| Gene Symbol | FARSA |
| Entrez ID | 2193 |
| Uniprot ID | Q9Y285 |
| Description | phenylalanyl-tRNA synthetase alpha subunit |
| Chromosomal Location | chr19: 12,922,479-12,934,037 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006418 |
tRNA aminoacylation for protein translation |
The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. |
TAS |
|
BP |
GO:0006432 |
phenylalanyl-tRNA aminoacylation |
The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
IBA|IDA |
|
BP |
GO:0051290 |
protein heterotetramerization |
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. |
IDA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
TAS |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
CC |
GO:0009328 |
phenylalanine-tRNA ligase complex |
An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe). |
IBA|IDA |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
MF |
GO:0000049 |
tRNA binding |
Interacting selectively and non-covalently with transfer RNA. |
IEA |
|
MF |
GO:0004826 |
phenylalanine-tRNA ligase activity |
Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). |
IDA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR002319 |
Phenylalanyl-tRNA synthetase |
|
IPR004529 |
Phenylalanyl-tRNA synthetase, class IIc, alpha subunit |
|
IPR006195 |
Aminoacyl-tRNA synthetase, class II |
|
IPR011991 |
Winged helix-turn-helix DNA-binding domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00970 |
Aminoacyl-tRNA biosynthesis |
KEGG |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
lung |
macrophages |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
ovarian stroma cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
small intestine |
glandular cells |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
RPLP0 |
6175 |
P05388 |
0.63 |
|
TDGF1 |
6997 |
P13385 |
0.63 |
|
HNRNPR |
10236 |
O43390 |
0.63 |
|
CCT6B |
10693 |
Q92526 |
0.63 |
|
ABI3 |
51225 |
Q9P2A4 |
0.63 |
|
ECSIT |
51295 |
Q9BQ95 |
0.68 |
|
FARSB |
10056 |
Q9NSD9 |
0.80 |
|
CDC42 |
998 |
P60953 |
0.49 |
|
EEF2 |
1938 |
P13639 |
0.49 |
|
PRPS1 |
5631 |
P60891 |
0.49 |
|
PSMD2 |
5708 |
Q13200 |
0.49 |
|
OGT |
8473 |
O15294 |
0.49 |
|
ECM29 |
23392 |
Q5VYK3 |
0.49 |
|
IRF2BP1 |
26145 |
Q8IU81 |
0.49 |
|
PSMG2 |
56984 |
Q969U7 |
0.49 |
|
ESR1 |
2099 |
P03372 |
0.56 |
|
TARS |
6897 |
P26639 |
0.56 |
|
A2M |
2 |
P01023 |
0.63 |
|
APOE |
348 |
P02649 |
0.63 |
|
CFTR |
1080 |
P13569 |
0.63 |
|
EGFR |
1956 |
P00533 |
0.63 |
|
ILK |
3611 |
Q13418 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MCM2 |
4171 |
P49736 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
NEDD8 |
4738 |
Q15843 |
0.63 |
|
NFKB1 |
4790 |
P19838 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
SUMO2 |
6613 |
P61956 |
0.63 |
|
SUMO1 |
7341 |
P63165 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
CUL1 |
8454 |
Q13616 |
0.63 |
|
PAN2 |
9924 |
Q504Q3 |
0.63 |
|
UBD |
10537 |
O15205 |
0.63 |
|
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
|
ASB4 |
51666 |
Q9Y574 |
0.63 |
|
WWOX |
51741 |
Q9NZC7 |
0.63 |
|
OTUB1 |
55611 |
Q96FW1 |
0.63 |
|
PUS1 |
80324 |
Q9Y606 |
0.63 |
|
UNC93B1 |
81622 |
Q9H1C4 |
0.63 |
|
GORAB |
92344 |
Q5T7V8 |
0.63 |
|
LRRK2 |
120892 |
Q5S007 |
0.63 |
|
RNF32 |
140545 |
Q9H0A6 |
0.63 |
|
EIF2AK2 |
5610 |
P19525 |
0.72 |
|
XRCC3 |
7517 |
O43542 |
0.72 |
|
OFD1 |
8481 |
O75665 |
0.72 |
|
USP11 |
8237 |
P51784 |
0.76 |
|
USP32 |
84669 |
Q8NFA0 |
0.76 |