Protein Description

Gene Symbol LCLAT1
Entrez ID 253558
Uniprot ID Q6UWP7
Description lysocardiolipin acyltransferase 1
Chromosomal Location chr2: 30,447,226-30,644,225
Ontology GO ID GO Term Definition Evidence

BP

GO:0006654

phosphatidic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.

TAS

BP

GO:0007275

multicellular organism development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

IEA

BP

GO:0016024

CDP-diacylglycerol biosynthetic process

The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.

IEA

BP

GO:0019432

triglyceride biosynthetic process

The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.

TAS

BP

GO:0035965

cardiolipin acyl-chain remodeling

Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids.

TAS

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

TAS

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0003841

1-acylglycerol-3-phosphate O-acyltransferase activity

Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.

TAS

MF

GO:0008374

O-acyltransferase activity

Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.

TAS

Domain ID Description

IPR002123

Phospholipid/glycerol acyltransferase

IPR032098

Acyltransferase, C-terminal domain

Pathway ID Pathway Term Pathway Source

hsa00561

Glycerolipid metabolism

KEGG

hsa00564

Glycerophospholipid metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

No diseases found.

No tissues found.

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

TCTN3

26123

Q6NUS6

0.49

ELAVL1

1994

Q15717

0.63

RNF2

6045

Q99496

0.63

GPR52

9293

Q9Y2T5

0.63

TSPAN5

10098

P62079

0.63

CHRNA9

55584

Q9UGM1

0.63

GOPC

57120

Q9HD26

0.63

PVRIG

79037

Q6DKI7

0.63

LNX1

84708

Q8TBB1

0.63

PRRT2

112476

Q7Z6L0

0.63

LYPD6

130574

Q86Y78

0.63

FAM134C

162427

Q86VR2

0.63