Protein Description

Gene Symbol FUS
Entrez ID 2521
Uniprot ID P35637
Description FUS RNA binding protein
Chromosomal Location chr16: 31,180,110-31,194,871
Ontology GO ID GO Term Definition Evidence

BP

GO:0000398

mRNA splicing, via spliceosome

The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

TAS

BP

GO:0071277

cellular response to calcium ion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.

IEA

BP

GO:1903506

regulation of nucleic acid-templated transcription

Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA|TAS

CC

GO:0005844

polysome

A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro.

IEA

CC

GO:0043204

perikaryon

The portion of the cell soma (cell body) that excludes the nucleus.

IEA

CC

GO:0044327

dendritic spine head

Distal part of the dendritic spine, that carries the post-synaptic density.

IEA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IEA

MF

GO:0000166

nucleotide binding

Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

IEA

MF

GO:0003677

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

IEA

MF

GO:0003713

transcription coactivator activity

Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.

IDA

MF

GO:0003723

RNA binding

Interacting selectively and non-covalently with an RNA molecule or a portion thereof.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008270

zinc ion binding

Interacting selectively and non-covalently with zinc (Zn) ions.

IEA

MF

GO:0030331

estrogen receptor binding

Interacting selectively and non-covalently with an estrogen receptor.

IEA

MF

GO:0031489

myosin V binding

Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.

IEA

MF

GO:0035255

ionotropic glutamate receptor binding

Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.

IEA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

MF

GO:0046965

retinoid X receptor binding

Interacting selectively and non-covalently with a retinoid X receptor.

IEA

MF

GO:0046966

thyroid hormone receptor binding

Interacting selectively and non-covalently with a thyroid hormone receptor.

IEA

Domain ID Description

IPR000504

RNA recognition motif domain

IPR001876

Zinc finger, RanBP2-type

IPR034459

RNA-binding protein FUS

Pathway ID Pathway Term Pathway Source

hsa05202

Transcriptional misregulation in cancer

KEGG

WP411

mRNA Processing

WikiPathways

UMLS CUI UMLS Term

C0002736

Amyotrophic Lateral Sclerosis

C0206634

Liposarcoma, Myxoid

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

appendix

lymphoid tissue

bone marrow

hematopoietic cells

breast

adipocytes

breast

glandular cells

breast

myoepithelial cells

bronchus

respiratory epithelial cells

caudate

glial cells

caudate

neuronal cells

cerebellum

cells in granular layer

cerebellum

cells in molecular layer

cerebellum

Purkinje cells

cerebral cortex

endothelial cells

cerebral cortex

glial cells

cerebral cortex

neuronal cells

cervix, uterine

glandular cells

cervix, uterine

squamous epithelial cells

colon

endothelial cells

colon

glandular cells

colon

peripheral nerve/ganglion

duodenum

glandular cells

endometrium

cells in endometrial stroma

endometrium

glandular cells

epididymis

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

heart muscle

myocytes

hippocampus

glial cells

hippocampus

neuronal cells

kidney

cells in glomeruli

kidney

cells in tubules

liver

bile duct cells

lung

macrophages

lung

pneumocytes

lymph node

germinal center cells

lymph node

non-germinal center cells

nasopharynx

respiratory epithelial cells

oral mucosa

squamous epithelial cells

ovary

follicle cells

ovary

ovarian stroma cells

pancreas

exocrine glandular cells

pancreas

islets of Langerhans

parathyroid gland

glandular cells

prostate

glandular cells

rectum

glandular cells

salivary gland

glandular cells

seminal vesicle

glandular cells

skeletal muscle

myocytes

skin

fibroblasts

skin

keratinocytes

skin

Langerhans

skin

melanocytes

skin

epidermal cells

small intestine

glandular cells

smooth muscle

smooth muscle cells

soft tissue

adipocytes

soft tissue

chondrocytes

soft tissue

fibroblasts

soft tissue

peripheral nerve

spleen

cells in red pulp

spleen

cells in white pulp

stomach

glandular cells

testis

cells in seminiferous ducts

testis

Leydig cells

thyroid gland

glandular cells

tonsil

germinal center cells

tonsil

non-germinal center cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

ACAT1

38

P24752

0.49

IL7R

3575

P16871

0.49

MEF2D

4209

Q14814

0.49

PFKP

5214

Q01813

0.49

RPLP1

6176

P05386

0.49

TARS

6897

P26639

0.49

TLN1

7094

Q9Y490

0.49

DNAJC7

7266

Q99615

0.49

VCL

7414

P18206

0.49

EIF4H

7458

Q15056

0.49

PICALM

8301

Q13492

0.49

HNRNPDL

9987

O14979

0.49

DDX17

10521

Q92841

0.49

GSE1

23199

Q14687

0.49

MRPS18B

28973

Q9Y676

0.49

SAP30BP

29115

Q9UHR5

0.49

MBD3

53615

O95983

0.49

ARMC1

55156

Q9NVT9

0.49

NPLOC4

55666

Q8TAT6

0.49

C2orf49

79074

Q9BVC5

0.49

NAA50

80218

Q9GZZ1

0.49

MAX

4149

P61244

0.56

HNRNPA3

220988

P51991

0.59

ABCA1

19

O95477

0.63

ACACA

31

Q13085

0.63

ACTB

60

P60709

0.63

AHCY

191

P23526

0.63

ALB

213

P02768

0.63

ALDOA

226

P04075

0.63

SLC25A5

292

P05141

0.63

ANXA2P2

304

A6NMY6

0.63

ANXA5

308

P08758

0.63

ATP5A1

498

P25705

0.63

ATP5B

506

P06576

0.63

BCS1L

617

Q9Y276

0.63

C6

729

P13671

0.63

CA2

760

P00918

0.63

CCT6A

908

P40227

0.63

CDH4

1002

P55283

0.63

CFL1

1072

P23528

0.63

CKB

1152

P12277

0.63

CSE1L

1434

P55060

0.63

DGKA

1606

P23743

0.63

DDX1

1653

Q92499

0.63

DDX5

1655

P17844

0.63

DHX15

1665

O43143

0.63

DLD

1738

P09622

0.63

EEF2

1938

P13639

0.63

EIF4A1

1973

P60842

0.63

ENO1

2023

P06733

0.63

F7

2155

P08709

0.63

FASN

2194

P49327

0.63

GAPDH

2597

P04406

0.63

GLUD1

2746

P00367

0.63

GNAS

2778

P84996

0.63

GOT2

2806

P00505

0.63

GPI

2821

P06744

0.63

PDIA3

2923

P30101

0.63

GSTP1

2950

P09211

0.63

H3F3A; H3F3B

3020

P84243

0.63

HNRNPF

3185

P52597

0.63

HNRNPH1

3187

P31943

0.63

HNRNPK

3190

P61978

0.63

HPRT1

3251

P00492

0.63

HSPA8

3312

P11142

0.63

HSPA9

3313

P38646

0.63

HSP90AA1

3320

P07900

0.63

HSP90AB1

3326

P08238

0.63

HSPD1

3329

P10809

0.63

ITK

3702

Q08881

0.63

KPNB1

3837

Q14974

0.63

KPNA2

3838

P52292

0.63

LDHA

3939

P00338

0.63

LDHB

3945

P07195

0.63

LYZ

4069

P61626

0.63

MAT2A

4144

P31153

0.63

MDH2

4191

P40926

0.63

MAP3K3

4215

Q99759

0.63

MFGE8

4240

Q08431

0.63

MTAP

4507

Q13126

0.63

MTHFD1

4522

P11586

0.63

MYH10

4628

P35580

0.63

NAP1L1

4673

P55209

0.63

NPM1

4869

P06748

0.63

OAT

4942

P04181

0.63

PRDX1

5052

Q06830

0.63

PCBP2

5094

Q15366

0.63

PCNA

5111

P12004

0.63

PFKL

5211

P17858

0.63

PFN1

5216

P07737

0.63

PGM1

5236

P36871

0.63

PHB

5245

P35232

0.63

SLC25A3

5250

Q00325

0.63

PKM

5315

P14618

0.63

PPIA

5478

P62937

0.63

PYCR1

5831

P32322

0.63

RAN

5901

P62826

0.63

RBBP4

5928

Q09028

0.63

RPL4

6124

P36578

0.63

RPL11

6135

P62913

0.63

RPL12

6136

P30050

0.63

RPL18

6141

Q07020

0.63

RPN2

6185

P04844

0.63

RPS5

6193

P46782

0.63

RPS8

6202

P62241

0.63

RPS9

6203

P46781

0.63

RPS14

6208

P62263

0.63

SEC13

6396

P55735

0.63

SLC1A5

6510

Q15758

0.63

SNRPD2

6633

P62316

0.63

SSBP1

6742

Q04837

0.63

ST13

6767

P50502

0.63

STATH

6779

P02808

0.63

TCEB1

6921

Q15369

0.63

TCF4

6925

P15884

0.63

TCF3

6929

P15923

0.63

TCF7L2

6934

Q9NQB0

0.63

TCP1

6950

P17987

0.63

TKT

7086

P29401

0.63

TP73

7161

O15350

0.63

HSP90B1

7184

P14625

0.63

CCT3

7203

P49368

0.63

TUFM

7284

P49411

0.63

VCP

7415

P55072

0.63

YWHAZ

7534

P63104

0.63

TUBA1A

7846

Q71U36

0.63

RAB7A

7879

P51149

0.63

HIST2H2BE

8349

Q16778

0.63

RPL14

9045

P50914

0.63

TRIP4

9325

Q15650

0.63

TBPL1

9519

P62380

0.63

UBAP2L

9898

Q14157

0.63

SAE1

10055

Q9UBE0

0.63

ABCF2

10061

Q9UG63

0.63

SF3B4

10262

Q15427

0.63

SF3A1

10291

Q15459

0.63

TUBA1B

10376

P68363

0.63

SYNCRIP

10492

O60506

0.63

CCT7

10574

Q99832

0.63

CCT4

10575

P50991

0.63

CCT2

10576

P78371

0.63

PAICS

10606

P22234

0.63

KHDRBS3

10656

O75525

0.63

CCT8

10694

P50990

0.63

SF3A3

10946

Q12874

0.63

CKAP4

10970

Q07065

0.63

YWHAQ

10971

P27348

0.63

NUDT21

11051

O43809

0.63

CPSF6

11052

Q16630

0.63

ATXN2L

11273

Q8WWM7

0.63

DDX42

11325

Q86XP3

0.63

CCT5

22948

P48643

0.63

NCOA6

23054

Q14686

0.63

ERP44

23071

Q9BS26

0.63

UFL1

23376

O94874

0.63

HARS2

23438

P49590

0.63

SF3B3

23450

Q15393

0.63

RAD54B

25788

Q9Y620

0.63

FAM98A

25940

Q8NCA5

0.63

SERBP1

26135

Q8NC51

0.63

PHGDH

26227

O43175

0.63

ERAL1

26284

O75616

0.63

GOLIM4

27333

O00461

0.63

IGKV1-5

28299

P01602

0.63

YPEL1

29799

O60688

0.63

NSDHL

50814

Q15738

0.63

KLHL5

51088

Q96PQ7

0.63

PLCE1

51196

Q9P212

0.63

RTCB

51493

Q9Y3I0

0.63

LARS

51520

Q9P2J5

0.63

C14orf166

51637

Q9Y224

0.63

DNAJC10

54431

Q8IXB1

0.63

SPATA6

54558

Q9NWH7

0.63

TRPM4

54795

Q8TD43

0.63

NCAPG2

54892

Q86XI2

0.63

TXNL4B

54957

Q9NX01

0.63

HERC6

55008

Q8IVU3

0.63

UACA

55075

Q9BZF9

0.63

PSPC1

55269

Q8WXF1

0.63

CCDC88A

55704

Q3V6T2

0.63

UBAP2

55833

Q5T6F2

0.63

SLC22A11

55867

Q9NSA0

0.63

FANCM

57697

Q8IYD8

0.63

HIVEP3

59269

Q5T1R4

0.63

ARHGEF28

64283

Q8N1W1

0.63

PYCRL

65263

Q53H96

0.63

DHX40

79665

Q8IX18

0.63

DBF4B

80174

Q8NFT6

0.63

TTI2

80185

Q6NXR4

0.63

COL18A1

80781

P39060

0.63

GPR101

83550

Q96P66

0.63

CEP78

84131

Q5JTW2

0.63

FAM71F1

84691

Q96KD3

0.63

C11orf70

85016

Q9BRQ4

0.63

PPIL4

85313

Q8WUA2

0.63

MTSS1L

92154

Q765P7

0.63

TIMM50

92609

Q3ZCQ8

0.63

ARMC6

93436

Q6NXE6

0.63

HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4

121504

P62805

0.63

LSM12

124801

Q3MHD2

0.63

RAVER1

125950

Q8IY67

0.63

KLHL40

131377

Q2TBA0

0.63

PM20D2

135293

Q8IYS1

0.63

AMOT

154796

Q4VCS5

0.63

GIMAP8

155038

Q8ND71

0.63

CEP112

201134

Q8N8E3

0.63

ADCK5

203054

Q3MIX3

0.63

TUBB

203068

P07437

0.63

ATXN1L

342371

P0C7T5

0.63

LRRIQ4

344657

A6NIV6

0.63

GEN1

348654

Q17RS7

0.63

FLJ22447

400221

N/A

0.63

RPL9; RPL9P7; RPL9P8; RPL9P9

6133

P32969

0.63

PTBP2

58155

Q9UKA9

0.72

HNRNPD

3184

Q14103

0.73

HNRNPL

3191

P14866

0.73

HNRNPU

3192

Q00839

0.73

PGK1

5230

P00558

0.73

NONO

4841

Q15233

0.74

TAF15

8148

Q92804

0.78

FUS

2521

P35637

0.80

SRSF10

10772

O75494

0.86

DYNC1H1

1778

Q14204

0.49

AURKA

6790

O14965

0.49

UFD1L

7353

Q92890

0.49

TOMM34

10953

Q15785

0.49

TXLNA

200081

P40222

0.49

GRIN2D

2906

O15399

0.52

POLR2A

5430

P24928

0.52

GRIN1

2902

Q05586

0.59

PLEC

5339

Q15149

0.59

ARHGDIA

396

P52565

0.63

BMI1

648

P35226

0.63

CDK9

1025

P50750

0.63

CSNK1A1

1452

P48729

0.63

CSNK1E

1454

P49674

0.63

EGFR

1956

P00533

0.63

EZH2

2146

Q15910

0.63

GSK3B

2932

P49841

0.63

HK1

3098

P19367

0.63

HLA-B

3106

P30480

0.63

HNRNPA1

3178

P09651

0.63

INSR

3643

P06213

0.63

ITGA4

3676

P13612

0.63

JUN

3725

P05412

0.63

MAGEB2

4113

O15479

0.63

MCM2

4171

P49736

0.63

MDH1

4190

P40925

0.63

MDM2

4193

Q00987

0.63

NEDD8

4738

Q15843

0.63

NTRK1

4914

P04629

0.63

PARK2

5071

O60260

0.63

PCM1

5108

Q15154

0.63

PHKG2

5261

P15735

0.63

PIK3R2

5296

O00459

0.63

MAPK13

5603

O15264

0.63

PSMB7

5695

Q99436

0.63

PSMD12

5718

O00232

0.63

RPA1

6117

P27694

0.63

RPA2

6118

P15927

0.63

RPA3

6119

P35244

0.63

RPL31

6160

P62899

0.63

RPS6KA1

6195

Q15418

0.63

RPS6KB2

6199

Q9UBS0

0.63

SUMO3

6612

P55854

0.63

SUMO2

6613

P61956

0.63

STK4

6789

Q13043

0.63

UBA1

7317

P22314

0.63

UBE2I

7329

P63279

0.63

SUMO1

7341

P63165

0.63

WHSC1

7468

O96028

0.63

CUL5

8065

Q93034

0.63

YEATS4

8089

O95619

0.63

SF3A2

8175

Q15428

0.63

UBL4A

8266

P11441

0.63

STK24

8428

Q9Y6E0

0.63

CUL4B

8450

Q13620

0.63

CUL4A

8451

Q13619

0.63

CUL3

8452

Q13618

0.63

CUL2

8453

Q13617

0.63

CUL1

8454

Q13616

0.63

CAMK1

8536

Q14012

0.63

CADPS

8618

Q9ULU8

0.63

SRSF9

8683

Q13242

0.63

SQSTM1

8878

Q13501

0.63

SAFB2

9667

Q14151

0.63

KIAA0101

9768

Q15004

0.63

CUL7

9820

Q14999

0.63

EIF1B

10289

O60739

0.63

TNIP1

10318

Q15025

0.63

STK25

10494

O00506

0.63

COPS6

10980

Q7L5N1

0.63

COPS5

10987

Q92905

0.63

GABARAP

11337

O95166

0.63

GABARAPL2

11345

P60520

0.63

SNW1

22938

Q13573

0.63

FBXW11

23291

Q9UKB1

0.63

OBSL1

23363

O75147

0.63

SUZ12

23512

Q15022

0.63

GABARAPL1

23710

Q9H0R8

0.63

NUPR1

26471

O60356

0.63

RBMX

27316

P38159

0.63

EEF2K

29904

O00418

0.63

LUZP4

51213

Q9P127

0.63

DDX41

51428

Q9UJV9

0.63

SIRT7

51547

Q9NRC8

0.63

WWOX

51741

Q9NZC7

0.63

DCUN1D1

54165

Q96GG9

0.63

DGCR8

54487

Q8WYQ5

0.63

LYAR

55646

Q9NX58

0.63

RIOK2

55781

Q9BVS4

0.63

CAND1

55832

Q86VP6

0.63

MAP1LC3B

81631

Q9GZQ8

0.63

MAP1LC3A

84557

Q9H492

0.63

NKD2

85409

Q969F2

0.63

FAM58A

92002

Q8N1B3

0.63

TP53RK

112858

Q96S44

0.63

SCARNA22

677770

N/A

0.63

ESRRA

2101

P11474

0.65

PA2G4

5036

Q9UQ80

0.65

PTBP1

5725

P26599

0.66

ESR1

2099

P03372

0.67

WBP4

11193

O75554

0.68

TARDBP

23435

Q13148

0.68

DROSHA

29102

Q9NRR4

0.68

BCAR3

8412

O75815

0.70

ABL1

25

P00519

0.72

CHEK1

1111

O14757

0.72

CTNNB1

1499

P35222

0.72

FN1

2335

P02751

0.72

GRB2

2885

P62993

0.72

KIF22

3835

Q14807

0.72

SRPK1

6732

Q96SB4

0.72

SUV39H1

6839

O43463

0.72

EMC2

9694

Q15006

0.72

MATR3

9782

P43243

0.72

SIK2

23235

Q9H0K1

0.72

OTUB1

55611

Q96FW1

0.72

SARNP

84324

P82979

0.72

CDK2

1017

P24941

0.73

EEF1A1

1915

P68104

0.73

LMNA

4000

P02545

0.73

UBD

10537

O15205

0.73

EIF6

3692

P56537

0.76

USF2

7392

Q15853

0.76

TP63

8626

Q9H3D4

0.76

ZMYM2

7750

Q9UBW7

0.77

EWSR1

2130

Q01844

0.79

CDC5L

988

Q99459

0.82

EEF1G

1937

P26641

0.82

HSPA5

3309

P11021

0.82

VCAM1

7412

P19320

0.82

TDRD3

81550

Q9H7E2

0.82

SFPQ

6421

P23246

0.84

SRRM1

10250

Q8IYB3

0.84

THRA

7067

P10827

0.85

RXRA

6256

P19793

0.86

ILF3

3609

Q12906

0.87

PRMT1

3276

Q99873

0.88

YBX1

4904

P67809

0.88

RELA

5970

Q04206

0.88

SF1

7536

Q15637

0.88

SPI1

6688

P17947

0.89