Protein Description

Gene Symbol GPX4
Entrez ID 2879
Uniprot ID P36969
Description glutathione peroxidase 4
Chromosomal Location chr19: 1,103,926-1,106,791
Ontology GO ID GO Term Definition Evidence

BP

GO:0006644

phospholipid metabolic process

The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.

TAS

BP

GO:0006979

response to oxidative stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

IEA

BP

GO:0007275

multicellular organism development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

IEA

BP

GO:0019372

lipoxygenase pathway

The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase.

TAS

BP

GO:0055114

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

TAS

BP

GO:0098869

cellular oxidant detoxification

Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

TAS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0004602

glutathione peroxidase activity

Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.

TAS

MF

GO:0047066

phospholipid-hydroperoxide glutathione peroxidase activity

Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione.

IEA

Domain ID Description

IPR000889

Glutathione peroxidase

IPR012336

Thioredoxin-like fold

IPR029759

Glutathione peroxidase active site

IPR029760

Glutathione peroxidase conserved site

Pathway ID Pathway Term Pathway Source

hsa00480

Glutathione metabolism

KEGG

WP15

Selenium Micronutrient Network

WikiPathways

WP100

Glutathione metabolism

WikiPathways

WP28

Selenium Metabolism and Selenoproteins

WikiPathways

WP702

Metapathway biotransformation

WikiPathways

WP176

Folate Metabolism

WikiPathways

WP3940

One carbon metabolism and related pathways

WikiPathways

UMLS CUI UMLS Term

C0006635

Cadmium Poisoning

C0009404

Colorectal Neoplasms

C0010417

Cryptorchidism

C0018801

Heart Failure

C0021364

Male Infertility

C0752351

Embryo Loss

C1458155

Mammary Neoplasms

Tissue Cell Type

testis

cells in seminiferous ducts

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

ALDOA

226

P04075

0.49

ALDOC

230

P09972

0.49

AKR1B1

231

P15121

0.49

DUT

1854

P33316

0.49

ENO1

2023

P06733

0.49

ENO2

2026

P09104

0.49

ENO3

2027

P13929

0.49

FKBP1A

2280

P62942

0.49

HSPE1

3336

P61604

0.49

ME1

4199

P48163

0.49

PIN1

5300

Q13526

0.49

PRDX2

7001

P32119

0.49

PPIF

10105

P30405

0.49

STIP1

10963

P31948

0.49

GLRX2

51022

Q9NS18

0.49

MAPK13

5603

O15264

0.63

PRDX6

9588

P30041

0.73

ETFA

2108

P13804

0.49

ETFB

2109

P38117

0.49

FKBP2

2286

P26885

0.49

HSD17B10

3028

Q99714

0.49

HINT1

3094

P49773

0.49

IMPA2

3613

O14732

0.49

SOD1

6647

P00441

0.49

SOD2

6648

P04179

0.49

TAGLN

6876

Q01995

0.49

TKT

7086

P29401

0.49

UCHL3

7347

P15374

0.49

VDAC1

7416

P21796

0.49

VDAC2

7417

P45880

0.49

EZR

7430

P15311

0.49

TAGLN2

8407

P37802

0.49

CEP170

9859

Q5SW79

0.49

NUTF2

10204

P61970

0.49

ERO1B

56605

Q86YB8

0.49

PGAM4

441531

Q8N0Y7

0.49

JUN

3725

P05412

0.63

OTUB1

55611

Q96FW1

0.63

OTUD5

55593

Q96G74

0.76