Protein Description

Gene Symbol ALOX5
Entrez ID 240
Uniprot ID P09917
Description arachidonate 5-lipoxygenase
Chromosomal Location chr10: 45,374,176-45,446,119
Ontology GO ID GO Term Definition Evidence

BP

GO:0002540

leukotriene production involved in inflammatory response

The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.

IEA

BP

GO:0006691

leukotriene metabolic process

The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.

TAS

BP

GO:0019370

leukotriene biosynthetic process

The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.

IDA

BP

GO:0019372

lipoxygenase pathway

The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase.

TAS

BP

GO:0055114

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

IEA

BP

GO:2001300

lipoxin metabolic process

The chemical reactions and pathways involving a lipoxin. A lipoxin is a non-classic eicosanoid and signalling molecule that has four conjugated double bonds and is derived from arachidonic acid.

TAS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0005635

nuclear envelope

The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

IDA|TAS

CC

GO:0005641

nuclear envelope lumen

The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IDA|TAS

CC

GO:0016363

nuclear matrix

The dense fibrillar network lying on the inner side of the nuclear membrane.

IDA

CC

GO:0031965

nuclear membrane

Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

IDA

MF

GO:0004051

arachidonate 5-lipoxygenase activity

Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate.

IDA

MF

GO:0005506

iron ion binding

Interacting selectively and non-covalently with iron (Fe) ions.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

Domain ID Description

IPR000907

Lipoxygenase

IPR001024

PLAT/LH2 domain

IPR001885

Lipoxygenase, mammalian

IPR013819

Lipoxygenase, C-terminal

IPR020833

Lipoxygenase, iron binding site

IPR020834

Lipoxygenase, conserved site

Pathway ID Pathway Term Pathway Source

hsa00590

Arachidonic acid metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

hsa04664

Fc epsilon RI signaling pathway

KEGG

hsa04726

Serotonergic synapse

KEGG

hsa04913

Ovarian steroidogenesis

KEGG

hsa05145

Toxoplasmosis

KEGG

WP167

Eicosanoid Synthesis

WikiPathways

WP15

Selenium Micronutrient Network

WikiPathways

h_eicosanoidPathway

Eicosanoid Metabolism

BioCarta

UMLS CUI UMLS Term

C0001430

Adenoma

C0003873

Rheumatoid Arthritis

C0004096

Asthma

C0004153

Atherosclerosis

C0009319

Colitis

C0009375

Colonic Neoplasms

C0009376

Colonic Polyps

C0011609

Drug Eruptions

C0020429

Hyperalgesia

C0020542

Pulmonary Hypertension

C0023473

Myeloid Leukemia, Chronic

C0026766

Multiple Organ Failure

C0027626

Neoplasm Invasiveness

C0027627

Neoplasm Metastasis

C0035126

Reperfusion Injury

C0038356

Stomach Neoplasms

C0042109

Urticaria

C0376618

Endotoxemia

C0740392

Infarction, Middle Cerebral Artery

Tissue Cell Type

caudate

glial cells

cerebral cortex

glial cells

hippocampus

glial cells

lung

macrophages

lymph node

germinal center cells

skin

Langerhans

spleen

cells in white pulp

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

ACTB

60

P60709

0.52

APP

351

P05067

0.56

MEOX1

4222

P50221

0.63

REL

5966

Q04864

0.63

MAD1L1

8379

Q9Y6D9

0.63

COTL1P1

27170

N/A

0.63

HHIPL2

79802

Q6UWX4

0.63

CEP63

80254

Q96MT8

0.63

SYCE1

93426

Q8N0S2

0.63

NUTM1

256646

Q86Y26

0.63

CEP57L1

285753

Q8IYX8

0.63

FGR

2268

P09769

0.70

HCK

3055

P08631

0.70

DICER1

23405

Q9UPY3

0.84

GRB2

2885

P62993

0.85

PIK3R1

5295

P27986

0.63

TGFBRAP1

9392

Q8WUH2

0.65

ALOX5AP

241

P20292

0.69

CAMK2G

818

Q13555

0.70

LTC4S

4056

Q16873

0.70

PRKACA

5566

P17612

0.70

YES1

7525

P07947

0.70

MAPKAPK2

9261

P49137

0.82

COTL1

23406

Q14019

0.90