurenine 3-monooxygenase activity

Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+).

KMO

GO:0004503

MF

monophenol monooxygenase activity

Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O.

TYR

GO:0004504

MF

peptidylglycine monooxygenase activity

Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O.

PAM

GO:0004506

MF

squalene monooxygenase activity

Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).

SQLE

GO:0004507

MF

steroid 11-beta-monooxygenase activity

Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.

CYP11B1, CYP11B2

GO:0004508

MF

steroid 17-alpha-monooxygenase activity

Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.

CYP17A1

GO:0004509

MF

steroid 21-monooxygenase activity

Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O.

CYP21A2

GO:0004510

MF

tryptophan 5-monooxygenase activity

Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O.

TPH2

GO:0004511

MF

tyrosine 3-monooxygenase activity

Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O.

TH

GO:0004512

MF

inositol-3-phosphate synthase activity

Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form.

ISYNA1

GO:0004514

MF

nicotinate-nucleotide diphosphorylase (carboxylating) activity

Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate.

NAMPT, QPRT

GO:0004515

MF

nicotinate-nucleotide adenylyltransferase activity

Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+.

NMNAT3

GO:0004517

MF

nitric-oxide synthase activity

Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.

NOS3

GO:0004518

MF

nuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids.

PARN, TDP2, MRE11A, DNA2, TATDN3, PGAP1, FANCM

GO:0004519

MF

endonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.

ZC3H12D, ANG, RNASE2, RAG1, RNASE4, FEN1, NTHL1, G3BP1, TSN, ZC3H12B, DCLRE1C, ELAC2, PELO, ZC3H12C, EXOG, DIS3

GO:0004520

MF

endodeoxyribonuclease activity

Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.

RAD51D, MBD4, MRE11A, RAD51, ERCC4, EME1

GO:0004521

MF

endoribonuclease activity

Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.

ERN1, RNASEL, LACTB2, RNASEK, ZC3H3, AGO2, NOB1, DICER1, RCL1

GO:0004522

MF

ribonuclease A activity

Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates.

RNASE1, RNASE2, RNASE4

GO:0004523

MF

RNA-DNA hybrid ribonuclease activity

Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.

RNASEH2A, FEN1, RNASEH2B, EXO1

GO:0004525

MF

ribonuclease III activity

Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.

MRPL44, DICER1

GO:0004526

MF

ribonuclease P activity

Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor.

KIAA0391, POP7, RPP40, POP4, RPP30, POP5, RPP25

GO:0004527

MF

exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.

ERI2, ERI3, FEN1, XRN1, REXO1, ISG20, TDP1, EXO1

GO:0004528

MF

phosphodiesterase I activity

Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.

ENPP3, ENPP1, ENPP2, FAN1