BP

GO:0001933

negative regulation of protein phosphorylation

Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.

IDA

BP

GO:0007162

negative regulation of cell adhesion

Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.

IDA

BP

GO:0007566

embryo implantation

Attachment of the blastocyst to the uterine lining.

IEA

BP

GO:0010952

positive regulation of peptidase activity

Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.

IEA

BP

GO:0016032

viral process

A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.

IEA

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

IEA

BP

GO:0070373

negative regulation of ERK1 and ERK2 cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

IDA

BP

GO:0072378

blood coagulation, fibrin clot formation

A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events.

IDA

BP

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.

IDA

BP

GO:2000146

negative regulation of cell motility

Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.

IDA

BP

GO:2000647

negative regulation of stem cell proliferation

Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation.

IDA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

NAS|TAS

CC

GO:0005577

fibrinogen complex

A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.

IDA

CC

GO:0005578

proteinaceous extracellular matrix

A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.

IDA

CC

GO:0005604

basement membrane

A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.

IEA

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0031012

extracellular matrix

A structure lying external to one or more cells, which provides structural support for cells or tissues.

IDA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

CC

GO:0071953

elastic fiber

An extracellular matrix part that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain.

IDA

MF

GO:0001968

fibronectin binding

Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.

IPI

MF

GO:0005201

extracellular matrix structural constituent

The action of a molecule that contributes to the structural integrity of the extracellular matrix.

IDA

MF

GO:0005509

calcium ion binding

Interacting selectively and non-covalently with calcium ions (Ca2+).

IDA

MF

GO:0008022

protein C-terminus binding

Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.

IPI

MF

GO:0016504

peptidase activator activity

Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

IEA

MF

GO:0032403

protein complex binding

Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0042802

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

IDA

MF

GO:0070051

fibrinogen binding

Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade.

IPI