| Gene Symbol | ALDH1B1 |
| Entrez ID | 219 |
| Uniprot ID | P30837 |
| Description | aldehyde dehydrogenase 1 family member B1 |
| Chromosomal Location | chr9: 38,392,664-38,398,661 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0005975 |
carbohydrate metabolic process |
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. |
NAS |
|
BP |
GO:0006068 |
ethanol catabolic process |
The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. |
IEA |
|
BP |
GO:0006069 |
ethanol oxidation |
An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate. |
TAS |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA |
|
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA |
|
CC |
GO:0005759 |
mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
TAS |
|
CC |
GO:0043231 |
intracellular membrane-bounded organelle |
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
IDA |
|
MF |
GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. |
IBA|TAS |
| Domain ID | Description |
|---|---|
|
IPR015590 |
Aldehyde dehydrogenase domain |
|
IPR016160 |
Aldehyde dehydrogenase, cysteine active site |
|
IPR016161 |
Aldehyde/histidinol dehydrogenase |
|
IPR016162 |
Aldehyde dehydrogenase N-terminal domain |
|
IPR029510 |
Aldehyde dehydrogenase, glutamic acid active site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00010 |
Glycolysis / Gluconeogenesis |
KEGG |
|
hsa00053 |
Ascorbate and aldarate metabolism |
KEGG |
|
hsa00071 |
Fatty acid degradation |
KEGG |
|
hsa00280 |
Valine, leucine and isoleucine degradation |
KEGG |
|
hsa00310 |
Lysine degradation |
KEGG |
|
hsa00330 |
Arginine and proline metabolism |
KEGG |
|
hsa00340 |
Histidine metabolism |
KEGG |
|
hsa00380 |
Tryptophan metabolism |
KEGG |
|
hsa00410 |
beta-Alanine metabolism |
KEGG |
|
hsa00561 |
Glycerolipid metabolism |
KEGG |
|
hsa00620 |
Pyruvate metabolism |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
| UMLS CUI | UMLS Term |
|---|---|
|
C0009375 |
Colonic Neoplasms |
|
C0023893 |
Liver Cirrhosis, Experimental |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
breast |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
cerebral cortex |
neuronal cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
kidney |
cells in tubules |
|
liver |
bile duct cells |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
pancreas |
exocrine glandular cells |
|
rectum |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
fibroblasts |
|
small intestine |
glandular cells |
|
soft tissue |
adipocytes |
|
stomach |
glandular cells |
|
testis |
Leydig cells |
|
urinary bladder |
urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
12734205 |
Wood et al. |
2003 |
The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ESD |
2098 |
P10768 |
0.49 |
|
PGM1 |
5236 |
P36871 |
0.49 |
|
SRP68 |
6730 |
Q9UHB9 |
0.49 |
|
UQCRB |
7381 |
P14927 |
0.49 |
|
UQCRC2 |
7385 |
P22695 |
0.49 |
|
XPNPEP1 |
7511 |
Q9NQW7 |
0.49 |
|
PDCD6IP |
10015 |
Q8WUM4 |
0.49 |
|
STIP1 |
10963 |
P31948 |
0.49 |
|
FH |
2271 |
P07954 |
0.63 |
|
HEXB |
3074 |
P07686 |
0.63 |
|
FEM1B |
10116 |
Q9UK73 |
0.63 |
|
DHRS4 |
10901 |
Q9BTZ2 |
0.63 |
|
PDCD10 |
11235 |
Q9BUL8 |
0.63 |
|
SUFU |
51684 |
Q9UMX1 |
0.63 |
|
ETFA |
2108 |
P13804 |
0.49 |
|
LDHA |
3939 |
P00338 |
0.49 |
|
LDHB |
3945 |
P07195 |
0.49 |
|
OAT |
4942 |
P04181 |
0.49 |
|
SOD2 |
6648 |
P04179 |
0.49 |
|
UQCRFS1 |
7386 |
P47985 |
0.49 |
|
ALDH5A1 |
7915 |
P51649 |
0.49 |
|
OFD1 |
8481 |
O75665 |
0.49 |
|
HIBADH |
11112 |
P31937 |
0.49 |
|
TCTN3 |
26123 |
Q6NUS6 |
0.49 |
|
UQCRQ |
27089 |
O14949 |
0.49 |
|
RPL6 |
6128 |
Q02878 |
0.56 |
|
ECT2 |
1894 |
Q9H8V3 |
0.63 |
|
FABP2 |
2169 |
P12104 |
0.63 |
|
ICT1 |
3396 |
Q14197 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
EXOSC10 |
5394 |
Q01780 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
XRN2 |
22803 |
Q9H0D6 |
0.63 |
|
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
|
UBR7 |
55148 |
Q8N806 |
0.63 |
|
OGFOD1 |
55239 |
Q8N543 |
0.63 |
|
MAP1LC3B |
81631 |
Q9GZQ8 |
0.63 |
|
TATDN1 |
83940 |
Q6P1N9 |
0.63 |
|
MAP1LC3A |
84557 |
Q9H492 |
0.63 |
|
FN1 |
2335 |
P02751 |
0.72 |
|
HDAC1 |
3065 |
Q13547 |
0.72 |
|
LLGL1 |
3996 |
Q15334 |
0.72 |
|
MYC |
4609 |
P01106 |
0.72 |
|
ATL3 |
25923 |
Q6DD88 |
0.72 |
|
SGO1 |
151648 |
Q5FBB7 |
0.72 |