Gene Symbol | ALOX5 |
Entrez ID | 240 |
Uniprot ID | P09917 |
Description | arachidonate 5-lipoxygenase |
Chromosomal Location | chr10: 45,374,176-45,446,119 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0002540 |
leukotriene production involved in inflammatory response |
The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. |
IEA |
BP |
GO:0006691 |
leukotriene metabolic process |
The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. |
TAS |
BP |
GO:0019370 |
leukotriene biosynthetic process |
The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. |
IDA |
BP |
GO:0019372 |
lipoxygenase pathway |
The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase. |
TAS |
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IEA |
BP |
GO:2001300 |
lipoxin metabolic process |
The chemical reactions and pathways involving a lipoxin. A lipoxin is a non-classic eicosanoid and signalling molecule that has four conjugated double bonds and is derived from arachidonic acid. |
TAS |
CC |
GO:0005615 |
extracellular space |
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
IDA |
CC |
GO:0005635 |
nuclear envelope |
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
IDA|TAS |
CC |
GO:0005641 |
nuclear envelope lumen |
The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide. |
IDA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
IDA|TAS |
CC |
GO:0016363 |
nuclear matrix |
The dense fibrillar network lying on the inner side of the nuclear membrane. |
IDA |
CC |
GO:0031965 |
nuclear membrane |
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
IDA |
MF |
GO:0004051 |
arachidonate 5-lipoxygenase activity |
Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. |
IDA |
MF |
GO:0005506 |
iron ion binding |
Interacting selectively and non-covalently with iron (Fe) ions. |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
Domain ID | Description |
---|---|
IPR000907 |
Lipoxygenase |
IPR001024 |
PLAT/LH2 domain |
IPR001885 |
Lipoxygenase, mammalian |
IPR013819 |
Lipoxygenase, C-terminal |
IPR020833 |
Lipoxygenase, iron binding site |
IPR020834 |
Lipoxygenase, conserved site |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00590 |
Arachidonic acid metabolism |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
hsa04664 |
Fc epsilon RI signaling pathway |
KEGG |
hsa04726 |
Serotonergic synapse |
KEGG |
hsa04913 |
Ovarian steroidogenesis |
KEGG |
hsa05145 |
Toxoplasmosis |
KEGG |
WP167 |
Eicosanoid Synthesis |
WikiPathways |
WP15 |
Selenium Micronutrient Network |
WikiPathways |
h_eicosanoidPathway |
Eicosanoid Metabolism |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0001430 |
Adenoma |
C0003873 |
Rheumatoid Arthritis |
C0004096 |
Asthma |
C0004153 |
Atherosclerosis |
C0009319 |
Colitis |
C0009375 |
Colonic Neoplasms |
C0009376 |
Colonic Polyps |
C0011609 |
Drug Eruptions |
C0020429 |
Hyperalgesia |
C0020542 |
Pulmonary Hypertension |
C0023473 |
Myeloid Leukemia, Chronic |
C0026766 |
Multiple Organ Failure |
C0027626 |
Neoplasm Invasiveness |
C0027627 |
Neoplasm Metastasis |
C0035126 |
Reperfusion Injury |
C0038356 |
Stomach Neoplasms |
C0042109 |
Urticaria |
C0376618 |
Endotoxemia |
C0740392 |
Infarction, Middle Cerebral Artery |
Tissue | Cell Type |
---|---|
caudate |
glial cells |
cerebral cortex |
glial cells |
hippocampus |
glial cells |
lung |
macrophages |
lymph node |
germinal center cells |
skin |
Langerhans |
spleen |
cells in white pulp |
urinary bladder |
urothelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ACTB |
60 |
P60709 |
0.52 |
APP |
351 |
P05067 |
0.56 |
MEOX1 |
4222 |
P50221 |
0.63 |
REL |
5966 |
Q04864 |
0.63 |
MAD1L1 |
8379 |
Q9Y6D9 |
0.63 |
COTL1P1 |
27170 |
N/A |
0.63 |
HHIPL2 |
79802 |
Q6UWX4 |
0.63 |
CEP63 |
80254 |
Q96MT8 |
0.63 |
SYCE1 |
93426 |
Q8N0S2 |
0.63 |
NUTM1 |
256646 |
Q86Y26 |
0.63 |
CEP57L1 |
285753 |
Q8IYX8 |
0.63 |
FGR |
2268 |
P09769 |
0.70 |
HCK |
3055 |
P08631 |
0.70 |
DICER1 |
23405 |
Q9UPY3 |
0.84 |
GRB2 |
2885 |
P62993 |
0.85 |
PIK3R1 |
5295 |
P27986 |
0.63 |
TGFBRAP1 |
9392 |
Q8WUH2 |
0.65 |
ALOX5AP |
241 |
P20292 |
0.69 |
CAMK2G |
818 |
Q13555 |
0.70 |
LTC4S |
4056 |
Q16873 |
0.70 |
PRKACA |
5566 |
P17612 |
0.70 |
YES1 |
7525 |
P07947 |
0.70 |
MAPKAPK2 |
9261 |
P49137 |
0.82 |
COTL1 |
23406 |
Q14019 |
0.90 |