GO:0072531

BP

pyrimidine-containing compound transmembrane transport

The directed movement of a pyrimidine-containing compound across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof.

AQP9, SLC28A3

GO:0072537

BP

fibroblast activation

A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.

RGCC

GO:0072539

BP

T-helper 17 cell differentiation

The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.

RORA

GO:0072540

BP

T-helper 17 cell lineage commitment

The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.

IL6

GO:0072553

BP

terminal button organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.

SNAPIN, CHD4, NLGN1

GO:0072554

BP

blood vessel lumenization

The process in which a developing blood vessel forms an endothelial lumen through which blood will flow.

DLL4

GO:0072573

BP

tolerance induction to lipopolysaccharide

Tolerance induction directed at lipopolysaccharide antigens.

TNFAIP3

GO:0072574

BP

hepatocyte proliferation

The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules.

CEBPB, RPS6KA1, PROX1

GO:0072576

BP

liver morphogenesis

The process in which the anatomical structures of the liver are generated and organized.

CUL3

GO:0072577

BP

endothelial cell apoptotic process

Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal.

IL10, COL4A3, BMPR2, MAP3K5

GO:0072579

BP

glycine receptor clustering

The receptor clustering process in which glycine receptors are localized to distinct domains in the cell membrane.

GPHN

GO:0072583

BP

clathrin-dependent endocytosis

An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.

HIP1, PIP5K1C, AP2A2, CLTA, CANX, AP2S1, AP2B1, FCHO2, PICALM, FNBP1L, AP2M1

GO:0072584

BP

caveolin-mediated endocytosis

An endocytosis process that begins when material is taken up into plasma membrane caveolae, which then pinch off to form endocytic caveolar carriers.

MAPK3, MAPK1, CAV1

GO:0072592

BP

oxygen metabolic process

The chemical reactions and pathways involving diatomic oxygen (O2).

ME3, FMO2

GO:0072593

BP

reactive oxygen species metabolic process

The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.

CYR61, NDUFS4, PDGFB, BCL2, VAV1, NDUFS1, CTGF, SESN2, AOX1, BNIP3, PRDX4, PMAIP1, PDK4, NDUFAF2, RFK, NOX4, DDIT4, NDUFA13, SESN1

GO:0072594

BP

establishment of protein localization to organelle

The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.

LAMP1, RAB11A, IFT122

GO:0072599

BP

establishment of protein localization to endoplasmic reticulum

The directed movement of a protein to a specific location in the endoplasmic reticulum.

RYR2

GO:0072600

BP

establishment of protein localization to Golgi

The directed movement of a protein to a specific location in the Golgi apparatus.

NRAS

GO:0072602

BP

interleukin-4 secretion

The regulated release of interleukin-4 from a cell.

NOTCH1, VTCN1, IL1RAP

GO:0072604

BP

interleukin-6 secretion

The regulated release of interleukin-6 from a cell.

LEP

GO:0072606

BP

interleukin-8 secretion

The regulated release of interleukin-8 from a cell.

CHI3L1, LEP, RAB1A

GO:0072608

BP

interleukin-10 secretion

The regulated release of interleukin-10 from a cell.

F2RL1

GO:0072615

BP

interleukin-17 secretion

The regulated release of any member of the interleukin-17 family of cytokines from a cell.

NR1H4

GO:0072619

BP

interleukin-21 secretion

The regulated release of interleukin-21 from a cell.

FOXP1

GO:0072643

BP

interferon-gamma secretion

The regulated release of interferon-gamma from a cell.

F2RL1, BTN3A2, VTCN1, LILRB1

GO:0072655

BP

establishment of protein localization to mitochondrion

The directed movement of a protein to the mitochondrion or a part of the mitochondrion.

HK1, AKT1, PINK1

GO:0072656

BP

maintenance of protein location in mitochondrion

Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere.

HK1, TSPO, AKT1, PINK1

GO:0072657

BP

protein localization to membrane

A process in which a protein is transported to, or maintained in, a specific location in a membrane.

SH3PXD2B, AP3D1, RAB29, CPE, CAPN3, TIAM1, RAB32, PACSIN1

GO:0072659

BP

protein localization to plasma membrane

A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.

FYB, RAMP1, RAMP3, LRP6, ATP1B1, RAP2A, AKT2, DPP6, CACNB3, ATP1B3, EMP2, STXBP1, RAB11A, RAC1, ANK2, FCHO2, ANK3, DLG1, PPIL2, MAP7, ADIPOQ, GPR158, DENND4C, PIGW, C2CD5, RAPGEF6, FGF13, RAB34, SYTL2, TNIK, EPB41L3, MYO5A

GO:0072660

BP

maintenance of protein location in plasma membrane

Any process in which a protein is maintained in a specific location in the plasma membrane, and is prevented from moving elsewhere.

ANK3

GO:0072661

BP

protein targeting to plasma membrane

The process of directing proteins towards the plasma membrane; usually uses signals contained within the protein.

ANXA2, BSG, SPTBN1, ANK2, ANK3, PTCH1, GAS6, TMED2, MYADM, INPP5K, WNK3, EHD3

GO:0072666

BP

establishment of protein localization to vacuole

The directed movement of a protein to a specific location in a vacuole.

TNFAIP3

GO:0072672

BP

neutrophil extravasation

The migration of a neutrophil from the blood vessels into the surrounding tissue.

PIK3CD, PIK3CG, TREM1

GO:0072673

BP

lamellipodium morphogenesis

A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized.

SNX1, PLEKHO1, ABI1, WASF2

GO:0072678

BP

T cell migration

The movement of a T cell within or between different tissues and organs of the body.

MYO1G, S1PR1, CCL20

GO:0072679

BP

thymocyte migration

The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development.

CCL20

GO:0072684

BP

mitochondrial tRNA 3'-trailer cleavage, endonucleolytic

Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA in the mitochondrion.

ELAC2

GO:0072697

BP

protein localization to cell cortex

A process in which a protein is transported to, or maintained in, the cell cortex.

EZR

GO:0072703

BP

cellular response to methyl methanesulfonate

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus.

TP53INP1

GO:0072709

BP

cellular response to sorbitol

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus.

MAP2K6

GO:0072711

BP

cellular response to hydroxyurea

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.

ATRX, BLM, RAD51, FMR1, SPIDR

GO:0072718

BP

response to cisplatin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus.

NUCB1

GO:0072719

BP

cellular response to cisplatin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus.

SLC31A1, HMOX1, RAD51, ADIRF

GO:0072750

BP

cellular response to leptomycin B

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus.

ID3

GO:0072755

BP

cellular response to benomyl

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus.

IMPACT

GO:0072757

BP

cellular response to camptothecin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus.

BLM, RAD51, SPIDR

GO:0075521

BP

microtubule-dependent intracellular transport of viral material towards nucleus

The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules.

DYNLT1

GO:0075522

BP

IRES-dependent viral translational initiation

Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation.

SSB, PTBP1, EIF3B, EIF3A

GO:0075525

BP

viral translational termination-reinitiation

A process which occurs as part of viral mRNA translation which allows expression of a downstream open reading frame (ORF) in a dicistronic mRNA. In this process, ribosomes translate the upstream ORF but following termination, a proportion of 40S subunits remain tethered to the mRNA and go on to re-initiate translation at the start codon of the downstream ORF.

EIF3B, EIF3A

GO:0075713

BP

establishment of integrated proviral latency

A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage.

PSIP1, BANF1, XRCC5, HMGA1, PPIA, XRCC4

GO:0075732

BP

viral penetration into host nucleus

The crossing by the virus of the host nuclear membrane, either as naked viral genome or for small viruses as an intact capsid.

KPNA3, NUP153

GO:0075733

BP

intracellular transport of virus

The directed movement of a virus, or part of a virus, within the host cell.

VPS37C, KPNA3, KPNA4, XPO1, KPNA5, NUPL2, NMT2, NUP155, UBC, TPR, NUP62, NUP153, RANBP2, KPNA2, KPNA1, NUP107, RPS27A, UBA52, RAE1, NUP160, KPNB1, NUP93, VPS37A, NUP43, NUP37, NUP35, NUP210, NUP205, SEH1L, NUP88, NDC1, NUP58, NUP85, CD209, NUP50

GO:0080009

BP

mRNA methylation

The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.

WTAP, METTL14

GO:0080058

BP

protein deglutathionylation

The protein modification process in which a glutathione molecule is removed from a protein amino acid by breaking a disulfide linkage.

GLRX

GO:0080111

BP

DNA demethylation

The removal of a methyl group from one or more nucleotides within an DNA molecule.

TDG, ALKBH1, FTO

GO:0080121

BP

AMP transport

The directed movement of AMP, adenosine monophosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

SLC25A17

GO:0080129

BP

proteasome core complex assembly

The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles.

PSMG1

GO:0080154

BP

regulation of fertilization

Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).

PLCB1

GO:0080164

BP

regulation of nitric oxide metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.

VIMP

GO:0080182

BP

histone H3-K4 trimethylation

The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone.

OGT, HIST1H1E, HIST1H1C, RTF1, ZNF335, KMT2B

GO:0085020

BP

protein K6-linked ubiquitination

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair.

PARK2, BRCA1, UBE2S, BARD1, UBE2T, RNF6, UBE2D4

GO:0085029

BP

extracellular matrix assembly

The aggregation, arrangement and bonding together of the extracellular matrix.

TGFB1, GPM6B, GAS6, HAS2

GO:0086001

BP

cardiac muscle cell action potential

An action potential that occurs in a cardiac muscle cell.

DMD, PKP2

GO:0086002

BP

cardiac muscle cell action potential involved in contraction

An action potential that occurs in a cardiac muscle cell and is involved in its contraction.

CACNA2D1, FGF12, CACNA1C, PKP2

GO:0086003

BP

cardiac muscle cell contraction

The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell.

CAMK2D

GO:0086004

BP

regulation of cardiac muscle cell contraction

Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction.

PLN, SRI, GATA4, ATP1A2, STC1, ANK2, PDE4D

GO:0086005

BP

ventricular cardiac muscle cell action potential

An action potential that occurs in a ventricular cardiac muscle cell.

GJA5, ANK2, KCNH2, SNTA1, RYR2, NEDD4L, PKP2

GO:0086009

BP

membrane repolarization

The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.

ATP1B1, ATP1A2, ATP1B3, KCNIP2

GO:0086010

BP

membrane depolarization during action potential

The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.

CACNA1G, YWHAH, KCNH2, SCN9A, CACNA1E, TPCN2

GO:0086011

BP

membrane repolarization during action potential

The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.

KCNH2

GO:0086012

BP

membrane depolarization during cardiac muscle cell action potential

The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.

ATP1A2, CACNA2D1, CACNA1C

GO:0086013

BP

membrane repolarization during cardiac muscle cell action potential

The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.

ATP1B1, YWHAE, KCNH2

GO:0086014

BP

atrial cardiac muscle cell action potential

An action potential that occurs in an atrial cardiac muscle cell.

NUP155, GJA1, GJC1, ANK2

GO:0086015

BP

SA node cell action potential

An action potential that occurs in a sinoatrial node cardiac muscle cell.

CACNA1G, GJA5, ANK2

GO:0086016

BP

AV node cell action potential

An action potential that occurs in an atrioventricular node cardiac muscle cell.

CACNA1G

GO:0086018

BP

SA node cell to atrial cardiac muscle cell signalling

Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte.

CACNA1G

GO:0086019

BP

cell-cell signaling involved in cardiac conduction

Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium.

PKP2

GO:0086023

BP

adrenergic receptor signaling pathway involved in heart process

A series of molecular signals beginning with a G-protein coupled adrenergic cell surface receptor combining with epinephrine or norepinephrine, which contributes to a circulatory system process carried out by the heart.

PLN, AKAP13

GO:0086024

BP

adrenergic receptor signaling pathway involved in positive regulation of heart rate

An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate.

PDE4D

GO:0086027

BP

AV node cell to bundle of His cell signaling

Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte.

CACNA1G

GO:0086029

BP

Purkinje myocyte to ventricular cardiac muscle cell signaling

Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell.

RYR2

GO:0086036

BP

regulation of cardiac muscle cell membrane potential

Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.

FXYD1, ATP2A2, PLN, EHD3

GO:0086042

BP

cardiac muscle cell-cardiac muscle cell adhesion

The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules.

DSC2

GO:0086045

BP

membrane depolarization during AV node cell action potential

The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.

CACNA1G, CACNA1C

GO:0086046

BP

membrane depolarization during SA node cell action potential

The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.

CACNA1G, ANK2

GO:0086053

BP

AV node cell to bundle of His cell communication by electrical coupling

The process that mediates signaling interactions between an AV node cardiomyocyte and a bundle of His cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.

GJA5

GO:0086054

BP

bundle of His cell to Purkinje myocyte communication by electrical coupling

The process that mediates signaling interactions between a bundle of His cardiac muscle cell and a Purkinje myocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels.

GJA5

GO:0086064

BP

cell communication by electrical coupling involved in cardiac conduction

The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction.

ATP1B1, GJA1, PRKACA, GJA5, ATP1A2, CACNA1C, RYR2, PKP2

GO:0086066

BP

atrial cardiac muscle cell to AV node cell communication

The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

ANK2

GO:0086067

BP

AV node cell to bundle of His cell communication

The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

CXADR

GO:0086070

BP

SA node cell to atrial cardiac muscle cell communication

The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

ANK2

GO:0086073

BP

bundle of His cell-Purkinje myocyte adhesion involved in cell communication

The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate.

JUP, DSP, DSC2, DSG2, PKP2

GO:0086091

BP

regulation of heart rate by cardiac conduction

A cardiac conduction process that modulates the frequency or rate of heart contraction.

CACNA1G, JUP, DSP, GJA5, CACNA2D1, YWHAE, ANK2, DSC2, CAV1, KCNH2, CAMK2D, CACNA1C, DSG2, PKP2

GO:0086092

BP

regulation of the force of heart contraction by cardiac conduction

A cardiac conduction process that modulates the extent of heart contraction, changing the force with which blood is propelled.

PLN

GO:0086097

BP

phospholipase C-activating angiotensin-activated signaling pathway

An angiotensin-mediated signaling pathway where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores.

AGTR1, ACTN2

GO:0086098

BP

angiotensin-activated signaling pathway involved in heart process

An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart.

CAV1

GO:0086100

BP

endothelin receptor signaling pathway

A series of molecular signals initiated by an endothelin receptor binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription.

EDNRA

GO:0086103

BP

G-protein coupled receptor signaling pathway involved in heart process

An G-protein coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart.

RAMP3

GO:0089700

BP

protein kinase D signaling

A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase D, which occurs as a result of a single trigger reaction or compound.

PRKD1, PRKD2

GO:0089709

BP

L-histidine transmembrane transport

The directed movement of L-histidine across a membrane.

SLC38A1