Protein Description

Gene Symbol MAST4
Entrez ID 375449
Uniprot ID O15021
Description microtubule associated serine/threonine kinase family member 4
Chromosomal Location chr5: 66,596,361-67,169,595
Ontology GO ID GO Term Definition Evidence

BP

GO:0018105

peptidyl-serine phosphorylation

The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

IBA

BP

GO:0035556

intracellular signal transduction

The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

IBA

CC

GO:0005622

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

IBA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IEA

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IEA

MF

GO:0004674

protein serine/threonine kinase activity

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

IBA

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

Domain ID Description

IPR000719

Protein kinase domain

IPR000961

AGC-kinase, C-terminal

IPR001478

PDZ domain

IPR008271

Serine/threonine-protein kinase, active site

IPR011009

Protein kinase-like domain

IPR015022

Microtubule-associated serine/threonine-protein kinase, domain

IPR023142

Microtubule-associated serine/threonine-protein kinase, pre-PK domain

No pathways found.

UMLS CUI UMLS Term

C0014544

Epilepsy

Tissue Cell Type

esophagus

squamous epithelial cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

EEF1A1

1915

P68104

0.63

SMAD1

4086

Q15797

0.63

MYC

4609

P01106

0.63