Resource Details

Pubmed ID15308691
AuthorJansen et al.
Year2004
TitleAbnormal Gene Expression Profiles in Human Ovaries from Polycystic Ovary Syndrome Patients
Biological SampleOvary
Sample Size11 non-PCOS women, 22 female-to-male transexual (TSX), 8 PCOS women
Analysis MethodAffymetrix GeneChips HG_U133A and HG_U133B
Source TypeTranscriptomics
Gene SymbolDescriptionEntrez IDUniprot IDChromosomal LocationExpressionCondition

ADAM12

ADAM metallopeptidase domain 12

8038

O43184

chr10: 126,012,381-126,388,455

up-regulated

N/A

ADAMTS1

ADAM metallopeptidase with thrombospondin type 1 motif 1

9510

Q9UHI8

chr21: 26,835,747-26,845,409

down-regulated

N/A

ADH1B

alcohol dehydrogenase 1B (class I), beta polypeptide

125

P00325

chr4: 99,304,964-99,352,760

down-regulated

N/A

ADRB3

adrenoceptor beta 3

155

P13945

chr8: 37,962,991-37,966,965

down-regulated

N/A

ALDH1A2

aldehyde dehydrogenase 1 family member A2

8854

O94788

chr15: 57,953,424-58,497,866

down-regulated

N/A

APOA1

apolipoprotein A-I

335

P02647

chr11: 116,835,751-116,837,950

up-regulated

N/A

ARHGDIB

Rho GDP dissociation inhibitor (GDI) beta

397

P52566

chr12: 14,942,017-14,961,728

down-regulated

N/A

ARHGEF3

Rho guanine nucleotide exchange factor 3

50650

Q9NR81

chr3: 56,727,418-57,079,329

down-regulated

N/A

ATF3

activating transcription factor 3

467

P18847

chr1: 212,565,334-212,620,777

down-regulated

N/A

ATP1B1

ATPase, Na+/K+ transporting, beta 1 polypeptide

481

P05026

chr1: 169,105,697-169,132,722

down-regulated

N/A

B4GALT1

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

2683

P15291

chr9: 33,104,082-33,167,356

down-regulated

N/A

B4GALT6

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6

9331

Q9UBX8

chr18: 31,622,247-31,685,836

up-regulated

N/A

BGN

biglycan

633

P21810

chrX: 153,494,939-153,509,554

up-regulated

N/A

BHLHE40

basic helix-loop-helix family member e40

8553

O14503

chr3: 4,979,116-4,985,323

down-regulated

N/A

BMP6

bone morphogenetic protein 6

654

P22004

chr6: 7,726,797-7,881,422

up-regulated

N/A

BTG2

BTG family member 2

7832

P78543

chr1: 203,305,491-203,309,602

down-regulated

N/A

C3

complement component 3

718

P01024

chr19: 6,677,704-6,730,562

down-regulated

N/A

C5AR1

complement component 5a receptor 1

728

P21730

chr19: 47,290,023-47,322,066

down-regulated

N/A

C6orf132

chromosome 6 open reading frame 132

647024

Q5T0Z8

chr6: 42,101,118-42,142,619

down-regulated

N/A

CCL3

chemokine (C-C motif) ligand 3

6348

P10147

chr17: 36,088,256-36,090,169

down-regulated

N/A

CD74

CD74 molecule, major histocompatibility complex, class II invariant chain

972

P04233

chr5: 150,401,637-150,412,929

down-regulated

N/A

CDC42EP3

CDC42 effector protein (Rho GTPase binding) 3

10602

Q9UKI2

chr2: 37,641,882-37,738,468

up-regulated

N/A

CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

1026

P38936

chr6: 36,676,460-36,687,339

down-regulated

N/A

CEBPB

CCAAT/enhancer binding protein (C/EBP), beta

1051

P17676

chr20: 50,190,734-50,192,689

down-regulated

N/A

CEBPD

CCAAT/enhancer binding protein (C/EBP), delta

1052

P49716

chr8: 47,736,909-47,739,086

down-regulated

N/A

CHST2

carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2

9435

Q9Y4C5

chr3: 143,119,331-143,124,014

up-regulated

N/A

CKB

creatine kinase, brain

1152

P12277

chr14: 103,519,659-103,523,111

down-regulated

N/A

COL4A6

collagen, type IV, alpha 6

1288

Q14031

chrX: 108,155,607-108,439,497

down-regulated

N/A

CPZ

carboxypeptidase Z

8532

Q66K79

chr4: 8,592,660-8,619,759

up-regulated

N/A

CREM

cAMP responsive element modulator

1390

Q03060

chr10: 35,126,791-35,212,958

down-regulated

N/A

CSRNP1

cysteine-serine-rich nuclear protein 1

64651

Q96S65

chr3: 39,141,855-39,154,562

down-regulated

N/A

CYFIP2

cytoplasmic FMR1 interacting protein 2

26999

Q96F07

chr5: 157,266,079-157,395,595

down-regulated

N/A

CYP1B1

cytochrome P450 family 1 subfamily B member 1

1545

Q16678

chr2: 38,066,973-38,109,902

down-regulated

N/A

DKK3

dickkopf WNT signaling pathway inhibitor 3

27122

Q9UBP4

chr11: 11,963,106-12,009,769

up-regulated

N/A

DNAJB1

DnaJ heat shock protein family (Hsp40) member B1

3337

P25685

chr19: 14,514,770-14,529,770

down-regulated

N/A

DUSP1

dual specificity phosphatase 1

1843

P28562

chr5: 172,768,090-172,771,195

down-regulated

N/A

DUSP26

dual specificity phosphatase 26 (putative)

78986

Q9BV47

chr8: 33,591,332-33,600,106

down-regulated

N/A

EGR1

early growth response 1

1958

P18146

chr5: 138,465,490-138,469,315

down-regulated

N/A

FAM46C

family with sequence similarity 46 member C

54855

Q5VWP2

chr1: 117,605,934-117,628,372

down-regulated

N/A

FBLN1

fibulin 1

2192

P23142

chr22: 45,502,238-45,601,135

down-regulated

N/A

FOS

FBJ murine osteosarcoma viral oncogene homolog

2353

P01100

chr14: 75,278,774-75,282,230

down-regulated

N/A

FOSB

FBJ murine osteosarcoma viral oncogene homolog B

2354

P53539

chr19: 45,467,995-45,475,179

down-regulated

N/A

GABARAPL1

GABA(A) receptor-associated protein like 1

23710

Q9H0R8

chr12: 10,212,458-10,223,130

down-regulated

N/A

GADD45B

growth arrest and DNA damage inducible beta

4616

O75293

chr19: 2,476,122-2,478,259

down-regulated

N/A

GEM

GTP binding protein overexpressed in skeletal muscle

2669

P55040

chr8: 94,249,253-94,262,350

down-regulated

N/A

GOLGA8B

golgin A8 family member B

440270

A8MQT2

chr15: 34,525,207-34,588,503

up-regulated

N/A

GPNMB

glycoprotein (transmembrane) nmb

10457

Q14956

chr7: 23,235,967-23,275,108

down-regulated

N/A

GSAP

gamma-secretase activating protein

54103

A4D1B5

chr7: 77,310,751-77,416,400

down-regulated

N/A

GSTO2

glutathione S-transferase omega 2

119391

Q9H4Y5

chr10: 104,268,873-104,304,945

down-regulated

N/A

HDAC3

histone deacetylase 3

8841

O15379

chr5: 141,620,876-141,636,870

down-regulated

N/A

HFE

hemochromatosis

3077

Q30201

chr6: 26,087,281-26,098,343

down-regulated

N/A

HIST1H1C

histone cluster 1, H1c

3006

P16403

chr6: 26,055,787-26,056,428

down-regulated

N/A

HIST1H2BD

histone cluster 1, H2bd

3017

P58876

chr6: 26,158,146-26,171,349

down-regulated

N/A

HIST2H2AA3

histone cluster 2, H2aa4

723790

Q6FI13

chr1: 149,851,061-149,851,624

down-regulated

N/A

HIST2H2BE

histone cluster 2, H2be

8349

Q16778

chr1: 149,884,459-149,886,652

down-regulated

N/A

HIST3H2A

histone cluster 3, H2a

92815

Q7L7L0

chr1: 228,456,979-228,457,873

down-regulated

N/A

HLA-DMA

major histocompatibility complex, class II, DM alpha

3108

P28067

chr6: 32,948,613-32,969,094

down-regulated

N/A

HLA-DMB

major histocompatibility complex, class II, DM beta

3109

P28068

chr6: 32,934,629-32,941,070

down-regulated

N/A

HLA-DPA1

major histocompatibility complex, class II, DP alpha 1

3113

P20036

chr6: 33,064,569-33,080,775

down-regulated

N/A

HLA-DQA1

major histocompatibility complex, class II, DQ alpha 1

3117

P01909

chr6: 32,628,179-32,647,062

down-regulated

N/A

HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

3119

P01920

chr6: 32,659,467-32,668,383

down-regulated

N/A

HLA-DRA

major histocompatibility complex, class II, DR alpha

3122

P01903

chr6: 32,439,842-32,445,046

down-regulated

N/A

HLA-DRB1

major histocompatibility complex, class II, DR beta 1

3123

P04229

chr6: 32,578,769-32,589,848

down-regulated

N/A

HLA-DRB5

major histocompatibility complex, class II, DR beta 5

3127

Q30154

chr6: 32,517,343-32,530,287

down-regulated

N/A

HS3ST1

heparan sulfate-glucosamine 3-sulfotransferase 1

9957

O14792

chr4: 11,393,150-11,429,765

up-regulated

N/A

HSP90AA1

heat shock protein 90kDa alpha family class A member 1

3320

P07900

chr14: 102,080,738-102,139,699

down-regulated

N/A

HSPA1A

heat shock protein family A (Hsp70) member 1A

3303

P0DMV8

chr6: 31,815,464-31,817,946

down-regulated

N/A

HSPA1B

heat shock protein family A (Hsp70) member 1B

3304

P0DMV9

chr6: 31,827,735-31,830,255

down-regulated

N/A

HSPA6

heat shock protein family A (Hsp70) member 6

3310

P17066

chr1: 161,524,540-161,526,910

down-regulated

N/A

IER2

immediate early response 2

9592

Q9BTL4

chr19: 13,150,415-13,154,908

down-regulated

N/A

IGKC

immunoglobulin kappa constant

3514

P01834

chr2: 88,857,161-88,857,683

down-regulated

N/A

IGLJ3

immunoglobulin lambda joining 3

28831

N/A

chr22: 22,904,850-22,905,025

down-regulated

N/A

ITPK1

inositol-tetrakisphosphate 1-kinase

3705

Q13572

chr14: 92,936,914-93,116,320

down-regulated

N/A

JUN

jun proto-oncogene

3725

P05412

chr1: 58,780,788-58,784,327

down-regulated

N/A

JUNB

jun B proto-oncogene

3726

P17275

chr19: 12,791,496-12,793,315

down-regulated

N/A

JUND

jun D proto-oncogene

3727

P17535

chr19: 18,279,760-18,281,622

down-regulated

N/A

KIF5C

kinesin family member 5C

3800

O60282

chr2: 148,875,250-149,026,759

up-regulated

N/A

KLF2

Kruppel-like factor 2

10365

Q9Y5W3

chr19: 16,324,817-16,327,874

down-regulated

N/A

KLF4

Kruppel-like factor 4 (gut)

9314

O43474

chr9: 107,484,852-107,490,482

down-regulated

N/A

KLK10

kallikrein related peptidase 10

5655

O43240

chr19: 51,012,739-51,020,175

down-regulated

N/A

LAMP5

lysosomal associated membrane protein family member 5

24141

Q9UJQ1

chr20: 9,514,358-9,530,524

up-regulated

N/A

LOC148936

hypothetical protein LOC148936

148936

N/A

chr1

up-regulated

N/A

LOC93622

Morf4 family associated protein 1-like 1 pseudogene

93622

N/A

chr4: 6,674,094-6,676,047

down-regulated

N/A

MAFF

v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F

23764

Q9ULX9

chr22: 38,200,767-38,216,511

down-regulated

N/A

MAPK8IP1

mitogen-activated protein kinase 8 interacting protein 1

9479

Q9UQF2

chr11: 45,885,651-45,906,465

down-regulated

N/A

MBOAT2

membrane bound O-acyltransferase domain containing 2

129642

Q6ZWT7

chr2: 8,852,690-9,003,813

up-regulated

N/A

MEIS1

Meis homeobox 1

4211

O00470

chr2: 66,433,452-66,573,869

down-regulated

N/A

MFSD4B

KIAA1919

91749

Q5TF39

chr6: 111,259,348-111,271,167

down-regulated

N/A

MIF4GD

MIF4G domain containing

57409

A9UHW6

chr17: 75,266,228-75,271,227

down-regulated

N/A

MXRA5

matrix-remodelling associated 5

25878

Q9NR99

chrX: 3,308,565-3,346,641

down-regulated

N/A

NFIL3

nuclear factor, interleukin 3 regulated

4783

Q16649

chr9: 91,409,045-91,423,862

down-regulated

N/A

NFKBIZ

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

64332

Q9BYH8

chr3: 101,827,991-101,861,022

down-regulated

N/A

NID2

nidogen 2

22795

Q14112

chr14: 52,004,803-52,069,228

up-regulated

N/A

NR4A1

nuclear receptor subfamily 4 group A member 1

3164

P22736

chr12: 52,022,832-52,059,507

down-regulated

N/A

NR4A2

nuclear receptor subfamily 4 group A member 2

4929

P43354

chr2: 156,324,432-156,342,348

down-regulated

N/A

OGN

osteoglycin

4969

P20774

chr9: 92,383,967-92,404,696

up-regulated

N/A

OMD

osteomodulin

4958

Q99983

chr9: 92,414,245-92,424,461

up-regulated

N/A

PAG1

phosphoprotein membrane anchor with glycosphingolipid microdomains 1

55824

Q9NWQ8

chr8: 80,967,810-81,112,068

up-regulated

N/A

PAPLN

papilin, proteoglycan-like sulfated glycoprotein

89932

O95428

chr14: 73,237,497-73,274,640

down-regulated

N/A

PCDH18

protocadherin 18

54510

Q9HCL0

chr4: 137,518,918-137,532,494

up-regulated

N/A

PDGFC

platelet derived growth factor C

56034

Q9NRA1

chr4: 156,760,454-156,971,394

up-regulated

N/A

PDPN

podoplanin

10630

Q86YL7

chr1: 13,583,465-13,617,957

up-regulated

N/A

PDS5B

PDS5 cohesin associated factor B

23047

Q9NTI5

chr13: 32,586,427-32,778,019

up-regulated

N/A

PGRMC2

progesterone receptor membrane component 2

10424

O15173

chr4: 128,269,237-128,288,829

down-regulated

N/A

PIEZO1

piezo-type mechanosensitive ion channel component 1

9780

Q92508

chr16: 88,715,343-88,785,211

up-regulated

N/A

PLA2G2A

phospholipase A2 group IIA

5320

P14555

chr1: 19,975,431-19,980,416

down-regulated

N/A

PLAG1

PLAG1 zinc finger

5324

Q6DJT9

chr8: 56,160,904-56,211,324

down-regulated

N/A

PLAT

plasminogen activator, tissue

5327

P00750

chr8: 42,175,233-42,207,724

up-regulated

N/A

POMK

protein-O-mannose kinase

84197

Q9H5K3

chr8: 43,093,506-43,123,434

down-regulated

N/A

PPARG

peroxisome proliferator-activated receptor gamma

5468

P37231

chr3: 12,287,368-12,434,356

up-regulated

N/A

PPP1R15A

protein phosphatase 1 regulatory subunit 15A

23645

O75807

chr19: 48,872,392-48,876,057

down-regulated

N/A

PRDM6

PR domain containing 6

93166

Q9NQX0

chr5: 123,089,121-123,194,266

up-regulated

N/A

PSEN2

presenilin 2

5664

P49810

chr1: 226,870,184-226,896,105

down-regulated

N/A

QPRT

quinolinate phosphoribosyltransferase

23475

Q15274

chr16: 29,679,008-29,698,699

down-regulated

N/A

RAB11FIP1

RAB11 family interacting protein 1 (class I)

80223

Q6WKZ4

chr8: 37,858,618-37,899,467

down-regulated

N/A

RAMP1

receptor (G protein-coupled) activity modifying protein 1

10267

O60894

chr2: 237,858,893-237,912,114

down-regulated

N/A

RERG

RAS-like, estrogen-regulated, growth inhibitor

85004

Q96A58

chr12: 15,107,783-15,348,675

down-regulated

N/A

RGS2

regulator of G-protein signaling 2

5997

P41220

chr1: 192,809,039-192,812,283

down-regulated

N/A

RHOB

ras homolog family member B

388

P62745

chr2: 20,447,074-20,449,445

down-regulated

N/A

RHOU

ras homolog family member U

58480

Q7L0Q8

chr1: 228,735,077-228,746,669

down-regulated

N/A

ROBO2

roundabout guidance receptor 2

6092

Q9HCK4

chr3: 75,906,695-77,649,964

up-regulated

N/A

RPS4Y1

ribosomal protein S4, Y-linked 1

6192

P22090

chrY: 2,841,486-2,932,000

up-regulated

N/A

S100A4

S100 calcium binding protein A4

6275

P26447

chr1: 153,543,613-153,550,136

down-regulated

N/A

SEC11C

SEC11 homolog C, signal peptidase complex subunit

90701

Q9BY50

chr18: 59,139,477-59,158,836

down-regulated

N/A

SERPINA3

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

12

P01011

chr14: 94,612,377-94,624,055

down-regulated

N/A

SGK3

serum/glucocorticoid regulated kinase family member 3

23678

Q96BR1

chr8: 66,712,418-66,862,022

down-regulated

N/A

SLC18A2

solute carrier family 18 (vesicular monoamine transporter), member 2

6571

Q05940

chr10: 117,241,093-117,279,430

up-regulated

N/A

SLC24A3

solute carrier family 24 (sodium/potassium/calcium exchanger), member 3

57419

Q9HC58

chr20: 19,212,646-19,722,937

down-regulated

N/A

SLC2A3

solute carrier family 2 (facilitated glucose transporter), member 3

6515

P11169

chr12: 7,919,230-7,936,275

down-regulated

N/A

SLC7A8

solute carrier family 7 (amino acid transporter light chain, L system), member 8

23428

Q9UHI5

chr14: 23,125,295-23,183,674

down-regulated

N/A

SLCO3A1

solute carrier organic anion transporter family member 3A1

28232

Q9UIG8

chr15: 91,853,695-92,172,435

up-regulated

N/A

SLIT2

slit guidance ligand 2

9353

O94813

chr4: 20,253,260-20,620,561

down-regulated

N/A

SMIM14

small integral membrane protein 14

201895

Q96QK8

chr4: 39,546,330-39,639,090

down-regulated

N/A

SOAT1

sterol O-acyltransferase 1

6646

P35610

chr1: 179,293,714-179,358,680

up-regulated

N/A

SOCS3

suppressor of cytokine signaling 3

9021

O14543

chr17: 78,356,778-78,360,077

down-regulated

N/A

SPIDR

scaffolding protein involved in DNA repair

23514

Q14159

chr8: 47,260,575-47,736,306

down-regulated

N/A

SPINT2

serine peptidase inhibitor, Kunitz type, 2

10653

O43291

chr19: 38,244,035-38,292,614

down-regulated

N/A

STAG3L4

stromal antigen 3-like 4 (pseudogene)

64940

Q8TBR4

chr7: 67,302,621-67,321,526

down-regulated

N/A

SYT1

synaptotagmin 1

6857

P21579

chr12: 78,863,993-79,452,008

up-regulated

N/A

TCF21

transcription factor 21

6943

O43680

chr6: 133,889,138-133,895,553

up-regulated

N/A

TFPI2

tissue factor pathway inhibitor 2

7980

P48307

chr7: 93,885,397-93,890,991

down-regulated

N/A

THBS1

thrombospondin 1

7057

P07996

chr15: 39,581,079-39,599,466

up-regulated

N/A

TM4SF18

transmembrane 4 L six family member 18

116441

Q96CE8

chr3: 149,318,498-149,334,414

up-regulated

N/A

TMEM176A

transmembrane protein 176A

55365

Q96HP8

chr7: 150,800,403-150,805,120

down-regulated

N/A

TMOD1

tropomodulin 1

7111

P28289

chr9: 97,501,180-97,601,748

down-regulated

N/A

TNFRSF25

tumor necrosis factor receptor superfamily member 25

8718

Q93038

chr1: 6,461,151-6,466,195

up-regulated

N/A

TRB

T cell receptor beta locus

6957

N/A

chr7: 142,299,051-142,874,380

down-regulated

N/A

TTC3

tetratricopeptide repeat domain 3

7267

P53804

chr21: 37,073,226-37,203,112

up-regulated

N/A

UBE2QL1

ubiquitin conjugating enzyme E2Q family-like 1

134111

A1L167

chr5: 6,448,623-6,494,909

up-regulated

N/A

UBXN8

UBX domain protein 8

7993

O00124

chr8: 30,732,247-30,767,006

up-regulated

N/A

UFSP2

UFM1-specific peptidase 2

55325

Q9NUQ7

chr4: 185,399,540-185,425,985

down-regulated

N/A

VMP1

vacuole membrane protein 1

81671

Q96GC9

chr17: 59,707,192-59,842,255

down-regulated

N/A

WISP1

WNT1 inducible signaling pathway protein 1

8840

O95388

chr8: 133,191,039-133,230,344

up-regulated

N/A

WNT5A

wingless-type MMTV integration site family member 5A

7474

P41221

chr3: 55,465,715-55,490,539

up-regulated

N/A

ZEB1

zinc finger E-box binding homeobox 1

6935

P37275

chr10: 31,318,495-31,529,814

down-regulated

N/A

ZNF331

zinc finger protein 331

55422

Q9NQX6

chr19: 53,520,981-53,580,269

down-regulated

N/A