GO:0004069

MF

L-aspartate:2-oxoglutarate aminotransferase activity

Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

GOT2

GO:0004070

MF

aspartate carbamoyltransferase activity

Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate.

CAD

GO:0004074

MF

biliverdin reductase activity

Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+.

BLVRB

GO:0004075

MF

biotin carboxylase activity

Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein.

ACACB, PCCA, PC, MCCC1

GO:0004082

MF

bisphosphoglycerate mutase activity

Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.

BPGM, PGAM1

GO:0004083

MF

bisphosphoglycerate 2-phosphatase activity

Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate.

BPGM, PGAM1

GO:0004084

MF

branched-chain-amino-acid transaminase activity

Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid.

BCAT1

GO:0004087

MF

carbamoyl-phosphate synthase (ammonia) activity

Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate.

CAD

GO:0004088

MF

carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.

CAD

GO:0004089

MF

carbonate dehydratase activity

Catalysis of the reaction: H2CO3 = CO2 + H2O.

CA12, CA2, CA3, CA4, CA8, CA13

GO:0004090

MF

carbonyl reductase (NADPH) activity

Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.

CBR1, DHRS4

GO:0004092

MF

carnitine O-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA.

CRAT

GO:0004095

MF

carnitine O-palmitoyltransferase activity

Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.

CPT1A, CPT1B

GO:0004096

MF

catalase activity

Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.

CYGB, GPX7

GO:0004098

MF

cerebroside-sulfatase activity

Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate.

ARSA

GO:0004103

MF

choline kinase activity

Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+).

CHKA, CHKB

GO:0004104

MF

cholinesterase activity

Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion.

CHKA

GO:0004105

MF

choline-phosphate cytidylyltransferase activity

Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline.

PCYT1A, PCYT1B

GO:0004109

MF

coproporphyrinogen oxidase activity

Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX.

CPOX

GO:0004111

MF

creatine kinase activity

Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+).

MAP4K4, CKB, CKMT1A, CKMT2

GO:0004113

MF

2',3'-cyclic-nucleotide 3'-phosphodiesterase activity

Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.

CNP

GO:0004114

MF

3',5'-cyclic-nucleotide phosphodiesterase activity

Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

PDE6D, PDE8A, PDE5A, PDE9A, PDE8B, PDE4D, PDE3B

GO:0004115

MF

3',5'-cyclic-AMP phosphodiesterase activity

Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

PDE8A, PDE8B, PDE4C, PDE4D, PDE3B, PDE7A, PDE3A, PDE7B

GO:0004119

MF

cGMP-inhibited cyclic-nucleotide phosphodiesterase activity

Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP.

PDE3B, PDE3A

GO:0004122

MF

cystathionine beta-synthase activity

Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.

CBS

GO:0004123

MF

cystathionine gamma-lyase activity

Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.

CTH

GO:0004124

MF

cysteine synthase activity

Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.

CBS

GO:0004126

MF

cytidine deaminase activity

Catalysis of the reaction: cytidine + H2O = uridine + NH3.

APOBEC3G

GO:0004127

MF

cytidylate kinase activity

Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP.

CMPK1, CMPK2, AK8

GO:0004128

MF

cytochrome-b5 reductase activity, acting on NAD(P)H

Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).

CYB5R3, NQO1

GO:0004129

MF

cytochrome-c oxidase activity

Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

NDUFA4, CYB5A, COX6C, COX5B, COX6A1, COX6B1, COX7C, COX5A, COX7B, COX7B2, NMES1, COX11

GO:0004132

MF

dCMP deaminase activity

Catalysis of the reaction: dCMP + H2O = dUMP + NH3.

DCTD

GO:0004133

MF

glycogen debranching enzyme activity

Catalysis of the cleavage of branch points in branched glycogen polymers.

AGL

GO:0004134

MF

4-alpha-glucanotransferase activity

Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan.

AGL

GO:0004135

MF

amylo-alpha-1,6-glucosidase activity

Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present.

AGL

GO:0004137

MF

deoxycytidine kinase activity

Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.

TK2, DCK

GO:0004138

MF

deoxyguanosine kinase activity

Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+).

DGUOK

GO:0004139

MF

deoxyribose-phosphate aldolase activity

Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.

DERA

GO:0004140

MF

dephospho-CoA kinase activity

Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+).

COASY, DCAKD

GO:0004142

MF

diacylglycerol cholinephosphotransferase activity

Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine.

CDS1, CEPT1

GO:0004143

MF

diacylglycerol kinase activity

Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.

DGKZ, DGKK, DGKH

GO:0004144

MF

diacylglycerol O-acyltransferase activity

Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.

DGAT2

GO:0004145

MF

diamine N-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.

SAT1, SAT2

GO:0004146

MF

dihydrofolate reductase activity

Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.

DHFR

GO:0004148

MF

dihydrolipoyl dehydrogenase activity

Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.

DLD

GO:0004149

MF

dihydrolipoyllysine-residue succinyltransferase activity

Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.

DLST

GO:0004151

MF

dihydroorotase activity

Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+).

CAD

GO:0004152

MF

dihydroorotate dehydrogenase activity

Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.

DHODH

GO:0004155

MF

6,7-dihydropteridine reductase activity

Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine.

QDPR

GO:0004157

MF

dihydropyrimidinase activity

Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate.

DPYSL2

GO:0004161

MF

dimethylallyltranstransferase activity

Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.

FDPS

GO:0004163

MF

diphosphomevalonate decarboxylase activity

Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate.

MVD

GO:0004164

MF

diphthine synthase activity

Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine.

DPH5

GO:0004165

MF

dodecenoyl-CoA delta-isomerase activity

Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA.

ECI2, ECI1

GO:0004167

MF

dopachrome isomerase activity

Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.

MIF, DDT

GO:0004169

MF

dolichyl-phosphate-mannose-protein mannosyltransferase activity

Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

SDF2, POMT1

GO:0004170

MF

dUTP diphosphatase activity

Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate.

DUT

GO:0004174

MF

electron-transferring-flavoprotein dehydrogenase activity

Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol.

ETFDH, AIFM2

GO:0004175

MF

endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.

ADAM10, TPP1, MMP1, KLK3, MME, CTSH, FURIN, ACE, MMP9, PCSK6, TPP2, CASP1, ECE1, PSEN1, PSEN2, HTRA3, PSMD2, FAM76B, ERAP2, TRABD2A, FAM76A, APH1B, APH1A, SENP5, TMEM59, SENP3, ERAP1, RCE1

GO:0004176

MF

ATP-dependent peptidase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds.

CLPX, LONRF1, LONRF2, LONRF3, LONP2, YME1L1

GO:0004177

MF

aminopeptidase activity

Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.

CTSH, LAP3, TPP2, METAP2, NPEPPS, BLMH, ERAP2, AOPEP, XPNPEP3, ERAP1, LNPEP

GO:0004180

MF

carboxypeptidase activity

Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide.

ACE, CPM, CPE, BLMH, AEBP1, CPQ

GO:0004181

MF

metallocarboxypeptidase activity

Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

CPM, CPN1, CPE, CPZ, AEBP1, CPB2, AGBL1, AGTPBP1

GO:0004185

MF

serine-type carboxypeptidase activity

Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

CPM, CPN1, CPE, CPZ, AEBP1, SCPEP1

GO:0004190

MF

aspartic-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.

CTSD, PSEN1, PSEN2, NRIP3

GO:0004197

MF

cysteine-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.

USP12, USP2, USP1, CTSD, CTSL, CTSB, CTSH, UCHL1, CTSS, CASP1, PDIA3, USP6, CTSK, USP11, CTSC, CASP9, CASP6, BLMH, ESPL1, CASP8, USP34, SFRP1, USP13, CTSZ, CTSF, RCE1, USP20, USP15

GO:0004198

MF

calcium-dependent cysteine-type endopeptidase activity

Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.

CAPN5, PDCD6, CAPN15, CAPN3, SRI, CAPN10

GO:0004222

MF

metalloendopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

ADAM10, ADAM12, NRDC, ADAM23, PMPCB, PAPLN, ECEL1, MMP1, MMP2, MME, MMP10, BMP1, IDE, MMP9, UQCRC2, MMP8, MMP11, UQCRC1, ECE1, MMP14, MMP15, MMP16, THOP1, ADAMTS12, YBEY, ADAMTS20, ADAM8, ADAM17, PMPCA, PAPPA, ADAM9, CLCA4, MMEL1, PITRM1, ADAMTSL4, THSD4, TRABD2A, ADAMTS17, ADAMTS15, ADAMTS18, OMA1, YME1L1, MMP19, MIPEP, NLN, ADAM19, ADAMTS10, MMP25, MMP26, ADAMTS9, ADAMTS1, ADAM21, ADAMTS7, ADAMTS6, ADAMTS5, ADAMTS8, RCE1, MMP24, XRCC6BP1

GO:0004252

MF

serine-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

MASP2, TPP1, KLK10, PRSS23, F8, F2, C1R, PLG, PLAU, PLAT, CFB, C3, C1QA, MMP1, CFI, KLK3, CTSD, PRSS1, CTSL, CTSB, CELA2A, CELA2B, MMP2, MMP10, CTSH, C1S, FURIN, C4A, C4B, MBL2, F5, BMP1, MMP9, KLK2, MMP8, MMP11, CTSS, MST1, DPP4, PCSK1, PCSK6, TPP2, PRSS3, CTSK, PREP, MMP14, MMP15, CTSC, PRSS12, ADAM8, HTRA3, FCN2, CLPP, MST1L, PREPL, CTRB2, RHBDD2, LONP2, TMPRSS6, PCSK9, RHBDD1, HTRA1, PCSK5, MMP19, C1RL

GO:0004298

MF

threonine-type endopeptidase activity

Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.

PSMB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMB8, PSMB9, PSMB4, PSMB5, PSMB10, PSMB3

GO:0004300

MF

enoyl-CoA hydratase activity

Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.

ECHS1, HADHB, AUH, ECHDC2

GO:0004301

MF

epoxide hydrolase activity

Catalysis of the reaction: an epoxide + H2O = a glycol.

EPHX1

GO:0004303

MF

estradiol 17-beta-dehydrogenase activity

Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.

HSD17B6, HSD17B1, HSD17B2, HSD17B7, HSD17B12, HSD17B11

GO:0004304

MF

estrone sulfotransferase activity

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.

SULT2A1

GO:0004305

MF

ethanolamine kinase activity

Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine.

CHKA, ETNK1, CHKB

GO:0004306

MF

ethanolamine-phosphate cytidylyltransferase activity

Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine.

PCYT2

GO:0004307

MF

ethanolaminephosphotransferase activity

Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine.

PIGF, EPT1, CEPT1

GO:0004308

MF

exo-alpha-sialidase activity

Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

NEU1

GO:0004310

MF

farnesyl-diphosphate farnesyltransferase activity

Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.

FDFT1

GO:0004312

MF

fatty acid synthase activity

Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.

FASN

GO:0004313

MF

[acyl-carrier-protein] S-acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein].

FASN

GO:0004314

MF

[acyl-carrier-protein] S-malonyltransferase activity

Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein].

FASN

GO:0004315

MF

3-oxoacyl-[acyl-carrier-protein] synthase activity

Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein].

FASN

GO:0004316

MF

3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity

Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+.

FASN

GO:0004317

MF

3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity

Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O.

FASN

GO:0004319

MF

enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity

Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+.

FASN

GO:0004320

MF

oleoyl-[acyl-carrier-protein] hydrolase activity

Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate.

FASN

GO:0004322

MF

ferroxidase activity

Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

FTH1, FXN, HEPH

GO:0004329

MF

formate-tetrahydrofolate ligase activity

Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.

MTHFD1, MTHFD1L

GO:0004331

MF

fructose-2,6-bisphosphate 2-phosphatase activity

Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.

PFKFB2, PFKFB1, PFKFB3, PFKFB4

GO:0004332

MF

fructose-bisphosphate aldolase activity

Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate.

ALDOA, ALDOC

GO:0004333

MF

fumarate hydratase activity

Catalysis of the reaction: (S)-malate = fumarate + H(2)O.

FH

GO:0004334

MF

fumarylacetoacetase activity

Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+).

FAH

GO:0004335

MF

galactokinase activity

Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+).

GALK2

GO:0004336

MF

galactosylceramidase activity

Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.

GALC

GO:0004337

MF

geranyltranstransferase activity

Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate.

FDPS

GO:0004339

MF

glucan 1,4-alpha-glucosidase activity

Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.

MGAM

GO:0004340

MF

glucokinase activity

Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.

HK1, HKDC1

GO:0004341

MF

gluconolactonase activity

Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate.

RGN

GO:0004342

MF

glucosamine-6-phosphate deaminase activity

Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+).

GNPDA1