PCOSBase

Protein Description

Gene Symbol	HNRNPA3
Entrez ID	220988
Uniprot ID	P51991
Description	heterogeneous nuclear ribonucleoprotein A3
Chromosomal Location	chr2: 177,212,563-177,223,958

Download CSV

Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000398	mRNA splicing, via spliceosome	The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.	IC\|TAS
BP	GO:0010467	gene expression	The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.	TAS
BP	GO:0051028	mRNA transport	The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.	IEA
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IDA
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	IDA\|TAS
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IEA
CC	GO:0030529	intracellular ribonucleoprotein complex	An intracellular macromolecular complex containing both protein and RNA molecules.	TAS
CC	GO:0035770	ribonucleoprotein granule	A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.	IEA
CC	GO:0043005	neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.	IEA
CC	GO:0071013	catalytic step 2 spliceosome	A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.	IDA
CC	GO:1990124	messenger ribonucleoprotein complex	A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules.	IEA
MF	GO:0000166	nucleotide binding	Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.	IEA
MF	GO:0003723	RNA binding	Interacting selectively and non-covalently with an RNA molecule or a portion thereof.	TAS
MF	GO:0003729	mRNA binding	Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.	IEA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA
MF	GO:0051033	RNA transmembrane transporter activity	Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other.	IEA

Download CSV

Domain ID	Description
IPR000504	RNA recognition motif domain
IPR034513	hnRNP A3, RNA recognition motif 1
IPR034516	hnRNP A3, RNA recognition motif 2

Download CSV

Pathway ID	Pathway Term	Pathway Source
hsa03040	Spliceosome	KEGG

Download CSV

UMLS CUI	UMLS Term
C0036341	Schizophrenia

Download CSV

Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
bone marrow	hematopoietic cells
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
caudate	glial cells
cerebellum	cells in granular layer
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cerebral cortex	glial cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	glandular cells
duodenum	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
hippocampus	neuronal cells
liver	bile duct cells
lung	pneumocytes
lymph node	germinal center cells
lymph node	non-germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
ovary	ovarian stroma cells
pancreas	exocrine glandular cells
pancreas	islets of Langerhans
parathyroid gland	glandular cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
seminal vesicle	glandular cells
skin	fibroblasts
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
small intestine	glandular cells
smooth muscle	smooth muscle cells
spleen	cells in red pulp
spleen	cells in white pulp
stomach	glandular cells
testis	cells in seminiferous ducts
tonsil	germinal center cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells

No databases found.

Download CSV

Pubmed ID	Author	Year	Title
17148555	Wood et al.	2007	Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis
17557764	Ma et al.	2007	Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Download CSV

Gene Symbol	Entrez ID	Uniprot ID	Score
ATP1B1	481	P05026	0.49
FDPS	2224	P14324	0.49
HNRNPAB	3182	Q99729	0.49
HNRNPF	3185	P52597	0.49
HNRNPH3	3189	P31942	0.49
IL7R	3575	P16871	0.49
ITPA	3704	Q9BY32	0.49
PGK1	5230	P00558	0.49
RPS13	6207	P62277	0.49
RPS28	6234	P62857	0.49
UBE2N	7334	P61088	0.49
RAB7A	7879	P51149	0.49
DDX17	10521	Q92841	0.49
RAB10	10890	P61026	0.49
PHB2	11331	Q99623	0.49
SRRM2	23524	Q9UQ35	0.49
CHMP2A	27243	O43633	0.49
MRPS26	64949	Q9BYN8	0.49
CYB5B	80777	O43169	0.49
UBQLN2	29978	Q9UHD9	0.63
HNRNPH2	3188	P55795	0.82
ATP5B	506	P06576	0.49
CRIP1	1396	P50238	0.49
EEF1G	1937	P26641	0.49
EEF2	1938	P13639	0.49
GAPDH	2597	P04406	0.49
HSD17B10	3028	Q99714	0.49
HNRNPA2B1	3181	P22626	0.49
HNRNPK	3190	P61978	0.49
HNRNPL	3191	P14866	0.49
HNRNPU	3192	Q00839	0.49
HSPA8	3312	P11142	0.49
SMAD2	4087	Q15796	0.49
NONO	4841	Q15233	0.49
RAB1A	5861	P62820	0.49
RPLP2	6181	P05387	0.49
RSU1	6251	Q15404	0.49
SFPQ	6421	P23246	0.49
UQCRC2	7385	P22695	0.49
HNRNPDL	9987	O14979	0.49
SYNCRIP	10492	O60506	0.49
GCN1	10985	Q92616	0.49
PROSC	11212	O94903	0.49
ZFAND6	54469	Q6FIF0	0.49
HNRNPA1L2	144983	Q32P51	0.49
CLK1	1195	P49759	0.52
SRPK2	6733	P78362	0.52
CD247	919	P20963	0.56
FUS	2521	P35637	0.59
HNRNPD	3184	Q14103	0.59
HNRNPH1	3187	P31943	0.59
PTBP1	5725	P26599	0.59
CD81	975	P60033	0.63
CRY1	1407	Q16526	0.63
EWSR1	2130	Q01844	0.63
FN1	2335	P02751	0.63
NR5A1	2516	Q13285	0.63
ICAM1	3383	P05362	0.63
ITGA4	3676	P13612	0.63
JUN	3725	P05412	0.63
MCM2	4171	P49736	0.63
MCM5	4174	P33992	0.63
MDM2	4193	Q00987	0.63
NTRK1	4914	P04629	0.63
PARK2	5071	O60260	0.63
PRKAA1	5562	Q13131	0.63
RAD21	5885	O60216	0.63
RNF2	6045	Q99496	0.63
RPA1	6117	P27694	0.63
RPA2	6118	P15927	0.63
RPA3	6119	P35244	0.63
SUMO3	6612	P55854	0.63
STAU1	6780	O95793	0.63
VHL	7428	P40337	0.63
WHSC1	7468	O96028	0.63
YWHAE	7531	P62258	0.63
CUL5	8065	Q93034	0.63
SF3A2	8175	Q15428	0.63
CUL4B	8450	Q13620	0.63
CUL3	8452	Q13618	0.63
CUL2	8453	Q13617	0.63
CUL1	8454	Q13616	0.63
EED	8726	O75530	0.63
RIPK2	8767	O43353	0.63
BTRC	8945	Q9Y297	0.63
ATG12	9140	O94817	0.63
KIAA0101	9768	Q15004	0.63
CUL7	9820	Q14999	0.63
PAN2	9924	Q504Q3	0.63
HDAC5	10014	Q9UQL6	0.63
UBD	10537	O15205	0.63
COPS5	10987	Q92905	0.63
GABARAP	11337	O95166	0.63
GABARAPL2	11345	P60520	0.63
ZBTB1	22890	Q9Y2K1	0.63
SNW1	22938	Q13573	0.63
TNIK	23043	Q9UKE5	0.63
OBSL1	23363	O75147	0.63
TARDBP	23435	Q13148	0.63
GABARAPL1	23710	Q9H0R8	0.63
EEF2K	29904	O00418	0.63
DDX41	51428	Q9UJV9	0.63
SIRT7	51547	Q9NRC8	0.63
WWOX	51741	Q9NZC7	0.63
DCUN1D1	54165	Q96GG9	0.63
HEMGN	55363	Q9BXL5	0.63
CAND1	55832	Q86VP6	0.63
USE1	55850	Q9NZ43	0.63
SMURF1	57154	Q9HCE7	0.63
POLR1E	64425	Q9GZS1	0.63
LIN28A	79727	Q9H9Z2	0.63
MAP1LC3B	81631	Q9GZQ8	0.63
PHF6	84295	Q8IWS0	0.63
MAP1LC3A	84557	Q9H492	0.63
IGSF8	93185	Q969P0	0.63
SREK1	140890	Q8WXA9	0.63
SCARNA22	677770	N/A	0.63
TOP1	7150	P11387	0.68
ARRB1	408	P49407	0.72
HDGF	3068	P51858	0.72
IFIT3	3437	O14879	0.72
TP63	8626	Q9H3D4	0.72
MATR3	9782	P43243	0.72
HSPA5	3309	P11021	0.73
NEDD8	4738	Q15843	0.73
SUMO2	6613	P61956	0.73
FBXW11	23291	Q9UKB1	0.73
SUMO1	7341	P63165	0.74
ARHGDIA	396	P52565	0.76
CNBP	7555	P62633	0.76
STK24	8428	Q9Y6E0	0.76
PUF60	22827	Q9UHX1	0.76
ESR1	2099	P03372	0.77
HNRNPA1	3178	P09651	0.82
VCAM1	7412	P19320	0.82