Protein Description

Gene Symbol FUT4
Entrez ID 2526
Uniprot ID P22083
Description fucosyltransferase 4
Chromosomal Location chr11: 94,543,840-94,549,898
Ontology GO ID GO Term Definition Evidence

BP

GO:0005975

carbohydrate metabolic process

The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.

TAS

BP

GO:0006486

protein glycosylation

A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

TAS

BP

GO:0006487

protein N-linked glycosylation

A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.

IBA

BP

GO:0036065

fucosylation

The covalent attachment of a fucosyl group to an acceptor molecule.

IEA

BP

GO:0042355

L-fucose catabolic process

The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose).

NAS

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IBA

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

TAS

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IEA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

TAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0032580

Golgi cisterna membrane

The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex.

IEA

CC

GO:0071944

cell periphery

The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.

IEA

MF

GO:0008417

fucosyltransferase activity

Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

TAS

MF

GO:0046920

alpha-(1->3)-fucosyltransferase activity

Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage.

TAS

Domain ID Description

IPR001503

Glycosyl transferase family 10

IPR031481

Fucosyltransferase, N-terminal

Pathway ID Pathway Term Pathway Source

hsa00515

Mannose type O-glycan biosynthesis

KEGG

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

KEGG

hsa01100

Metabolic pathways

KEGG

h_aMANpathway

Steps in the Glycosylation of Mammalian N-linked Oligosaccarides

BioCarta

UMLS CUI UMLS Term

C0017661

Iga Glomerulonephritis

C0040053

Thrombosis

Tissue Cell Type

bone marrow

hematopoietic cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

CR1

1378

P17927

0.52

ITGB2

3689

P05107

0.52

SELP

6403

P16109

0.52

HLA-DPA1

3113

P20036

0.63

ISG15

9636

P05161

0.63