Gene Symbol | NMNAT3 |
Entrez ID | 349565 |
Uniprot ID | Q96T66 |
Description | nicotinamide nucleotide adenylyltransferase 3 |
Chromosomal Location | chr3: 139,560,180-139,678,017 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0009435 |
NAD biosynthetic process |
The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. |
IC |
BP |
GO:0009611 |
response to wounding |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. |
IEA |
BP |
GO:0019674 |
NAD metabolic process |
The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. |
TAS |
BP |
GO:0034628 |
de novo' NAD biosynthetic process from aspartate |
The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. |
IBA |
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
MF |
GO:0000309 |
nicotinamide-nucleotide adenylyltransferase activity |
Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. |
IBA|TAS |
MF |
GO:0004515 |
nicotinate-nucleotide adenylyltransferase activity |
Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+. |
IDA |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
Domain ID | Description |
---|---|
IPR004821 |
Cytidyltransferase-like domain |
IPR005248 |
Nicotinate/nicotinamide nucleotide adenylyltransferase |
IPR014729 |
Rossmann-like alpha/beta/alpha sandwich fold |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00760 |
Nicotinate and nicotinamide metabolism |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
WP3644 |
NAD+ metabolism |
WikiPathways |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
appendix |
glandular cells |
bone marrow |
hematopoietic cells |
cerebellum |
cells in granular layer |
cerebral cortex |
neuropil |
cervix, uterine |
squamous epithelial cells |
colon |
glandular cells |
colon |
peripheral nerve/ganglion |
duodenum |
glandular cells |
endometrium |
glandular cells |
esophagus |
squamous epithelial cells |
fallopian tube |
glandular cells |
gallbladder |
glandular cells |
heart muscle |
myocytes |
kidney |
cells in tubules |
lung |
macrophages |
lymph node |
non-germinal center cells |
nasopharynx |
respiratory epithelial cells |
oral mucosa |
squamous epithelial cells |
pancreas |
exocrine glandular cells |
parathyroid gland |
glandular cells |
placenta |
trophoblastic cells |
rectum |
glandular cells |
salivary gland |
glandular cells |
skin |
fibroblasts |
skin |
keratinocytes |
skin |
Langerhans |
skin |
melanocytes |
skin |
epidermal cells |
small intestine |
glandular cells |
stomach |
glandular cells |
tonsil |
squamous epithelial cells |
urinary bladder |
urothelial cells |
vagina |
squamous epithelial cells |
Database Name |
---|
DisGeNET |
Pubmed ID | Author | Year | Title |
---|---|---|---|
21411543 |
Savaris et al. |
2011 |
Progesterone Resistance in PCOS Endometrium: A Microarray Analysis in Clomiphene Citrate-Treated and Artificial Menstrual Cycles |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
NMNAT3 |
349565 |
Q96T66 |
0.49 |
DCX |
1641 |
O43602 |
0.63 |
HS2ST1 |
9653 |
Q7LGA3 |
0.63 |