Protein Description

Gene Symbol GPX8
Entrez ID 493869
Uniprot ID Q8TED1
Description glutathione peroxidase 8 (putative)
Chromosomal Location chr5: 55,160,118-55,167,071
Ontology GO ID GO Term Definition Evidence

BP

GO:0000302

response to reactive oxygen species

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.

TAS

BP

GO:0055114

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

IEA

BP

GO:0098869

cellular oxidant detoxification

Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.

IEA

CC

GO:0005788

endoplasmic reticulum lumen

The volume enclosed by the membranes of the endoplasmic reticulum.

TAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0004601

peroxidase activity

Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.

EXP

MF

GO:0004602

glutathione peroxidase activity

Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O.

IEA

Domain ID Description

IPR000889

Glutathione peroxidase

IPR012336

Thioredoxin-like fold

IPR013376

Glutathione peroxidase Gpx7, putative

IPR029760

Glutathione peroxidase conserved site

Pathway ID Pathway Term Pathway Source

hsa00480

Glutathione metabolism

KEGG

hsa00590

Arachidonic acid metabolism

KEGG

hsa04918

Thyroid hormone synthesis

KEGG

No diseases found.

Tissue Cell Type

smooth muscle

smooth muscle cells

stomach

glandular cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

23824412

Piltonen et al.

2013

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

Gene Symbol Entrez ID Uniprot ID Score

GAPDHS

26330

O14556

0.63