Protein Description

Gene Symbol FN1
Entrez ID 2335
Uniprot ID P02751
Description fibronectin 1
Chromosomal Location chr2: 215,360,440-215,436,172
Ontology GO ID GO Term Definition Evidence

BP

GO:0001525

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

IEA

BP

GO:0001932

regulation of protein phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

IDA

BP

GO:0002576

platelet degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.

TAS

BP

GO:0006953

acute-phase response

An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.

IEA

BP

GO:0007044

cell-substrate junction assembly

The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.

IEA

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

NAS

BP

GO:0007161

calcium-independent cell-matrix adhesion

The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction.

IEA

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

IDA

BP

GO:0008360

regulation of cell shape

Any process that modulates the surface configuration of a cell.

IEA

BP

GO:0009611

response to wounding

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

NAS

BP

GO:0010628

positive regulation of gene expression

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

IDA

BP

GO:0010952

positive regulation of peptidase activity

Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.

IEA

BP

GO:0018149

peptide cross-linking

The formation of a covalent cross-link between or within protein chains.

IDA

BP

GO:0022617

extracellular matrix disassembly

A process that results in the breakdown of the extracellular matrix.

TAS

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

TAS

BP

GO:0033622

integrin activation

The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands.

IMP

BP

GO:0034446

substrate adhesion-dependent cell spreading

The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.

IDA|IMP

BP

GO:0035987

endodermal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.

IDA

BP

GO:0042060

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

IEA

BP

GO:0045773

positive regulation of axon extension

Any process that activates or increases the frequency, rate or extent of axon extension.

IEA

BP

GO:0048146

positive regulation of fibroblast proliferation

Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.

IDA

BP

GO:0050900

leukocyte migration

The movement of a leukocyte within or between different tissues and organs of the body.

TAS

BP

GO:0070372

regulation of ERK1 and ERK2 cascade

Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

IDA

BP

GO:1904237

positive regulation of substrate-dependent cell migration, cell attachment to substrate

Any process that activates or increases the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate.

IDA

BP

GO:2001202

negative regulation of transforming growth factor-beta secretion

Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor-beta secretion.

IDA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

NAS|TAS

CC

GO:0005577

fibrinogen complex

A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.

IDA

CC

GO:0005605

basal lamina

A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix.

IEA

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0005793

endoplasmic reticulum-Golgi intermediate compartment

A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.

IDA

CC

GO:0016324

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

IEA

CC

GO:0031012

extracellular matrix

A structure lying external to one or more cells, which provides structural support for cells or tissues.

IDA|ISS

CC

GO:0031093

platelet alpha granule lumen

The volume enclosed by the membrane of the platelet alpha granule.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

CC

GO:0072562

blood microparticle

A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.

IDA

MF

GO:0002020

protease binding

Interacting selectively and non-covalently with any protease or peptidase.

IPI

MF

GO:0005178

integrin binding

Interacting selectively and non-covalently with an integrin.

IDA|IMP|IPI

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005518

collagen binding

Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).

NAS

MF

GO:0008201

heparin binding

Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

NAS

MF

GO:0016504

peptidase activator activity

Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

IEA

Domain ID Description

IPR000083

Fibronectin, type I

IPR000562

Fibronectin, type II, collagen-binding

IPR003961

Fibronectin type III

IPR013783

Immunoglobulin-like fold

IPR013806

Kringle-like fold

Pathway ID Pathway Term Pathway Source

hsa04151

PI3K-Akt signaling pathway

KEGG

hsa04510

Focal adhesion

KEGG

hsa04512

ECM-receptor interaction

KEGG

hsa04810

Regulation of actin cytoskeleton

KEGG

hsa04933

AGE-RAGE signaling pathway in diabetic complications

KEGG

hsa05100

Bacterial invasion of epithelial cells

KEGG

hsa05146

Amoebiasis

KEGG

hsa05200

Pathways in cancer

KEGG

hsa05205

Proteoglycans in cancer

KEGG

hsa05222

Small cell lung cancer

KEGG

WP3859

TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition

WikiPathways

WP306

Focal Adhesion

WikiPathways

WP3967

miR-509-3p alteration of YAP1/ECM axis

WikiPathways

WP366

TGF-beta Signaling Pathway

WikiPathways

WP3303

Rac1/Pak1/p38/MMP-2 pathway

WikiPathways

WP3287

Overview of nanoparticle effects

WikiPathways

WP51

Regulation of Actin Cytoskeleton

WikiPathways

WP2911

miRNA targets in ECM and membrane receptors

WikiPathways

WP2643

Nanoparticle-mediated activation of receptor signaling

WikiPathways

WP3670

Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway

WikiPathways

WP615

Senescence and Autophagy in Cancer

WikiPathways

WP453

Inflammatory Response Pathway

WikiPathways

WP3680

Association Between Physico-Chemical Features and Toxicity Associated Pathways

WikiPathways

WP3932

Focal Adhesion-PI3K-Akt-mTOR-signaling pathway

WikiPathways

UMLS CUI UMLS Term

C0000786

Spontaneous Abortion

C0003504

Aortic Valve Insufficiency

C0007621

Neoplastic Cell Transformation

C0010346

Crohn Disease

C0011849

Diabetes Mellitus

C0017636

Glioblastoma

C0017668

Focal Glomerulosclerosis

C0020538

Hypertensive Disease

C0024667

Animal Mammary Neoplasms

C0024668

Mammary Neoplasms, Experimental

C0027626

Neoplasm Invasiveness

C0149721

Left Ventricular Hypertrophy

C1458155

Mammary Neoplasms

Tissue Cell Type

kidney

cells in tubules

No databases found.

Pubmed ID Author Year Title

19141487

Kenigsberg et al.

2009

Gene expression microarray profiles of cumulus cells in lean and overweightobese polycystic ovary syndrome patients

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

23824412

Piltonen et al.

2013

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

25393639

Ambekar et al.

2014

Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development

Gene Symbol Entrez ID Uniprot ID Score

IRS1

3667

P35568

0.00

ITGA7

3679

Q13683

0.00

ITGA9

3680

Q13797

0.00

ITGAL

3683

P20701

0.00

ITGB4

3691

P16144

0.00

ITGB5

3693

P18084

0.00

ITGB8

3696

P26012

0.00

MMP1

4312

P03956

0.00

MMP7

4316

P09237

0.00

MMP14

4323

P50281

0.00

PLAU

5328

P00749

0.00

PTK2

5747

Q05397

0.00

PTPN1

5770

P18031

0.00

SRC

6714

P12931

0.00

SYK

6850

P43405

0.00

TGFBR1

7046

P36897

0.00

TGFBR2

7048

P37173

0.00

THY1

7070

P04216

0.00

VCAM1

7412

P19320

0.00

VWF

7450

P04275

0.00

ITGA11

22801

Q9UKX5

0.00

COL1A2

1278

P08123

0.52

COL4A1

1282

P02462

0.52

COL4A2

1284

P08572

0.52

COL4A3

1285

Q01955

0.52

COL4A4

1286

P53420

0.52

COL13A1

1305

Q5TAT6

0.52

CTSD

1509

P07339

0.52

DCN

1634

P07585

0.52

MMP9

4318

P14780

0.52

FST

10468

P19883

0.52

COL2A1

1280

P02458

0.62

ACP1

52

P24666

0.63

ACTB

60

P60709

0.63

ACTG1

71

P63261

0.63

PARP1

142

P09874

0.63

SLC25A5

292

P05141

0.63

APRT

353

P07741

0.63

CFB

629

P00751

0.63

C1QC

714

P02747

0.63

C1S

716

P09871

0.63

C3

718

P01024

0.63

C4A

720

P0C0L4

0.63

C4BPA

722

P04003

0.63

C6

729

P13671

0.63

C9

735

P02748

0.63

CAPN1

823

P07384

0.63

CAPNS1

826

P04632

0.63

SERPINA6

866

P08185

0.63

CCT6A

908

P40227

0.63

CDK1

983

P06493

0.63

CDKN2A

1029

P42771

0.63

CIRBP

1153

Q14011

0.63

CLIC1

1192

O00299

0.63

CLTA

1211

P09496

0.63

CPB2

1361

Q96IY4

0.63

CSE1L

1434

P55060

0.63

DARS

1615

P14868

0.63

DBN1

1627

Q16643

0.63

DDOST

1650

P39656

0.63

DDX3X

1654

O00571

0.63

DDX5

1655

P17844

0.63

DHX9

1660

Q08211

0.63

DECR1

1666

Q16698

0.63

NQO1

1728

P15559

0.63

DYNC1H1

1778

Q14204

0.63

DNM2

1785

P50570

0.63

EEF1A1

1915

P68104

0.63

EEF1D

1936

P29692

0.63

EEF1G

1937

P26641

0.63

EIF2S1

1965

P05198

0.63

EIF4G1

1981

Q04637

0.63

EIF4G2

1982

P78344

0.63

EP300

2033

Q09472

0.63

EPRS

2058

P07814

0.63

FBL

2091

P22087

0.63

ESD

2098

P10768

0.63

EWSR1

2130

Q01844

0.63

F2

2147

P00734

0.63

FASN

2194

P49327

0.63

FAU

2197

P35544

0.63

FAU

2197

P62861

0.63

FGA

2243

P02671

0.63

FGB

2244

P02675

0.63

FGG

2266

P02679

0.63

FLNC

2318

Q14315

0.63

HIST1H1D

3007

P16402

0.63

HIST1H2AD

3013

P20671

0.63

HSD17B10

3028

Q99714

0.63

HBA1 HBA2

3039

P69905

0.63

HBZ

3050

P02008

0.63

HNRNPA1

3178

P09651

0.63

HNRNPA2B1

3181

P22626

0.63

HNRNPAB

3182

Q99729

0.63

HNRNPC

3183

P07910

0.63

HNRNPD

3184

Q14103

0.63

HNRNPH1

3187

P31943

0.63

HNRNPH3

3189

P31942

0.63

HNRNPL

3191

P14866

0.63

HNRNPU

3192

Q00839

0.63

HRG

3273

P04196

0.63

HSPA8

3312

P11142

0.63

HSPA9

3313

P38646

0.63

HSPB1

3315

P04792

0.63

HSP90AA1

3320

P07900

0.63

HSP90AB1

3326

P08238

0.63

HSPD1

3329

P10809

0.63

HSPE1

3336

P61604

0.63

IARS

3376

P41252

0.63

ILF2

3608

Q12905

0.63

EIF3E

3646

P60228

0.63

ITIH1

3697

P19827

0.63

ITIH2

3698

P19823

0.63

ITIH4

3700

Q14624

0.63

KRT8

3856

P05787

0.63

KRT9

3857

P35527

0.63

KRT16

3868

P08779

0.63

KRT19

3880

P08727

0.63

KRT81

3887

Q14533

0.63

RPSA

3921

P08865

0.63

STMN1

3925

P16949

0.63

LMNA

4000

P02545

0.63

LMNB1

4001

P20700

0.63

SMAD9

4093

O15198

0.63

MARS

4141

P56192

0.63

MBNL1

4154

Q9NR56

0.63

MCM5

4174

P33992

0.63

MCM7

4176

P33993

0.63

MIF

4282

P14174

0.63

MYL1

4632

P05976

0.63

HNRNPM

4670

P52272

0.63

DRG1

4733

Q9Y295

0.63

NONO

4841

Q15233

0.63

PRDX1

5052

Q06830

0.63

PCBP1

5093

Q15365

0.63

PCBP2

5094

Q15366

0.63

PCMT1

5110

P22061

0.63

PFN1

5216

P07737

0.63

SERPINA1

5265

P01009

0.63

SERPINA4

5267

P29622

0.63

PLEC

5339

Q15149

0.63

SERPINF2

5345

P08697

0.63

PPA1

5464

Q15181

0.63

PPIA

5478

P62937

0.63

PRKDC

5591

P78527

0.63

PSMA7

5688

O14818

0.63

PSMD5

5711

Q16401

0.63

PTBP1

5725

P26599

0.63

PTPRCAP

5790

Q14761

0.63

RAN

5901

P62826

0.63

RANBP1

5902

P43487

0.63

RARA

5914

P10276

0.63

RBL1

5933

P28749

0.63

RBM3

5935

P98179

0.63

RBM4

5936

Q9BWF3

0.63

UPF1

5976

Q92900

0.63

RFC4

5984

P35249

0.63

RPL3

6122

P39023

0.63

RPL7A

6130

P62424

0.63

RPL10

6134

P27635

0.63

RPL11

6135

P62913

0.63

RPL13

6137

P26373

0.63

RPL17

6139

P18621

0.63

RPL18

6141

Q07020

0.63

RPL22

6146

P35268

0.63

RPL26

6154

P61254

0.63

RPL30

6156

P62888

0.63

RPLP0

6175

P05388

0.63

RPS2

6187

P15880

0.63

RPS3

6188

P23396

0.63

RPS3A

6189

P61247

0.63

RPS4X

6191

P62701

0.63

RPS5

6193

P46782

0.63

RPS6

6194

P62753

0.63

RPS8

6202

P62241

0.63

RPS9

6203

P46781

0.63

RPS11

6205

P62280

0.63

RPS12

6206

P25398

0.63

RPS13

6207

P62277

0.63

RPS14

6208

P62263

0.63

RPS15A

6210

P62244

0.63

RPS17

6218

P08708

0.63

RPS18

6222

P62269

0.63

RPS19

6223

P39019

0.63

RPS20

6224

P60866

0.63

RPS27

6232

P42677

0.63

RPS27A

6233

P62979

0.63

RPS28

6234

P62857

0.63

SDHA

6389

P31040

0.63

SFPQ

6421

P23246

0.63

SKIL

6498

P12757

0.63

SLC5A3

6526

P53794

0.63

SNRPD1

6632

P62314

0.63

SNRPD2

6633

P62316

0.63

SNRPF

6636

P62306

0.63

SRM

6723

P19623

0.63

SERPINA7

6906

P05543

0.63

TCP1

6950

P17987

0.63

PRDX2

7001

P32119

0.63

TIA1

7072

P31483

0.63

TIAL1

7073

Q01085

0.63

TOP2A

7153

P11388

0.63

CCT3

7203

P49368

0.63

TUFM

7284

P49411

0.63

UBB

7314

P0CG47

0.63

VARS

7407

P26640

0.63

VCP

7415

P55072

0.63

VDAC2

7417

P45880

0.63

EZR

7430

P15311

0.63

VIM

7431

P08670

0.63

DDX39B

7919

Q13838

0.63

TAGLN2

8407

P37802

0.63

NR0B2

8431

Q15466

0.63

YARS

8565

P54577

0.63

KHSRP

8570

Q92945

0.63

AKR7A2

8574

O43488

0.63

EIF3A

8661

Q14152

0.63

EIF3D

8664

O15371

0.63

VAMP8

8673

Q9BV40

0.63

PABPC4

8761

Q13310

0.63

RAB11A

8766

P62491

0.63

FUBP1

8880

Q96AE4

0.63

FUBP3

8939

Q96I24

0.63

HIP1R

9026

O75146

0.63

BUB3

9184

O43684

0.63

DDX21

9188

Q9NR30

0.63

RAB11B

9230

Q15907

0.63

RPL23

9349

P62829

0.63

H2AFY

9555

O75367

0.63

EIF4A3

9775

P38919

0.63

MATR3

9782

P43243

0.63

IST1

9798

P53990

0.63

UBAP2L

9898

Q14157

0.63

PDCD6

10016

O75340

0.63

ACTR2

10097

P61160

0.63

LRPPRC

10128

P42704

0.63

G3BP1

10146

Q13283

0.63

TRIM28

10155

Q13263

0.63

HNRNPR

10236

O43390

0.63

TUBA1B

10376

P68363

0.63

RACK1

10399

P63244

0.63

RBM14

10432

Q96PK6

0.63

LYPLA1

10434

O75608

0.63

PPIH

10465

O43447

0.63

DDX17

10521

Q92841

0.63

CCT7

10574

Q99832

0.63

PRPF8

10594

Q6P2Q9

0.63

IGF2BP1

10642

Q9NZI8

0.63

IGF2BP2

10644

Q9Y6M1

0.63

CCT8

10694

P50990

0.63

TCERG1

10915

O14776

0.63

HNRNPA0

10949

Q13151

0.63

TOMM34

10953

Q15785

0.63

GCN1

10985

Q92616

0.63

KIF2C

11004

Q99661

0.63

NUDT21

11051

O43809

0.63

PHB2

11331

Q99623

0.63

COPG1

22820

Q9Y678

0.63

SNRNP200

23020

O75643

0.63

TAB2

23118

Q9NYJ8

0.63

TARDBP

23435

Q13148

0.63

DDAH2

23564

O95865

0.63

CASP14

23581

P31944

0.63

RSL1D1

26156

O76021

0.63

DAZAP1

26528

Q96EP5

0.63

PABPC1

26986

P11940

0.63

RBMX

27316

P38159

0.63

IGKV3-20

28912

N/A

0.63

SNX15

29907

Q9NRS6

0.63

UBQLN1

29979

Q9UMX0

0.63

EIF3L

51386

Q9Y262

0.63

LARS

51520

Q9P2J5

0.63

PPIL1

51645

Q9Y3C6

0.63

H2BFS

54145

P57053

0.63

ATAD3A

55210

Q9NVI7

0.63

PELI2

57161

Q9HAT8

0.63

XPO5

57510

Q9HAV4

0.63

CCAR2

57805

Q8N163

0.63

LY6G5B

58496

Q8NDX9

0.63

MRPS6

64968

P82932

0.63

APOLD1

81575

Q96LR9

0.63

NTPCR

84284

Q9BSD7

0.63

SARNP

84324

P82979

0.63

HIST1H2BK

85236

O60814

0.63

MYL12B

103910

O14950

0.63

HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4

121504

P62805

0.63

RAVER1

125950

Q8IY67

0.63

APOBEC3D

140564

Q96AK3

0.63

TUBB

203068

P07437

0.63

HNRNPA3

220988

P51991

0.63

FAM86B3P

286042

N/A

0.63

ACTBL2

345651

Q562R1

0.63

RPL23AP42

647099

N/A

0.63

PPIAP22

653214

N/A

0.63

RPS21

100291837

P63220

0.63

IGLL5

100423062

B9A064

0.63

RPL9; RPL9P7; RPL9P8; RPL9P9

6133

P32969

0.63

HIST2H3A; HIST2H3C; HIST2H3D

126961

Q71DI3

0.63

HGF

3082

P14210

0.65

ADAMTS4

9507

O75173

0.65

FSTL3

10272

O95633

0.65

IGFBP5

3488

P24593

0.67

AARS

16

P49588

0.72

ABCF1

23

Q8NE71

0.72

ACACA

31

Q13085

0.72

ACLY

47

P53396

0.72

ACTN4

81

O43707

0.72

AP2A1

160

O95782

0.72

AP2A2

161

O94973

0.72

AP2B1

163

P63010

0.72

ALDH1B1

219

P30837

0.72

ALDOA

226

P04075

0.72

ANXA1

301

P04083

0.72

ANXA2

302

P07355

0.72

ARF6

382

P62330

0.72

ARL2

402

P36404

0.72

ATP5A1

498

P25705

0.72

ATP5B

506

P06576

0.72

ATP5C1

509

P36542

0.72

ATP6V1B2

526

P21281

0.72

C1QBP

708

Q07021

0.72

CAPZA1

829

P52907

0.72

CAPZB

832

P47756

0.72

LRBA

987

P50851

0.72

CFL1

1072

P23528

0.72

RCC1

1104

P18754

0.72

AP2M1

1173

Q96CW1

0.72

CLIC2

1193

O15247

0.72

CLNS1A

1207

P54105

0.72

CLTB

1212

P09497

0.72

CLTC

1213

Q00610

0.72

CNN2

1265

Q99439

0.72

COMT

1312

P21964

0.72

COPB1

1315

P53618

0.72

CSNK2A1

1457

P68400

0.72

CSNK2B

1460

P67870

0.72

DAB2

1601

P98082

0.72

AKR1C1

1645

Q04828

0.72

DDX1

1653

Q92499

0.72

DDX6

1656

P26196

0.72

DHX15

1665

O43143

0.72

DIAPH1

1729

O60610

0.72

DLD

1738

P09622

0.72

EEF1B2

1933

P24534

0.72

EEF2

1938

P13639

0.72

EGFR

1956

P00533

0.72

EIF2S3

1968

P41091

0.72

EIF4A1

1973

P60842

0.72

EIF5

1983

P55010

0.72

ELAVL1

1994

Q15717

0.72

ENO1

2023

P06733

0.72

EPB41

2035

P11171

0.72

STOM

2040

P27105

0.72

EPS15

2060

P42566

0.72

FDFT1

2222

P37268

0.72

FEN1

2237

P39748

0.72

FLNA

2316

P21333

0.72

FLNB

2317

O75369

0.72

FLOT2

2319

Q14254

0.72

FUS

2521

P35637

0.72

G6PD

2539

P11413

0.72

XRCC6

2547

P12956

0.72

GALE

2582

Q14376

0.72

GART

2618

P22102

0.72

GDI2

2665

P50395

0.72

GLUD1

2746

P00367

0.72

GNAI3

2773

P08754

0.72

HIST1H1B

3009

P16401

0.72

HADHA

3030

P40939

0.72

HDAC1

3065

Q13547

0.72

HMGB1

3146

P09429

0.72

HMGB2

3148

P26583

0.72

HMGA1

3159

P17096

0.72

HNRNPF

3185

P52597

0.72

HNRNPH2

3188

P55795

0.72

HNRNPK

3190

P61978

0.72

PRMT1

3276

Q99873

0.72

HSPA1A

3303

P0DMV8

0.72

HSPA1B

3304

P0DMV9

0.72

HSPA5

3309

P11021

0.72

DNAJB1

3337

P25685

0.72

IDI1

3422

Q13907

0.72

IGF2R

3482

P11717

0.72

ILF3

3609

Q12906

0.72

ILK

3611

Q13418

0.72

IMPDH2

3615

P12268

0.72

KARS

3735

Q15046

0.72

KPNB1

3837

Q14974

0.72

IPO5

3843

O00410

0.72

KRT1

3848

P04264

0.72

KRT2

3849

P35908

0.72

KRT5

3852

P13647

0.72

KRT10

3858

P13645

0.72

KRT18

3875

P05783

0.72

KRT31

3881

Q15323

0.72

LASP1

3927

Q14847

0.72

LCP1

3936

P13796

0.72

LDHA

3939

P00338

0.72

LDHB

3945

P07195

0.72

LGALS1

3956

P09382

0.72

MAP4

4134

P27816

0.72

MCM2

4171

P49736

0.72

MCM3

4172

P25205

0.72

MCM6

4175

Q14566

0.72

MDH2

4191

P40926

0.72

MLLT4

4301

P55196

0.72

MPP1

4354

Q00013

0.72

MSN

4478

P26038

0.72

MT-CO2

4513

P00403

0.72

MYH10

4628

P35580

0.72

MYL4

4635

P12829

0.72

MYL6

4637

P60660

0.72

NACA

4666

Q13765

0.72

NARS

4677

O43776

0.72

NCBP1

4686

Q09161

0.72

NCL

4691

P19338

0.72

NDUFA2

4695

O43678

0.72

NDUFA5

4698

Q16718

0.72

NDUFA9

4704

Q16795

0.72

NDUFS3

4722

O75489

0.72

NDUFV2

4729

P19404

0.72

SEPT2

4735

Q15019

0.72

RPL10A

4736

P62906

0.72

SNU13

4809

P55769

0.72

NPM1

4869

P06748

0.72

YBX1

4904

P67809

0.72

PA2G4

5036

Q9UQ80

0.72

PAFAH1B2

5049

P68402

0.72

PCNA

5111

P12004

0.72

PDHB

5162

P11177

0.72

PFKL

5211

P17858

0.72

PFKP

5214

Q01813

0.72

PGK1

5230

P00558

0.72

PHB

5245

P35232

0.72

PI4KA

5297

P42356

0.72

PKM

5315

P14618

0.72

POLR2C

5432

P19387

0.72

PPID

5481

Q08752

0.72

PPP1CA

5499

P62136

0.72

PPP2CA

5515

P67775

0.72

PPP2R1A

5518

P30153

0.72

PRKCB

5579

P05771

0.72

PRPS2

5634

P11908

0.72

PSMA2

5683

P25787

0.72

PSMA5

5686

P28066

0.72

PSMA6

5687

P60900

0.72

PSMB1

5689

P20618

0.72

PSMB2

5690

P49721

0.72

PSMB3

5691

P49720

0.72

PSMB5

5693

P28074

0.72

PSMC6

5706

P62333

0.72

PSMD11

5717

O00231

0.72

PSMD13

5719

Q9UNM6

0.72

QARS

5859

P47897

0.72

RAB5C

5878

P51148

0.72

RAC1

5879

P63000

0.72

RAP1B

5908

P61224

0.72

RAP2B

5912

P61225

0.72

RBBP4

5928

Q09028

0.72

RNH1

6050

P13489

0.72

RPA1

6117

P27694

0.72

RPA2

6118

P15927

0.72

RPL4

6124

P36578

0.72

RPL5

6125

P46777

0.72

RPL6

6128

Q02878

0.72

RPL7

6129

P18124

0.72

RPL8

6132

P62917

0.72

RPL12

6136

P30050

0.72

RPL15

6138

P61313

0.72

RPL21

6144

P46778

0.72

RPL23A

6147

P62750

0.72

RPL24

6152

P83731

0.72

RPL27A

6157

P46776

0.72

RPL28

6158

P46779

0.72

RPL29

6159

P47914

0.72

RPL31

6160

P62899

0.72

RPLP2

6181

P05387

0.72

RPN1

6184

P04843

0.72

RPS7

6201

P62081

0.72

RPS10

6204

P46783

0.72

RPS15

6209

P62841

0.72

RPS16

6217

P62249

0.72

RPS23

6228

P62266

0.72

RPS24

6229

P62847

0.72

RPS25

6230

P62851

0.72

RPS26

6231

P62854

0.72

RSU1

6251

Q15404

0.72

SET

6418

Q01105

0.72

SRSF1

6426

Q07955

0.72

SRSF3

6428

P84103

0.72

SIPA1

6494

Q96FS4

0.72

SLC3A2

6520

P08195

0.72

SLC25A1

6576

P53007

0.72

FSCN1

6624

Q16658

0.72

SNRNP70

6625

P08621

0.72

SNRPA

6626

P09012

0.72

SNRPB

6628

P14678

0.72

SNRPD3

6634

P62318

0.72

SNRPE

6635

P62304

0.72

SPTBN1

6711

Q01082

0.72

SRI

6717

P30626

0.72

SRP14

6727

P37108

0.72

SSB

6741

P05455

0.72

SSBP1

6742

Q04837

0.72

ST13

6767

P50502

0.72

STX4

6810

Q12846

0.72

STXBP3

6814

O00186

0.72

SUPT5H

6829

O00267

0.72

TARS

6897

P26639

0.72

TFAM

7019

Q00059

0.72

TFRC

7037

P02786

0.72

TK1

7083

P04183

0.72

TKT

7086

P29401

0.72

TLN1

7094

Q9Y490

0.72

TPM3

7170

P06753

0.72

TPR

7175

P12270

0.72

U2AF1

7307

Q01081

0.72

UBE2L3

7332

P68036

0.72

UBE2N

7334

P61088

0.72

VASP

7408

P50552

0.72

VCL

7414

P18206

0.72

EIF4H

7458

Q15056

0.72

XPO1

7514

O14980

0.72

XRCC5

7520

P13010

0.72

YES1

7525

P07947

0.72

YWHAB

7529

P31946

0.72

YWHAE

7531

P62258

0.72

YWHAG

7532

P61981

0.72

YWHAH

7533

Q04917

0.72

YWHAZ

7534

P63104

0.72

SF1

7536

Q15637

0.72

RAB7A

7879

P51149

0.72

BAG6

7917

P46379

0.72

AIMP2

7965

Q13155

0.72

PICALM

8301

Q13492

0.72

RAE1

8480

P78406

0.72

PSMG1

8624

O95456

0.72

EIF3B

8662

P55884

0.72

EIF3F

8665

O00303

0.72

SRSF9

8683

Q13242

0.72

SNAP23

8773

O00161

0.72

NAPG

8774

Q99747

0.72

NAPA

8775

P54920

0.72

IQGAP1

8826

P46940

0.72

GMPS

8833

P49915

0.72

DDX18

8886

Q9NVP1

0.72

CPNE1

8904

Q99829

0.72

HIST1H2BJ

8970

P06899

0.72

UBE2M

9040

P61081

0.72

RPL14

9045

P50914

0.72

PRPF4

9128

O43172

0.72

ARHGEF1

9138

Q92888

0.72

PDCD5

9141

O14737

0.72

ZW10

9183

O43264

0.72

VAPA

9218

Q9P0L0

0.72

EFTUD2

9343

Q15029

0.72

QKI

9444

Q96PU8

0.72

GSTO1

9446

P78417

0.72

BAG2

9532

O95816

0.72

POLR1C

9533

O15160

0.72

SEC22B

9554

O75396

0.72

VPS26A

9559

O75436

0.72

PRDX6

9588

P30041

0.72

NUP155

9631

O75694

0.72

SEC24C

9632

P53992

0.72

EIF5B

9669

O60841

0.72

CKAP5

9793

Q14008

0.72

USP15

9958

Q9Y4E8

0.72

HNRNPDL

9987

O14979

0.72

FARSB

10056

Q9NSD9

0.72

ARPC4

10093

P59998

0.72

ARPC3

10094

O15145

0.72

ACTR3

10096

P61158

0.72

PDIA6

10130

Q15084

0.72

TRAP1

10131

Q12931

0.72

RBM12

10137

Q9NTZ6

0.72

ALYREF

10189

Q86V81

0.72

FLOT1

10211

O75955

0.72

TUBB4B

10383

P68371

0.72

PRMT5

10419

O14744

0.72

EMG1

10436

Q92979

0.72

SEC23B

10483

Q15437

0.72

CAP1

10487

Q01518

0.72

SYNCRIP

10492

O60506

0.72

GLRX3

10539

O76003

0.72

ANP32B

10541

Q92688

0.72

CCT4

10575

P50991

0.72

CCT2

10576

P78371

0.72

PAICS

10606

P22234

0.72

PDLIM5

10611

Q96HC4

0.72

IGF2BP3

10643

O00425

0.72

CELF2

10659

O95319

0.72

USP39

10713

Q53GS9

0.72

PTGES3

10728

Q15185

0.72

SEPT9

10801

Q9UHD8

0.72

RUVBL2

10856

Q9Y230

0.72

RAB10

10890

P61026

0.72

SUB1

10923

P53999

0.72

PRDX3

10935

P30048

0.72

SF3A3

10946

Q12874

0.72

SEC61B

10952

P60468

0.72

STIP1

10963

P31948

0.72

YWHAQ

10971

P27348

0.72

RAB35

11021

Q15286

0.72

CPSF6

11052

Q16630

0.72

ERLIN2

11160

O94905

0.72

RPL35

11224

P42766

0.72

PDCD10

11235

Q9BUL8

0.72

COPE

11316

O14579

0.72

PDAP1

11333

Q13442

0.72

CBX3

11335

Q13185

0.72

PUF60

22827

Q9UHX1

0.72

DHX30

22907

Q7L2E3

0.72

RALY

22913

Q9UKM9

0.72

MAPRE1

22919

Q15691

0.72

CCT5

22948

P48643

0.72

CNOT1

23019

A5YKK6

0.72

NUP205

23165

Q92621

0.72

TTLL12

23170

Q14166

0.72

MDN1

23195

Q9NU22

0.72

NUP210

23225

Q8TEM1

0.72

ESYT1

23344

Q9BSJ8

0.72

SMCHD1

23347

A6NHR9

0.72

ECM29

23392

Q5VYK3

0.72

SF3B1

23451

O75533

0.72

MACF1

23499

Q9UPN3

0.72

SCRIB

23513

Q14160

0.72

RPL13A

23521

P40429

0.72

GTPBP4

23560

Q9BZE4

0.72

CORO1C

23603

Q9ULV4

0.72

RPL36

25873

Q9Y3U8

0.72

KANK2

25959

Q63ZY3

0.72

PHGDH

26227

O43175

0.72

PELP1

27043

Q8IZL8

0.72

SND1

27044

Q7KZF4

0.72

CACYBP

27101

Q9HB71

0.72

DIMT1

27292

Q9UNQ2

0.72

EIF3K

27335

Q9UBQ5

0.72

PRPF19

27339

Q9UMS4

0.72

APOBEC3C

27350

Q9NRW3

0.72

MRPS28

28957

Q9Y2Q9

0.72

BZW2

28969

Q9Y6E2

0.72

MRPL13

28998

Q9BYD1

0.72

OLA1

29789

Q9NTK5

0.72

EPN1

29924

Q9Y6I3

0.72

MRTO4

51154

Q9UKD2

0.72

VPS28

51160

Q9UK41

0.72

DDX47

51202

Q9H0S4

0.72

YTHDF2

51441

Q9Y5A9

0.72

RTCB

51493

Q9Y3I0

0.72

NOP58

51602

Q9Y2X3

0.72

C14orf166

51637

Q9Y224

0.72

SF3B6

51639

Q9Y3B4

0.72

MRPS23

51649

Q9Y3D9

0.72

CLIC5

53405

Q9NZA1

0.72

GAR1

54433

Q9NY12

0.72

NAT10

55226

Q9H0A0

0.72

LRRC59

55379

Q96AG4

0.72

BMP2K

55589

Q9NSY1

0.72

NHP2

55651

Q9NX24

0.72

NECAP2

55707

Q9NVZ3

0.72

VPS35

55737

Q96QK1

0.72

CAND1

55832

Q86VP6

0.72

ACOT13

55856

Q9NPJ3

0.72

RCC2

55920

Q9P258

0.72

SAR1A

56681

Q9NR31

0.72

PSMG2

56984

Q969U7

0.72

CORO1B

57175

Q9BR76

0.72

ESYT2

57488

A0FGR8

0.72

KIDINS220

57498

Q9ULH0

0.72

SMAP2

64744

Q8WU79

0.72

MRPS34

65993

P82930

0.72

AHNAK

79026

Q09666

0.72

IPO4

79711

Q8TEX9

0.72

CPSF7

79869

Q8N684

0.72

NAA15

80155

Q9BXJ9

0.72

FERMT3

83706

Q86UX7

0.72

TUBB6

84617

Q9BUF5

0.72

STON2

85439

Q8WXE9

0.72

H2AFV

94239

Q71UI9

0.72

LSM12

124801

Q3MHD2

0.72

BROX

148362

Q5VW32

0.72

PGAM5

192111

Q96HS1

0.72

HIST1H2AA

221613

Q96QV6

0.72

TTC9C

283237

Q8N5M4

0.72

GSTK1

373156

Q9Y2Q3

0.72

APCS

325

P02743

0.73

C1QB

713

P02746

0.73

GAPDH

2597

P04406

0.73

GSTP1

2950

P09211

0.73

SMAD4

4089

Q13485

0.73

PRPF40A

55660

O75400

0.73

C1QA

712

P02745

0.75

CRP

1401

P02741

0.75

F13A1

2162

P00488

0.75

PLAT

5327

P00750

0.75

PLG

5340

P00747

0.75

FYN

2534

P06241

0.76

CTGF

1490

P29279

0.78

MYH9

4627

P35579

0.82

COL1A1

1277

P02452

0.83

COL7A1

1294

Q02388

0.85

FASLG

356

P48023

0.86

KPNA2

3838

P52292

0.86

ZYX

7791

Q15942

0.86

FN1

2335

P02751

0.90

COL5A1

1289

P20908

0.00

CFD

1675

P00746

0.00

EGF

1950

P01133

0.00

EPHA1

2041

P21709

0.00

FLT4

2324

P35916

0.00

BCAR1

9564

P56945

0.00

COL4A5

1287

P29400

0.52

COL4A6

1288

Q14031

0.52

COL6A2

1292

P12110

0.52

COMP

1311

P49747

0.52

FBN1

2200

P35555

0.52

FBN2

2201

P35556

0.52

ITGA3

3675

P26006

0.52

LGALS3BP

3959

Q08380

0.52

TNFRSF11B

4982

O00300

0.52

PRELP

5549

P51888

0.52

SPARC

6678

P09486

0.52

TAC1

6863

P20366

0.52

ITGA8

8516

P53708

0.52

FBN3

84467

Q75N90

0.52

LRG1

116844

P02750

0.52

TMPRSS6

164656

Q8IU80

0.52

GALNT6

11226

Q8NCL4

0.55

MAG

4099

P20916

0.59

ITGB3

3690

P05106

0.62

LTBP1

4052

Q14766

0.62

MATN2

4147

O00339

0.62

NT5E

4907

P21589

0.62

THBS1

7057

P07996

0.62

CD79A

973

P11912

0.63

COL8A2

1296

P25067

0.63

IGHA1

3493

P01876

0.63

IGHG1

3500

P01857

0.63

IGHM

3507

P01871

0.63

LGALS3

3958

P17931

0.63

LGALS8

3964

O00214

0.63

LGALS9

3965

O00182

0.63

LOX

4015

P28300

0.63

MTNR1A

4543

P48039

0.63

ATXN7

6314

O15265

0.63

SGCA

6442

Q16586

0.63

SUMO2

6613

P61956

0.63

STAT5A

6776

P42229

0.63

TEAD4

7004

Q15561

0.63

TFAP2C

7022

Q92754

0.63

TTN

7273

Q8WZ42

0.63

RPS6KA5

9252

O75582

0.63

CER1

9350

O95813

0.63

TAB1

10454

Q15750

0.63

DUSP10

11221

Q9Y6W6

0.63

ATXN10

25814

Q9UBB4

0.63

SH3GLB1

51100

Q9Y371

0.63

SIRT7

51547

Q9NRC8

0.63

GRDX

117189

N/A

0.63

KLK3

354

P07288

0.65

MEP1A

4224

Q16819

0.67

MEP1B

4225

Q16820

0.67

GZMB

3002

P10144

0.68

ALB

213

P02768

0.72

APOA1

335

P02647

0.72

HIF1A

3091

Q16665

0.72

MYC

4609

P01106

0.72

SYMPK

8189

Q92797

0.72

CTR9

9646

Q6PD62

0.72

AMBP

259

P02760

0.73

ITGB7

3695

P26010

0.73

ITGB6

3694

P18564

0.75

MYOC

4653

Q99972

0.75

NOV

4856

P48745

0.75

REG3A

5068

Q06141

0.75

PKD1

5310

P98161

0.75

CXCL12

6387

P48061

0.75

TSHR

7253

P16473

0.75

MIA

8190

Q16674

0.75

LACRT

90070

Q9GZZ8

0.75

SDC2

6383

P34741

0.76

TRIB3

57761

Q96RU7

0.76

CD44

960

P16070

0.78

TNC

3371

P24821

0.79

GRB2

2885

P62993

0.82

TF

7018

P02787

0.82

ITGAV

3685

P06756

0.83

PXN

5829

P49023

0.83

SCGB1A1

7356

P11684

0.84

ITGA4

3676

P13612

0.85

TGFBI

7045

Q15582

0.85

FBLN2

2199

P98095

0.86

ITGB1

3688

P05556

0.86

GSN

2934

P06396

0.87

FBLN1

2192

P23142

0.88

HSPG2

3339

P98160

0.88

VHL

7428

P40337

0.88

IGFBP3

3486

P17936

0.89

LPA

4018

P08519

0.89

TGM2

7052

P21980

0.90

ITGA5

3678

P08648

0.96