PCOSBase

Protein Description

Gene Symbol	FOXK1
Entrez ID	221937
Uniprot ID	P85037
Description	forkhead box K1
Chromosomal Location	chr7: 4,682,309-4,771,443

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006351	transcription, DNA-templated	The cellular synthesis of RNA on a template of DNA.	IEA
BP	GO:0006357	regulation of transcription from RNA polymerase II promoter	Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.	IEA
BP	GO:0007517	muscle organ development	The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.	IEA
BP	GO:0030154	cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.	IEA
BP	GO:0030308	negative regulation of cell growth	Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.	IEA
BP	GO:0045892	negative regulation of transcription, DNA-templated	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.	IEA
BP	GO:0045893	positive regulation of transcription, DNA-templated	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.	IEA
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IBA
MF	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.	IEA
MF	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.	IBA

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Domain ID	Description
IPR000253	Forkhead-associated (FHA) domain
IPR001766	Fork head domain
IPR008984	SMAD/FHA domain
IPR011991	Winged helix-turn-helix DNA-binding domain
IPR018122	Fork head domain conserved site1
IPR030456	Fork head domain conserved site 2

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No pathways found.

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No diseases found.

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
bone marrow	hematopoietic cells
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
caudate	glial cells
cerebellum	cells in granular layer
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cerebral cortex	endothelial cells
cerebral cortex	glial cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	endothelial cells
colon	glandular cells
colon	peripheral nerve/ganglion
duodenum	glandular cells
endometrium	cells in endometrial stroma
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
heart muscle	myocytes
hippocampus	glial cells
hippocampus	neuronal cells
kidney	cells in glomeruli
kidney	cells in tubules
lung	pneumocytes
lymph node	germinal center cells
lymph node	non-germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
ovary	ovarian stroma cells
pancreas	exocrine glandular cells
parathyroid gland	glandular cells
placenta	decidual cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skin	fibroblasts
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
small intestine	glandular cells
smooth muscle	smooth muscle cells
soft tissue	adipocytes
soft tissue	fibroblasts
soft tissue	peripheral nerve
spleen	cells in red pulp
spleen	cells in white pulp
stomach	glandular cells
testis	cells in seminiferous ducts
testis	Leydig cells
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
NAA10	8260	P41227	0.49
EEF1D	1936	P29692	0.63
HCFC1	3054	P51610	0.63
PHKG2	5261	P15735	0.63
POLD2	5425	P49005	0.63
VASP	7408	P50552	0.63
PRMT5	10419	O14744	0.63
PPP6R1	22870	Q9UPN7	0.63
USP24	23358	Q9UPU5	0.63
GAPVD1	26130	Q14C86	0.63
CMYA5	202333	Q8N3K9	0.63
FOXK1	221937	P85037	0.63
AHCY	191	P23526	0.72
HDAC2	3066	Q92769	0.72
FOXK2	3607	Q01167	0.72
ING2	3622	Q9H160	0.72
PHKA2	5256	P46019	0.72
RB1	5925	P06400	0.72
ARID4A	5926	P29374	0.72
RBL1	5933	P28749	0.72
RBL2	5934	Q08999	0.72
TP53	7157	P04637	0.72
TP53BP1	7158	Q12888	0.72
UBA7	7318	P41226	0.72
EIF2AK3	9451	Q9NZJ5	0.72
NCOR1	9611	O75376	0.72
KIAA0513	9764	O60268	0.72
TBC1D4	9882	O60343	0.72
AP5Z1	9907	O43299	0.72
CHEK2	11200	O96017	0.72
ANKRD28	23243	O15084	0.72
AGTPBP1	23287	Q9UPW5	0.72
UBR4	23352	Q5T4S7	0.72
SCRIB	23513	Q14160	0.72
BRMS1	25855	Q9HCU9	0.72
SIN3A	25942	Q96ST3	0.72
KANK2	25959	Q63ZY3	0.72
ARID4B	51742	Q4LE39	0.72
UHRF1BP1	54887	Q6BDS2	0.72
USP47	55031	Q96K76	0.72
AGGF1	55109	Q8N302	0.72
ABHD10	55347	Q9NUJ1	0.72
USP28	57646	Q96RU2	0.72
SUDS3	64426	Q9H7L9	0.72
SAP130	79595	Q9H0E3	0.72
TBL1XR1	79718	Q9BZK7	0.72
BRMS1L	84312	Q5PSV4	0.72
ANKRD52	283373	Q8NB46	0.72
DVL2	1856	O14641	0.79
UBA2	10054	Q9UBT2	0.49
UBE4B	10277	O95155	0.49
MAPK14	1432	Q16539	0.63
CTBP1	1487	Q13363	0.63
NTRK1	4914	P04629	0.63
PSMA1	5682	P25786	0.63
RABGGTB	5876	P53611	0.63
RBBP7	5931	Q16576	0.63
TPM1	7168	P09493	0.63
VIM	7431	P08670	0.63
XPO1	7514	O14980	0.63
TEX264	51368	Q9Y6I9	0.63
TRAK2	66008	O60296	0.63
METTL22	79091	Q9BUU2	0.63
MAP1LC3B	81631	Q9GZQ8	0.63
MAP1LC3A	84557	Q9H492	0.63
KLHDC3	116138	Q9BQ90	0.63
FAM129A	116496	Q9BZQ8	0.63
ASXL1	171023	Q8IXJ9	0.63
HDAC1	3065	Q13547	0.72
MAX	4149	P61244	0.72
PDGFRB	5159	P09619	0.72
DYRK1B	9149	Q9Y463	0.72
RNPS1	10921	Q15287	0.72
FYCO1	79443	Q9BQS8	0.72
ASXL2	55252	Q76L83	0.73
FOXO3	2309	O43524	0.75
IRF2	3660	P14316	0.75
AMOT	154796	Q4VCS5	0.76
GPS2	2874	Q13227	0.82
YWHAB	7529	P31946	0.82
SAP30	8819	O75446	0.86
BAP1	8314	Q92560	0.89