Protein Description

Gene Symbol ST8SIA6
Entrez ID 338596
Uniprot ID P61647
Description ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
Chromosomal Location chr10: 17,318,383-17,454,330
Ontology GO ID GO Term Definition Evidence

BP

GO:0001574

ganglioside biosynthetic process

The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.

ISS

BP

GO:0006493

protein O-linked glycosylation

A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.

ISS

BP

GO:0009100

glycoprotein metabolic process

The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.

ISS

BP

GO:0009247

glycolipid biosynthetic process

The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).

ISS

BP

GO:0009311

oligosaccharide metabolic process

The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.

ISS

BP

GO:0016051

carbohydrate biosynthetic process

The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

ISS

BP

GO:0097503

sialylation

The covalent attachment of sialic acid to a substrate molecule.

IEA

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

TAS

CC

GO:0030173

integral component of Golgi membrane

The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0003828

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.

TAS

MF

GO:0008373

sialyltransferase activity

Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.

ISS

Domain ID Description

IPR001675

Glycosyl transferase family 29

IPR012163

Sialyltransferase

No pathways found.

No diseases found.

No tissues found.

No databases found.

Pubmed ID Author Year Title

23824412

Piltonen et al.

2013

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

No partners found.