PCOSBase

Protein Description

Gene Symbol	FKBP5
Entrez ID	2289
Uniprot ID	Q13451
Description	FK506 binding protein 5
Chromosomal Location	chr6: 35,573,585-35,728,583

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000413	protein peptidyl-prolyl isomerization	The modification of a protein by cis-trans isomerization of a proline residue.	IEA
BP	GO:0006457	protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.	TAS
BP	GO:0061077	chaperone-mediated protein folding	The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.	IDA
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	IDA
CC	GO:0005789	endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.	IBA
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).	IDA
MF	GO:0005528	FK506 binding	Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506.	IEA
MF	GO:0031072	heat shock protein binding	Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.	IPI

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Domain ID	Description
IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain
IPR001440	Tetratricopeptide repeat 1
IPR011990	Tetratricopeptide-like helical domain
IPR013026	Tetratricopeptide repeat-containing domain
IPR019734	Tetratricopeptide repeat
IPR023566	Peptidyl-prolyl cis-trans isomerase, FKBP-type
IPR031210	Peptidyl-prolyl cis-trans isomerase FKBP5

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Pathway ID	Pathway Term	Pathway Source
hsa04915	Estrogen signaling pathway	KEGG
WP3584	MECP2 and Associated Rett Syndrome	WikiPathways
WP2879	Farnesoid X Receptor Pathway	WikiPathways

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UMLS CUI	UMLS Term
C0003873	Rheumatoid Arthritis
C0014175	Endometriosis
C0021290	Neonatal Disorder
C0525041	Neurobehavioral Manifestations
C1269683	Major Depressive Disorder

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
bronchus	respiratory epithelial cells
cervix, uterine	glandular cells
colon	endothelial cells
colon	glandular cells
endometrium	glandular cells
endometrium	cells in endometrial stroma
epididymis	glandular cells
fallopian tube	glandular cells
gallbladder	glandular cells
kidney	cells in glomeruli
kidney	cells in tubules
lung	macrophages
lung	pneumocytes
lymph node	germinal center cells
nasopharynx	respiratory epithelial cells
pancreas	exocrine glandular cells
pancreas	islets of Langerhans
parathyroid gland	glandular cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skeletal muscle	myocytes
skin	fibroblasts
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
small intestine	glandular cells
smooth muscle	smooth muscle cells
soft tissue	adipocytes
soft tissue	fibroblasts
stomach	glandular cells
testis	cells in seminiferous ducts
testis	Leydig cells
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome
23824412	Piltonen et al.	2013	Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

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Gene Symbol	Entrez ID	Uniprot ID	Score
DUT	1854	P33316	0.49
MCM7	4176	P33993	0.49
TLE3	7090	Q04726	0.49
NR1H3	10062	Q13133	0.49
NOD1	10392	Q9Y239	0.49
USP18	11274	Q9UMW8	0.49
WSB2	55884	Q9NYS7	0.49
RNF219	79596	Q5W0B1	0.49
CCDC57	284001	Q2TAC2	0.49
APP	351	P05067	0.56
STIP1	10963	P31948	0.56
AKT1	207	P31749	0.63
HSPA9	3313	P38646	0.63
MAGEA11	4110	P43364	0.63
HGH1	51236	Q9BTY7	0.72
HSP90AB1	3326	P08238	0.72
ILK	3611	Q13418	0.72
MCM4	4173	P33991	0.72
PDCD2	5134	Q16342	0.72
PYGL	5836	P06737	0.72
TTC4	7268	O95801	0.72
TUBA1A	7846	Q71U36	0.72
IKBKG	8517	Q9Y6K9	0.72
AURKB	9212	Q96GD4	0.72
DNAJB6	10049	O75190	0.72
NUDC	10726	Q9Y266	0.72
SUGT1	10910	Q9Y2Z0	0.72
GLMN	11146	Q92990	0.72
NUDCD3	23386	Q8IVD9	0.72
KIF1BP	26128	Q96EK5	0.72
CHORDC1	26973	Q9UHD1	0.72
CACYBP	27101	Q9HB71	0.72
AGO2	27161	Q9UKV8	0.72
EGLN1	54583	Q9GZT9	0.72
CXorf57	55086	Q6NSI4	0.72
LRRC40	55631	Q9H9A6	0.72
ANKMY2	57037	Q8IV38	0.72
PNPLA2	57104	Q96AD5	0.72
C14orf80	283643	Q86SX3	0.72
CDK11A	728642	Q9UQ88	0.72
MOS	4342	P00540	0.73
IKBKE	9641	Q14164	0.78
ARAF	369	P10398	0.82
CDK4	1019	P11802	0.82
AGO1	26523	Q9UL18	0.82
CHUK	1147	O15111	0.86
HSP90AA1	3320	P07900	0.90
EGFR	1956	P00533	0.49
ERBB2	2064	P04626	0.49
GABRB1	2560	P18505	0.49
MUSK	4593	O15146	0.49
RAG1	5896	P15918	0.49
SIM2	6493	Q14190	0.49
SMARCD2	6603	Q92925	0.49
MORF4L2	9643	Q15014	0.49
TESK2	10420	Q96S53	0.49
AAR2	25980	Q9Y312	0.49
DNM3	26052	Q9UQ16	0.49
FBXO25	26260	Q8TCJ0	0.49
DET1	55070	Q7L5Y6	0.49
PIWIL2	55124	Q8TC59	0.49
KLHL1	57626	Q9NR64	0.49
TRIM56	81844	Q9BRZ2	0.49
DHX57	90957	Q6P158	0.49
NLRP12	91662	P59046	0.49
CTCFL	140690	Q8NI51	0.49
PIWIL4	143689	Q7Z3Z4	0.49
FBXL14	144699	Q8N1E6	0.49
KSR2	283455	Q6VAB6	0.49
C12orf76	400073	Q8N812	0.49
FOXD4L6	653404	Q3SYB3	0.49
NR2C2	7182	P49116	0.52
PIWIL1	9271	Q96J94	0.56
AR	367	P10275	0.63
CDK3	1018	Q00526	0.63
CDK7	1022	P50613	0.63
HSPA4	3308	P34932	0.63
MCM3	4172	P25205	0.63
NR3C2	4306	P08235	0.63
NTRK1	4914	P04629	0.63
CDK18	5129	Q07002	0.63
REL	5966	Q04864	0.63
RPS6KB2	6199	Q9UBS0	0.63
SGK1	6446	O00141	0.63
AURKC	6795	Q9UQB9	0.63
TPM3	7170	P06753	0.63
USP7	7874	Q93009	0.63
CDK13	8621	Q14004	0.63
CDKL1	8814	Q00532	0.63
TRAP1	10131	Q12931	0.63
RIPK3	11035	Q9Y572	0.63
OGFR	11054	Q9NZT2	0.63
ULK3	25989	Q6PHR2	0.63
PIPOX	51268	Q9P0Z9	0.63
FBXW7	55294	Q969H0	0.63
LRRK1	79705	Q38SD2	0.63
PSKH2	85481	Q96QS6	0.63
AGO3	192669	Q9H9G7	0.63
CDKL4	344387	Q5MAI5	0.63
CLK3	1198	P49761	0.72
HSF4	3299	Q9ULV5	0.72
IKBKB	3551	O14920	0.72
LIMK2	3985	P53671	0.72
MAP3K7	6885	O43318	0.72
XRCC3	7517	O43542	0.72
IRS4	8471	O14654	0.72
SGK2	10110	Q9HBY8	0.72
AHSA1	10598	O95433	0.72
CDC37	11140	Q16543	0.72
TINF2	26277	Q9BSI4	0.72
CDC37L1	55664	Q7L3B6	0.72
MCMBP	79892	Q9BTE3	0.72
TSSK6	83983	Q9BXA6	0.72
MCM5	4174	P33992	0.73
MGEA5	10724	O60502	0.73
MAGED2	10916	Q9UNF1	0.73
ESR1	2099	P03372	0.75
FES	2242	P07332	0.75
HSF1	3297	Q00613	0.75
PHLPP1	23239	O60346	0.76
MAP3K1	4214	Q13233	0.78
PTGES3	10728	Q15185	0.82
STK11	6794	Q15831	0.83
CDK15	65061	Q96Q40	0.83
PGR	5241	P06401	0.84
PRKAA1	5562	Q13131	0.86
USP49	25862	Q70CQ1	0.86
NR3C1	2908	P04150	0.88
CDK9	1025	P50750	0.89