Protein Description

Gene Symbol ERH
Entrez ID 2079
Uniprot ID P84090
Description enhancer of rudimentary homolog (Drosophila)
Chromosomal Location chr14: 69,380,123-69,398,627
Ontology GO ID GO Term Definition Evidence

BP

GO:0006139

nucleobase-containing compound metabolic process

Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

TAS

BP

GO:0006213

pyrimidine nucleoside metabolic process

The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).

TAS

BP

GO:0006221

pyrimidine nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

IEA

BP

GO:0007049

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

IEA

BP

GO:0045747

positive regulation of Notch signaling pathway

Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.

IEA

CC

GO:0030496

midbody

A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.

IDA

CC

GO:0034709

methylosome

A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008327

methyl-CpG binding

Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide.

IDA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

Domain ID Description

IPR000781

Enhancer of rudimentary

No pathways found.

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

appendix

lymphoid tissue

breast

adipocytes

breast

glandular cells

breast

myoepithelial cells

bronchus

respiratory epithelial cells

caudate

neuronal cells

cerebellum

cells in granular layer

cerebellum

cells in molecular layer

cerebellum

Purkinje cells

cerebral cortex

endothelial cells

cerebral cortex

neuronal cells

cervix, uterine

glandular cells

cervix, uterine

squamous epithelial cells

colon

endothelial cells

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

endometrium

cells in endometrial stroma

epididymis

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

hippocampus

neuronal cells

kidney

cells in glomeruli

kidney

cells in tubules

lung

macrophages

lung

pneumocytes

nasopharynx

respiratory epithelial cells

oral mucosa

squamous epithelial cells

ovary

ovarian stroma cells

parathyroid gland

glandular cells

placenta

decidual cells

placenta

trophoblastic cells

rectum

glandular cells

salivary gland

glandular cells

seminal vesicle

glandular cells

skeletal muscle

myocytes

skin

fibroblasts

skin

keratinocytes

skin

Langerhans

skin

melanocytes

skin

epidermal cells

small intestine

glandular cells

soft tissue

adipocytes

soft tissue

fibroblasts

soft tissue

peripheral nerve

stomach

glandular cells

testis

cells in seminiferous ducts

thyroid gland

glandular cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

12734205

Wood et al.

2003

The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis

Gene Symbol Entrez ID Uniprot ID Score

APP

351

P05067

0.56

COPS6

10980

Q7L5N1

0.63

CIZ1

25792

Q9ULV3

0.63

MED31

51003

Q9Y3C7

0.63

RBM48

84060

Q5RL73

0.63

POLDIP3

84271

Q9BY77

0.63

IGSF21

84966

Q96ID5

0.63

Q9P078_HUMAN

N/A

Q9P078

0.63

SH3GL2

6456

Q99962

0.73

FAM208B

54906

Q5VWN6

0.73

CHTOP

26097

Q9Y3Y2

0.82

CSNK2A1

1457

P68400

0.52

BMI1

648

P35226

0.63

CDK2

1017

P24941

0.63

ELAVL1

1994

Q15717

0.63

EZH2

2146

Q15910

0.63

HSPA8

3312

P11142

0.63

NOTCH1

4851

P46531

0.63

PRKAB1

5564

Q9Y478

0.63

PSPH

5723

P78330

0.63

RNF2

6045

Q99496

0.63

TERF2

7014

Q15554

0.63

TLE1

7088

Q04724

0.63

TRAF6

7189

Q9Y4K3

0.63

UBL4A

8266

P11441

0.63

HIST1H3A

8350

P68431

0.63

EED

8726

O75530

0.63

UNC119

9094

Q13432

0.63

RPS6KA5

9252

O75582

0.63

KIAA0101

9768

Q15004

0.63

SETDB1

9869

Q15047

0.63

RNPS1

10921

Q15287

0.63

PAXIP1

22976

Q6ZW49

0.63

SUZ12

23512

Q15022

0.63

ASB3

51130

Q9Y575

0.63

LUZP4

51213

Q9P127

0.63

DGCR8

54487

Q8WYQ5

0.63

MAP1LC3A

84557

Q9H492

0.63

ASB18

401036

Q6ZVZ8

0.63

ARRB2

409

P32121

0.72

MAGOH

4116

P61326

0.72

EIF4A3

9775

P38919

0.72

ACP6

51205

Q9NPH0

0.72

BIN3

55909

Q9NQY0

0.72

SMN1; SMN2

6606

Q16637

0.72

TP53

7157

P04637

0.73

CTDP1

9150

Q9Y5B0

0.73

CSNK2A2

1459

P19784

0.75

ILK

3611

Q13418

0.76

CNBP

7555

P62633

0.76

EIF1B

10289

O60739

0.76