| Gene Symbol | PRUNE2 |
| Entrez ID | 158471 |
| Uniprot ID | Q8WUY3 |
| Description | prune homolog 2 (Drosophila) |
| Chromosomal Location | chr9: 76,611,376-76,906,087 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006915 |
apoptotic process |
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
IBA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IEA |
|
MF |
GO:0016462 |
pyrophosphatase activity |
Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments. |
IEA |
|
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR001251 |
CRAL-TRIO lipid binding domain |
|
IPR004097 |
DHHA2 domain |
|
IPR022181 |
Bcl2-/adenovirus E1B 19kDa-interacting protein 2 |
| Tissue | Cell Type |
|---|---|
|
bronchus |
respiratory epithelial cells |
|
caudate |
neuronal cells |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
kidney |
cells in tubules |
|
liver |
hepatocytes |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
rectum |
glandular cells |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
soft tissue |
chondrocytes |
|
soft tissue |
peripheral nerve |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
DYNC1H1 |
1778 |
Q14204 |
0.63 |
|
DYNC1I2 |
1781 |
Q13409 |
0.63 |
|
DYNC1LI2 |
1783 |
O43237 |
0.63 |
|
RPSA |
3921 |
P08865 |
0.63 |
|
RPS5 |
6193 |
P46782 |
0.63 |
|
RPS24 |
6229 |
P62847 |
0.63 |
|
RPS26 |
6231 |
P62854 |
0.63 |
|
EIF3K |
27335 |
Q9UBQ5 |
0.63 |
|
EIF2A |
83939 |
Q9BY44 |
0.63 |
|
EWSR1 |
2130 |
Q01844 |
0.63 |
|
LYN |
4067 |
P07948 |
0.63 |
|
RCN3 |
57333 |
Q96D15 |
0.63 |