GO:0098592

CC

cytoplasmic side of apical plasma membrane

The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm.

EZR, EXOC1

GO:0098636

CC

protein complex involved in cell adhesion

Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion.

CD28

GO:0098745

CC

Dcp1-Dcp2 complex

A protein complex consisting of a Dcp1 regulatory subunit and a Dcp2 catalytic subunit that has mRNA cap binding activity and is involved in decapping of nuclear-transcribed mRNA.

ZFP36

GO:0098793

CC

presynapse

The part of a synapse that is part of the presynaptic cell.

SNAP23, SYNJ1, PARK2, PIP5K1C, SNAP29, PSEN1, CDK5, FMR1, EEA1, PDZD11, NLGN1, SYTL5, SYTL4, SYT11, LIN7B, LIN7C, BLOC1S6, HRH3

GO:0098794

CC

postsynapse

The part of a synapse that is part of the post-synaptic cell.

AKT1, SNCA, GSK3B, MEF2C, FMR1, PPP3CA, RAB3GAP1, SLC29A1, GHRL

GO:0098857

CC

membrane microdomain

A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it.

LAMP2

GO:0099053

CC

activating signal cointegrator 1 complex

A protein complex that contains TRIP4 (ASC1) and acts a transcriptional coactivator by interacting with transcription factors such as NF-kappa B. In humans this complex has 4 subunits: TRIP4 + ASCC1-3.

ASCC3, ASCC2

GO:0099073

CC

mitochondrion-derived vesicle

A vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae.

PARK2

GO:0099078

CC

BORC complex

A protein complex that is invovled in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors.

SNAPIN, BLOC1S1, LOH12CR1, BORCS7, BORCS6

GO:0099503

CC

secretory vesicle

A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.

DYNLT1

GO:1902554

CC

serine/threonine protein kinase complex

A protein complex which is capable of protein serine/threonine kinase activity.

CAB39

GO:1902560

CC

GMP reductase complex

An oxidoreductase complex which is capable of GMP reductase activity. It catalyses the irreversible reaction: GMP + 2 H(+) + NADPH => IMP + NADP(+) + NH(4)(+).

GMPR

GO:1902636

CC

kinociliary basal body

A ciliary basal body that is part of a kinocilium.

MKKS

GO:1902711

CC

GABA-A receptor complex

A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor).

GABRA5

GO:1902737

CC

dendritic filopodium

A small, membranous protrusion found primarily on dendritic stretches of developing neurons. May receive synaptic input, and can develop into dendritic spines.

FMR1

GO:1902911

CC

protein kinase complex

A protein complex which is capable of protein kinase activity.

NEK10, MAP3K5

GO:1902937

CC

inward rectifier potassium channel complex

A protein complex which is capable of inward rectifier potassium channel activity.

KCNK1

GO:1903561

CC

extracellular vesicle

Any vesicle that is part of the extracellular region.

SDCBP, EDIL3, EFEMP2, APOA1, APOE, FGA, FGB, TFRC, GNAI2, ATP1B1, ITGB2, SERPINE2, COL6A2, COL6A3, F5, PKM, CBR1, OGN, CD9, PCMT1, GRIA4, ATP1A2, SLC12A2, GNB1, TUBB4B, FBLN2, MFGE8, DNAJC3, TUBB2A, PDCD6IP, SLC5A5, COL12A1, OLFML3, CTSF, MAN1B1

GO:1904115

CC

axon cytoplasm

Any cytoplasm that is part of a axon.

AP3D1, OPA1, KIF1B, KIF4A, SNAPIN, UCHL1, RANGAP1, AP3M2, AP3S2, BLOC1S1, HIF1A, BLOC1S3, MGARP, NDEL1, SPAST, RAB21, BLOC1S6, AP3M1

GO:1905103

CC

integral component of lysosomal membrane

The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

ATP13A2

GO:1905202

CC

methylcrotonoyl-CoA carboxylase complex

A protein complex which is capable of methylcrotonoyl-CoA carboxylase activity.

MCCC1, MCCC2

GO:1990008

CC

neurosecretory vesicle

A large cytoplasmic membrane-bounded vesicle with an electron dense granular core, up to 150-200 nm in diameter, found in neurosecretory cells in the hypothalamus.

GNRH1

GO:1990023

CC

mitotic spindle midzone

The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner.

EML1, CENPE, CTTN, MAP9, KIF18A, KIF20B

GO:1990037

CC

Lewy body core

The center portion of a Lewy body. In Parkinson's disease, it contains a matted meshwork of filaments.

ATF4

GO:1990047

CC

spindle matrix

A proteinaceous, nuclear-derived structure that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner during mitosis.

ZNF207

GO:1990071

CC

TRAPPII protein complex

A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the pre-autophagosomal structure. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself.

TRAPPC10

GO:1990075

CC

periciliary membrane compartment

A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis.

RP2, KIFAP3

GO:1990077

CC

primosome complex

Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart.

PRIM1, PRIM2

GO:1990111

CC

spermatoproteasome complex

A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity.

PSMB8, PSMB9, PSMB10, PSME4

GO:1990124

CC

messenger ribonucleoprotein complex

A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules.

HNRNPA3, CPEB4, CPEB2, CPEB3

GO:1990130

CC

Iml1 complex

A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3.

NPRL3

GO:1990131

CC

Gtr1-Gtr2 GTPase complex

A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins.

RRAGC, RRAGD

GO:1990234

CC

transferase complex

A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).

UBE2I, PDSS1, PDSS2

GO:1990246

CC

uniplex complex

A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.

MICU2

GO:1990298

CC

bub1-bub3 complex

Protein complex that associates with the kinetochores.

BUB3

GO:1990316

CC

ATG1/ULK1 kinase complex

A protein complex consisting of ATG1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation.

ATG13, ULK1, SESN2, RB1CC1, TBC1D5

GO:1990332

CC

Ire1 complex

A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript.

ERN1

GO:1990356

CC

sumoylated E2 ligase complex

A protein complex consisting of a SUMO (small ubiquitin-related modifier) protein bound to a SUMO-conjugating E2 ligase. Sumoylation of the E2 ligase is an intermediate step required for the formation of covalent bonds between a SUMO protein and its ultimate protein target. SUMO is transferred to the E2 ligase by a SUMO-activating E1 enzyme. Sumoylation of the target protein is either facilitated directly by the sumoylated E2 ligase or aided by an optional E3 ligase.

UBE2I

GO:1990357

CC

terminal web

An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells.

KRT19, PLS1, HFE

GO:1990391

CC

DNA repair complex

A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

KDM1A

GO:1990393

CC

3M complex

A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity.

OBSL1, CUL7, CCDC8

GO:1990423

CC

RZZ complex

A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints.

KNTC1, ZWILCH

GO:1990429

CC

peroxisomal importomer complex

A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners.

PEX12

GO:1990452

CC

Parkin-FBXW7-Cul1 ubiquitin ligase complex

A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein.

PARK2

GO:1990454

CC

L-type voltage-gated calcium channel complex

A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation.

CACNB3, CACNA2D1, CACNA1C

GO:1990565

CC

HSP90-CDC37 chaperone complex

A protein complex involved in stress-induced mitophagy (mitochondrial degradation). In mammals it consists of heat shock protein HSP90 and its co-chaperone CDC37. Experimental evidence suggests that the complex enables the autophosphorylation of ULK1. Phosphorylated ULK1 in turn phosphorylates ATG13 which is an essential step in mitophagy. HSP90-CDC37 binding prevents rapid ubiquitin-dependent proteosomal degradation of its targets.

CDC37

GO:1990578

CC

perinuclear endoplasmic reticulum membrane

The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus.

PIK3R1

GO:1990589

CC

ATF4-CREB1 transcription factor complex

Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway.

CREB1, ATF4

GO:1990590

CC

ATF1-ATF4 transcription factor complex

Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway.

ATF1, ATF4

GO:1990597

CC

AIP1-IRE1 complex

A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein).

ERN1

GO:1990604

CC

IRE1-TRAF2-ASK1 complex

A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K).

ERN1, MAP3K5

GO:1990617

CC

CHOP-ATF4 complex

A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits.

ATF4, DDIT3

GO:1990622

CC

CHOP-ATF3 complex

A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits.

ATF3, DDIT3

GO:1990630

CC

IRE1-RACK1-PP2A complex

A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A.

ERN1, RACK1

GO:1990666

CC

PCSK9-LDLR complex

A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway.

LDLR, PCSK9

GO:1990667

CC

PCSK9-AnxA2 complex

A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and Annexin A2 (AnxA2).

ANXA2, PCSK9

GO:1990682

CC

CSF1-CSF1R complex

A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand.

CSF1R

GO:1990707

CC

nuclear subtelomeric heterochromatin

Heterochromatic regions of the chromosome found at the subtelomeric regions of a chromosome in the nucleus.

ATRX

GO:1990712

CC

HFE-transferrin receptor complex

A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.

TFRC, TF, BMPR1A, B2M, HFE, TFR2

GO:1990723

CC

cytoplasmic periphery of the nuclear pore complex

Cytoplasm situated in close proximity to a nuclear pore complex.

RANGAP1, RANBP2

GO:1990726

CC

Lsm1-7-Pat1 complex

A conserved protein complex that plays an important role in coupling deadenylation and decapping in the 5'-to-3' mRNA decay pathway. An example is found in S. cerevisiae.

LSM3, LSM7, LSM2, LSM5

GO:1990730

CC

VCP-NSFL1C complex

A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97.

VCP, NSFL1C

GO:1990745

CC

EARP complex

A quatrefoil tethering complex required for endocytic recycling.

VPS52

GO:1990752

CC

microtubule end

Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end.

CLIP1, ACTR1B, KIF18B

GO:1990761

CC

growth cone lamellipodium

A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments.

APBB1, APP

GO:1990796

CC

photoreceptor cell terminal bouton

A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light.

STX3

GO:1990812

CC

growth cone filopodium

A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone.

APBB1, APP, FMR1

GO:1990843

CC

subsarcolemmal mitochondrion

A mitochondrion that occurs adjacent to the sarcolemma in striated muscle cells and responds in distinct ways to physiological triggers.

PPARGC1A

GO:1990844

CC

interfibrillar mitochondrion

A mitochondrion that occurs in between fibrils of striated muscle cells and responds in distinct ways to physiological triggers.

PPARGC1A

GO:1990851

CC

Wnt-Frizzled-LRP5/6 complex

A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6.

LRP5, LRP6, FZD8

GO:1990879

CC

CST complex

A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection.

OBFC1

GO:1990904

CC

ribonucleoprotein complex

A macromolecular complex containing both protein and RNA molecules.

ZFP36, FMR1, ELAVL1

GO:1990907

CC

beta-catenin-TCF complex

A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors.

CTNNB1

GO:1990909

CC

Wnt signalosome

A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein.

LRP5, LRP6, WNT2, APC, CTNNB1, GSK3B, WNT3

GO:1990913

CC

sperm head plasma membrane

The plasma membrane that is part of the head section of a sperm cell.

HSP90AB1

GO:1990917

CC

ooplasm

The cytoplasm of an ovum.

HSP90AB1

GO:0000010

MF

trans-hexaprenyltranstransferase activity

Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate.

PDSS1, PDSS2

GO:0000014

MF

single-stranded DNA endodeoxyribonuclease activity

Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks.

ERCC1, MRE11A, RAD50, ERCC4, DCLRE1C

GO:0000016

MF

lactase activity

Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose.

LCT

GO:0000026

MF

alpha-1,2-mannosyltransferase activity

Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage.

ALG9

GO:0000030

MF

mannosyltransferase activity

Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

DPY19L2, DPY19L3, DPY19L4, ALG9, POMT1

GO:0000033

MF

alpha-1,3-mannosyltransferase activity

Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage.

ALG8

GO:0000036

MF

ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process

Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis.

NDUFAB1

GO:0000049

MF

tRNA binding

Interacting selectively and non-covalently with transfer RNA.

PTCD1, TRMU, FARS2, SSB, RPL35A, RARS, YARS, EEF1A1, NSUN2, IFIT5, KARS, EARS2, TRMT1L, TRNT1, THUMPD3, SEPSECS, EIF2AK4, FARSA

GO:0000062

MF

fatty-acyl-CoA binding

Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.

ACOT7, ACOX3, ECI2, SCP2, SOAT1, HMGCL, ACADSB, ACADVL, ALDH6A1, ACOX1, ACBD5, ACOX2, ACBD3

GO:0000064

MF

L-ornithine transmembrane transporter activity

Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid.

SLC25A15

GO:0000095

MF

S-adenosyl-L-methionine transmembrane transporter activity

Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.

SLC25A26

GO:0000104

MF

succinate dehydrogenase activity

Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor.

SDHB, SDHA, SDHC

GO:0000146

MF

microfilament motor activity

Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).

MYO1C, MYO1D, MYH9, MYO1E, MYO9B, MYH2, MYO5B, MYO5A, MYH4

GO:0000149

MF

SNARE binding

Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.

GOSR2, STX7, EXOC3, VAMP4, SEC22B, STX11, SNAPIN, SYT1, STX2, VAMP7, GABARAPL2, STXBP1, VAMP2, TNFAIP2, STX4, STX3, VAMP3, SEC22A, ANKRD27, TRIM9, CAPN10, VTI1B

GO:0000150

MF

recombinase activity

Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.

RAD51C, RAD51D, RAD51

GO:0000155

MF

phosphorelay sensor kinase activity

Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.

KCNH2

GO:0000166

MF

nucleotide binding

Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

RBM47, IGF2BP3, HNRNPDL, U2SURP, SYNJ2, POLR2D, RBFOX2, HNRNPR, SYNJ1, ORC5, SYNCRIP, REV3L, SRSF10, CRCP, DHRS3, DXO, TMEM63A, SCAF4, CELF2, PARN, CNOT4, PTBP3, TYMS, SSB, HSP90AA1, HNRNPC, SNRPA, HNRNPA1, POLA1, PYGM, HNRNPL, NT5E, HNRNPA2B1, SFPQ, EIF4B, PTBP1, POLD1, RBMS1, TIA1, HNRNPH3, HNRNPH1, FUS, RBMX, MATR3, VDAC2, RBM25, HINT1, FHIT, HDGF, HNRNPA3, HNRNPM, RBM5, RCAN1, HNRNPH2, EIF3B, RPL23A, TRA2B, RBM6, GPSM2, RBM3, SRSF2, EWSR1, SRSF11, POLE, SRSF1, GRSF1, TARDBP, SRSF9, SRSF5, SRSF6, TRA2A, CIRBP, HNRNPD, RBM39, ELAVL3, ZNF638, SART3, NONO, RNPS1, RBMS2, ELAVL1, CRY1, MRPL23, SNRNP35, CPEB4, LARP7, PABPC1L, NCBP3, RBM48, RBM26, SLC27A4, SLC27A1, RBPMS2, RBM43, LARP4, NOL8, CPEB2, PABPN1, ALYREF, CHD1L, PPARGC1B, RBM45, TNRC6A, CPEB3, NUP35, ZCRB1, ENOX1, PPIL4, SREK1, PSPC1, TAF15, RBPMS, MSI2, DAZAP1, RBM33, RBM17, RNPC3, RBM15, SPEN, HNRNPAB, CDC6, RBM4B, LARP6, RBM4, RBM24, HINT2, POLDIP3, NIFK, SLIRP, RBM38, UPF3A, PABPC3, ESRP2, TNRC6C, RAVER2, NOX4, HINT3, PRTFDC1, RBM22, RBFOX1, SLTM, TRNAU1AP, AKAP7, MYEF2, PPARGC1A, NXF1, PUF60, PTBP2, G3BP2, PPIE, SCAF8, TNRC6B, VDAC3, SLC27A6, LEMD3, RBMX2, RRP7A, SF3B6, R3HCC1, KIAA0430, RBM8A, IGF2BP2

GO:0000171

MF

ribonuclease MRP activity

Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA.

POP4

GO:0000175

MF

3'-5'-exoribonuclease activity

Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.

EXOSC9, EXOSC2, EXOSC7, PNPT1, ISG20, EXOSC4, EXOSC3, CNOT7, DIS3, REXO2

GO:0000179

MF

rRNA (adenine-N6,N6-)-dimethyltransferase activity

Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor.

DIMT1

GO:0000182

MF

rDNA binding

Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA.

H2AFY, TSPYL2

GO:0000213

MF

tRNA-intron endonuclease activity

Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.

TSEN15

GO:0000215

MF

tRNA 2'-phosphotransferase activity

Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate.

TRPT1

GO:0000246

MF

delta24(24-1) sterol reductase activity

Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH.

DHCR24