Protein Description

Gene Symbol ENO1
Entrez ID 2023
Uniprot ID P06733
Description enolase 1, (alpha)
Chromosomal Location chr1: 8,861,002-8,879,249
Ontology GO ID GO Term Definition Evidence

BP

GO:0006094

gluconeogenesis

The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.

TAS

BP

GO:0006351

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

IEA

BP

GO:0009615

response to virus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.

IEP

BP

GO:0030308

negative regulation of cell growth

Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.

IDA

BP

GO:0045892

negative regulation of transcription, DNA-templated

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

IDA|IMP

BP

GO:0061621

canonical glycolysis

The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.

TAS

BP

GO:0098609

cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules.

IEA

CC

GO:0000015

phosphopyruvate hydratase complex

A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water.

IEA

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IC|IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IEA

CC

GO:0005913

cell-cell adherens junction

An adherens junction which connects a cell to another cell.

IDA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0031430

M band

The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IEA

MF

GO:0003677

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

IEA

MF

GO:0004634

phosphopyruvate hydratase activity

Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

MF

GO:0051020

GTPase binding

Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.

IPI

MF

GO:0098641

cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.

IDA

Domain ID Description

IPR000941

Enolase

IPR020809

Enolase, conserved site

IPR020810

Enolase, C-terminal TIM barrel domain

IPR020811

Enolase, N-terminal

IPR029017

Enolase N-terminal domain-like

IPR029065

Enolase C-terminal domain-like

IPR034390

Enolase-like superfamily

Pathway ID Pathway Term Pathway Source

hsa00010

Glycolysis / Gluconeogenesis

KEGG

hsa01100

Metabolic pathways

KEGG

hsa01200

Carbon metabolism

KEGG

hsa01230

Biosynthesis of amino acids

KEGG

hsa03018

RNA degradation

KEGG

hsa04066

HIF-1 signaling pathway

KEGG

WP534

Glycolysis and Gluconeogenesis

WikiPathways

h_glycolysisPathway

Glycolysis Pathway

BioCarta

UMLS CUI UMLS Term

C0001418

Adenocarcinoma

C0002395

Alzheimer'S Disease

C0003873

Rheumatoid Arthritis

C0007131

Non-Small Cell Lung Carcinoma

C0007137

Squamous Cell Carcinoma

C0014859

Esophageal Neoplasms

C0024667

Animal Mammary Neoplasms

C0024668

Mammary Neoplasms, Experimental

C0026640

Mouth Neoplasms

C0027626

Neoplasm Invasiveness

C0029408

Degenerative Polyarthritis

C0029456

Osteoporosis

C0038356

Stomach Neoplasms

C0520459

Necrotizing Enterocolitis

C0860207

Drug-Induced Liver Injury

C0948089

Acute Coronary Syndrome

C1458155

Mammary Neoplasms

C2239176

Liver Carcinoma

Tissue Cell Type

lung

pneumocytes

No databases found.

Pubmed ID Author Year Title

17900306

Borro et al.

2007

Proteomic analysis of peripheral T lymphocytes, suitable circulating biosensors of strictly related diseases

19141577

Kim et al.

2009

Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome

19820292

Misti et al.

2010

Proteomic profiles in hyperandrogenic syndromes

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

23824412

Piltonen et al.

2013

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

Gene Symbol Entrez ID Uniprot ID Score

AKR1B1

231

P15121

0.49

CALR

811

P27797

0.49

DUT

1854

P33316

0.49

FABP5

2171

Q01469

0.49

FKBP1A

2280

P62942

0.49

FKBP1B

2281

P68106

0.49

GPI

2821

P06744

0.49

ITPA

3704

Q9BY32

0.49

MIF

4282

P14174

0.49

PMP2

5375

P02689

0.49

PPIA

5478

P62937

0.49

PXN

5829

P49023

0.49

SRI

6717

P30626

0.49

TALDO1

6888

P37837

0.49

TXN

7295

P10599

0.49

UCHL3

7347

P15374

0.49

FKBP7

51661

Q9Y680

0.49

PUS7

54517

Q96PZ0

0.49

NIT2

56954

Q9NQR4

0.49

AKR1B15

441282

C9JRZ8

0.49

PEF1

553115

Q9UBV8

0.49

CXCL2

2920

P19875

0.55

EEF2

1938

P13639

0.56

ENO3

2027

P13929

0.56

PGAM1

5223

P18669

0.56

GAPDH

2597

P04406

0.59

AARS

16

P49588

0.63

ACACA

31

Q13085

0.63

ACO1

48

P21399

0.63

BIN1

274

O00499

0.63

ANXA1

301

P04083

0.63

SERPING1

710

P05155

0.63

RCC1

1104

P18754

0.63

CHD3

1107

Q12873

0.63

COPB1

1315

P53618

0.63

CPT1A

1374

P50416

0.63

DHX8

1659

Q14562

0.63

DHX15

1665

O43143

0.63

CYB5R3

1727

P00387

0.63

E2F4

1874

Q16254

0.63

EEF1B2

1933

P24534

0.63

EP300

2033

Q09472

0.63

STX2

2054

P32856

0.63

FBL

2091

P22087

0.63

EFEMP1

2202

Q12805

0.63

FHL1

2273

Q13642

0.63

XRCC6

2547

P12956

0.63

GSTM3

2947

P21266

0.63

HDAC2

3066

Q92769

0.63

HDGF

3068

P51858

0.63

HNRNPD

3184

Q14103

0.63

HNRNPH3

3189

P31942

0.63

HSPA8

3312

P11142

0.63

LMNA

4000

P02545

0.63

M6PR

4074

P20645

0.63

MVK

4598

Q03426

0.63

MYO1E

4643

Q12965

0.63

MYO6

4646

Q9UM54

0.63

NAB1

4664

Q13506

0.63

HNRNPM

4670

P52272

0.63

NAP1L4

4676

Q99733

0.63

NFATC3

4775

Q12968

0.63

PNP

4860

P00491

0.63

NUMA1

4926

Q14980

0.63

OGDH

4967

Q02218

0.63

POLA1

5422

P09884

0.63

PPP2R5E

5529

Q16537

0.63

PPP5C

5536

P53041

0.63

PTPN9

5780

P43378

0.63

RBMS2

5939

Q15434

0.63

SET

6418

Q01105

0.63

SRSF7

6432

Q16629

0.63

SMARCE1

6605

Q969G3

0.63

STK10

6793

O94804

0.63

SUPT5H

6829

O00267

0.63

TEAD1

7003

P28347

0.63

THRA

7067

P10827

0.63

TP53BP1

7158

Q12888

0.63

TSG101

7251

Q99816

0.63

TTN

7273

Q8WZ42

0.63

COL14A1

7373

Q05707

0.63

ZNF16

7564

P17020

0.63

IFRD2

7866

Q12894

0.63

CLTCL1

8218

P53675

0.63

HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI

8339

P62807

0.63

PPFIBP1

8496

Q86W92

0.63

NIPSNAP1

8508

Q9BPW8

0.63

TCAP

8557

O15273

0.63

YARS

8565

P54577

0.63

MPDZ

8777

O75970

0.63

BTRC

8945

Q9Y297

0.63

DEDD

9191

O75618

0.63

CRLF1

9244

O75462

0.63

KIF23

9493

Q02241

0.63

PMPCB

9512

O75439

0.63

NCOR1

9611

O75376

0.63

MTFR1

9650

Q15390

0.63

RNF10

9921

Q8N5U6

0.63

MED13

9969

Q9UHV7

0.63

ARPC4

10093

P59998

0.63

BCAP31

10134

P51572

0.63

MBNL2

10150

Q5VZF2

0.63

ABI2

10152

Q9NYB9

0.63

STX6

10228

O43752

0.63

STUB1

10273

Q9UNE7

0.63

SF3A1

10291

Q15459

0.63

YAP1

10413

P46937

0.63

NOP56

10528

O00567

0.63

PRDX4

10549

Q13162

0.63

CCT7

10574

Q99832

0.63

FARS2

10667

O95363

0.63

EBP

10682

Q15125

0.63

NUDC

10726

Q9Y266

0.63

ASCC3

10973

Q8N3C0

0.63

C14orf1

11161

Q9UKR5

0.63

CEP250

11190

Q9BV73

0.63

XRN2

22803

Q9H0D6

0.63

SCAF8

22828

Q9UPN6

0.63

DHX30

22907

Q7L2E3

0.63

KDM2A

22992

Q9Y2K7

0.63

XPO7

23039

Q9UIA9

0.63

ENDOD1

23052

O94919

0.63

POGZ

23126

Q7Z3K3

0.63

NUP205

23165

Q92621

0.63

KANK1

23189

Q14678

0.63

AGTPBP1

23287

Q9UPW5

0.63

NCAPD3

23310

P42695

0.63

HEY2

23493

Q9UBP5

0.63

POFUT1

23509

Q9H488

0.63

PITPNB

23760

P48739

0.63

LETMD1

25875

Q6P1Q0

0.63

POLR1A

25885

O95602

0.63

OSBPL3

26031

Q9H4L5

0.63

SZRD1

26099

Q7Z422

0.63

FBXO5

26271

Q9UKT4

0.63

PRPF19

27339

Q9UMS4

0.63

DCPS

28960

Q96C86

0.63

SH3KBP1

30011

Q96B97

0.63

TXNDC11

51061

Q6PKC3

0.63

MRPL37

51253

Q9BZE1

0.63

UBAP1

51271

Q9NZ09

0.63

SCARA3

51435

Q6AZY7

0.63

DPH5

51611

Q9H2P9

0.63

SLC25A39

51629

Q9BZJ4

0.63

RAPGEF6

51735

Q8TEU7

0.63

LUC7L3

51747

O95232

0.63

ERAP1

51752

Q9NZ08

0.63

POLE3

54107

Q9NRF9

0.63

RHOF

54509

Q9HBH0

0.63

MPHOSPH8

54737

Q99549

0.63

QRICH1

54870

Q2TAL8

0.63

PDPR

55066

Q8NCN5

0.63

CEP192

55125

Q8TEP8

0.63

MED29

55588

Q9NX70

0.63

NPLOC4

55666

Q8TAT6

0.63

IWS1

55677

Q96ST2

0.63

VPS35

55737

Q96QK1

0.63

NAXD

55739

Q8IW45

0.63

TXLNG

55787

Q9NUQ3

0.63

CDC42SE1

56882

Q9NRR8

0.63

ZNFX1

57169

Q9P2E3

0.63

GATAD1

57798

Q8WUU5

0.63

RBM25

58517

P49756

0.63

NTN4

59277

Q9HB63

0.63

TNS3

64759

Q68CZ2

0.63

C8orf33

65265

Q9H7E9

0.63

SNRNP25

79622

Q9BV90

0.63

FAT4

79633

Q6V0I7

0.63

MORC4

79710

Q8TE76

0.63

IPO4

79711

Q8TEX9

0.63

ISOC2

79763

Q96AB3

0.63

CPSF7

79869

Q8N684

0.63

THOC7

80145

Q6I9Y2

0.63

CYB5B

80777

O43169

0.63

DIAPH3

81624

Q9NSV4

0.63

RAB34

83871

Q9BZG1

0.63

TOMM40L

84134

Q969M1

0.63

STRIP1

85369

Q5VSL9

0.63

KNSTRN

90417

Q9Y448

0.63

ANKRD40

91369

Q6AI12

0.63

SYT12

91683

Q8IV01

0.63

VPS26B

112936

Q4G0F5

0.63

LRRC42

115353

Q9Y546

0.63

KLHDC3

116138

Q9BQ90

0.63

HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4

121504

P62805

0.63

WDR81

124997

Q562E7

0.63

GIPC3

126326

Q8TF64

0.63

DCLK2

166614

Q8N568

0.63

GLIS3

169792

Q8NEA6

0.63

HIST2H2AB

317772

Q8IUE6

0.63

MYO18A

399687

Q92614

0.63

SNORA6

574040

N/A

0.63

PGK1

5230

P00558

0.65

TPI1

7167

P60174

0.65

PDE4DIP

9659

Q5VU43

0.65

HSPA9

3313

P38646

0.70

HSP90AB1

3326

P08238

0.70

ATP5J

522

P18859

0.73

CAT

847

P04040

0.73

PCNA

5111

P12004

0.75

HDAC1

3065

Q13547

0.84

TRAPPC2

6399

P0DI81

0.87

ABAT

18

P80404

0.49

CFL1

1072

P23528

0.49

FH

2271

P07954

0.49

FKBP2

2286

P26885

0.49

GPX4

2879

P36969

0.49

HSD17B10

3028

Q99714

0.49

HINT1

3094

P49773

0.49

LDHA

3939

P00338

0.49

LDHB

3945

P07195

0.49

MSN

4478

P26038

0.49

NME2

4831

P22392

0.49

PCMT1

5110

P22061

0.49

PGM1

5236

P36871

0.49

PPIB

5479

P23284

0.49

RCN1

5954

Q15293

0.49

RDX

5962

P35241

0.49

SOD1

6647

P00441

0.49

TAGLN

6876

Q01995

0.49

TKT

7086

P29401

0.49

EZR

7430

P15311

0.49

TAGLN2

8407

P37802

0.49

ALDH4A1

8659

P30038

0.49

WDR1

9948

O75083

0.49

PDCD6IP

10015

Q8WUM4

0.49

ACAA2

10449

P42765

0.49

PARK7

11315

Q99497

0.49

TAGLN3

29114

Q9UI15

0.49

CLK1

1195

P49759

0.52

ACTB

60

P60709

0.55

PGK2

5232

P07205

0.56

FYN

2534

P06241

0.62

AKT1

207

P31749

0.63

AMBP

259

P02760

0.63

BCL6

604

P41182

0.63

BRCA1

672

P38398

0.63

CD4

920

P01730

0.63

CDK2

1017

P24941

0.63

DES

1674

P17661

0.63

ESR1

2099

P03372

0.63

FANCA

2175

O15360

0.63

FUS

2521

P35637

0.63

GJA1

2697

P17302

0.63

GRB2

2885

P62993

0.63

HK2

3099

P52789

0.63

HNRNPA1

3178

P09651

0.63

HSPB2

3316

Q16082

0.63

ITGA4

3676

P13612

0.63

ITGB1

3688

P05556

0.63

JUN

3725

P05412

0.63

MCM2

4171

P49736

0.63

MCM5

4174

P33992

0.63

MDM2

4193

Q00987

0.63

NFKB1

4790

P19838

0.63

NPM1

4869

P06748

0.63

NTRK1

4914

P04629

0.63

MAPK13

5603

O15264

0.63

MAP2K5

5607

Q13163

0.63

PSMA3

5684

P25788

0.63

SGCG

6445

Q13326

0.63

SNAPC3

6619

Q92966

0.63

SRC

6714

P12931

0.63

STAU1

6780

O95793

0.63

TERT

7015

O14746

0.63

SUMO1

7341

P63165

0.63

CUL5

8065

Q93034

0.63

CUL4B

8450

Q13620

0.63

CUL4A

8451

Q13619

0.63

CUL3

8452

Q13618

0.63

CUL2

8453

Q13617

0.63

CUL1

8454

Q13616

0.63

BHLHE40

8553

O14503

0.63

EED

8726

O75530

0.63

MDC1

9656

Q14676

0.63

KIAA0101

9768

Q15004

0.63

CUL7

9820

Q14999

0.63

HUWE1

10075

Q7Z6Z7

0.63

AHSA1

10598

O95433

0.63

COPS5

10987

Q92905

0.63

CHEK2

11200

O96017

0.63

GABARAP

11337

O95166

0.63

GABARAPL2

11345

P60520

0.63

EMC1

23065

Q8N766

0.63

FAF2

23197

Q96CS3

0.63

OBSL1

23363

O75147

0.63

CBX5

23468

P45973

0.63

GABARAPL1

23710

Q9H0R8

0.63

UPF2

26019

Q9HAU5

0.63

FBXO25

26260

Q8TCJ0

0.63

FBXO6

26270

Q9NRD1

0.63

ZBTB44

29068

Q8NCP5

0.63

INSIG2

51141

Q9Y5U4

0.63

WWOX

51741

Q9NZC7

0.63

PAF1

54623

Q8N7H5

0.63

HEMGN

55363

Q9BXL5

0.63

OTUB1

55611

Q96FW1

0.63

PARVA

55742

Q9NVD7

0.63

CAND1

55832

Q86VP6

0.63

ARID1B

57492

Q8NFD5

0.63

TXNDC16

57544

Q9P2K2

0.63

LONRF3

79836

Q496Y0

0.63

MAP1LC3B

81631

Q9GZQ8

0.63

CCDC8

83987

Q9H0W5

0.63

ACHE

43

P22303

0.65

MYOC

4653

Q99972

0.65

SUMO4

387082

Q6EEV6

0.65

HTT

3064

P42858

0.68

YWHAQ

10971

P27348

0.68

ENO2

2026

P09104

0.70

ATF2

1386

P15336

0.72

FN1

2335

P02751

0.72

H2AFX

3014

P16104

0.72

LIG4

3981

P49917

0.72

RAD52

5893

P43351

0.72

MAP3K7

6885

O43318

0.72

RIPK2

8767

O43353

0.72

ATP6AP2

10159

O75787

0.72

ALDOA

226

P04075

0.73

FLNC

2318

Q14315

0.73

P4HB

5034

P07237

0.73

SUMO3

6612

P55854

0.73

UBD

10537

O15205

0.73

ISG15

9636

P05161

0.74

SUMO2

6613

P61956

0.79

VCAM1

7412

P19320

0.82

IVNS1ABP

10625

Q9Y6Y0

0.83

PLG

5340

P00747

0.86

YWHAZ

7534

P63104

0.89