BP

GO:0000165

MAPK cascade

An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

TAS

BP

GO:0000187

activation of MAPK activity

The initiation of the activity of the inactive enzyme MAP kinase (MAPK).

TAS

BP

GO:0001658

branching involved in ureteric bud morphogenesis

The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.

IDA

BP

GO:0001938

positive regulation of endothelial cell proliferation

Any process that activates or increases the rate or extent of endothelial cell proliferation.

IDA|IMP

BP

GO:0002042

cell migration involved in sprouting angiogenesis

The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.

IDA|IGI

BP

GO:0006661

phosphatidylinositol biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.

IDA

BP

GO:0006935

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

TAS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

NAS

BP

GO:0007265

Ras protein signal transduction

A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.

TAS

BP

GO:0007399

nervous system development

The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

TAS

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

IDA|IGI

BP

GO:0008543

fibroblast growth factor receptor signaling pathway

The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.

IDA|IGI|IPI|TAS

BP

GO:0009887

animal organ morphogenesis

Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

TAS

BP

GO:0010764

negative regulation of fibroblast migration

Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.

IDA

BP

GO:0010863

positive regulation of phospholipase C activity

Any process that increases the rate of phospholipase C activity.

IDA

BP

GO:0014066

regulation of phosphatidylinositol 3-kinase signaling

Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.

TAS

BP

GO:0014843

growth factor dependent regulation of skeletal muscle satellite cell proliferation

Any process that modulates the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta.

IMP

BP

GO:0018108

peptidyl-tyrosine phosphorylation

The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.

IEA

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

TAS

BP

GO:0030214

hyaluronan catabolic process

The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.

IDA

BP

GO:0031334

positive regulation of protein complex assembly

Any process that activates or increases the frequency, rate or extent of protein complex assembly.

IDA

BP

GO:0032958

inositol phosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.

IDA

BP

GO:0035019

somatic stem cell population maintenance

Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.

TAS

BP

GO:0036092

phosphatidylinositol-3-phosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.

IEA

BP

GO:0042060

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

IDA|TAS

BP

GO:0042660

positive regulation of cell fate specification

Any process that activates or enables a cell to adopt a specific fate.

IDA

BP

GO:0043406

positive regulation of MAP kinase activity

Any process that activates or increases the frequency, rate or extent of MAP kinase activity.

IDA

BP

GO:0043536

positive regulation of blood vessel endothelial cell migration

Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.

IDA

BP

GO:0043537

negative regulation of blood vessel endothelial cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.

IDA

BP

GO:0043547

positive regulation of GTPase activity

Any process that activates or increases the activity of a GTPase.

IEA

BP

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.

IDA

BP

GO:0045765

regulation of angiogenesis

Any process that modulates the frequency, rate or extent of angiogenesis.

TAS

BP

GO:0045766

positive regulation of angiogenesis

Any process that activates or increases angiogenesis.

IDA

BP

GO:0045893

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

IDA

BP

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA

BP

GO:0046854

phosphatidylinositol phosphorylation

The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.

IEA

BP

GO:0048015

phosphatidylinositol-mediated signaling

A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

TAS

BP

GO:0048598

embryonic morphogenesis

The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.

TAS

BP

GO:0050918

positive chemotaxis

The directed movement of a motile cell or organism towards a higher concentration of a chemical.

IEA

BP

GO:0051209

release of sequestered calcium ion into cytosol

The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.

IDA

BP

GO:0051781

positive regulation of cell division

Any process that activates or increases the frequency, rate or extent of cell division.

IEA

BP

GO:0060045

positive regulation of cardiac muscle cell proliferation

Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.

IDA

BP

GO:0060548

negative regulation of cell death

Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

IDA

BP

GO:0060591

chondroblast differentiation

The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes.

IDA

BP

GO:0061045

negative regulation of wound healing

Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

IDA

BP

GO:0070374

positive regulation of ERK1 and ERK2 cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

IC|IDA

BP

GO:1903672

positive regulation of sprouting angiogenesis

Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.

IDA|IMP

BP

GO:2000544

regulation of endothelial cell chemotaxis to fibroblast growth factor

Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor.

IDA

BP

GO:2000546

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor.

IDA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IEA

MF

GO:0004713

protein tyrosine kinase activity

Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

TAS

MF

GO:0005088

Ras guanyl-nucleotide exchange factor activity

Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

TAS

MF

GO:0005104

fibroblast growth factor receptor binding

Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR).

IPI

MF

GO:0005125

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008083

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

IDA

MF

GO:0008201

heparin binding

Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

IEA

MF

GO:0016303

1-phosphatidylinositol-3-kinase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).

TAS

MF

GO:0030374

ligand-dependent nuclear receptor transcription coactivator activity

The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.

IDA

MF

GO:0042056

chemoattractant activity

Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.

IDA

MF

GO:0046934

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).

TAS