BP

GO:0050848

regulation of calcium-mediated signaling

Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.

IMP

BP

GO:0050860

negative regulation of T cell receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.

IMP

BP

GO:0051607

defense response to virus

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

IEA

BP

GO:0060333

interferon-gamma-mediated signaling pathway

A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.

TAS

BP

GO:0070373

negative regulation of ERK1 and ERK2 cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

IMP

BP

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.

IMP

BP

GO:1900041

negative regulation of interleukin-2 secretion

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2 secretion.

IMP

BP

GO:1903076

regulation of protein localization to plasma membrane

Any process that modulates the frequency, rate or extent of protein localization to plasma membrane.

IGI

BP

GO:1903077

negative regulation of protein localization to plasma membrane

Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.

IMP

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IEA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IDA|TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IEA

MF

GO:0003779

actin binding

Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.

IDA

MF

GO:0003924

GTPase activity

Catalysis of the reaction: GTP + H2O = GDP + phosphate.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005525

GTP binding

Interacting selectively and non-covalently with GTP, guanosine triphosphate.

IEA

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI

MF

GO:0019955

cytokine binding

Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.

IPI

MF

GO:0030507

spectrin binding

Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.

IPI

MF

GO:0042802

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

IPI

MF

GO:0051879

Hsp90 protein binding

Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.

IPI