Protein Description

Gene Symbol NMNAT3
Entrez ID 349565
Uniprot ID Q96T66
Description nicotinamide nucleotide adenylyltransferase 3
Chromosomal Location chr3: 139,560,180-139,678,017
Ontology GO ID GO Term Definition Evidence

BP

GO:0009435

NAD biosynthetic process

The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.

IC

BP

GO:0009611

response to wounding

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

IEA

BP

GO:0019674

NAD metabolic process

The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.

TAS

BP

GO:0034628

de novo' NAD biosynthetic process from aspartate

The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.

IBA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

MF

GO:0000309

nicotinamide-nucleotide adenylyltransferase activity

Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+.

IBA|TAS

MF

GO:0004515

nicotinate-nucleotide adenylyltransferase activity

Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+.

IDA

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

Domain ID Description

IPR004821

Cytidyltransferase-like domain

IPR005248

Nicotinate/nicotinamide nucleotide adenylyltransferase

IPR014729

Rossmann-like alpha/beta/alpha sandwich fold

Pathway ID Pathway Term Pathway Source

hsa00760

Nicotinate and nicotinamide metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

WP3644

NAD+ metabolism

WikiPathways

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

bone marrow

hematopoietic cells

cerebellum

cells in granular layer

cerebral cortex

neuropil

cervix, uterine

squamous epithelial cells

colon

glandular cells

colon

peripheral nerve/ganglion

duodenum

glandular cells

endometrium

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

heart muscle

myocytes

kidney

cells in tubules

lung

macrophages

lymph node

non-germinal center cells

nasopharynx

respiratory epithelial cells

oral mucosa

squamous epithelial cells

pancreas

exocrine glandular cells

parathyroid gland

glandular cells

placenta

trophoblastic cells

rectum

glandular cells

salivary gland

glandular cells

skin

fibroblasts

skin

keratinocytes

skin

Langerhans

skin

melanocytes

skin

epidermal cells

small intestine

glandular cells

stomach

glandular cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

vagina

squamous epithelial cells

Database Name

DisGeNET

Pubmed ID Author Year Title

21411543

Savaris et al.

2011

Progesterone Resistance in PCOS Endometrium: A Microarray Analysis in Clomiphene Citrate-Treated and Artificial Menstrual Cycles

Gene Symbol Entrez ID Uniprot ID Score

NMNAT3

349565

Q96T66

0.49

DCX

1641

O43602

0.63

HS2ST1

9653

Q7LGA3

0.63