| Gene Symbol | ENO2 |
| Entrez ID | 2026 |
| Uniprot ID | P09104 |
| Description | enolase 2 (gamma, neuronal) |
| Chromosomal Location | chr12: 6,913,745-6,923,698 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006094 |
gluconeogenesis |
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. |
TAS |
|
BP |
GO:0061621 |
canonical glycolysis |
The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP. |
TAS |
|
CC |
GO:0000015 |
phosphopyruvate hydratase complex |
A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. |
IEA |
|
CC |
GO:0001917 |
photoreceptor inner segment |
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. |
IEA |
|
CC |
GO:0005615 |
extracellular space |
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
IDA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IEA |
|
CC |
GO:0043204 |
perikaryon |
The portion of the cell soma (cell body) that excludes the nucleus. |
IEA |
|
CC |
GO:0043209 |
myelin sheath |
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. |
IEA |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0000287 |
magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. |
IEA |
|
MF |
GO:0004634 |
phosphopyruvate hydratase activity |
Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. |
TAS |
| Domain ID | Description |
|---|---|
|
IPR000941 |
Enolase |
|
IPR020809 |
Enolase, conserved site |
|
IPR020810 |
Enolase, C-terminal TIM barrel domain |
|
IPR020811 |
Enolase, N-terminal |
|
IPR029017 |
Enolase N-terminal domain-like |
|
IPR029065 |
Enolase C-terminal domain-like |
|
IPR034390 |
Enolase-like superfamily |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00010 |
Glycolysis / Gluconeogenesis |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa01200 |
Carbon metabolism |
KEGG |
|
hsa01230 |
Biosynthesis of amino acids |
KEGG |
|
hsa03018 |
RNA degradation |
KEGG |
|
hsa04066 |
HIF-1 signaling pathway |
KEGG |
|
WP534 |
Glycolysis and Gluconeogenesis |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0005695 |
Bladder Neoplasm |
|
C0007131 |
Non-Small Cell Lung Carcinoma |
|
C0007621 |
Neoplastic Cell Transformation |
|
C0023467 |
Leukemia, Myelocytic, Acute |
|
C0023904 |
Liver Neoplasms, Experimental |
|
C0027659 |
Neoplasms, Experimental |
| Tissue | Cell Type |
|---|---|
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebral cortex |
neuronal cells |
|
cerebral cortex |
neuropil |
|
hippocampus |
neuronal cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
AKR1B1 |
231 |
P15121 |
0.49 |
|
ARHGDIA |
396 |
P52565 |
0.49 |
|
CALR |
811 |
P27797 |
0.49 |
|
DUT |
1854 |
P33316 |
0.49 |
|
EEF1A1 |
1915 |
P68104 |
0.49 |
|
FABP5 |
2171 |
Q01469 |
0.49 |
|
FKBP1A |
2280 |
P62942 |
0.49 |
|
FKBP1B |
2281 |
P68106 |
0.49 |
|
HSPE1 |
3336 |
P61604 |
0.49 |
|
SUMO3 |
6612 |
P55854 |
0.49 |
|
SUMO2 |
6613 |
P61956 |
0.49 |
|
TXN |
7295 |
P10599 |
0.49 |
|
UCHL3 |
7347 |
P15374 |
0.49 |
|
FKBP7 |
51661 |
Q9Y680 |
0.49 |
|
PUS7 |
54517 |
Q96PZ0 |
0.49 |
|
AKR1B15 |
441282 |
C9JRZ8 |
0.49 |
|
PGAM1 |
5223 |
P18669 |
0.56 |
|
TPI1 |
7167 |
P60174 |
0.56 |
|
ENSA |
2029 |
O43768 |
0.63 |
|
FLNB |
2317 |
O75369 |
0.63 |
|
HK1 |
3098 |
P19367 |
0.63 |
|
HSF1 |
3297 |
Q00613 |
0.63 |
|
MAP4 |
4134 |
P27816 |
0.63 |
|
PNP |
4860 |
P00491 |
0.63 |
|
RAB1A |
5861 |
P62820 |
0.63 |
|
RCN1 |
5954 |
Q15293 |
0.63 |
|
ST3GAL2 |
6483 |
Q16842 |
0.63 |
|
TUBA4A |
7277 |
P68366 |
0.63 |
|
TUBA1A |
7846 |
Q71U36 |
0.63 |
|
GMPS |
8833 |
P49915 |
0.63 |
|
SNUPN |
10073 |
O95149 |
0.63 |
|
EXOC5 |
10640 |
O00471 |
0.63 |
|
UBE2C |
11065 |
O00762 |
0.63 |
|
HABP4 |
22927 |
Q5JVS0 |
0.63 |
|
NAT9 |
26151 |
Q9BTE0 |
0.63 |
|
IL17B |
27190 |
Q9UHF5 |
0.63 |
|
C6orf47 |
57827 |
O95873 |
0.63 |
|
SIGIRR |
59307 |
Q6IA17 |
0.63 |
|
C16orf45 |
89927 |
Q96MC5 |
0.63 |
|
NDUFS7 |
374291 |
O75251 |
0.63 |
|
ENO1 |
2023 |
P06733 |
0.70 |
|
ENO3 |
2027 |
P13929 |
0.79 |
|
POC1A |
25886 |
Q8NBT0 |
0.49 |
|
CTH |
1491 |
P32929 |
0.49 |
|
FKBP2 |
2286 |
P26885 |
0.49 |
|
GAPDH |
2597 |
P04406 |
0.49 |
|
GPX4 |
2879 |
P36969 |
0.49 |
|
HSD17B10 |
3028 |
Q99714 |
0.49 |
|
HINT1 |
3094 |
P49773 |
0.49 |
|
MSN |
4478 |
P26038 |
0.49 |
|
NME2 |
4831 |
P22392 |
0.49 |
|
PCMT1 |
5110 |
P22061 |
0.49 |
|
PLS3 |
5358 |
P13797 |
0.49 |
|
PPIB |
5479 |
P23284 |
0.49 |
|
SOD1 |
6647 |
P00441 |
0.49 |
|
TAGLN |
6876 |
Q01995 |
0.49 |
|
TKT |
7086 |
P29401 |
0.49 |
|
TPD52 |
7163 |
P55327 |
0.49 |
|
EZR |
7430 |
P15311 |
0.49 |
|
TAGLN2 |
8407 |
P37802 |
0.49 |
|
WDR1 |
9948 |
O75083 |
0.49 |
|
STIP1 |
10963 |
P31948 |
0.49 |
|
SEC31A |
22872 |
O94979 |
0.49 |
|
TAGLN3 |
29114 |
Q9UI15 |
0.49 |
|
CENPJ |
55835 |
Q9HC77 |
0.49 |
|
PGK1 |
5230 |
P00558 |
0.56 |
|
A2M |
2 |
P01023 |
0.63 |
|
ANXA11 |
311 |
P50995 |
0.63 |
|
CDK2 |
1017 |
P24941 |
0.63 |
|
MTNR1A |
4543 |
P48039 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
PPP1CA |
5499 |
P62136 |
0.63 |
|
PPP1CC |
5501 |
P36873 |
0.63 |
|
SUMO1 |
7341 |
P63165 |
0.63 |
|
CUL4B |
8450 |
Q13620 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
CUL2 |
8453 |
Q13617 |
0.63 |
|
CUL1 |
8454 |
Q13616 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
UBD |
10537 |
O15205 |
0.63 |
|
GABARAP |
11337 |
O95166 |
0.63 |
|
GABARAPL2 |
11345 |
P60520 |
0.63 |
|
GABARAPL1 |
23710 |
Q9H0R8 |
0.63 |
|
CAND1 |
55832 |
Q86VP6 |
0.63 |
|
EFHD2 |
79180 |
Q96C19 |
0.63 |
|
COASY |
80347 |
Q13057 |
0.63 |
|
MAP1LC3A |
84557 |
Q9H492 |
0.63 |
|
ASB5 |
140458 |
Q8WWX0 |
0.63 |
|
ASB9 |
140462 |
Q96DX5 |
0.63 |
|
SUMO4 |
387082 |
Q6EEV6 |
0.65 |
|
TERF1 |
7013 |
P54274 |
0.73 |
|
POT1 |
25913 |
Q9NUX5 |
0.73 |
|
ACD |
65057 |
Q96AP0 |
0.73 |
|
TINF2 |
26277 |
Q9BSI4 |
0.75 |
|
AKT1 |
207 |
P31749 |
0.82 |