| Gene Symbol | GPX8 |
| Entrez ID | 493869 |
| Uniprot ID | Q8TED1 |
| Description | glutathione peroxidase 8 (putative) |
| Chromosomal Location | chr5: 55,160,118-55,167,071 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0000302 | response to reactive oxygen species |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. | TAS |
BP | GO:0055114 | oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. | IEA |
BP | GO:0098869 | cellular oxidant detoxification |
Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. | IEA |
CC | GO:0005788 | endoplasmic reticulum lumen |
The volume enclosed by the membranes of the endoplasmic reticulum. | TAS |
CC | GO:0016021 | integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. | IEA |
MF | GO:0004601 | peroxidase activity |
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O. | EXP |
MF | GO:0004602 | glutathione peroxidase activity |
Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. | IEA |
| Domain ID | Description |
|---|---|
IPR000889 | Glutathione peroxidase |
IPR012336 | Thioredoxin-like fold |
IPR013376 | Glutathione peroxidase Gpx7, putative |
IPR029760 | Glutathione peroxidase conserved site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa00480 | Glutathione metabolism | KEGG |
hsa00590 | Arachidonic acid metabolism | KEGG |
hsa04918 | Thyroid hormone synthesis | KEGG |
| Tissue | Cell Type |
|---|---|
smooth muscle | smooth muscle cells |
stomach | glandular cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22951915 | Haozi et al. | 2012 | Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
23824412 | Piltonen et al. | 2013 | Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
GAPDHS | 26330 | O14556 | 0.63 |