| Gene Symbol | FARSA |
| Entrez ID | 2193 |
| Uniprot ID | Q9Y285 |
| Description | phenylalanyl-tRNA synthetase alpha subunit |
| Chromosomal Location | chr19: 12,922,479-12,934,037 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0006418 | tRNA aminoacylation for protein translation |
The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. | TAS |
BP | GO:0006432 | phenylalanyl-tRNA aminoacylation |
The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | IBA|IDA |
BP | GO:0051290 | protein heterotetramerization |
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. | IDA |
CC | GO:0005737 | cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | TAS |
CC | GO:0005829 | cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. | TAS |
CC | GO:0009328 | phenylalanine-tRNA ligase complex |
An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe). | IBA|IDA |
CC | GO:0016020 | membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. | IDA |
MF | GO:0000049 | tRNA binding |
Interacting selectively and non-covalently with transfer RNA. | IEA |
MF | GO:0004826 | phenylalanine-tRNA ligase activity |
Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). | IDA |
MF | GO:0005515 | protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). | IPI |
MF | GO:0005524 | ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | IEA |
MF | GO:0044822 | poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. | IDA |
| Domain ID | Description |
|---|---|
IPR002319 | Phenylalanyl-tRNA synthetase |
IPR004529 | Phenylalanyl-tRNA synthetase, class IIc, alpha subunit |
IPR006195 | Aminoacyl-tRNA synthetase, class II |
IPR011991 | Winged helix-turn-helix DNA-binding domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa00970 | Aminoacyl-tRNA biosynthesis | KEGG |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
appendix | glandular cells |
appendix | lymphoid tissue |
bone marrow | hematopoietic cells |
bronchus | respiratory epithelial cells |
caudate | glial cells |
caudate | neuronal cells |
cerebellum | cells in granular layer |
cerebellum | cells in molecular layer |
cerebellum | Purkinje cells |
cerebral cortex | glial cells |
cerebral cortex | neuronal cells |
cervix, uterine | glandular cells |
cervix, uterine | squamous epithelial cells |
colon | glandular cells |
colon | peripheral nerve/ganglion |
duodenum | glandular cells |
endometrium | glandular cells |
epididymis | glandular cells |
esophagus | squamous epithelial cells |
fallopian tube | glandular cells |
gallbladder | glandular cells |
heart muscle | myocytes |
hippocampus | glial cells |
hippocampus | neuronal cells |
kidney | cells in glomeruli |
kidney | cells in tubules |
lung | macrophages |
lymph node | germinal center cells |
lymph node | non-germinal center cells |
nasopharynx | respiratory epithelial cells |
oral mucosa | squamous epithelial cells |
ovary | ovarian stroma cells |
pancreas | exocrine glandular cells |
pancreas | islets of Langerhans |
parathyroid gland | glandular cells |
placenta | decidual cells |
placenta | trophoblastic cells |
prostate | glandular cells |
rectum | glandular cells |
salivary gland | glandular cells |
seminal vesicle | glandular cells |
skin | keratinocytes |
skin | Langerhans |
skin | melanocytes |
small intestine | glandular cells |
spleen | cells in red pulp |
spleen | cells in white pulp |
stomach | glandular cells |
testis | cells in seminiferous ducts |
thyroid gland | glandular cells |
tonsil | germinal center cells |
tonsil | non-germinal center cells |
tonsil | squamous epithelial cells |
urinary bladder | urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22617121 | Ouandaogo et al. | 2012 | Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
RPLP0 | 6175 | P05388 | 0.63 |
TDGF1 | 6997 | P13385 | 0.63 |
HNRNPR | 10236 | O43390 | 0.63 |
CCT6B | 10693 | Q92526 | 0.63 |
ABI3 | 51225 | Q9P2A4 | 0.63 |
ECSIT | 51295 | Q9BQ95 | 0.68 |
FARSB | 10056 | Q9NSD9 | 0.8 |
CDC42 | 998 | P60953 | 0.49 |
EEF2 | 1938 | P13639 | 0.49 |
PRPS1 | 5631 | P60891 | 0.49 |
PSMD2 | 5708 | Q13200 | 0.49 |
OGT | 8473 | O15294 | 0.49 |
ECM29 | 23392 | Q5VYK3 | 0.49 |
IRF2BP1 | 26145 | Q8IU81 | 0.49 |
PSMG2 | 56984 | Q969U7 | 0.49 |
ESR1 | 2099 | P03372 | 0.56 |
TARS | 6897 | P26639 | 0.56 |
A2M | 2 | P01023 | 0.63 |
APOE | 348 | P02649 | 0.63 |
CFTR | 1080 | P13569 | 0.63 |
EGFR | 1956 | P00533 | 0.63 |
ILK | 3611 | Q13418 | 0.63 |
JUN | 3725 | P05412 | 0.63 |
MCM2 | 4171 | P49736 | 0.63 |
MDM2 | 4193 | Q00987 | 0.63 |
NEDD8 | 4738 | Q15843 | 0.63 |
NFKB1 | 4790 | P19838 | 0.63 |
NTRK1 | 4914 | P04629 | 0.63 |
SUMO2 | 6613 | P61956 | 0.63 |
SUMO1 | 7341 | P63165 | 0.63 |
CUL3 | 8452 | Q13618 | 0.63 |
CUL1 | 8454 | Q13616 | 0.63 |
PAN2 | 9924 | Q504Q3 | 0.63 |
UBD | 10537 | O15205 | 0.63 |
FBXO6 | 26270 | Q9NRD1 | 0.63 |
ASB4 | 51666 | Q9Y574 | 0.63 |
WWOX | 51741 | Q9NZC7 | 0.63 |
OTUB1 | 55611 | Q96FW1 | 0.63 |
PUS1 | 80324 | Q9Y606 | 0.63 |
UNC93B1 | 81622 | Q9H1C4 | 0.63 |
GORAB | 92344 | Q5T7V8 | 0.63 |
LRRK2 | 120892 | Q5S007 | 0.63 |
RNF32 | 140545 | Q9H0A6 | 0.63 |
EIF2AK2 | 5610 | P19525 | 0.72 |
XRCC3 | 7517 | O43542 | 0.72 |
OFD1 | 8481 | O75665 | 0.72 |
USP11 | 8237 | P51784 | 0.76 |
USP32 | 84669 | Q8NFA0 | 0.76 |