Protein Description

Gene Symbol ESR1
Entrez ID 2099
Uniprot ID P03372
Description estrogen receptor 1
Chromosomal Location chr6: 151,656,691-152,129,619
Ontology GO ID GO Term Definition Evidence

BP

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IMP

BP

GO:0001547

antral ovarian follicle growth

Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity.

IEA

BP

GO:0002064

epithelial cell development

The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.

IEA

BP

GO:0006338

chromatin remodeling

Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.

NAS

BP

GO:0006351

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

TAS

BP

GO:0006355

regulation of transcription, DNA-templated

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

NAS

BP

GO:0006366

transcription from RNA polymerase II promoter

The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

IDA

BP

GO:0006367

transcription initiation from RNA polymerase II promoter

Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.

TAS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0007200

phospholipase C-activating G-protein coupled receptor signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).

ISS

BP

GO:0007204

positive regulation of cytosolic calcium ion concentration

Any process that increases the concentration of calcium ions in the cytosol.

ISS

BP

GO:0008209

androgen metabolic process

The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.

IEA

BP

GO:0008584

male gonad development

The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.

IEA

BP

GO:0010629

negative regulation of gene expression

Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

IDA

BP

GO:0010863

positive regulation of phospholipase C activity

Any process that increases the rate of phospholipase C activity.

ISS

BP

GO:0030518

intracellular steroid hormone receptor signaling pathway

A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands.

ISS

BP

GO:0030520

intracellular estrogen receptor signaling pathway

Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).

NAS

BP

GO:0032355

response to estradiol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.

IDA

BP

GO:0034121

regulation of toll-like receptor signaling pathway

Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.

IEA

BP

GO:0042981

regulation of apoptotic process

Any process that modulates the occurrence or rate of cell death by apoptotic process.

IEA

BP

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.

IDA

BP

GO:0043433

negative regulation of sequence-specific DNA binding transcription factor activity

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

IDA

BP

GO:0043627

response to estrogen

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.

IDA

BP

GO:0045893

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

IDA

BP

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA

BP

GO:0048146

positive regulation of fibroblast proliferation

Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.

IEA

BP

GO:0050727

regulation of inflammatory response

Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.

IEA

BP

GO:0051091

positive regulation of sequence-specific DNA binding transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

IDA

BP

GO:0060065

uterus development

The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure.

IEA

BP

GO:0060068

vagina development

The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure.

IEA

BP

GO:0060523

prostate epithelial cord elongation

The developmental growth process in which solid chords of prostate epithelium increase in length.

IEA

BP

GO:0060527

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini.

IEA

BP

GO:0060687

regulation of branching involved in prostate gland morphogenesis

Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem.

IEA

BP

GO:0060745

mammary gland branching involved in pregnancy

The process in which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy.

IEA

BP

GO:0060749

mammary gland alveolus development

The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland.

IEA

BP

GO:0060750

epithelial cell proliferation involved in mammary gland duct elongation

The multiplication or reproduction of mammary gland branch epithelial cells, resulting in the elongation of the branch. The mammary gland branch differs from the bud in that it is not the initial curved portion of the outgrowth.

IEA

BP

GO:0071168

protein localization to chromatin

Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin.

IMP

BP

GO:0071391

cellular response to estrogen stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.

IEA

BP

GO:0071392

cellular response to estradiol stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.

IDA|ISS

BP

GO:1903799

negative regulation of production of miRNAs involved in gene silencing by miRNA

Any process that stops, prevents or reduces the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA.

IMP

CC

GO:0000790

nuclear chromatin

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

TAS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

NAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0035327

transcriptionally active chromatin

The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.

IDA

MF

GO:0000978

RNA polymerase II core promoter proximal region sequence-specific DNA binding

Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.

IDA

MF

GO:0001046

core promoter sequence-specific DNA binding

Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.

IDA

MF

GO:0001077

transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding

Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.

IDA

MF

GO:0003682

chromatin binding

Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

IDA

MF

GO:0003700

transcription factor activity, sequence-specific DNA binding

Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

NAS

MF

GO:0003707

steroid hormone receptor activity

Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.

TAS

MF

GO:0005496

steroid binding

Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.

ISS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008013

beta-catenin binding

Interacting selectively and non-covalently with the beta subunit of the catenin complex.

IPI

MF

GO:0008134

transcription factor binding

Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.

IPI

MF

GO:0008270

zinc ion binding

Interacting selectively and non-covalently with zinc (Zn) ions.

IEA

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI

MF

GO:0030235

nitric-oxide synthase regulator activity

Modulates the activity of nitric oxide synthase.

NAS

MF

GO:0030284

estrogen receptor activity

Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.

NAS

MF

GO:0034056

estrogen response element binding

Interacting selectively and non-covalently with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen.

IDA

MF

GO:0038052

RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding

Combining with estrogen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.

IDA|IGI

MF

GO:0042802

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

IPI

MF

GO:0051117

ATPase binding

Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.

IDA

Domain ID Description

IPR000536

Nuclear hormone receptor, ligand-binding domain

IPR001292

Oestrogen receptor

IPR001628

Zinc finger, nuclear hormone receptor-type

IPR001723

Nuclear hormone receptor

IPR013088

Zinc finger, NHR/GATA-type

IPR024178

Oestrogen receptor/oestrogen-related receptor

IPR024736

Oestrogen-type nuclear receptor final C-terminal domain

Pathway ID Pathway Term Pathway Source

hsa01522

Endocrine resistance

KEGG

hsa04915

Estrogen signaling pathway

KEGG

hsa04917

Prolactin signaling pathway

KEGG

hsa04919

Thyroid hormone signaling pathway

KEGG

hsa04961

Endocrine and other factor-regulated calcium reabsorption

KEGG

hsa05205

Proteoglycans in cancer

KEGG

hsa05224

Breast cancer

KEGG

WP1984

Integrated Breast Cancer Pathway

WikiPathways

WP2034

Leptin signaling pathway

WikiPathways

WP2881

Estrogen Receptor Pathway

WikiPathways

WP170

Nuclear Receptors

WikiPathways

WP2586

Aryl Hydrocarbon Receptor

WikiPathways

WP712

Estrogen signaling pathway

WikiPathways

h_carm-erPathway

CARM1 and Regulation of the Estrogen Receptor

BioCarta

h_mta3Pathway

Downregulated of MTA-3 in ER-negative Breast Tumors

BioCarta

h_EfpPathway

Estrogen-responsive protein Efp controls cell cycle and breast tumors growth

BioCarta

h_pelp1Pathway

Pelp1 Modulation of Estrogen Receptor Activity

BioCarta

h_her2Pathway

Role of ERBB2 in Signal Transduction and Oncology

BioCarta

UMLS CUI UMLS Term

C0001418

Adenocarcinoma

C0002395

Alzheimer'S Disease

C0004114

Astrocytoma

C0004153

Atherosclerosis

C0005695

Bladder Neoplasm

C0005944

Metabolic Bone Disorder

C0007621

Neoplastic Cell Transformation

C0014170

Endometrial Neoplasms

C0015799

Feminization

C0017658

Glomerulonephritis

C0021361

Female Infertility

C0021364

Male Infertility

C0023267

Fibroid Tumor

C0023418

Leukemia

C0023903

Liver Neoplasms

C0024121

Lung Neoplasms

C0024667

Animal Mammary Neoplasms

C0024668

Mammary Neoplasms, Experimental

C0025500

Mesothelioma

C0027051

Myocardial Infarction

C0027627

Neoplasm Metastasis

C0027643

Neoplasm Recurrence, Local

C0028754

Obesity

C0028960

Oligospermia

C0031117

Peripheral Neuropathy

C0033578

Prostatic Neoplasms

C0033941

Psychoses, Substance-Induced

C0149931

Migraine Disorders

C0242656

Disease Progression

C0282612

Prostatic Intraepithelial Neoplasias

C1458155

Mammary Neoplasms

C1720824

Sudden Cardiac Arrest

C1720887

Female Urogenital Diseases

C1956346

Coronary Artery Disease

C2239176

Liver Carcinoma

Tissue Cell Type

cervix, uterine

glandular cells

cervix, uterine

squamous epithelial cells

endometrium

glandular cells

endometrium

cells in endometrial stroma

fallopian tube

glandular cells

Database Name

DisGeNET

DGA

Pubmed ID Author Year Title

19141487

Kenigsberg et al.

2009

Gene expression microarray profiles of cumulus cells in lean and overweightobese polycystic ovary syndrome patients

Gene Symbol Entrez ID Uniprot ID Score

NR0B1

190

P51843

0.52

BDNF

627

P23560

0.52

JUNB

3726

P17275

0.52

JUND

3727

P17535

0.52

POLR2B

5431

P30876

0.52

POLR2C

5432

P19387

0.52

POLR2E

5434

P19388

0.52

POLR2F

5435

P61218

0.52

POLR2G

5436

P62487

0.52

POLR2H

5437

P52434

0.52

POLR2I

5438

P36954

0.52

POLR2J

5439

P52435

0.52

POLR2K

5440

P53803

0.52

POLR2L

5441

P62875

0.52

PRKACA

5566

P17612

0.52

SOS1

6654

Q07889

0.52

THRB

7068

P10828

0.52

USF1

7391

P22415

0.52

YWHAH

7533

Q04917

0.52

ZBTB17

7709

Q13105

0.52

PIK3R3

8503

Q92569

0.52

MBD2

8932

Q9UBB5

0.52

ANXA2P2

304

A6NMY6

0.55

MAPK3

5595

P27361

0.55

SREBF1

6720

P36956

0.55

PIAS3

10401

Q9Y6X2

0.55

SLC30A9

10463

Q6PML9

0.55

CIRBP

1153

Q14011

0.56

DDX1

1653

Q92499

0.56

EIF5A

1984

P63241

0.56

FARSA

2193

Q9Y285

0.56

HIST1H2BD

3017

P58876

0.56

HDLBP

3069

Q00341

0.56

KARS

3735

Q15046

0.56

LYZ

4069

P61626

0.56

NAP1L4

4676

Q99733

0.56

SEPT2

4735

Q15019

0.56

NSF

4905

P46459

0.56

PA2G4

5036

Q9UQ80

0.56

PPIB

5479

P23284

0.56

SET

6418

Q01105

0.56

PLA2G7

7941

Q13093

0.56

SMC1A

8243

Q14683

0.56

HIST2H2AC

8338

Q16777

0.56

YARS

8565

P54577

0.56

FUBP1

8880

Q96AE4

0.56

EIF2S2

8894

P20042

0.56

TAF1A

9015

Q15573

0.56

SMC3

9126

Q9UQE7

0.56

ZNHIT3

9326

Q15649

0.56

MED27

9442

Q6P2C8

0.56

HDAC9

9734

Q9UKV0

0.56

EIF4A3

9775

P38919

0.56

HDAC5

10014

Q9UQL6

0.56

ABCC5

10057

O15440

0.56

PQBP1

10084

O60828

0.56

MRPS31

10240

Q92665

0.56

UTP14A

10813

Q9BVJ6

0.56

TCERG1

10915

O14776

0.56

EHMT2

10919

Q96KQ7

0.56

NUDT21

11051

O43809

0.56

TOPBP1

11073

Q92547

0.56

MRPS27

23107

Q92552

0.56

SEPT8

23176

Q92599

0.56

SERBP1

26135

Q8NC51

0.56

SND1

27044

Q7KZF4

0.56

PRPF19

27339

Q9UMS4

0.56

MED4

29079

Q9NPJ6

0.56

MRPS2

51116

Q9Y399

0.56

MRPS17

51373

Q9Y2R5

0.56

EXOSC4

54512

Q9NPD3

0.56

WDR5B

54554

Q86VZ2

0.56

SARS2

54938

Q9NP81

0.56

PTCD3

55037

Q96EY7

0.56

PSPC1

55269

Q8WXF1

0.56

ZC3HAV1

56829

Q7Z2W4

0.56

MRPS22

56945

P82650

0.56

NCOA5

57727

Q9HCD5

0.56

SNX6

58533

Q9UNH7

0.56

MRPS35

60488

P82673

0.56

IL25

64806

Q9H293

0.56

MRPS15

64960

P82914

0.56

MRPS6

64968

P82932

0.56

GRWD1

83743

Q9BQ67

0.56

SARNP

84324

P82979

0.56

FBXO18

84893

Q8NFZ0

0.56

MED30

90390

Q96HR3

0.56

PABPC5

140886

Q96DU9

0.56

ATAD3C

219293

Q5T2N8

0.56

CALM2

805

P62158

0.59

CALM3

808

P62158

0.59

RBM23

55147

Q86U06

0.59

AARS

16

P49588

0.63

ABAT

18

P80404

0.63

ABCF1

23

Q8NE71

0.63

ACAA1

30

P09110

0.63

ACLY

47

P53396

0.63

ACO2

50

Q99798

0.63

ACTA1

58

P68133

0.63

AP2A2

161

O94973

0.63

ALDOA

226

P04075

0.63

ALDOC

230

P09972

0.63

SLC25A6

293

P12236

0.63

APEX1

328

P27695

0.63

ARF1

375

P84077

0.63

ARHGAP1

392

Q07960

0.63

ARHGDIA

396

P52565

0.63

ARSB

411

P15848

0.63

ASNS

440

P08243

0.63

ATIC

471

P31939

0.63

ATP1A1

476

P05023

0.63

ATP2A2

488

P16615

0.63

ATP5F1

515

P24539

0.63

KIF1A

547

Q12756

0.63

BCL3

602

P20749

0.63

SLC25A20

788

O43772

0.63

CAPZB

832

P47756

0.63

CAT

847

P04040

0.63

CD47

961

Q08722

0.63

CDK5

1020

Q00535

0.63

CHD4

1108

Q14839

0.63

CISH

1154

Q9NSE2

0.63

AP2M1

1173

Q96CW1

0.63

CLIC1

1192

O00299

0.63

COPA

1314

P53621

0.63

COPB1

1315

P53618

0.63

CSE1L

1434

P55060

0.63

CSRP1

1465

P21291

0.63

CTSD

1509

P07339

0.63

DDOST

1650

P39656

0.63

DECR1

1666

Q16698

0.63

DSP

1832

P15924

0.63

DUT

1854

P33316

0.63

E2F6

1876

O75461

0.63

EEF1A1

1915

P68104

0.63

EEF1A2

1917

Q05639

0.63

EEF1G

1937

P26641

0.63

EIF4G1

1981

Q04637

0.63

MARK2

2011

Q7KZI7

0.63

CTTN

2017

Q14247

0.63

ENO1

2023

P06733

0.63

STOM

2040

P27105

0.63

ETFA

2108

P13804

0.63

FHL2

2274

Q14192

0.63

FKBP1A

2280

P62942

0.63

FLNC

2318

Q14315

0.63

G6PD

2539

P11413

0.63

GAK

2580

O14976

0.63

GALK1

2584

P51570

0.63

GARS

2617

P41250

0.63

KAT2A

2648

Q92830

0.63

GOLGA2

2801

Q08379

0.63

GOT1

2805

P17174

0.63

CXCL1

2919

P09341

0.63

GSTM3

2947

P21266

0.63

MSH6

2956

P52701

0.63

HIST1H1B

3009

P16401

0.63

HIST1H2AD

3013

P20671

0.63

HIST1H2BB

3018

P33778

0.63

HADHA

3030

P40939

0.63

HADHB

3032

P55084

0.63

HADH

3033

Q16836

0.63

FOXA1

3169

P55317

0.63

HNRNPAB

3182

Q99729

0.63

HNRNPH2

3188

P55795

0.63

HNRNPL

3191

P14866

0.63

HNRNPU

3192

Q00839

0.63

HOXC10

3226

Q9NYD6

0.63

HOXD9

3235

P28356

0.63

AGFG1

3267

P52594

0.63

DNAJA1

3301

P31689

0.63

HSPA1A

3303

P0DMV8

0.63

HSPA1B

3304

P0DMV9

0.63

HSPE1

3336

P61604

0.63

IARS

3376

P41252

0.63

IDH1

3417

O75874

0.63

IDH2

3418

P48735

0.63

IMPDH2

3615

P12268

0.63

IRS1

3667

P35568

0.63

EIF6

3692

P56537

0.63

KPNB1

3837

Q14974

0.63

KRT1

3848

P04264

0.63

KRT4

3851

P19013

0.63

KRT6A

3853

P02538

0.63

KRT13

3860

P13646

0.63

KRT16

3868

P08779

0.63

KRT35

3886

Q92764

0.63

RPSA

3921

P08865

0.63

LDHA

3939

P00338

0.63

LMNA

4000

P02545

0.63

LMNB1

4001

P20700

0.63

MCM2

4171

P49736

0.63

MCM5

4174

P33992

0.63

MDH2

4191

P40926

0.63

MT-CO2

4513

P00403

0.63

TRIM37

4591

O94972

0.63

MYC

4609

P01106

0.63

MYH10

4628

P35580

0.63

MYO1D

4642

O94832

0.63

MYO6

4646

Q9UM54

0.63

MYOD1

4654

P15172

0.63

NACA

4666

Q13765

0.63

RPL10A

4736

P62906

0.63

NFKB2

4791

Q00653

0.63

NFYA

4800

P23511

0.63

NME1

4830

P15531

0.63

NOP2

4839

P46087

0.63

NOS3

4846

P29474

0.63

NPPA

4878

P01160

0.63

OPA1

4976

O60313

0.63

PABPC3

5042

Q9H361

0.63

PRDX1

5052

Q06830

0.63

PCBP1

5093

Q15365

0.63

PCK2

5106

Q16822

0.63

PFKL

5211

P17858

0.63

PFKP

5214

Q01813

0.63

PGK1

5230

P00558

0.63

SERPINB5

5268

P36952

0.63

PIK3R2

5296

O00459

0.63

PKLR

5313

P30613

0.63

PKM

5315

P14618

0.63

PLCB3

5331

Q01970

0.63

POR

5447

P16435

0.63

PPIA

5478

P62937

0.63

PPP2CA

5515

P67775

0.63

PPP2CB

5516

P62714

0.63

PPP2R3A

5523

Q06190

0.63

PRKAR2A

5576

P13861

0.63

PRKCZ

5590

Q05513

0.63

PSMA5

5686

P28066

0.63

PSMA7

5688

O14818

0.63

PSMB2

5690

P49721

0.63

PSMC2

5701

P35998

0.63

PSMC4

5704

P43686

0.63

PSMC6

5706

P62333

0.63

PTBP1

5725

P26599

0.63

ALDH18A1

5832

P54886

0.63

PYGB

5834

P11216

0.63

RAB1A

5861

P62820

0.63

RAP1A

5906

P62834

0.63

RARB

5915

P10826

0.63

RARG

5916

P13631

0.63

RBBP6

5930

Q7Z6E9

0.63

RCN2

5955

Q14257

0.63

UPF1

5976

Q92900

0.63

RPL5

6125

P46777

0.63

RPL23A

6147

P62750

0.63

RPL31

6160

P62899

0.63

RPS3

6188

P23396

0.63

RPS5

6193

P46782

0.63

RPS7

6201

P62081

0.63

RPS10

6204

P46783

0.63

RPS15A

6210

P62244

0.63

RPS17

6218

P08708

0.63

RPS19

6223

P39019

0.63

RPS25

6230

P62851

0.63

SARS

6301

P49591

0.63

SEMG1

6406

P04279

0.63

SEMG2

6407

Q02383

0.63

SRSF6

6431

Q13247

0.63

SLC1A5

6510

Q15758

0.63

SLC3A2

6520

P08195

0.63

SNRPD1

6632

P62314

0.63

SNRPN

6638

P63162

0.63

SOS2

6655

Q07890

0.63

SP2

6668

Q02086

0.63

SPAG1

6674

Q07617

0.63

SPTBN1

6711

Q01082

0.63

SRPK1

6732

Q96SB4

0.63

SRPK2

6733

P78362

0.63

SSB

6741

P05455

0.63

SSR3

6747

Q9UNL2

0.63

STAT1

6772

P42224

0.63

SUPT6H

6830

Q7KZ85

0.63

TAF2

6873

Q6P1X5

0.63

TCOF1

6949

Q13428

0.63

TFAP2C

7022

Q92754

0.63

TIA1

7072

P31483

0.63

TKT

7086

P29401

0.63

TPM1

7168

P09493

0.63

TRAF3

7187

Q13114

0.63

TRAF6

7189

Q9Y4K3

0.63

CCT3

7203

P49368

0.63

TSC1

7248

Q92574

0.63

TTK

7272

P33981

0.63

TTN

7273

Q8WZ42

0.63

TUBB2A

7280

Q13885

0.63

TUBG1

7283

P23258

0.63

UBE2L3

7332

P68036

0.63

UGDH

7358

O60701

0.63

VCL

7414

P18206

0.63

VDAC1

7416

P21796

0.63

VDAC3

7419

Q9Y277

0.63

EZR

7430

P15311

0.63

YWHAB

7529

P31946

0.63

YWHAE

7531

P62258

0.63

ZNF182

7569

P17025

0.63

ZNF131

7690

P52739

0.63

MOGS

7841

Q13724

0.63

RAB7A

7879

P51149

0.63

DEK

7913

P35659

0.63

CCDC6

8030

Q16204

0.63

SHOC2

8036

Q9UQ13

0.63

GDF5

8200

P43026

0.63

TAGLN2

8407

P37802

0.63

DCHS1

8642

Q96JQ0

0.63

IRS2

8660

Q9Y4H2

0.63

EIF3B

8662

P55884

0.63

EIF3F

8665

O00303

0.63

KRT37

8688

O76014

0.63

INPP4B

8821

O15327

0.63

PRPF4B

8899

Q13523

0.63

KYNU

8942

Q16719

0.63

AP3D1

8943

O14617

0.63

PLOD3

8985

O60568

0.63

INA

9118

Q16352

0.63

AIFM1

9131

O95831

0.63

LRRFIP1

9208

Q32MZ4

0.63

VAPB

9217

O95292

0.63

VAPA

9218

Q9P0L0

0.63

GTF3C4

9329

Q9UKN8

0.63

EFTUD2

9343

Q15029

0.63

SLC9A3R1

9368

O14745

0.63

NPEPPS

9520

P55786

0.63

H2AFY

9555

O75367

0.63

PRDX6

9588

P30041

0.63

PDIA4

9601

P13667

0.63

IKBKE

9641

Q14164

0.63

BZW1

9689

Q7L1Q6

0.63

UBE3C

9690

Q15386

0.63

SPCS2

9789

Q15005

0.63

RNF40

9810

O75150

0.63

PSMD6

9861

Q15008

0.63

UBAP2L

9898

Q14157

0.63

G3BP2

9908

Q9UN86

0.63

SEC16A

9919

O15027

0.63

OXSR1

9943

O95747

0.63

WDR1

9948

O75083

0.63

NUP153

9972

P49790

0.63

ATP9A

10079

O75110

0.63

ARPC4

10093

P59998

0.63

RAD50

10111

Q92878

0.63

PDIA6

10130

Q15084

0.63

TRAP1

10131

Q12931

0.63

G3BP1

10146

Q13283

0.63

LANCL1

10314

O43813

0.63

TUBB4B

10383

P68371

0.63

NDC80

10403

O14777

0.63

TIMM44

10469

O43615

0.63

SEC23A

10484

Q15436

0.63

IPO7

10527

O95373

0.63

DCTN2

10540

Q13561

0.63

CCT4

10575

P50991

0.63

USP16

10600

Q9Y5T5

0.63

TBR1

10716

Q16650

0.63

HSPH1

10808

Q92598

0.63

RAB10

10890

P61026

0.63

POP1

10940

Q99575

0.63

HNRNPA0

10949

Q13151

0.63

TMED2

10959

Q15363

0.63

TMED10

10972

P49755

0.63

FERMT2

10979

Q96AC1

0.63

IMMT

10989

Q16891

0.63

HNRNPUL1

11100

Q9BUJ2

0.63

PSIP1

11168

O75475

0.63

SUPT16H

11198

Q9Y5B9

0.63

VPS45

11311

Q9NRW7

0.63

COPG1

22820

Q9Y678

0.63

PPP6R1

22870

Q9UPN7

0.63

ARHGEF15

22899

O94989

0.63

DHX30

22907

Q7L2E3

0.63

SNW1

22938

Q13573

0.63

KDM1A

23028

O60341

0.63

MPRIP

23164

Q6WCQ1

0.63

GANAB

23193

Q14697

0.63

FAM120A

23196

Q9NZB2

0.63

FAF2

23197

Q96CS3

0.63

RRS1

23212

Q15050

0.63

SIN3B

23309

O75182

0.63

SASH1

23328

O94885

0.63

ESYT1

23344

Q9BSJ8

0.63

SYNE1

23345

Q8NF91

0.63

SUN1

23353

O94901

0.63

LARP1

23367

Q6PKG0

0.63

ECM29

23392

Q5VYK3

0.63

SEC11A

23478

P67812

0.63

SUZ12

23512

Q15022

0.63

SRRM2

23524

Q9UQ35

0.63

HEBP2

23593

Q9Y5Z4

0.63

PATZ1

23598

Q9HBE1

0.63

CORO1C

23603

Q9ULV4

0.63

SGK3

23678

Q96BR1

0.63

HECTD1

25831

Q9ULT8

0.63

TOR1AIP1

26092

Q5JTV8

0.63

INTS1

26173

Q8N201

0.63

FAM162A

26355

Q96A26

0.63

TBL2

26608

Q9Y4P3

0.63

COPG2

26958

Q9UBF2

0.63

CECR5

27440

Q9BXW7

0.63

ACAD9

28976

Q9H845

0.63

TBK1

29110

Q9UHD2

0.63

GNL2

29889

Q13823

0.63

CERS2

29956

Q96G23

0.63

TNPO2

30000

O14787

0.63

NSDHL

50814

Q15738

0.63

FIS1

51024

Q9Y3D6

0.63

YTHDF2

51441

Q9Y5A9

0.63

DHRS7

51635

Q9Y394

0.63

DNAJB11

51726

Q9UBS4

0.63

LUC7L3

51747

O95232

0.63

DHX29

54505

Q7Z478

0.63

BCOR

54880

Q6W2J9

0.63

ELOVL2

54898

Q9NXB9

0.63

YTHDF1

54915

Q9BYJ9

0.63

MED9

55090

Q9NWA0

0.63

PGM2

55276

Q96G03

0.63

LRRC59

55379

Q96AG4

0.63

ZDHHC7

55625

Q9NXF8

0.63

LYAR

55646

Q9NX58

0.63

SCYL2

55681

Q6P3W7

0.63

CNDP2

55748

Q96KP4

0.63

CAND1

55832

Q86VP6

0.63

PPP2R2D

55844

Q66LE6

0.63

UNC45A

55898

Q9H3U1

0.63

WRNIP1

56897

Q96S55

0.63

UTP3

57050

Q9NQZ2

0.63

ZNFX1

57169

Q9P2E3

0.63

PRR12

57479

Q9ULL5

0.63

XPO5

57510

Q9HAV4

0.63

EP400

57634

Q96L91

0.63

EPB41L5

57669

Q9HCM4

0.63

RAP2C

57826

Q9Y3L5

0.63

NIF3L1

60491

Q9GZT8

0.63

VIPAS39

63894

Q9H9C1

0.63

FKBPL

63943

Q9UIM3

0.63

MRPS9

64965

P82933

0.63

DDX50

79009

Q9BQ39

0.63

CDC73

79577

Q6P1J9

0.63

ARMT1

79624

Q9H993

0.63

TBL1XR1

79718

Q9BZK7

0.63

TUBAL3

79861

A6NHL2

0.63

LPCAT1

79888

Q8NF37

0.63

CENPT

80152

Q96BT3

0.63

CEP290

80184

O15078

0.63

TMEM254

80195

Q8TBM7

0.63

WDR26

80232

Q9H7D7

0.63

PUS1

80324

Q9Y606

0.63

PABPC1L

80336

Q4VXU2

0.63

HM13

81502

Q8TCT9

0.63

TMX1

81542

Q9H3N1

0.63

FIP1L1

81608

Q6UN15

0.63

MED25

81857

Q71SY5

0.63

RAB1B

81876

Q9H0U4

0.63

KATNAL2

83473

Q8IYT4

0.63

CHD6

84181

Q8TD26

0.63

ALKBH7

84266

Q9BT30

0.63

ARFGAP2

84364

Q8N6H7

0.63

TUBB6

84617

Q9BUF5

0.63

GLYR1

84656

Q49A26

0.63

DTD1

92675

Q8TEA8

0.63

REEP6

92840

Q96HR9

0.63

H2AFV

94239

Q71UI9

0.63

LARP4

113251

Q71RC2

0.63

LACTB

114294

P83111

0.63

ANIB1

116833

N/A

0.63

HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4

121504

P62805

0.63

WDR36

134430

Q8NI36

0.63

DNAH2

146754

Q9P225

0.63

DYX1C1

161582

Q8WXU2

0.63

KRT78

196374

Q8N1N4

0.63

FBXO45

200933

P0C2W1

0.63

DAGLB

221955

Q8NCG7

0.63

CCDC110

256309

Q8TBZ0

0.63

TAB3

257397

Q8N5C8

0.63

C20orf197

284756

Q8N268

0.63

CFAP47

286464

Q6ZTR5

0.63

LUZP2

338645

Q86TE4

0.63

KRT79

338785

Q5XKE5

0.63

ZDHHC21

340481

Q8IVQ6

0.63

KRT77

374454

Q7Z794

0.63

RPS26P11

441502

Q5JNZ5

0.63

DDB1

100290337

Q16531

0.63

TUBA3C; TUBA3D

113457

Q13748

0.63

HIST2H3A; HIST2H3C; HIST2H3D

126961

Q71DI3

0.63

FOXO3

2309

O43524

0.65

HNF4A

3172

P41235

0.65

THRA

7067

P10827

0.65

COPS5

10987

Q92905

0.65

DKC1

1736

O60832

0.67

ERBB2

2064

P04626

0.67

EWSR1

2130

Q01844

0.67

FUS

2521

P35637

0.67

GATA3

2625

P23771

0.67

GNAI2

2771

P04899

0.67

GNAI3

2773

P08754

0.67

SFN

2810

P31947

0.67

H2AFX

3014

P16104

0.67

HNRNPF

3185

P52597

0.67

HSPA1L

3305

P34931

0.67

ILF2

3608

Q12905

0.67

CAPRIN1

4076

Q14444

0.67

MKI67

4288

P46013

0.67

PLEC

5339

Q15149

0.67

EXOSC10

5394

Q01780

0.67

RDX

5962

P35241

0.67

RPL3

6122

P39023

0.67

RPL4

6124

P36578

0.67

RPL6

6128

Q02878

0.67

RPL10

6134

P27635

0.67

RPL12

6136

P30050

0.67

RPL15

6138

P61313

0.67

RPL17

6139

P18621

0.67

RPL18A

6142

Q02543

0.67

RPL19

6143

P84098

0.67

RPL21

6144

P46778

0.67

RPL22

6146

P35268

0.67

RPL24

6152

P83731

0.67

RPL27A

6157

P46776

0.67

RPL28

6158

P46779

0.67

RPL29

6159

P47914

0.67

RPL37A

6168

P61513

0.67

RPL36A

6173

P83881

0.67

RPN1

6184

P04843

0.67

RPS6

6194

P62753

0.67

RPS23

6228

P62266

0.67

S100A7

6278

P31151

0.67

SERPINB4

6318

P48594

0.67

SRSF1

6426

Q07955

0.67

SRSF2

6427

Q01130

0.67

SRSF3

6428

P84103

0.67

SRSF5

6430

Q13243

0.67

SRSF7

6432

Q16629

0.67

TF

7018

P02787

0.67

TFRC

7037

P02786

0.67

TOP1

7150

P11387

0.67

TOP2A

7153

P11388

0.67

UBB

7314

P0CG47

0.67

UBTF

7343

P17480

0.67

DDX3Y

8653

O15523

0.67

DDX18

8886

Q9NVP1

0.67

RPL14

9045

P50914

0.67

DDX21

9188

Q9NR30

0.67

MAPKAPK2

9261

P49137

0.67

TRIP12

9320

Q14669

0.67

TECR

9524

Q9NZ01

0.67

THRAP3

9967

Q9Y2W1

0.67

HNRNPR

10236

O43390

0.67

SRRM1

10250

Q8IYB3

0.67

AKAP8

10270

O43823

0.67

RBM14

10432

Q96PK6

0.67

NOP56

10528

O00567

0.67

KHDRBS1

10657

Q07666

0.67

SEC61B

10952

P60468

0.67

U2AF2

11338

P26368

0.67

RRP1B

23076

Q14684

0.67

RRP12

23223

Q5JTH9

0.67

U2SURP

23350

O15042

0.67

RPL13A

23521

P40429

0.67

GTPBP4

23560

Q9BZE4

0.67

RSL1D1

26156

O76021

0.67

GNL3

26354

Q9BVP2

0.67

RBMX

27316

P38159

0.67

THEM6

51337

Q8WUY1

0.67

HACD3

51495

Q9P035

0.67

VPS13D

55187

Q5THJ4

0.67

ATAD3A

55210

Q9NVI7

0.67

DDX27

55661

Q96GQ7

0.67

WDR18

57418

Q9BV38

0.67

ZNF512B

57473

Q96KM6

0.67

POF1B

79983

Q8WVV4

0.67

EPPK1

83481

P58107

0.67

ELMSAN1

91748

Q6PJG2

0.67

FTSJ3

117246

Q8IY81

0.67

MYL6B

140465

P14649

0.67

HNRNPA1L2

144983

Q32P51

0.67

PGAM5

192111

Q96HS1

0.67

TRIM59

286827

Q8IWR1

0.67

NCCRP1

342897

Q6ZVX7

0.67

LGALS7; LGALS7B

3963

P47929

0.67

APOD

347

P05090

0.68

KLF5

688

Q13887

0.68

SERPINH1

871

P50454

0.68

DSG1

1828

Q02413

0.68

EZH2

2146

Q15910

0.68

BLOC1S1

2647

P78537

0.68

HIF1A

3091

Q16665

0.68

HPCAL1

3241

P37235

0.68

MUC1

4582

P15941

0.68

SUMO1

7341

P63165

0.68

TAF1B

9014

Q53T94

0.68

SMYD3

64754

Q9H7B4

0.68

BUD13

84811

Q9BRD0

0.68

ESRRA

2101

P11474

0.69

GTF2B

2959

Q00403

0.70

PSMB9

5698

P28065

0.70

MPG

4350

P29372

0.71

HEXIM1

10614

O94992

0.71

MEN1

4221

O00255

0.72

SMARCB1

6598

Q12824

0.72

SMARCC2

6601

Q8TAQ2

0.72

STAT3

6774

P40763

0.72

CBLL1

79872

Q75N03

0.72

ACTN1

87

P12814

0.73

BARD1

580

Q99728

0.73

CCNH

902

P51946

0.73

CCNT1

904

O60563

0.73

FLNB

2317

O75369

0.73

FMR1

2332

Q06787

0.73

XRCC6

2547

P12956

0.73

GNB1

2782

P62873

0.73

GNB2

2783

P62879

0.73

HSPA5

3309

P11021

0.73

HSPA9

3313

P38646

0.73

NME2

4831

P22392

0.73

YBX1

4904

P67809

0.73

PIK3CA

5290

P42336

0.73

RPL11

6135

P62913

0.73

RPS13

6207

P62277

0.73

RPS24

6229

P62847

0.73

SPTAN1

6709

Q13813

0.73

PRDX2

7001

P32119

0.73

XRCC5

7520

P13010

0.73

TUBA1A

7846

Q71U36

0.73

ANP32A

8125

P39687

0.73

CUL3

8452

Q13618

0.73

YBX3

8531

P16989

0.73

RUVBL1

8607

Q9Y265

0.73

EIF4G3

8672

O43432

0.73

IQGAP1

8826

P46940

0.73

ACTR3

10096

P61158

0.73

ACTR2

10097

P61160

0.73

HAX1

10456

O00165

0.73

PRPF8

10594

Q6P2Q9

0.73

GCN1

10985

Q92616

0.73

WDR5

11091

P61964

0.73

ASF1A

25842

Q9Y294

0.73

RPL36

25873

Q9Y3U8

0.73

TMOD3

29766

Q9NYL9

0.73

NOP58

51602

Q9Y2X3

0.73

RBM28

55131

Q9NW13

0.73

NDRG2

57447

Q9UN36

0.73

GNB4

59345

Q9HAV0

0.73

AHNAK

79026

Q09666

0.73

TUBB1

81027

Q9H4B7

0.73

MTDH

92140

Q86UE4

0.73

BRI3BP

140707

Q8WY22

0.73

HSPD1

3329

P10809

0.74

PRKDC

5591

P78527

0.74

UBE3A

7337

Q05086

0.74

CDK2

1017

P24941

0.75

CDK8

1024

P49336

0.75

NR2F6

2063

P10588

0.75

FKBP4

2288

Q02790

0.75

FKBP5

2289

Q13451

0.75

PRMT1

3276

Q99873

0.75

FOXK2

3607

Q01167

0.75

SMAD4

4089

Q13485

0.75

POLR2D

5433

O15514

0.75

PPID

5481

Q08752

0.75

RXRA

6256

P19793

0.75

MED21

9412

Q13503

0.75

MED7

9443

O43513

0.75

BCAR1

9564

P56945

0.75

MED13

9969

Q9UHV7

0.75

TRIM28

10155

Q13263

0.75

ARID5A

10865

Q03989

0.75

MACROD1

28992

Q9BQ69

0.75

UIMC1

51720

Q96RL1

0.75

OTUB1

55611

Q96FW1

0.75

MTA3

57504

Q9BTC8

0.75

PAGR1

79447

Q9BTK6

0.75

CITED1

4435

Q99966

0.76

PARP1

142

P09874

0.77

SLC25A5

292

P05141

0.77

ANXA2

302

P07355

0.77

BTF3

689

P20290

0.77

CLTC

1213

Q00610

0.77

CTNNB1

1499

P35222

0.77

DHX15

1665

O43143

0.77

EMD

2010

P50402

0.77

GAPDH

2597

P04406

0.77

HDAC2

3066

Q92769

0.77

HNRNPK

3190

P61978

0.77

JUP

3728

P14923

0.77

SMAD3

4088

P84022

0.77

MYO1B

4430

O43795

0.77

MYO1C

4641

O00159

0.77

HNRNPM

4670

P52272

0.77

NUMA1

4926

Q14980

0.77

RNF4

6047

P78317

0.77

RPL7A

6130

P62424

0.77

RPL8

6132

P62917

0.77

RPL13

6137

P26373

0.77

RPN2

6185

P04844

0.77

RPS2

6187

P15880

0.77

RPS3A

6189

P61247

0.77

RPS8

6202

P62241

0.77

RPS9

6203

P46781

0.77

RPS16

6217

P62249

0.77

TOP2B

7155

Q02880

0.77

BCLAF1

9774

Q9NYF8

0.77

SF3B1

23451

O75533

0.77

PABPC1

26986

P11940

0.77

NAT10

55226

Q9H0A0

0.77

HNRNPA3

220988

P51991

0.77

ACTC1

70

P68032

0.78

ARG1

383

P05089

0.78

CBR1

873

P16152

0.78

CCNC

892

P24863

0.78

DARS

1615

P14868

0.78

DBN1

1627

Q16643

0.78

EEF2

1938

P13639

0.78

EPRS

2058

P07814

0.78

PDIA3

2923

P30101

0.78

H3F3A; H3F3B

3020

P84243

0.78

HNRNPC

3183

P07910

0.78

HNRNPD

3184

Q14103

0.78

ILF3

3609

Q12906

0.78

KRT8

3856

P05787

0.78

KRT10

3858

P13645

0.78

KRT18

3875

P05783

0.78

KRT19

3880

P08727

0.78

MARS

4141

P56192

0.78

MSH2

4436

P43246

0.78

MTHFD1

4522

P11586

0.78

NONO

4841

Q15233

0.78

P4HB

5034

P07237

0.78

PPP1CA

5499

P62136

0.78

PPP2R1A

5518

P30153

0.78

PRKCSH

5589

P14314

0.78

RBBP4

5928

Q09028

0.78

RBBP5

5929

Q15291

0.78

RBBP7

5931

Q16576

0.78

RPL7

6129

P18124

0.78

RPL18

6141

Q07020

0.78

RPS11

6205

P62280

0.78

RPS20

6224

P60866

0.78

SFPQ

6421

P23246

0.78

SHMT2

6472

P34897

0.78

STAU1

6780

O95793

0.78

HSP90B1

7184

P14625

0.78

UBE2I

7329

P63279

0.78

VCP

7415

P55072

0.78

SF1

7536

Q15637

0.78

CLTCL1

8218

P53675

0.78

HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI

8339

P62807

0.78

ASH2L

9070

Q9UBL3

0.78

MED23

9439

Q9ULK4

0.78

MED20

9477

Q9H944

0.78

MED6

10001

O75586

0.78

MED16

10025

Q9Y2X0

0.78

ALYREF

10189

Q86V81

0.78

RACK1

10399

P63244

0.78

ANP32B

10541

Q92688

0.78

CCT2

10576

P78371

0.78

TRAM1

23471

Q15629

0.78

RTCB

51493

Q9Y3I0

0.78

LARS

51520

Q9P2J5

0.78

MED10

84246

Q9BTT4

0.78

LCOR

84458

Q96JN0

0.78

TUBA1C

84790

Q9BQE3

0.78

RPLP0P6

220717

Q8NHW5

0.78

CDC25B

994

P30305

0.79

CDKN1A

1026

P38936

0.79

EIF4A1

1973

P60842

0.79

HNRNPA2B1

3181

P22626

0.79

HSPB1

3315

P04792

0.79

MGMT

4255

P16455

0.79

STUB1

10273

Q9UNE7

0.79

RPL9; RPL9P7; RPL9P8; RPL9P9

6133

P32969

0.79

GNAI1

2770

P63096

0.80

NFKB1

4790

P19838

0.80

PFN1

5216

P07737

0.80

KMT2D

8085

O14686

0.80

HNRNPA1

3178

P09651

0.81

NCL

4691

P19338

0.81

POLR2A

5430

P24928

0.81

PSMC5

5705

P62195

0.81

RPL36AL

6166

Q969Q0

0.81

TSC2

7249

P49815

0.81

MYBBP1A

10514

Q9BQG0

0.81

TUBB

203068

P07437

0.81

ACTB

60

P60709

0.82

CAD

790

P27708

0.82

CFL1

1072

P23528

0.82

DDX3X

1654

O00571

0.82

DHX9

1660

Q08211

0.82

DYNC1H1

1778

Q14204

0.82

FASN

2194

P49327

0.82

HSPA8

3312

P11142

0.82

KRT15

3866

P19012

0.82

NPM1

4869

P06748

0.82

PSMC1

5700

P62191

0.82

PSMD2

5708

Q13200

0.82

RPS12

6206

P25398

0.82

RPS18

6222

P62269

0.82

YWHAZ

7534

P63104

0.82

SEC22B

9554

O75396

0.82

HUWE1

10075

Q7Z6Z7

0.82

TUBB3

10381

Q13509

0.82

SYNCRIP

10492

O60506

0.82

HYOU1

10525

Q9Y4L1

0.82

CCT7

10574

Q99832

0.82

RUVBL2

10856

Q9Y230

0.82

PRDX3

10935

P30048

0.82

MTCH2

23788

Q9Y6C9

0.82

PHGDH

26227

O43175

0.82

MYH14

79784

Q7Z406

0.82

ATP5B

506

P06576

0.83

IGF1R

3480

P08069

0.84

POU4F2

5458

Q12837

0.84

RPS26

6231

P62854

0.84

S100A8

6279

P05109

0.84

MTA2

9219

O94776

0.84

MED17

9440

Q9NVC6

0.84

HDAC4

9759

P56524

0.84

TUBA1B

10376

P68363

0.84

FLNA

2316

P21333

0.85

GSN

2934

P06396

0.85

MYH9

4627

P35579

0.85

POU4F1

5457

Q01851

0.85

PSMD1

5707

Q99460

0.85

RPS14

6208

P62263

0.85

GRIP1

23426

Q9Y3R0

0.85

MYLK2

85366

Q9H1R3

0.85

MYL6

4637

P60660

0.86

RARA

5914

P10276

0.86

RELA

5970

Q04206

0.86

SP3

6670

Q02447

0.86

DNM1L

10059

O00429

0.86

RPLP0

6175

P05388

0.87

RPS4X

6191

P62701

0.87

SP1

6667

P08047

0.87

PHB2

11331

Q99623

0.87

EGFR

1956

P00533

0.88

MED12

9968

Q93074

0.88

KAT5

10524

Q92993

0.88

HDAC1

3065

Q13547

0.89

HSPA4

3308

P34932

0.89

NR2F1

7025

P10589

0.89

MED14

9282

O60244

0.89

BRCA1

672

P38398

0.90

ESR1

2099

P03372

0.90

DDX17

10521

Q92841

0.90

KDM6B

23135

O15054

0.14

CACUL1

143384

Q86Y37

0.21

ARNT

405

P27540

0.52

CSNK2B

1460

P67870

0.52

GADD45B

4616

O75293

0.52

SUV39H1

6839

O43463

0.52

TAF10

6881

Q12962

0.52

TAP1

6890

Q03518

0.52

TFF1

7031

P04155

0.52

WHSC1

7468

O96028

0.52

CUL4B

8450

Q13620

0.52

TNFRSF14

8764

Q92956

0.52

PRPF6

24148

O94906

0.52

KMT5B

51111

Q4FZB7

0.52

SMYD2

56950

Q9NRG4

0.52

POLR1B

84172

Q9H9Y6

0.52

CHUK

1147

O15111

0.55

MAPK14

1432

Q16539

0.55

GRB2

2885

P62993

0.55

LCK

3932

P06239

0.55

RGS3

5998

P49796

0.55

TCF20

6942

Q9UGU0

0.55

RNF14

9604

Q9UBS8

0.55

ITGB3BP

23421

Q13352

0.55

ING1

3621

Q9UK53

0.56

PGC

5225

P20142

0.56

ARID1A

8289

O14497

0.56

RANBP9

10048

Q96S59

0.56

VAV3

10451

Q9UKW4

0.56

LRIF1

55791

Q5T3J3

0.56

AKT1

207

P31749

0.58

WIPI1

55062

Q5MNZ9

0.59

CHD9

80205

Q3L8U1

0.59

AR

367

P10275

0.62

RFX4

5992

Q33E94

0.62

SETD7

80854

Q8WTS6

0.62

E2F1

1869

Q01094

0.63

MKNK2

2872

Q9HBH9

0.63

MAP3K1

4214

Q13233

0.63

PPARG

5468

P37231

0.63

RAD51

5888

Q06609

0.63

SKI

6497

P12755

0.63

SKP1

6500

P63208

0.63

SVIL

6840

O95425

0.63

XPO1

7514

O14980

0.63

KAT6A

7994

Q92794

0.63

BAP1

8314

Q92560

0.63

SPOP

8405

O43791

0.63

CUL1

8454

Q13616

0.63

EIF3I

8668

Q13347

0.63

RBX1

9978

P62877

0.63

UBE4B

10277

O95155

0.63

KDM4B

23030

O94953

0.63

SIRT1

23411

Q96EB6

0.63

KLK5

25818

Q9Y337

0.63

GLCE

26035

O94923

0.63

HBP1

26959

O60381

0.63

RABGEF1

27342

Q9UJ41

0.63

PSMC3IP

29893

Q9P2W1

0.63

ASCC1

51008

Q8N9N2

0.63

ANGPTL4

51129

Q9BY76

0.63

HDAC7

51564

Q8WUI4

0.63

WHSC1L1

54904

Q9BZ95

0.63

RNF31

55072

Q96EP0

0.63

AHRR

57491

A9YTQ3

0.63

TTC5

91875

Q8N0Z6

0.63

EPSTI1

94240

Q96J88

0.63

KLK9

284366

Q9UKQ9

0.63

ATF1

466

P18846

0.65

SKP2

6502

Q13309

0.65

SMARCA2

6595

P51531

0.65

EDF1

8721

O60869

0.65

STRN

6801

O43815

0.67

CDK11B

984

P21127

0.68

SKIL

6498

P12757

0.68

LMO4

8543

P61968

0.68

RLIM

51132

Q9NVW2

0.68

BCAS3

54828

Q9H6U6

0.68

SMURF1

57154

Q9HCE7

0.68

ASXL1

171023

Q8IXJ9

0.68

RPS6KA1

6195

Q15418

0.69

SMARCD3

6604

Q6STE5

0.69

PTPN1

5770

P18031

0.70

PTPN6

5777

P29350

0.70

MMS19

64210

Q96T76

0.70

FLII

2314

Q13045

0.71

GADD45A

1647

P24522

0.72

BAZ1B

9031

Q9UIG0

0.72

PDLIM1

9124

O00151

0.72

CRIPAK

285464

Q8N1N5

0.72

RAN

5901

P62826

0.73

PIAS1

8554

O75925

0.73

SRA1

10011

Q9HD15

0.73

BLCAP

10904

P62952

0.73

SENP5

205564

Q96HI0

0.73

SIN3A

25942

Q96ST3

0.74

CEBPA

1050

P49715

0.75

FOXO4

4303

P98177

0.75

POU2F1

5451

P14859

0.75

POU2F2

5452

P09086

0.75

PTEN

5728

P60484

0.75

PTMA

5757

P06454

0.75

SMARCD1

6602

Q96GM5

0.75

NR2C2

7182

P49116

0.75

ZBTB16

7704

Q05516

0.75

NCOA4

8031

Q13772

0.75

LDB1

8861

Q86U70

0.75

PIAS2

9063

O75928

0.75

YWHAQ

10971

P27348

0.75

RBFOX2

23543

O43251

0.75

LINC00312

29931

Q9Y6C7

0.75

NSD1

64324

Q96L73

0.75

HSP90AB1

3326

P08238

0.76

TRIP4

9325

Q15650

0.76

BCAS2

10286

O75934

0.76

PPARGC1A

10891

Q9UBK2

0.76

PAK6

56924

Q9NQU5

0.76

CDK7

1022

P50613

0.77

CHD3

1107

Q12873

0.77

ZNF366

167465

Q8N895

0.77

GTF2H1

2965

P32780

0.78

PHB

5245

P35232

0.78

PPP5C

5536

P53041

0.78

RPS6KA3

6197

P51812

0.78

RBCK1

10616

Q9BYM8

0.78

TAB2

23118

Q9NYJ8

0.78

REXO4

57109

Q9GZR2

0.78

PBXIP1

57326

Q96AQ6

0.78

ZNF398

57541

Q8TD17

0.78

ISL1

3670

P61371

0.79

PPP1CC

5501

P36873

0.79

KDM5A

5927

P29375

0.79

TDG

6996

Q13569

0.79

NR2C1

7181

P13056

0.79

XBP1

7494

P17861

0.79

SAFB2

9667

Q14151

0.79

MVP

9961

Q14764

0.79

AKAP13

11214

Q12802

0.79

NELFB

25920

Q8WX92

0.79

DNTTIP2

30836

Q5QJE6

0.79

AKT2

208

P31751

0.80

TXNRD1

7296

Q16881

0.80

PPARGC1B

133522

Q86YN6

0.80

HDAC3

8841

O15379

0.81

FHL1

2273

Q13642

0.82

FOS

2353

P01100

0.82

PAK1

5058

Q13153

0.82

NR1H4

9971

Q96RI1

0.83

PNRC2

55629

Q9NPJ4

0.83

AHR

196

P35869

0.84

PIK3R1

5295

P27986

0.84

DAP3

7818

P51398

0.84

ACTN4

81

O43707

0.85

SMAD2

4087

Q15796

0.85

PGR

5241

P06401

0.85

TADA3

10474

O75528

0.85

GADD45G

10912

O95257

0.85

NCOA7

135112

Q8NI08

0.85

TBP

6908

P20226

0.86

NCOR2

9612

Q9Y618

0.86

MAPK1

5594

P28482

0.87

ATAD2

29028

Q6PL18

0.87

CUEDC2

79004

Q9H467

0.87

BAG1

573

Q99933

0.88

RAC3

5881

P60763

0.88

STAT5A

6776

P42229

0.88

PRDM2

7799

Q13029

0.88

NR0B2

8431

Q15466

0.88

PTGES3

10728

Q15185

0.88

PELP1

27043

Q8IZL8

0.88

DDX54

79039

Q8TDD1

0.88

CEBPB

1051

P17676

0.89

FOXO1

2308

Q12778

0.89

PRMT2

3275

P55345

0.89

HSP90AA1

3320

P07900

0.89

JUN

3725

P05412

0.89

MDM2

4193

Q00987

0.89

MNAT1

4331

P51948

0.89

SAFB

6294

Q15424

0.89

SMARCE1

6605

Q969G3

0.89

TP53

7157

P04637

0.89

TRIM25

7706

Q14258

0.89

NRIP1

8204

P48552

0.89

TRRAP

8295

Q9Y4A5

0.89

NCOA6

23054

Q14686

0.89

CCND1

595

P24385

0.90

CAV1

857

Q03135

0.90

CREBBP

1387

Q92793

0.90

DDX5

1655

P17844

0.90

EP300

2033

Q09472

0.90

ESR2

2100

Q92731

0.90

MED1

5469

Q15648

0.90

SHC1

6464

P29353

0.90

SMARCA4

6597

P51532

0.90

SRC

6714

P12931

0.90

NCOA3

8202

Q9Y6Q9

0.90

NCOA1

8648

Q15788

0.90

MTA1

9112

Q13330

0.90

RBM39

9584

Q14498

0.90

NCOR1

9611

O75376

0.90

MED24

9862

O75448

0.90

TRIM24

8805

O15164

0.95

NCOA2

10499

Q15596

0.97