BP

GO:0006464

cellular protein modification process

The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

TAS

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.

IBA

BP

GO:0007204

positive regulation of cytosolic calcium ion concentration

Any process that increases the concentration of calcium ions in the cytosol.

IMP

BP

GO:0010506

regulation of autophagy

Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

TAS

BP

GO:0010863

positive regulation of phospholipase C activity

Any process that increases the rate of phospholipase C activity.

IMP

BP

GO:0010976

positive regulation of neuron projection development

Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

IMP

BP

GO:0016477

cell migration

The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.

IEA

BP

GO:0018108

peptidyl-tyrosine phosphorylation

The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.

IDA

BP

GO:0030036

actin cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.

IEA

BP

GO:0030100

regulation of endocytosis

Any process that modulates the frequency, rate or extent of endocytosis.

TAS

BP

GO:0030155

regulation of cell adhesion

Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.

TAS

BP

GO:0038083

peptidyl-tyrosine autophosphorylation

The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein.

IBA

BP

GO:0042127

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

IBA

BP

GO:0045087

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

IBA

BP

GO:0051353

positive regulation of oxidoreductase activity

Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.

IDA

BP

GO:0071300

cellular response to retinoic acid

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.

IMP

BP

GO:2000145

regulation of cell motility

Any process that modulates the frequency, rate or extent of cell motility.

TAS

BP

GO:2000249

regulation of actin cytoskeleton reorganization

Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization.

TAS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0015629

actin cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.

TAS

CC

GO:0031234

extrinsic component of cytoplasmic side of plasma membrane

The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.

IBA

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IDA

MF

GO:0003785

actin monomer binding

Interacting selectively and non-covalently with monomeric actin, also known as G-actin.

TAS

MF

GO:0004672

protein kinase activity

Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

TAS

MF

GO:0004713

protein tyrosine kinase activity

Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

IDA|TAS

MF

GO:0004715

non-membrane spanning protein tyrosine kinase activity

Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0030145

manganese ion binding

Interacting selectively and non-covalently with manganese (Mn) ions.

IDA

MF

GO:0051015

actin filament binding

Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

TAS