Gene Symbol | GPX8 |
Entrez ID | 493869 |
Uniprot ID | Q8TED1 |
Description | glutathione peroxidase 8 (putative) |
Chromosomal Location | chr5: 55,160,118-55,167,071 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000302 |
response to reactive oxygen species |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. |
TAS |
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IEA |
BP |
GO:0098869 |
cellular oxidant detoxification |
Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. |
IEA |
CC |
GO:0005788 |
endoplasmic reticulum lumen |
The volume enclosed by the membranes of the endoplasmic reticulum. |
TAS |
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
MF |
GO:0004601 |
peroxidase activity |
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O. |
EXP |
MF |
GO:0004602 |
glutathione peroxidase activity |
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. |
IEA |
Domain ID | Description |
---|---|
IPR000889 |
Glutathione peroxidase |
IPR012336 |
Thioredoxin-like fold |
IPR013376 |
Glutathione peroxidase Gpx7, putative |
IPR029760 |
Glutathione peroxidase conserved site |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00480 |
Glutathione metabolism |
KEGG |
hsa00590 |
Arachidonic acid metabolism |
KEGG |
hsa04918 |
Thyroid hormone synthesis |
KEGG |
Tissue | Cell Type |
---|---|
smooth muscle |
smooth muscle cells |
stomach |
glandular cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
23824412 |
Piltonen et al. |
2013 |
Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
GAPDHS |
26330 |
O14556 |
0.63 |