GO:0001596

MF

angiotensin type I receptor activity

An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms.

AGTR1

GO:0001601

MF

peptide YY receptor activity

Combining with gut peptide YY to initiate a change in cell activity.

NPY1R, NPY2R, NPY5R

GO:0001602

MF

pancreatic polypeptide receptor activity

Combining with pancreatic polypeptide PP to initiate a change in cell activity.

NPY1R, NPY5R

GO:0001609

MF

G-protein coupled adenosine receptor activity

Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

ADORA2B, ADORA1

GO:0001614

MF

purinergic nucleotide receptor activity

Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

P2RX4

GO:0001616

MF

growth hormone secretagogue receptor activity

Combining with ghrelin to initiate a change in cell activity.

GHSR

GO:0001618

MF

virus receptor activity

Combining with a virus component and mediating entry of the virus into the cell.

NPC1, SIVA1, CLDN1, LDLR, CD4, GYPA, TFRC, ITGB3, ICAM1, ITGB1, ITGAV, CD55, ITGA5, RPSA, HSPA1A, HSPA1B, LAMP1, NCAM1, IDE, PVR, CD46, ITGA2, CR1, ITGB5, MRC1, DPP4, SERPINB3, EFNB2, CXCR4, CXADR, TYRO3, SLC20A2, HYAL2, DAG1, SELPLG, NECTIN1, SLC1A5, SCARB1, CD209, F11R

GO:0001626

MF

nociceptin receptor activity

Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein.

OPRL1

GO:0001635

MF

calcitonin gene-related peptide receptor activity

Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity.

CRCP

GO:0001641

MF

group II metabotropic glutamate receptor activity

A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity.

GRM3

GO:0001642

MF

group III metabotropic glutamate receptor activity

A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity.

GRM8, GRM6

GO:0001664

MF

G-protein coupled receptor binding

Interacting selectively and non-covalently with a G-protein coupled receptor.

PARK2, POMC, GNAI2, FYN, PSAP, GNAI3, SAA1, HSPA1A, HSPA1B, ITGB4, FLNA, S1PR1, ADORA1, DNAJA1, GNAI1, NPB, PACRG, GPRC5B, GHRL, APLN, STUB1, USP20

GO:0001665

MF

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity

Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein.

ST6GALNAC5, ST6GALNAC4, ST6GALNAC2

GO:0001671

MF

ATPase activator activity

Binds to and increases the ATP hydrolysis activity of an ATPase.

DNAJB6, ATP1B1, DNAJB1, ATP1B3, AHSA2, DNAJC10, DNAJC1, DNAJC7

GO:0001735

MF

prenylcysteine oxidase activity

Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.

PCYOX1

GO:0001758

MF

retinal dehydrogenase activity

Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.

ALDH1A2, ALDH1A1, AKR1C3, ALDH1A3, ALDH8A1

GO:0001784

MF

phosphotyrosine binding

Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.

FGR, MAPK3, MAPK1, GRB2, CBLB, LDLRAP1, SAMSN1

GO:0001785

MF

prostaglandin J receptor activity

Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.

PTGDR

GO:0001786

MF

phosphatidylserine binding

Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.

THBS1, HMGB1, GAP43, SYT1, PLCD1, MFGE8, FCHO2, GAS6, SCARB1, OSBPL10, OSBPL8, SYTL2, MARK1

GO:0001846

MF

opsonin binding

Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material.

ITGAV

GO:0001847

MF

opsonin receptor activity

Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

CD14

GO:0001848

MF

complement binding

Interacting selectively and non-covalently with any component or product of the complement cascade.

CFB, C8G, C4A, C4B

GO:0001849

MF

complement component C1q binding

Interacting selectively and non-covalently with the C1q component of the classical complement cascade.

CRP, APCS, C4A, PTX3, CALR, C1QBP, CD93

GO:0001850

MF

complement component C3a binding

Interacting selectively and non-covalently with the C3a product of the complement cascade.

PHB

GO:0001851

MF

complement component C3b binding

Interacting selectively and non-covalently with the C3b product of the complement cascade.

CR1, PHB

GO:0001855

MF

complement component C4b binding

Interacting selectively and non-covalently with the C4b product of the classical complement cascade.

MASP2, CR1

GO:0001856

MF

complement component C5a binding

Interacting selectively and non-covalently with the C5a product of the complement cascade.

C5AR1

GO:0001861

MF

complement component C4b receptor activity

Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

CR1

GO:0001872

MF

(1->3)-beta-D-glucan binding

Interacting selectively and non-covalently with (1->3)-beta-D-glucans.

PTX3

GO:0001875

MF

lipopolysaccharide receptor activity

Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.

TLR4, TLR2, PTAFR, SCARB1

GO:0001882

MF

nucleoside binding

Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.

ACTN4, PNP, POLA1

GO:0001883

MF

purine nucleoside binding

Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose.

ADA, ADORA1

GO:0001948

MF

glycoprotein binding

Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans.

SDCBP, EGFR, PLAT, SERPINA1, LDLR, TGFB1, CD4, APOH, TFRC, VWF, ITGB2, FYN, HSP90AA1, THBS1, HSP90AB1, VIM, LGALS1, HSPA5, ITGAM, IGF2R, IDE, SDC1, RASA1, FLNA, AZGP1, ITGA3, CALR, CANX, BMPR1A, CSNK1D, B2M, VLDLR, CNTN1, OS9, SHB, EDEM1, FBXO17, BBC3, TFR2

GO:0001965

MF

G-protein alpha-subunit binding

Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.

RGS10, IGF2R, F2R, RGS2, HTR2B, RGS4, F2RL1, GPSM2, NUCB1

GO:0001968

MF

fibronectin binding

Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.

ITGB3, ITGB1, ITGAV, CTSL, THBS1, VEGFA, IGFBP3, FBLN1, IGFBP5, CTSS, ITGA3, CTGF, SDC4, CTSK, HSD17B12, CCDC80, PLEKHA2

GO:0001972

MF

retinoic acid binding

Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid.

CYP26A1, SERPINA5, IGF2R, NR2F2, CYP26B1

GO:0002020

MF

protease binding

Interacting selectively and non-covalently with any protease or peptidase.

CHL1, CFLAR, FLOT1, BCL10, SERPINC1, SERPINA1, A2M, TIMP1, CST3, CSTA, LDLR, INS, TNF, FN1, CSTB, VWF, TP53, ITGB3, SERPINE1, SERPINA5, ITGB1, ITGAV, ANXA2, CST2, FURIN, UBC, BCL2, KIT, CD28, HSPD1, SELL, IL1R1, TIMP2, TNFAIP3, ITGA3, DPP4, SERPINB3, SRI, TIMP3, SERPINB4, COMP, SERPINB9, INSL3, BRCA2, POLG, CRADD, FADD, OS9, ADRM1, NFRKB, CCBE1, ADAMTSL4, LONP2, TTN, RFFL, PANX1, PEO1, PINK1, SERPINB13, PYCARD

GO:0002039

MF

p53 binding

Interacting selectively and non-covalently with one of the p53 family of proteins.

TRIAP1, NUAK1, KDM1A, BRD4, TP53, HSPD1, EEF2, MUC1, HTT, GSK3B, SMARCA4, PTTG1IP, BLM, PSME3, CDK5, MDM2, EP300, TP53BP2, ANKRD1, STK11, ZNF385B, ZMAT1, RFWD3, BANP, SETD7, RFFL, CREBBP, EHMT2, TP53RK, TEP1, DUSP26, BCL2L12, CHD8, BRD7, KMT5A, CDKN2AIP

GO:0002055

MF

adenine binding

Interacting selectively and non-covalently with adenine, a purine base.

APRT

GO:0002060

MF

purine nucleobase binding

Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton.

PNP

GO:0002083

MF

4-hydroxybenzoate decaprenyltransferase activity

Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate.

COQ2

GO:0002113

MF

interleukin-33 binding

Interacting selectively and non-covalently with interleukin-33.

IL1RL1

GO:0002114

MF

interleukin-33 receptor activity

Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IL1RL1, IL1RAP

GO:0002134

MF

UTP binding

Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate.

HSP90AA1, HSP90AB1, MTPAP

GO:0002135

MF

CTP binding

Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate.

HSP90AA1, HSP90AB1

GO:0002151

MF

G-quadruplex RNA binding

Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad.

FXR1, AFF2, FMR1, DHX36, LIN28A

GO:0002153

MF

steroid receptor RNA activator RNA binding

Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding.

THRA

GO:0002161

MF

aminoacyl-tRNA editing activity

The hydrolysis of an incorrectly aminoacylated tRNA.

LARS2, DTD2

GO:0002162

MF

dystroglycan binding

Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal).

MAP2, DMD, DAG1, AGR3

GO:0002950

MF

ceramide phosphoethanolamine synthase activity

Catalysis of the reaction: CDP-ethanolamine + a ceramide = CMP + a ceramide phosphoethanolamine.

SGMS1

GO:0003674

MF

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

TMEM129, TMEM120B, ILVBL, SBNO1, MATN2, DSCR3, KHNYN, CTDSPL, DENR, C21orf2, ORC5, ZNF862, NUPR1, HIST1H2BK, ARL6IP5, ZFAND5, SEC24D, HAUS5, AP2A2, NXPH3, SFT2D2, LRG1, A1BG, PRB1, COL5A2, TPM3, CLTA, NUDT7, HIST1H2AG, ZNF688, TPR, TMEM11, HIST1H2AD, MST1, G0S2, PBLD, TM4SF1, MPV17, IFI27, NPTX2, SLC6A8, NES, MEOX1, LRBA, PTTG1IP, CRISP3, TMEM50B, HIST1H2BD, ROMO1, RAB4B, HIST1H2BC, SNRPN, DLK1, MRPS10, SERF2, ZXDB, ZNF200, REEP5, LMNB2, ICA1, DMWD, ELP6, MN1, IFRD2, NPRL3, MLLT11, SCGB2A2, GPM6B, MAMLD1, FHL1, DGCR6, TRIM14, FAM53B, POLA2, TMEM187, LPIN1, NOMO1, ADIRF, FAM189A2, ZNF77, CSRP2, CARTPT, TMEM132A, QRICH1, FILIP1L, ARID4B, LRRC23, TMEM35, ACSM3, ANKRD39, BOLA3, TMEM128, SLC25A30, EYS, KIAA1217, IDNK, ACBD5, RSPH4A, NDUFAF5, ANKRD45, STRIP1, CDKAL1, ANKRD40, HIST2H2AA3, ZFAND6, ADNP2, TTC27, INO80C, BLOC1S3, WDR74, POTEE, SBSN, C5orf46, TMEM107, TMEM108, HSDL2, TMEM91, FAM65A, LHFPL2, PTCHD4, H2AFV, KNDC1, BTN2A1, HAUS6, KDELC2, CENPV, THNSL2, TDRP, CARKD, SLC35F2, ZC3H3, THNSL1, BEST3, TMEM256, TMEM132C, ZADH2, OXR1, TMEM57, ZNF655, ABTB2, FAM184A, PDDC1, SLC43A3, GSTCD, ABHD11, BPIFB1, SCFD2, CHAC2, CHCHD10, SUSD6, DCUN1D4, LPGAT1, N4BP2L2, HIST1H2AC, TMEM106A, KIAA1191, PTER, DOCK10, HAUS1, DTD2, ZNF486, CYYR1, L3MBTL3, ZNF75A, ZFP3, PTCHD1, KLHL5, CSRNP1, MYADM, CDCA3, PKP2, TMEM47, TMEM121, H2AFJ, HGH1, TUBB6, C9orf16, TIMM21, TMEM106C, C1QTNF3, TMEM120A, FSD1L, RTFDC1, TRIM34, NUF2, ASPSCR1, UACA, GPR63, FAM129A, UBXN6, TM6SF1, TRIM6, ZC3H12C, KLHL4, C20orf27, C6orf62, SPATC1L, CYSTM1, ADAMTS10, TMEM245, CRISPLD1, GHITM, C11orf1, FAM96A, HAUS4, SEC61A2, C17orf75, FANCE, POPDC2, POPDC3, EML4, WFDC1, TMEM8A, EPB41L4A, CD248, MRPL47, IFT46, MXRA5, SMCO4, TM7SF3, BRWD1, TMEM106B, SDAD1, HAUS2, TMEM51, C1orf123, DONSON, MIS18A, GTSE1, FMN2, SEPN1, EMC3, TMEM9, IMPACT, STOML1, HECA, ARPP21, CFDP1, EPHA6, FETUB, TMEFF2, GGA1, C14orf1, CCPG1, NDRG4, NDRG2, TRIM35, DIP2C, KIAA0430, GPSM3, AIM1, AMMECR1, CEP83, RAI2

GO:0003676

MF

nucleic acid binding

Interacting selectively and non-covalently with any nucleic acid.

ERI2, ENPP3, ZNF862, RNASE1, ZNF853, RNASE2, SON, ENPP1, RNASE4, USP6, POLR2I, ZXDB, ENPP2, GTF2H2, KRBOX4, THOC7, ZNF585A, ZNF880, CBLL1, ZNF720, JAZF1, CHD1L, REXO1, METTL4, ZNF843, SREK1IP1, DBF4B, OSR1, ZCCHC10, ENOX1, HELQ, N6AMT2, SNRNP27, ZCCHC14, DPF3, R3HDM4, ZNF503, CHAMP1, ZFP91, TTC14, RBM15, SPEN, TREX2, SCAPER, ZCCHC2, PEG3, EHD4, SMARCAD1, RAVER2, PRDM6, METTL5, GPATCH2, RBAK, EHD3, ZNRD1, ARPP21, DBF4, TBK1, PNMA3, CIZ1, EXOG, POLR3K, REXO2, R3HCC1, SAMHD1, N6AMT1

GO:0003677

MF

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

ZNF320, EME2, ZNF233, ZNF785, STRA13, AHRR, CENPBD1, ZNF879, NACA, ARNTL, NR5A2, ZNF593, DDX3X, NFIB, ARID1A, CHD1, CHD2, PDCD5, IRF6, TFEC, HNRNPDL, BTAF1, ZNF646, ZBTB5, POLR1C, PLSCR1, SMAD9, SOX12, FOXP2, ZBTB24, PAX4, RAD51C, FOXO3, ZNF207, SOX15, SMARCA5, ZEB2, NUPR1, HBP1, CCNT1, REV3L, HIST1H2BK, PQBP1, ZNF623, DNAJB6, H2AFY, TADA2A, SUPT3H, BANF1, WDHD1, TCEA3, RAD51D, ZNF189, KLF7, ZFAND5, TOX4, TOX, FSBP, ZFPL1, LUC7L3, KIF4A, ZBTB7A, POLR1A, YEATS4, ZMYM6, AIFM1, MBD3, SERPINA3, MYC, ALB, ANG, MYCN, TP53, APP, JUN, RB1, PGR, ENO1, NPM1, PARP1, POLA1, HIST1H2AG, ZNF688, AR, IRF1, TOP1, TOP2A, VDR, ESRRA, PC, XRCC5, GTF2F2, ETS1, ETS2, ZNF44, ZNF250, HIVEP1, TCF4, RAG1, TCF3, H2AFX, ZNF823, ZFX, ZNF12, ZNF14, ZNF17, ZNF19, ZNF20, ZNF182, ZNF22, ZNF23, ZNF24, ZNF25, ZNF43, HMGA1, JUNB, CEBPB, XBP1, ERCC2, RPL7, EGR1, SON, ATF4, LIG1, POLR2E, HIST1H2AD, BCL3, TNFAIP3, NME2, NR4A1, SP100, POLR2A, MCM3, NFYB, YY1, DNMT1, HMGB2, ZFP36, CALR, POLD1, SMARCA1, MAPK1, KDM5A, EEF1D, POLR2B, HIVEP2, HIST1H2BB, MCM7, GTF2F1, RORA, FUS, DDIT3, DEK, SOX6, ZNF93, AHR, SREBF1, PPARG, BRCA1, FEN1, PBX1, STAT3, RFC3, ETV5, MNDA, TMPO, TMPO, STAT5A, RPS27, MSH2, NR4A2, GATA4, NKX2-1, MKI67, RECQL, ATRX, ZFP36L2, RFX2, RFX5, PRIM2, MCM2, NUP153, MRE11A, MXI1, ASCL1, ZNF83, ZNF84, DNA2, NR0B1, HDGF, POLR2J, AGFG1, STAT2, GTF2A1, ZNF133, ZNF136, ZNF140, RBM5, HMGA2, FOSB, CEBPG, POLR2K, RCAN1, POLG, ATXN1, TERF1, PMS1, NR1H2, MLLT10, FOXG1, POLE2, SOX8, KLF3, PCBP4, FOXL2, HIST1H2BD, ZNF445, HIST1H4A, HIST1H2BC, POLR2L, YBX1, RBM6, GTF2I, NUCB2, SIM1, TMF1, SARNP, FOXO4, HNRNPU, E2F1, SET, DR1, POU5F1, BNC1, NUCB1, CREM, PPARD, CENPC, CEBPZ, ZNF85, RELA, EGR4, ZNF91, ZBTB16, APLP2, GABPA, PAX8, ZNF33A, EGR3, ZFP36L1, KHDRBS1, POLE, PPARA, SOS1, SOS2, SSRP1, ZNF844, ZNF616, EP300, ZNF763, FAAP100, ZNF816, TFCP2, TCF15, TRIM26, ILF2, ILF3, FOXC1, PRDM2, ZBTB17, NR1H3, TRIM28, G3BP1, ORC1, IKZF1, NFATC2, SMAD4, NACA, KLF9, C1D, CBFB, NFYC, VEZF1, POLA2, TFDP1, SIM2, ZMYM3, E2F2, HES1, MXD4, ZNF345, ZNF268, ZNF846, KIF22, CHD4, ARID5B, MTF1, DRAP1, SHPRH, ANKRD1, PUM3, NR0B2, TEAD4, TEAD2, TAF1A, TSN, SMAD2, EZH2, ZNF77, ZNF124, PDCD2, TAF12, CRY1, HLF, NFIL3, HIST2H2BE, ZNF423, ZNF630, ERCC6L, QRICH1, LRRFIP1, ZNF791, CHD9, GON4L, ZNF568, ZNF404, GLYR1, ZFP69, ZBED5, FLYWCH1, SMUG1, ZNF326, CENPW, ZNF789, ZMAT1, ZNF766, ZNF667, ZBTB41, ZNF684, ZNF648, ZNF618, ERCC6L2, SPTY2D1, ZNF776, ZNF57, ZNF518A, ZNF787, HIST2H2AA3, ZFAND6, OTUD7B, ADNP2, ZNF280D, TIGD7, MIS18BP1, ZNF529, NFRKB, CERS6, BNC2, ZNF600, ZNF621, TSHZ1, H2AFV, SSH2, ZNF534, ASXL2, SUPT6H, ZNF765, ZNF771, BEND5, EPM2AIP1, HIST3H2A, ZNF627, ZNF367, SETX, ZNF550, MIER3, DENND4A, HUWE1, ZNF467, PEG10, TADA2B, PBRM1, CASZ1, SPATA24, GPBP1, ZNF677, ZNF573, ZNF280B, NOSTRIN, MGA, BAP18, ZC3H3, SRRM1, SUPV3L1, FANCM, ZNF440, ZBED8, ZNF101, XRN1, ZNF654, ZFP82, APITD1, PHTF2, LCORL, ZNF808, ZNF276, CERS5, ZNF655, ZNF283, ZNF513, ZNF615, KIAA1958, ZNF709, ZNF557, ZNF565, BANP, ZNF610, THAP8, ZNF579, ZNF511, HJURP, ZNF485, ZBTB34, MSANTD4, PAPD5, ZNF248, PHC3, GLIS3, ZNF555, KMT2C, ARID1B, ZFP28, CTCFL, ZNF420, THAP6, ZSCAN18, ZNF596, ZNF507, ZNF675, SSH3, ZNF721, ZNF526, ZNF384, THAP3, GTF3C2, NAT14, RNF141, ZFPM2, ZNF606, BBX, KAT6B, AHCTF1, H1FX, TOPBP1, NR4A3, GTF3A, RAD54L, ESR2, PROX1, KAT6A, TAF15, RAD50, KHSRP, SNAPC3, HIST1H2AC, HIST1H2BH, ZNF566, EME1, ZNF669, ZNF689, ZBTB10, ZNF764, ZNF625, ZNF845, ZBED3, HIC2, ZNF333, ZNF462, LCOR, ZBTB45, ZNF521, DNAJC1, SCYL1, ZNF512B, ZFR, ZNF75A, ZNF578, ZNF641, ZMAT2, ZNF285, ZFP3, TOX2, ZNF317, UHRF2, PPP1R10, ZNF300, CIC, ZNF347, STRBP, ZNF607, ZNF587, SPEN, SETDB2, CDC5L, TEAD3, KLF6, NPAS2, EPAS1, HOPX, TCF25, ZNF559, AIFM2, ZNF2, IER2, H2AFJ, ZNF692, POLR3C, ZNF426, PHF20, TIPIN, REPIN1, NUSAP1, HELZ2, ZNF518B, ZNF436, ZNF407, POLR2J2, POLR1E, ZNF350, ZNF700, THAP2, DNTTIP1, CDT1, BLZF1, PNN, SMARCAD1, TAF1D, ZNF395, ZFAND3, LIN28A, CERS4, SAP30L, SP110, RC3H2, PATZ1, ZNF287, GPBP1L1, ZBTB20, HES4, ZNF160, CHD8, TCF7L1, ZNF334, HMG20A, MYNN, PRDM10, ZNF71, ZNF302, POLE4, ASH1L, SLC2A4RG, TSHZ2, POLE3, CHRAC1, KIF15, PDS5B, ZFP64, FANCI, ZNF358, POLR3B, PARPBP, SPHK1, ABI2, BCLAF1, ZNF226, EHF, ZNF224, ZKSCAN7, HMG20B, MYEF2, PSMC3IP, PPARGC1A, ASH2L, ZMYM2, KDM5B, PARP2, TCF20, HMGXB4, MLX, DDX20, NUFIP1, PUF60, DACH1, ZNF230, MUTYH, RABGEF1, ZMYM5, MCM8, ZFP69B, ZNF112, PURG, ZNF222, ZNF580, GTF3C4, ZHX1, ZNF236, TCFL5, MYT1L, PLAGL1, KMT2B, PHTF1, SCML1, GTF2A1L, TTF2, TRIM33, PA2G4, EXO1, SCML2, PIN4, LZTS1, RNF6, MYRF, KDM2A, HIF3A, POLR1D, POLDIP2, LEMD3, CARHSP1, ZNF337, RABGAP1, ZNF175, MTF2, JRKL, CSDC2, NCOR2, RAD54B, LHFP

GO:0003678

MF

DNA helicase activity

Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.

FSBP, MCM3, MCM5, RECQL, ATRX, MCM2, DNA2, SETX, SUPV3L1, FBXO18, CHD8, RUVBL2, RUVBL1, RAD54B

GO:0003680

MF

AT DNA binding

Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA).

HMGA1, HMGA2, MEF2C, HNRNPD

GO:0003682

MF

chromatin binding

Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

APBB1, SUPT5H, MEIS1, NR5A2, HDAC3, TOX3, SMAD6, SNAI2, RAD21, SOX15, KDM1A, NUPR1, CCNT1, CCNT2, BRD4, SIN3B, POLQ, TADA2A, RNF8, URI1, TRIM37, CBX7, ACTL6A, WHSC1, EGFR, FOS, ESR1, TP53, MPO, JUN, PRKCB, CDK1, CENPB, POLA1, GLI2, GLI3, AR, EGR2, TOP1, TOP2A, PCNA, TPR, SKI, SKIL, FOSL2, HMGA1, TAL1, CEBPB, RCC1, ELK1, NFKB1, SFPQ, BRD2, POLD1, HOXD10, POLR2B, GTF2H1, CKS2, MCM5, DEK, SREBF1, NUP62, PPARG, ZEB1, RBMX, PBX2, MLH1, BCL6, NCAPD3, GATA4, CBX5, ATRX, YAP1, SOX9, CENPA, CENPF, MEOX1, LHX2, ASCL1, SMARCA2, STAT5B, MSH6, POLG, PRKAA2, HDAC4, CTBP2, YBX1, CBX1, TFAM, RELB, SATB1, MEF2A, SP3, HHEX, RELA, SSBP1, REL, MEF2C, GABPA, RING1, RAD51, FMR1, DLX2, POLE, SSRP1, EP300, FOXO1, CHAF1A, CHAF1B, TRIM28, MTA1, ORC1, NFATC2, SMAD4, RUNX2, HNRNPD, SMC1A, KIAA0101, NCAPD2, BRD3, NONO, ZMYND11, NCOA2, NCOA1, SMAD2, EZH2, PKN1, MSL1, NIPBL, ATAD2, SLC30A9, SMARCD3, TSHZ1, DHX30, TADA2B, PBRM1, SIRT2, FANCM, APITD1, NKAP, SETD7, HDAC7, JDP2, BAP1, HDAC2, CREBBP, EZH1, KAT2B, GATA6, MED12, CREB3L1, MBD6, CDCA5, ZNF274, SMARCD1, AJUBA, PRMT6, IFT74, PRIMPOL, PHF12, CIC, GPER1, MNT, MEIS3, ARID3A, CITED1, CITED2, PYGO2, WAC, NUCKS1, EBF2, PATZ1, CHD8, ENY2, UBE2T, ASH1L, TSHZ2, MBD5, CHD7, RERE, DNMT3B, UXT, MORF4L1, LRWD1, MLH3, TRPS1, BAZ1B, NAP1L2, EXO1, SMC3, HDAC5, ASF1A, NOC2L, L3MBTL1, LOXL2

GO:0003684

MF

damaged DNA binding

Interacting selectively and non-covalently with damaged DNA.

FANCG, RAD1, NBN, POLQ, TP53, ERCC1, HMGB1, PCNA, XRCC5, UNG, H2AFX, MSH3, XPA, HMGB2, POLD1, MPG, RPA3, BRCA1, FEN1, RAD23A, RAD23B, XPC, EP300, TDG, CUL4B, NEIL3, CREBBP, ERCC4, DCLRE1C, RAD18, POLK, POLI, POLH

GO:0003688

MF

DNA replication origin binding

Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.

ORC5, HSPD1, MCM5, MCM2, MCM10, ORC3, ORC6

GO:0003689

MF

DNA clamp loader activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex.

RFC4, RFC2, RFC5, RFC3, CHTF18, DSCC1

GO:0003690

MF

double-stranded DNA binding

Interacting selectively and non-covalently with double-stranded DNA.

STRA13, HMGB3, RAD51C, RAD51D, EGFR, TP53, HMGB1, XRCC5, HMGB2, RBMS1, CTNNB1, FEN1, MSH2, MRE11A, AFF3, MSH6, YBX1, PRKDC, NTHL1, SATB1, RAD51, TARDBP, TDG, ZNF638, SMAD2, CRY1, HLF, IFI16, APITD1, LSM14A, FBXO18, NEIL3, GTF2H4, RAD51AP1, MTERF1, MND1, NUCKS1, TDP1, SLTM, HES2

GO:0003691

MF

double-stranded telomeric DNA binding

Interacting selectively and non-covalently with double-stranded telomere-associated DNA.

XRCC5, TERF1, PURA, RAD50

GO:0003696

MF

satellite DNA binding

Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA.

MBD4, CENPB, MLH3

GO:0003697

MF

single-stranded DNA binding

Interacting selectively and non-covalently with single-stranded DNA.

POLR2D, RAD51C, RAD51D, TDP2, ANXA1, ERCC1, HMGB1, HNRNPA1, HSPD1, NME1, MSH3, HMGB2, RBMS1, MCM4, MCM7, RPA3, MLH1, LRPPRC, MSH2, BRCA2, SUB1, BLM, PMS1, RAD23A, RAD23B, POLR2G, YBX1, SSBP2, PURA, XPC, SSBP1, RAD51, MCM6, PCBP1, TSN, MCM10, NUP35, FBXO18, NEIL3, RTF1, ERCC4, FUBP1, NABP1, RAD51AP1, PURB, PEO1, NABP2, SSBP4, SSBP3, OBFC1, TDP1, MLH3

GO:0003700

MF

transcription factor activity, sequence-specific DNA binding

Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

E2F8, ZNF320, ZNF879, FOXN3, NR5A2, BHLHE40, ZNF213, BACH1, IRF6, TFEC, BTAF1, SMAD7, SMAD9, FOXP2, MAFG, ZSCAN9, HOXA3, CBFA2T2, KLF4, FOXO3, SMAD6, ZNF207, SOX15, PARK2, KDM1A, CREBL2, GAS7, ZNF623, TSC22D2, ZNF217, TADA2A, TADA3, CAPN15, ZNF189, KLF7, NFAT5, ZNF205, ZRANB2, YEATS4, NFATC1, PTTG1, ZBED1, FOS, MYC, ESR1, NR3C1, MYCN, TP53, JUN, RB1, ZFY, NFIC, HOXC4, HMGB1, GLI2, GLI3, MYBL2, AR, NR2F1, THRA, EGR2, VDR, POU2F1, ETS1, ETS2, FOSL1, FOSL2, VAV1, ZNF250, TCF4, TCF3, CREB1, ZFX, ZNF12, ZNF19, ZNF182, ZNF23, ZNF24, ZKSCAN1, ZNF43, HMGA1, TAL1, ATF7, CEBPB, XBP1, EGR1, ATF1, ATF3, ATF4, ATF6, ELK1, TFEB, WT1, NFKB1, BCL3, HNF1A, NME2, NR2F2, NFYB, YY1, HMGB2, ARNT, HOXD10, MZF1, RXRB, KDM5A, HOXA6, HIVEP2, FOXN2, CTNNB1, RORA, DDIT3, SOX6, ZNF93, AHR, SREBF1, PPARG, ZEB1, PBX1, PBX2, STAT3, ID1, ETV5, BCL6, WNT5A, BUD31, ELK3, STAT5A, GATA4, NKX2-1, NOTCH1, ZFP36L2, RFX2, RFX5, SOX9, MEOX1, ETV1, ASCL1, ZNF83, STAT5B, STAT2, ZNF133, ZNF140, ZNF138, RCAN1, HIRA, MLLT10, PRDM15, KLF3, FOXL2, ZNF445, LMO4, YBX1, GTF2I, ELF3, SIM1, SMAD3, ZBED6, FOXO4, ZNF200, TFAM, HSF1, IRF9, E2F1, INSM1, RELB, POU5F1, BNC1, MEF2A, ID3, CREB5, POU3F1, CREM, PPARD, ZNF85, ZNF117, ZNF92, RELA, REL, MXD1, EGR4, ZNF91, MEF2C, GABPA, PAX8, ZNF33A, EGR3, SOX4, ZFP36L1, DLX2, PPARA, ZNF616, ZNF816, TFCP2, TCF15, FOXC1, TAF10, PRDM2, ZBTB17, KLF10, TARDBP, TRIM28, MTA1, ZNF211, IKZF1, NFATC2, SMAD4, HDAC1, RUNX3, KLF9, GTF2H2, RUNX2, CBFB, NFYC, TFDP1, SIM2, E2F2, TRIM25, HES1, NFE2L1, ZNF345, ZNF268, MEF2D, POU6F1, MTF1, DRAP1, TCEAL1, TAF5, TEAD4, TEAD2, TSC22D1, SMAD2, SMAD1, USF2, ZFHX3, ZIC1, TAF12, NFIL3, HIF1A, ZSCAN26, ZNF630, ZSCAN23, ZNF568, TAF1B, ZNF789, HIVEP3, ZNF658, PLAG1, ZNF585A, ZNF449, ZNF880, SLC30A9, ZNF600, ZNF621, ZNF534, SUPT6H, ZNF367, ZSCAN2, TADA2B, ZSCAN30, GPBP1, ZNF677, ZNF573, GATAD2A, CREBRF, AEBP1, MGA, TRIM22, ZFP82, ZNF567, ZNF808, ZNF655, ZNF283, ZNF615, ZNF565, ZBTB38, ZNF548, ZNF397, ZFP28, ZNF420, ZNF564, GATAD1, GLMP, ZNF606, ARNTL2, CSRNP3, AHCTF1, ESR2, GTF2H4, PROX1, CREBBP, GATA6, FUBP1, ZBED6CL, ZNF274, ZNF419, HES6, ZSCAN31, ZFP3, ZNF317, ZNF300, NR1H4, CSRNP1, ZNF607, ATOH8, ZNF382, UHRF1, TCF12, TSC22D3, MNT, TEAD3, PITX2, SMAD5, HNRNPAB, NPAS2, CITED1, CITED2, TCF25, ZNF2, SALL3, BACH2, FOXP3, ZNF436, CSRNP2, BLZF1, IKZF4, IKZF5, ZNF552, ZNF287, GPBP1L1, ZNF532, TCF7L1, ZNF334, HMG20A, MYNN, HEYL, TCF7L2, ZNF71, ZNF302, SLC2A4RG, TULP4, ZNF586, AATF, ZNF226, EHF, ZNF224, ZKSCAN7, ZNFX1, RCOR3, RERE, KDM5B, TCF20, MLX, AFF4, TRPS1, ZNF639, CNOT7, ZFP69B, ZNF112, NOCT, ZHX1, TCFL5, MYT1L, KMT2B, PHTF1, SCML1, PA2G4, SCML2, TCF19, LZTS1, MYRF, TSC22D4, L3MBTL1, ZNF175, NFE2L3, ZNF451, HEY1, KLF2

GO:0003705

MF

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II.

MEIS1, NR5A2, BHLHE40, SNAI2, NFATC1, PTH, JUN, CREB1, CEBPB, ATF1, ARNT, NKX2-1, SOX9, PURA, MEF2A, RELA, FOXC1, TEAD2, USF2, ZFHX3, HIF1A, PROX1, GATA6, NR1H4, FOXP3, SOX17

GO:0003707

MF

steroid hormone receptor activity

Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.

NR5A2, PGRMC2, ESR1, PGR, NR2F1, THRA, VDR, ESRRA, NR1D1, NR4A1, NR2F2, RXRB, RORA, PPARG, NR4A2, NR0B1, NR1H2, PPARD, PPARA, NR1H3, NR1D2, NR0B2, PAQR8, NR4A3, ESR2, NR1H4, OR51E2, PAQR5

GO:0003712

MF

transcription cofactor activity

Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.

LDB2, MED14, LPXN, TADA2A, MUC1, CREB1, BTG1, TMF1, NRG1, MXD1, ZNF763, NMI, CBFB, NFE2L1, ZMYND11, TRIP13, ZNF667, KAT2B, MED12, MED30, HES6, NFKBIZ, MED4, MED17, THRAP3, MED16, TRRAP

GO:0003713

MF

transcription coactivator activity

Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.

PDLIM1, AIP, ARID1A, TFEC, TGFB1I1, MED7, MED14, PQBP1, EDF1, TADA2A, SUPT3H, TADA3, MED6, KLF7, SUPT7L, BCL10, ACTL6A, JUN, RB1, NPM1, NR2F1, JUP, TCF3, ZFX, JUNB, JUND, DDX5, PSMC3, ATF6, MAK, SP100, YY1, ARNT, RXRB, KDM5A, CTNNB1, GTF2F1, FUS, ZEB1, BRCA1, GATA4, YAP1, NRIP1, CDK7, SMARCA2, SMARCA4, GTF2A1, GTF2A2, SUB1, CTBP2, ELF3, PPARD, GABPA, EP300, TAF10, NR1H3, MTA1, MED21, NCOA4, CBFB, NFYC, TFDP1, NPAT, LPIN1, ARID5B, MTF1, NFATC4, TAF11, NCOA2, TRIP11, NCOA1, SMARCD3, TADA2B, MTDH, CARM1, WWC1, CCAR1, YAF2, KMT2E, MAML2, JMY, ARID1B, SMARCC2, ESR2, CREBBP, KAT6A, KAT2B, DDX17, SMARCC1, RBPMS, MED12, TADA1, SMARCD1, MAML3, NR1H4, CITED4, MYCBP, MNT, CITED1, CITED2, HTATIP2, SOX17, MED20, SRA1, ENY2, BRD7, MED17, PPARGC1A, RNF14, TCF20, MKL2, GTF2A1L, USP22, THRAP3, MED16, NFE2L3, HCFC2, NCOA3

GO:0003714

MF

transcription corepressor activity

Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.

E2F8, SAP18, ZNF593, BHLHE40, TFEC, HDAC3, RBFOX2, SIAH2, CBFA2T2, TBL1X, NCOR1, PEX14, GMNN, HSBP1, CREG1, TDP2, SKI, JUNB, PSMC3, ATF3, NR1D1, SP100, NR2F2, YY1, YWHAB, DDIT3, ZEB1, ELK3, YAP1, ID4, NRIP1, MXI1, ERF, SMARCA4, NR0B1, ZNF136, HIRA, ATN1, HDAC4, CTBP2, SRSF2, RELB, DR1, ID3, ZNF85, MXD1, C1QBP, AES, GPS2, TRIM28, MTA1, C1D, TOB2, NPAT, MXD4, DRAP1, ZMYND11, ANKRD1, NR0B2, NFIL3, GON4L, ATF7IP, KCTD1, JAZF1, AEBP1, CCAR1, YAF2, TRIM22, DDX54, PPP1R13L, HDAC7, ZFPM2, PROX1, PBXIP1, ZNF274, TONSL, AJUBA, PAWR, NR1H4, TRIB3, PFDN5, MNT, CITED2, MYBBP1A, TBL1XR1, FOXP3, HIPK2, TAF9B, BRD7, HEYL, KMT5A, RLIM, LMCD1, RCOR3, DNMT3B, KDM5B, LIMD1, HDAC9, ZHX1, SUFU, CDYL, NOC2L, LOXL2, NCOR2, EID1

GO:0003720

MF

telomerase activity

Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.

DKC1, TERF1, PTGES3, TEP1

GO:0003723

MF

RNA binding

Interacting selectively and non-covalently with an RNA molecule or a portion thereof.

MIF4GD, IGF2BP3, RTCA, NOP56, DDX3X, RNASET2, XPO1, KHNYN, SYNJ2, RBFOX2, CTIF, HNRNPR, SYNJ1, NUDT21, AHCYL1, HBP1, SYNCRIP, DKC1, NOL3, DUSP11, PRPF40A, SRSF10, KHDRBS3, RNASEH2A, RSL1D1, UBR5, ZRANB2, CELF2, POP4, PTBP3, LSM8, NR3C1, NPM1, HNRNPC, SNRPA, CNP, HNRNPA1, TROVE2, HSP90B1, HNRNPL, RPL7, SON, WT1, RPS4Y1, HNRNPA2B1, EIF4B, YY1, PSMA1, DNMT1, RPL13, PTBP1, TARS, RBMS1, HNRNPH3, HNRNPH1, RPL22, FUS, RPL4, SRP14, RBMX, BRCA1, LRPPRC, RPL27A, RPL5, RPL21, RPL28, RPS5, RPL29, RPL34, SRP9, SARS, RANBP2, RPL14, PAPOLA, FXR1, NOVA1, NR0B1, HNRNPA3, HNRNPM, AGFG1, RBM5, MRPL12, HNRNPH2, PCBP4, RPS3A, RPL26, RPL15, RPL37, RPS7, RPS15A, RPS16, RPS14, SNRPF, LSM3, LSM6, SNRPD1, RPL7A, RPS25, RPL30, RPL31, RPL10A, RPL11, RPL41, SNRPN, RPL38, EIF5A, YBX1, RBM6, RPP30, RAE1, RPL24, RPL19, RBM3, HNRNPU, EWSR1, RPL18A, RNASEL, EXOSC9, FMR1, RPL18, KHDRBS1, SRSF1, NCBP1, GRSF1, SF3A3, ILF3, CSTF3, TARDBP, SRSF6, IFIT5, C1D, HNRNPD, MORC3, FASTK, CAPRIN1, PUM1, ZNF638, SUZ12, EXOSC7, PCBP1, RBMS2, ELAVL1, MRPL23, TIMM50, PABPC1L, PDCD4, ZNF385B, NOM1, ZMAT1, DDX60L, EARS2, RBM48, THOC7, MRM1, JMJD6, RBM43, PARS2, NUFIP2, PABPN1, PPARGC1B, DCP2, RBM45, ZC3H3, SUPV3L1, ARHGEF28, AGGF1, CPEB3, PUM2, ZCRB1, TRUB1, NANOS1, GTF3A, AKAP1, DDX17, EMG1, RBPMS, NABP1, RAD51AP1, RPL39L, DAZAP1, NAF1, RBM17, THOC3, YTHDC1, ZMAT2, BARD1, HNRNPAB, TEP1, LARP6, HNRNPUL1, RBM4, PAPOLG, MRPL4, MRPL1, NIFK, PUS3, CRNKL1, PAIP1, UPF3A, PHAX, LIN28A, UPF2, APOBEC3G, CWC22, TNRC6C, EXOSC3, MBNL1, RBFOX1, CDKN2AIP, DDX43, CWC15, CPSF2, PPARGC1A, NUFIP1, CNOT7, LSM7, CNOT6, PPIE, NOVA2, SCAF8, DIS3, RCL1, LSM2, RBMX2, SAMHD1, KIAA0430, LSM5, CSDC2, RBM8A

GO:0003724

MF

RNA helicase activity

Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix.

DHX15, DHX16, FSBP, DDX5, SKIV2L2, DDX17, DDX24, RAD54B

GO:0003725

MF

double-stranded RNA binding

Interacting selectively and non-covalently with double-stranded RNA.

TLR3, DHX15, PRKRA, STAU1, TFRC, SLC3A2, HSP90AB1, VIM, HSPD1, ACTN1, EIF4A1, TUBA1B, TUBB4B, ILF2, ILF3, RFTN1, ELAVL1, LRRFIP1, DHX30, MTDH, SUPV3L1, LSM14A, STRBP, DHX36, MRPL44, AGO4, MBNL1, STAU2, AGO2, DICER1, MYH4

GO:0003726

MF

double-stranded RNA adenosine deaminase activity

Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule.

ADARB1

GO:0003727

MF

single-stranded RNA binding

Interacting selectively and non-covalently with single-stranded RNA.

POLR2D, CBX7, ANXA1, SNRPC, HNRNPA1, ZFP36, POLR2G, DLX2, IFIT5, LACTB2, JMJD6, LSM14A, STRBP, AGO4, NXF1, AGO2

GO:0003729

MF

mRNA binding

Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

RBFOX2, NUDT21, DXO, LUC7L3, DHFR, TYMS, SSB, HSP90AA1, SNRPC, TPR, RPS2, RPL7, ZFP36, CALR, RBMX, RPL13A, RPL35, RPS5, RBM25, FXR1, NOVA1, HNRNPA3, RBM5, EIF4A1, RPS13, RPS26, TRA2B, ADARB1, FMR1, C1QBP, ZFP36L1, SRSF1, GRSF1, CSTF3, G3BP1, EIF3A, SLBP, PCBP1, PUM3, TSN, ELAVL1, SNRNP35, NCBP3, SAMD4B, RBPMS2, THOC2, UHMK1, NUDT16, EDC3, QKI, PURB, HNRNPAB, PAIP2, RBM4, RBM38, ESRP2, RC3H2, METTL14, LUC7L, EIF4ENIF1, RBFOX1, NXF1, NOCT, PTBP2, AGO2, G3BP2, SAMD4A, LUC7L2, RBM8A

GO:0003730

MF

mRNA 3'-UTR binding

Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.

IGF2BP3, HNRNPR, PARN, HNRNPC, HNRNPA2B1, ZFP36, ZFP36L2, FXR1, PCBP4, FMR1, ZFP36L1, CRYZ, TARDBP, AUH, CIRBP, PUM1, RNPS1, ELAVL1, CPEB4, LARP1, CPEB2, SERBP1, CPEB3, PUM2, SECISBP2L, SECISBP2, RBM4, RBM24, CARHSP1, IGF2BP2

GO:0003735

MF

structural constituent of ribosome

The action of a molecule that contributes to the structural integrity of the ribosome.

MRPS12, SLC25A17, MRPS14, MRPL33, SLC25A12, NDUFA7, SLC25A14, SLC25A5, RPLP1, RPLP2, RPLP0, RPS17, RPSA, SLC25A4, RPS2, SLC25A16, RPL35A, RPL7, RPL17, RPS4Y1, UCP1, RPL13, RPL10, RPL12, RPL22, RPL4, RPL13A, RPS27, RPL35, RPL27A, RPL5, RPL21, RPL28, RPS9, RPS5, RPS10, RPL29, RPL34, MRPL19, RPL14, DAP3, MRPL12, SLC25A1, UCP2, UCP3, RPS20, RPS3A, RPL26, RPL15, RPL27, RPL37A, RPL37, RPS7, RPS8, RPS15A, RPS16, RPS14, RPS18, RPS13, RPS11, RPL7A, RPL23A, RPS6, RPS26, RPL30, RPL31, RPL10A, RPL32, RPL11, RPL41, RPS27A, UBA52, RPL38, RPS21, MRPS25, MRPS5, MRPS36, MRPS21, MRPS34, RPL24, RPL36A, RPL19, SLC25A3, RPL18A, RPL18, MRPL23, MRPL51, SLC25A30, MRPL14, RPL22L1, SLC25A26, RPS27L, MRPL21, MRPL55, MRPL52, MRPL41, MRPL30, SLC25A43, MRPS31, RPL36AL, SLC25A36, RPL39L, SLC25A44, MRPL34, MRPL57, SLC25A23, MRPL32, MRPL4, MRPL1, MRPL37, SLC25A39, SLC25A18, SLC25A19, MRPL47, MRPL17, MRPS18A, MRPL16, SLC25A37, MRPL35, MRPL15, MRPL36, SLC25A10, SLC25A13, MRPS2, RPL36, SLC25A15, MRPS18B, MRPL42

GO:0003743

MF

translation initiation factor activity

Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

EIF4G3, DENR, EIF4E2, EIF1B, EIF5B, EIF3J, EIF2S1, EIF4E, EIF4B, EIF2S3, EIF1, EIF1AX, EIF5, EIF3B, EIF6, EIF4A1, EIF2B5, EIF3A, EIF2B1, EIF4A2, DHX29, EIF1AD, MTIF3, EIF2B3, EIF3K, EIF2B4, AGO2

GO:0003746

MF

translation elongation factor activity

Functions in chain elongation during polypeptide synthesis at the ribosome.

EEF1E1, EEF2, EEF1B2, EEF1D, TSFM, EIF5A, EEF1A1, EEF1A2, GFM1, EIF5A2, HBS1L

GO:0003747

MF

translation release factor activity

Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.

GSPT1

GO:0003755

MF

peptidyl-prolyl cis-trans isomerase activity

Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

PPIH, PPIB, FKBP2, PPIF, NKTR, PPIC, RANBP2, PPIA, FKBP3, FKBP4, PPID, PPIL2, PPIG, FKBP5, PPP2R4, CWC27, PPIL4, FKBP10, FKBP14, FKBP11, PPIE, PIN4, FKBP7

GO:0003756

MF

protein disulfide isomerase activity

Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.

ITGB3, P4HB, PDIA4, PDIA3, PDIA5, PDIA6, TXNDC11, QSOX2, ERO1B, PIGK, ERO1A, ERP44, TMX4, GLRX2

GO:0003774

MF

motor activity

Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate.

MYO1G, DYNC1I1, KIF1C, MYL6B, MYH9, MYH11, MYL6, DYNLL1, DYNLT1, MYO1E, DCTN2, DCTN1, KIF18B, DYNC2LI1, MYO10, KIF15, DNAH9, DNAI1, MYO6

GO:0003777

MF

microtubule motor activity

Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).

DYNC1I1, DNALI1, DYNC1LI2, KIF1C, KIF5C, KIF1B, KIF20A, KIF4A, DNAL4, KIF11, CENPE, KIF23, DNAH14, DYNC1I2, DYNC1H1, KIF22, KIF14, KLC3, DNAH12, DNAH10, DNAH5, APPBP2, DNAH11, KIF2C, KIFC1, KIF13B, KIF15, DNAH9, DNAH1, STARD9, SMC3

GO:0003779

MF

actin binding

Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.

WASH1, MYO1G, MYO1C, HIP1, WASL, ABLIM1, ENC1, ACTN4, PARK2, DIAPH2, PHACTR2, FLNB, RP2, MICAL2, ABLIM3, GC, ANG, ALDOA, ITGB1, TPM3, PFN1, TPM2, TPM1, DMD, LCP1, HCLS1, EZR, SYN1, TNNI3, S100A4, TMOD1, LMOD1, CORO1A, GBP1, LSP1, NF2, RDX, MYH9, CAPG, CAPZB, EMD, CNN1, CAPZA1, SMTN, CXCR4, NCALD, TPM4, MYBPC1, SPTBN1, TAGLN, DST, YWHAH, PTK2, CALD1, KCNMA1, EPS8, SNTA1, SNTB2, MYO9B, IQGAP2, SHROOM2, SNTB1, COTL1, DAG1, CNN3, DIXDC1, MYLK, DBN1, FSCN1, CCDC88A, CROCC, MPRIP, SSH2, MAEA, PXK, GAS2L3, PLEKHH2, PHACTR4, ENAH, JMY, MYRIP, KIF18A, FBXO25, MICAL1, SSH3, PALLD, SYNE2, MIB2, MYO19, PDLIM5, PAWR, FGD4, PACRG, KLHL5, FMNL2, TRPM7, MLPH, SORBS1, KLHL4, SPTBN4, EPB41L1, PSTPIP2, TRPV4, TNS1, MYOZ1, ANLN, DIAPH3, PARVA, TBCCD1, FMN2, IMPACT, MYOT, HDAC6, ADD3, KLHL3, BAIAP2L1, EVL, MYH2, MYO5B, MYO6, SYNPO2, MACF1, LIMCH1, TRPC6, STK38L, EPB41L3, DAAM1, MYO5A, FHOD1, MYH4, WASF2

GO:0003785

MF

actin monomer binding

Interacting selectively and non-covalently with monomeric actin, also known as G-actin.

MTSS1, COBL, PFN1, TMSB15A, MYL4, NOS3, CORO1A, ABL2, TMSB4X, TMSB10, TWF1, COBLL1, TWF2, LIMA1

GO:0003796

MF

lysozyme activity

Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan.

LYZL6, LYZ, LYG2

GO:0003810

MF

protein-glutamine gamma-glutamyltransferase activity

Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.

F13A1, TGM2, TGM4

GO:0003823

MF

antigen binding

Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.

IGLL5, TSPAN4, TGFB1, HLA-B, IL7R, HLA-G, LAG3, AZGP1, PPP2R1A, FCN2, MICB, MICA, HFE, MR1, SPON2, ULBP3, ULBP2

GO:0003824

MF

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

HSD17B6, AZIN1, MGAM, ALDH1L1, DDAH1, DDAH2, SLC3A2, ALAD, HSD17B1, HPGD, SYN1, CAPN3, AADAC, AOAH, GTF2F1, FHIT, ASAH1, ITPK1, PIGH, ESPL1, DIP2A, OLFM4, SPATA20, PIGC, SYN2, ECHDC3, DIP2C, MED16

GO:0003826

MF

alpha-ketoacid dehydrogenase activity

Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid.

BCKDHA, BCKDHB

GO:0003828

MF

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.

ST8SIA6, ST8SIA4

GO:0003831

MF

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity

Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide.

B4GALT5, B4GALT4, B4GALT1, B4GALT6

GO:0003835

MF

beta-galactoside alpha-2,6-sialyltransferase activity

Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine.

ST6GAL1, ST6GAL2

GO:0003836

MF

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R.

ST3GAL1, ST3GAL3, ST3GAL4, ST3GAL2, ST3GAL6

GO:0003839

MF

gamma-glutamylcyclotransferase activity

Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.

CHAC2, CHAC1, GGACT

GO:0003840

MF

gamma-glutamyltransferase activity

Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid.

GGT7

GO:0003841

MF

1-acylglycerol-3-phosphate O-acyltransferase activity

Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.

GPAT3, LPCAT3, LCLAT1, MBOAT2, LPCAT2, GPAT4, ABHD5, LPGAT1, MBOAT7, AGPAT4, AGPAT3, CRLS1

GO:0003844

MF

1,4-alpha-glucan branching enzyme activity

Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain.

GBE1