| Gene Symbol | EIF5 |
| Entrez ID | 1983 |
| Uniprot ID | P55010 |
| Description | eukaryotic translation initiation factor 5 |
| Chromosomal Location | chr14: 103,333,544-103,345,025 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0001731 |
formation of translation preinitiation complex |
The joining of the small ribosomal subunit, ternary complex, and mRNA. |
IEA |
|
BP |
GO:0006413 |
translational initiation |
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
NAS |
|
BP |
GO:0006446 |
regulation of translational initiation |
Any process that modulates the frequency, rate or extent of translational initiation. |
IDA |
|
BP |
GO:0090630 |
activation of GTPase activity |
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
IEA |
|
BP |
GO:0098609 |
cell-cell adhesion |
The attachment of one cell to another cell via adhesion molecules. |
IEA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
NAS|TAS |
|
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IDA |
|
CC |
GO:0005913 |
cell-cell adherens junction |
An adherens junction which connects a cell to another cell. |
IDA |
|
MF |
GO:0003743 |
translation initiation factor activity |
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
NAS |
|
MF |
GO:0003924 |
GTPase activity |
Catalysis of the reaction: GTP + H2O = GDP + phosphate. |
TAS |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0005525 |
GTP binding |
Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
IEA |
|
MF |
GO:0008135 |
translation factor activity, RNA binding |
Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome. |
TAS |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
|
MF |
GO:0071074 |
eukaryotic initiation factor eIF2 binding |
Interacting selectively and non-covalently with eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation. |
IEA |
|
MF |
GO:0098641 |
cadherin binding involved in cell-cell adhesion |
Any cadherin binding that occurs as part of the process of cell-cell adhesion. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR002735 |
Translation initiation factor IF2/IF5 |
|
IPR003307 |
W2 domain |
|
IPR016024 |
Armadillo-type fold |
|
IPR016189 |
Translation initiation factor IF2/IF5, N-terminal |
|
IPR016190 |
Translation initiation factor IF2/IF5, zinc-binding |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa03013 |
RNA transport |
KEGG |
|
WP107 |
Translation Factors |
WikiPathways |
|
h_eifPathway |
Eukaryotic protein translation |
BioCarta |
|
h_eif2Pathway |
Regulation of eIF2 |
BioCarta |
| UMLS CUI | UMLS Term |
|---|---|
|
C0036341 |
Schizophrenia |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
epididymis |
glandular cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
lung |
macrophages |
|
lymph node |
germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
skin |
keratinocytes |
|
skin |
melanocytes |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
squamous epithelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
CHD4 |
1108 |
Q14839 |
0.49 |
|
RPL29 |
6159 |
P47914 |
0.49 |
|
SRSF2 |
6427 |
Q01130 |
0.49 |
|
CHD5 |
26038 |
Q8TDI0 |
0.49 |
|
BZW2 |
28969 |
Q9Y6E2 |
0.49 |
|
EIF1AY |
9086 |
O14602 |
0.52 |
|
APP |
351 |
P05067 |
0.56 |
|
EIF2S1 |
1965 |
P05198 |
0.56 |
|
RPS6 |
6194 |
P62753 |
0.56 |
|
EIF3I |
8668 |
Q13347 |
0.56 |
|
EIF1 |
10209 |
P41567 |
0.56 |
|
CAPNS1 |
826 |
P04632 |
0.63 |
|
TBCB |
1155 |
Q99426 |
0.63 |
|
DFFA |
1676 |
O00273 |
0.63 |
|
GLA |
2717 |
P06280 |
0.63 |
|
HNRNPK |
3190 |
P61978 |
0.63 |
|
HSPA9 |
3313 |
P38646 |
0.63 |
|
NRGN |
4900 |
Q92686 |
0.63 |
|
PAFAH1B1 |
5048 |
P43034 |
0.63 |
|
PDHB |
5162 |
P11177 |
0.63 |
|
PCYT2 |
5833 |
Q99447 |
0.63 |
|
SNRPD1 |
6632 |
P62314 |
0.63 |
|
EIF4H |
7458 |
Q15056 |
0.63 |
|
YWHAE |
7531 |
P62258 |
0.63 |
|
YWHAH |
7533 |
Q04917 |
0.63 |
|
YWHAZ |
7534 |
P63104 |
0.63 |
|
PUM1 |
9698 |
Q14671 |
0.63 |
|
YWHAQ |
10971 |
P27348 |
0.63 |
|
DUSP12 |
11266 |
Q9UNI6 |
0.63 |
|
MAT2B |
27430 |
Q9NZL9 |
0.63 |
|
ISOC1 |
51015 |
Q96CN7 |
0.63 |
|
SCLY |
51540 |
Q96I15 |
0.63 |
|
UBFD1 |
56061 |
O14562 |
0.63 |
|
TUBB |
203068 |
P07437 |
0.63 |
|
EIF1AX |
1964 |
P47813 |
0.84 |
|
LMNA |
4000 |
P02545 |
0.49 |
|
BZW1 |
9689 |
Q7L1Q6 |
0.49 |
|
EIF4G2 |
1982 |
P78344 |
0.52 |
|
EIF3D |
8664 |
O15371 |
0.52 |
|
NCBP2 |
22916 |
P52298 |
0.52 |
|
CSNK2A1 |
1457 |
P68400 |
0.55 |
|
CSNK2B |
1460 |
P67870 |
0.55 |
|
DDX3X |
1654 |
O00571 |
0.55 |
|
EIF4G1 |
1981 |
Q04637 |
0.55 |
|
EIF2B2 |
8892 |
P49770 |
0.56 |
|
ALDH7A1 |
501 |
P49419 |
0.63 |
|
G6PD |
2539 |
P11413 |
0.63 |
|
GNAI3 |
2773 |
P08754 |
0.63 |
|
HSPB1 |
3315 |
P04792 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
PFAS |
5198 |
O15067 |
0.63 |
|
VCL |
7414 |
P18206 |
0.63 |
|
XPO1 |
7514 |
O14980 |
0.63 |
|
SLC30A4 |
7782 |
O14863 |
0.63 |
|
STK24 |
8428 |
Q9Y6E0 |
0.63 |
|
IKBKE |
9641 |
Q14164 |
0.63 |
|
HUWE1 |
10075 |
Q7Z6Z7 |
0.63 |
|
FERMT2 |
10979 |
Q96AC1 |
0.63 |
|
DDA1 |
79016 |
Q9BW61 |
0.63 |
|
EIF3B |
8662 |
P55884 |
0.65 |
|
FN1 |
2335 |
P02751 |
0.72 |
|
EIF3G |
8666 |
O75821 |
0.91 |
|
EIF2S2 |
8894 |
P20042 |
0.94 |