| Gene Symbol | CHSY3 |
| Entrez ID | 337876 |
| Uniprot ID | Q70JA7 |
| Description | chondroitin sulfate synthase 3 |
| Chromosomal Location | chr5: 129,904,472-130,186,634 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0030206 |
chondroitin sulfate biosynthetic process |
The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. |
TAS |
|
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
TAS |
|
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
|
CC |
GO:0032580 |
Golgi cisterna membrane |
The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. |
IEA |
|
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IEA |
|
MF |
GO:0047238 |
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity |
Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP. |
TAS |
|
MF |
GO:0050510 |
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity |
Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. |
TAS |
| Domain ID | Description |
|---|---|
|
IPR008428 |
Chondroitin N-acetylgalactosaminyltransferase |
|
IPR029044 |
Nucleotide-diphospho-sugar transferases |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00532 |
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
23824412 |
Piltonen et al. |
2013 |
Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ISLR |
3671 |
O14498 |
0.63 |
|
PLAUR |
5329 |
Q03405 |
0.63 |
|
SIAE |
54414 |
Q9HAT2 |
0.63 |
|
FOXN3 |
1112 |
O00409 |
0.72 |