GO:1905176

BP

positive regulation of vascular smooth muscle cell dedifferentiation

Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell dedifferentiation.

PDGFB

GO:1905206

BP

positive regulation of hydrogen peroxide-induced cell death

Any process that activates or increases the frequency, rate or extent of cell death in response to hydrogen peroxide.

RIPK1

GO:1905223

BP

epicardium morphogenesis

The developmental process by which an epicardium is generated and organized.

TGFBR1

GO:1905259

BP

negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress.

DNAJA1

GO:1905285

BP

fibrous ring of heart morphogenesis

The developmental process by which a fibrous ring of heart is generated and organized.

BMPR1A

GO:1905305

BP

negative regulation of cardiac myofibril assembly

Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly.

SMAD4

GO:1905313

BP

transforming growth factor beta receptor signaling pathway involved in heart development

Any transforming growth factor beta receptor signaling pathway that is involved in heart development.

TGFB1

GO:1905314

BP

semi-lunar valve development

The process whose specific outcome is the progression of a semi-lunar valve over time, from its formation to the mature structure.

BMPR2

GO:1905337

BP

positive regulation of aggrephagy

Any process that activates or increases the frequency, rate or extent of aggrephagy.

HTT

GO:1905342

BP

positive regulation of protein localization to kinetochore

Any process that activates or increases the frequency, rate or extent of protein localization to kinetochore.

CENPQ

GO:1905408

BP

negative regulation of creatine transmembrane transporter activity

Any process that stops, prevents or reduces the frequency, rate or extent of creatine transmembrane transporter activity.

OSR1

GO:1905426

BP

positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation

Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation.

CSNK1D, CSNK1E

GO:1990000

BP

amyloid fibril formation

The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins. An example of this is seen when human RIP1 and RIP3 kinases form a heterodimeric functional amyloid signaling complex (PMID:22817896).

APP, CD36, RIPK1

GO:1990001

BP

inhibition of cysteine-type endopeptidase activity involved in apoptotic process

Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process.

BIRC5, NOL3, XIAP, BIRC3, BCL2L12

GO:1990029

BP

vasomotion

The rhythmical contraction and relaxation of arterioles, observed as slow and fast waves, with frequencies of 1-2 and 10-20 cpm.

GJA5

GO:1990035

BP

calcium ion import into cell

The directed movement of calcium ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.

TRPV1, TRPV6

GO:1990036

BP

calcium ion import into sarcoplasmic reticulum

The directed movement of calcium ions into a sarcoplasmic reticulum.

ATP2A2

GO:1990051

BP

activation of protein kinase C activity

Any process that initiates the activity of the inactive enzyme protein kinase C.

LEP

GO:1990086

BP

lens fiber cell apoptotic process

Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.

TGFBR2, E2F1, E2F2

GO:1990090

BP

cellular response to nerve growth factor stimulus

A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.

ARPC3, FOXO3, NTRK1, APP, CREB1, AKT1, ID1, CSNK1D, CSNK1E, RAP1A, E2F1, RAPGEF1, ACAP2, MAGI2, TRPV1, CDC5L, CIB1, KIDINS220

GO:1990117

BP

B cell receptor apoptotic signaling pathway

An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell.

BAX

GO:1990126

BP

retrograde transport, endosome to plasma membrane

The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.

WASH1, VPS26A, RAB11B, ANKRD27, VPS35, VPS29, ANKRD50

GO:1990138

BP

neuron projection extension

Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

AURKA, IQGAP1, PLXNA3, TIAM1, ALCAM, POSTN, NDEL1, FLRT3, FLRT1, EIF2AK4, IMPACT, PLXNA1

GO:1990144

BP

intrinsic apoptotic signaling pathway in response to hypoxia

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered.

BNIP3

GO:1990145

BP

maintenance of translational fidelity

Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template.

CDKAL1

GO:1990166

BP

protein localization to site of double-strand break

Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred.

SLF2, SLF1

GO:1990168

BP

protein K33-linked deubiquitination

A protein deubiquitination process in which a K33-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is removed from a protein.

ZRANB1

GO:1990180

BP

mitochondrial tRNA 3'-end processing

The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion.

TRNT1

GO:1990182

BP

exosomal secretion

The process whereby a membrane-bounded vesicle are released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.

RAB27A, RAB11A

GO:1990253

BP

cellular response to leucine starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine.

GCN1, EIF2AK4, IMPACT

GO:1990256

BP

signal clustering

Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response.

SEMA5A

GO:1990261

BP

pre-mRNA catabolic process

The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA).

ZPR1

GO:1990262

BP

anti-Mullerian hormone signaling pathway

A series of molecular signals initiated by the binding of anti-Mullerian hormone to its receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

AMHR2

GO:1990268

BP

response to gold nanoparticle

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold nanoparticle stimulus.

MPO

GO:1990314

BP

cellular response to insulin-like growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.

TGFB1, CREB1, CCNA2, FBN1

GO:1990349

BP

gap junction-mediated intercellular transport

The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells.

MIP

GO:1990379

BP

lipid transport across blood brain barrier

The directed movement of lipid molecules passing through the blood-brain barrier.

MFSD2A

GO:1990401

BP

embryonic lung development

The process occurring during the embryonic phase whose specific outcome is the progression of the lung over time, from its formation to the mature structure.

PDGFA

GO:1990402

BP

embryonic liver development

The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure.

TGFB1

GO:1990403

BP

embryonic brain development

The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure.

CTNNB1, TRA2B, MED12, MKS1, CC2D2A

GO:1990414

BP

replication-born double-strand break repair via sister chromatid exchange

The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks.

RAD51

GO:1990416

BP

cellular response to brain-derived neurotrophic factor stimulus

A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus.

EEF2

GO:1990418

BP

response to insulin-like growth factor stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.

XBP1, AKT1

GO:1990426

BP

mitotic recombination-dependent replication fork processing

Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart.

BRCA2, RAD51

GO:1990428

BP

miRNA transport

The directed movement of microRNA (miRNA) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.

HNRNPA2B1

GO:1990440

BP

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress.

TP53, HSPA5, CEBPB, ATF3, ATF4, ATF6, DDIT3, CREB3L1

GO:1990441

BP

negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress.

PPP1R15A, JUN

GO:1990481

BP

mRNA pseudouridine synthesis

The intramolecular conversion of uridine to pseudouridine in an mRNA molecule.

DKC1, TRUB1

GO:1990502

BP

dense core granule maturation

Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis.

SNX19

GO:1990523

BP

bone regeneration

The regrowth of bone following its loss or destruction.

POSTN

GO:1990539

BP

fructose import across plasma membrane

The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol.

SLC2A5

GO:1990569

BP

UDP-N-acetylglucosamine transmembrane transport

The directed movement of UDP-N-acetylglucosamine across a membrane.

SLC35A3

GO:1990573

BP

potassium ion import across plasma membrane

The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.

ATP1B1, ATP1A2

GO:1990579

BP

peptidyl-serine trans-autophosphorylation

The phosphorylation of a peptidyl-serine to form peptidyl-O-phospho-L-serine on an identical protein. For example, phosphorylation by the other kinase within a homodimer.

ERN1

GO:1990592

BP

protein K69-linked ufmylation

A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein.

UFM1, UBA5

GO:1990603

BP

dark adaptation

The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light.

PAPD4

GO:1990614

BP

mitochondrial magnesium ion transmembrane transport

A process in which a magnesium ion is transported from one side of a mitochondrial membrane to the other by means of some agent such as a transporter or pore.

MRS2

GO:1990637

BP

response to prolactin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. The anterior pituitary hormone prolactin has a number of roles including being essential for lactation.

GNRH1

GO:1990641

BP

response to iron ion starvation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion.

HAMP, HFE

GO:1990646

BP

cellular response to prolactin

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus.

IL6, CDC5L

GO:1990737

BP

response to manganese-induced endoplasmic reticulum stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus.

EIF2S1, ATF4

GO:1990774

BP

tumor necrosis factor secretion

The regulated release of tumor necrosis factor from a cell. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.

HMGB1

GO:1990776

BP

response to angiotensin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.

CYBB, IQGAP1

GO:1990785

BP

response to water-immersion restraint stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of water immersion while being held immobile.

FOXO3, FOXO4, MDM2

GO:1990791

BP

dorsal root ganglion development

The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.

CTNNB1

GO:1990809

BP

endoplasmic reticulum tubular network membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane.

ARL6IP1

GO:1990822

BP

basic amino acid transmembrane transport

The directed movement of basic amino acids from one side of a membrane to the other.

SLC7A2, SLC7A7

GO:1990828

BP

hepatocyte dedifferentiation

The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.

HNRNPD

GO:1990845

BP

adaptive thermogenesis

The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature.

PPARGC1A

GO:1990910

BP

response to hypobaric hypoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level).

HSF1

GO:1990911

BP

response to psychosocial stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism.

HSF1

GO:1990927

BP

calcium ion regulated lysosome exocytosis

The process of secretion by a cell that results in the release of intracellular molecules contained within a lysosome by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.

SYT11

GO:1990928

BP

response to amino acid starvation

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.

EIF4EBP1

GO:1990938

BP

peptidyl-aspartic acid autophosphorylation

The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein.

ATP13A2

GO:1990966

BP

ATP generation from poly-ADP-D-ribose

The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.

PARP1, NUDT5

GO:1990967

BP

multi-organism toxin transport

The directed movement of a toxin into, out of or within a cell, or between cells where two or more organisms of the same or different species are involved.

RAB29, RAB40B

GO:1990968

BP

modulation by host of RNA binding by virus

A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA.

NUCKS1

GO:1990969

BP

modulation by host of viral RNA-binding transcription factor activity

A process in which a host organism modulates the frequency, rate or extent of the activity of a viral RNA-binding transcription factor.

NUCKS1

GO:2000001

BP

regulation of DNA damage checkpoint

Any process that modulates the frequency, rate or extent of a DNA damage checkpoint.

CUL4A, CRY1, RNASEH2B, RFWD3, FEM1B

GO:2000003

BP

positive regulation of DNA damage checkpoint

Any process that activates or increases the frequency, rate or extent of a DNA damage checkpoint.

CCAR2

GO:2000005

BP

negative regulation of metanephric S-shaped body morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric S-shaped body morphogenesis.

BMP4

GO:2000007

BP

negative regulation of metanephric comma-shaped body morphogenesis

Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric comma-shaped body morphogenesis.

BMP4

GO:2000008

BP

regulation of protein localization to cell surface

Any process that modulates the frequency, rate or extent of protein localization to the cell surface.

TOR1A, CTNNB1, RAB11B, HFE, GBF1

GO:2000009

BP

negative regulation of protein localization to cell surface

Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface.

TAX1BP3, LEPROT, ACTN2, GPM6B, COMMD1, SNX33, NEDD4L

GO:2000010

BP

positive regulation of protein localization to cell surface

Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface.

TNF, SYNJ2BP, NRG1, STX4, STX3, ERBB4, SNX33, RANGRF

GO:2000016

BP

negative regulation of determination of dorsal identity

Any process that stops, prevents, or reduces the frequency, rate or extent of determination of dorsal identity.

DDIT3

GO:2000017

BP

positive regulation of determination of dorsal identity

Any process that activates or increases the frequency, rate or extent of determination of dorsal identity.

CTNNB1, ACVR1

GO:2000020

BP

positive regulation of male gonad development

Any process that activates or increases the frequency, rate or extent of male gonad development.

WT1, SOX9, SEMA3A, ZFPM2, CITED2

GO:2000021

BP

regulation of ion homeostasis

Any process that modulates the frequency, rate or extent of ion homeostasis.

WNK3, WNK1

GO:2000027

BP

regulation of organ morphogenesis

Any process that modulates the frequency, rate or extent of animal organ morphogenesis.

TBX1

GO:2000035

BP

regulation of stem cell division

Any process that modulates the frequency, rate or extent of stem cell division.

SOX17, NAP1L2

GO:2000036

BP

regulation of stem cell population maintenance

Any process that modulates the frequency, rate or extent of stem cell population maintenance.

CNOT1, CNOT3, TAL1, HMGA2, ELAVL1

GO:2000041

BP

negative regulation of planar cell polarity pathway involved in axis elongation

Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation.

SFRP1

GO:2000042

BP

negative regulation of double-strand break repair via homologous recombination

Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination.

POLQ, FBXO18, PARPBP

GO:2000043

BP

regulation of cardiac cell fate specification

Any process that modulates the frequency, rate or extent of cardiac cell fate specification.

SOX17

GO:2000045

BP

regulation of G1/S transition of mitotic cell cycle

Any cell cycle regulatory process that controls the commitment of a cell from G1 to S phase of the mitotic cell cycle.

BID, PSME3, E2F1, ID2, KIF14, PID1, PDPN

GO:2000048

BP

negative regulation of cell-cell adhesion mediated by cadherin

Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin.

PLG, EPCAM, RGCC

GO:2000049

BP

positive regulation of cell-cell adhesion mediated by cadherin

Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin.

FLOT1, WNT5A

GO:2000050

BP

regulation of non-canonical Wnt signaling pathway

Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway.

TIAM1

GO:2000052

BP

positive regulation of non-canonical Wnt signaling pathway

Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway.

WNT5A, CSNK1D, CSNK1E, SFRP1, RSPO3