| Gene Symbol | FANCB |
| Entrez ID | 2187 |
| Uniprot ID | Q8NB91 |
| Description | Fanconi anemia complementation group B |
| Chromosomal Location | chrX: 14,843,407-14,873,069 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0036297 | interstrand cross-link repair |
Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. | TAS |
CC | GO:0005654 | nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. | TAS |
CC | GO:0043240 | Fanconi anaemia nuclear complex |
A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage. | IDA |
| Domain ID | Description |
|---|---|
IPR033333 | Fanconi anemia group B protein |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa03460 | Fanconi anemia pathway | KEGG |
| UMLS CUI | UMLS Term |
|---|---|
C0015625 | Fanconi Anemia |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22617121 | Ouandaogo et al. | 2012 | Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
F3 | 2152 | P13726 | 0.63 |
FANCG | 2189 | O15287 | 0.82 |
FANCL | 55120 | Q9NW38 | 0.86 |
THBS3 | 7059 | P49746 | 0.63 |
FAAP24 | 91442 | Q9BTP7 | 0.63 |
APITD1 | 378708 | Q8N2Z9 | 0.63 |
FAAP20 | 199990 | Q6NZ36 | 0.73 |
FANCA | 2175 | O15360 | 0.83 |
FANCM | 57697 | Q8IYD8 | 0.83 |
FAAP100 | 80233 | Q0VG06 | 0.88 |