Protein Description

Gene Symbol CCDC103
Entrez ID 388389
Uniprot ID Q8IW40
Description coiled-coil domain containing 103
Chromosomal Location chr17: 44,899,142-44,905,390
Ontology GO ID GO Term Definition Evidence

BP

GO:0001947

heart looping

The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.

IMP

BP

GO:0003341

cilium movement

The directed, self-propelled movement of a cilium.

IGI

BP

GO:0036158

outer dynein arm assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.

IGI

BP

GO:0036159

inner dynein arm assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.

IGI

BP

GO:0060287

epithelial cilium movement involved in determination of left/right asymmetry

The movement of cilia of epithelial cells resulting in the transport of signals which determine asymmetry in an organism's body plan with respect to the left and right halves.

IC

BP

GO:0070286

axonemal dynein complex assembly

The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.

IMP

BP

GO:0071907

determination of digestive tract left/right asymmetry

Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed.

IMP

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

ISS

CC

GO:0005930

axoneme

The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.

ISS

CC

GO:0031514

motile cilium

A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

IDA

Domain ID Description

IPR025986

RNA-polymerase II-associated protein 3-like, C-terminal domain

IPR031733

Dynein attachment factor, N-terminal

No pathways found.

UMLS CUI UMLS Term

C0022521

Kartagener Syndrome

Tissue Cell Type

heart muscle

myocytes

smooth muscle

smooth muscle cells

No databases found.

Pubmed ID Author Year Title

26459919

Lan et al.

2015

Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling

Gene Symbol Entrez ID Uniprot ID Score

MEOX2

4223

P50222

0.63

HGS

9146

O14964

0.63

RUVBL2

10856

Q9Y230

0.63

R3HCC1L

27291

Q7Z5L2

0.63

VAC14

55697

Q08AM6

0.63